Cloned (Comment) | Organism |
---|---|
expression pattern of mEH | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00025 | - |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.0005 | - |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.001 | - |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.001 | - |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | specific nuclei | Mus musculus | - |
astrocyte | - |
Mus musculus | - |
brain | mEH distribution, immunohistochemical analysis, overview. mEH immunoreactivity is present in specific neuronal populations of the hippocampus, striatum, amygdala, and cerebellum, as well as in a fraction of astrocytes | Mus musculus | - |
cerebellum | - |
Mus musculus | - |
choroid plexus | - |
Mus musculus | - |
corpus striatum | - |
Mus musculus | - |
hindbrain | specific nuclei | Mus musculus | - |
hippocampus | - |
Mus musculus | - |
midbrain | specific nuclei | Mus musculus | - |
neuron | - |
Mus musculus | - |
vascular cell | endothelial and smooth muscle cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mEH | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | epoxide hydrolases comprise a family of enzymes important in detoxification and conversion of lipid signaling molecules, namely epoxyeicosatrienoic acids. Microsomal epoxide hydrolase is involved in the cerebral epoxyeicosatrienoic acid metabolism | Mus musculus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.01 | - |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.02 | - |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid | - |
Mus musculus | |
5 | - |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid | - |
Mus musculus |