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Literature summary for 3.3.2.9 extracted from

  • Li, X.Q.; Hayes, M.A.; Groenberg, G.; Berggren, K.; Castagnoli, N.Jr.; Weidolf, L.
    Discovery of a novel microsomal epoxide hydrolase-catalyzed hydration of a spiro oxetane (2016), Drug Metab. Dispos., 44, 1341-1348.
    View publication on PubMed
Search for more literature for 3.3.2.9

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by trans-4-[4-(1-adamantylcarbamoylamino)cyclohexyloxy] benzoic acid Homo sapiens
progabide less than 20% residual activity at 0.02 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.542
-
 (3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-ethoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone at pH 7.4 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cis-stilbene oxide + H2O Homo sapiens
-
 (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-ethoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone + H2O
-
 Homo sapiens (3-[4-[([[3-(hydroxymethyl)oxetan-3-yl]methyl]amino)methyl]phenoxy]azetidin-1-yl)[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
-
 ?
(3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-ethoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone + H2O
-
 Homo sapiens ?
-
 ?
(3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-ethoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone + H2O
-
 Homo sapiens [3-(4-[[3,3-bis(hydroxymethyl)azetidin-1-yl]methyl]phenoxy)azetidin-1-yl][5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methanone
-
 ?
cis-stilbene oxide + H2O
-
 Homo sapiens (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Synonyms

Synonyms Comment Organism
mEH
-
 Homo sapiens