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Information on EC 3.3.2.9 - microsomal epoxide hydrolase

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EC Tree
     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.9 microsomal epoxide hydrolase
IUBMB Comments
This is a key hepatic enzyme that is involved in the metabolism of numerous xenobiotics, such as 1,3-butadiene oxide, styrene oxide and the polycyclic aromatic hydrocarbon benzo[a]pyrene 4,5-oxide [5--7]. In a series of oxiranes with a lipophilic substituent of sufficient size (styrene oxides), monosubstituted as well as 1,1- and cis-1,2-disubstituted oxiranes serve as substrates or inhibitors of the enzyme. However, trans-1,2-disubstituted, tri-and tetra-substituted oxiranes are not substrates . The reaction involves the formation of an hydroxyalkyl---enzyme intermediate . In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase) .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
meh, ephx1, mephx, jh epoxide hydrolase, juvenile hormone epoxide hydrolase, xenobiotic epoxide hydrolase, e1-b', microsomal xenobiotic epoxide hydrolase, xehase, tcjheh-r3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol
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(2)
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cis-stilbene oxide + H2O = (1R,2R)-1,2-diphenylethane-1,2-diol
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PATHWAY SOURCE
PATHWAYS