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Disease on EC 3.3.2.9 - microsomal epoxide hydrolase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
abc-type xenobiotic transporter deficiency
Effect of ABCC2 (MRP2) Transport Function on Erythromycin Metabolism.
Aberrant Crypt Foci
Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice.
[Effects of astragalosides on induction of colorectal aberrant crypt foci by dimethylhydrazine and metabolizing enzymes in liver microsomes in rats]
Abetalipoproteinemia
17?-Estradiol-Induced Conformational Changes of Human Microsomal Triglyceride Transfer Protein: A Computational Molecular Modelling Study.
A 30-amino acid truncation of the microsomal triglyceride transfer protein large subunit disrupts its interaction with protein disulfide-isomerase and causes abetalipoproteinemia.
A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.
A Male Infant with Abetalipoproteinemia: A Case Report from Iran.
A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triglyceride transfer protein that prevents complex formation with protein disulfide isomerase.
A severe form of abetalipoproteinemia caused by new splicing mutations of microsomal triglyceride transfer protein.
Abetalipoproteinemia caused by maternal isodisomy of chromosome 4q containing an intron 9 splice acceptor mutation in the microsomal triglyceride transfer protein gene.
Abetalipoproteinemia Due to a Novel Splicing Variant in MTTP in 3 Siblings.
Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein.
Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia.
Adenovirus-mediated overexpression of microsomal triglyceride transfer protein (MTP): mechanistic studies on the role of MTP in apolipoprotein B-100 biogenesis.
An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.
An Unusual Presentation of Hemorrhagic Disease in an Infant: A Probable Case of Abetalipoproteinemia.
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice.
Apolipoprotein B48 glycosylation in abetalipoproteinemia and Anderson's disease.
Chronic adrenal failure and hypergonadotropic hypogonadism in a patient with abetalipoproteinemia.
Contemporary aspects of the biology and therapeutic regulation of the microsomal triglyceride transfer protein.
Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease.
Hypobetalipoproteinemia with an apparently recessive inheritance due to a "de novo" mutation of apolipoprotein B.
Identification of two classes of lipid molecule binding sites on the microsomal triglyceride transfer protein.
Identification of two novel mutations and long-term follow-up in abetalipoproteinemia: a report of four cases.
Impaired Chylomicron Assembly Modifies Hepatic Metabolism Through Bile Acid-Dependent and Transmissible Microbial Adaptations.
Insights from human congenital disorders of intestinal lipid metabolism.
Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.
Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress.
Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia.
Microsomal triglyceride transfer protein (MTP) gene mutations in Canadian subjects with abetalipoproteinemia.
Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells.
Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia.
Mutations in MTP gene in abeta- and hypobeta-lipoproteinemia.
Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia.
Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal ?-Barrel in Microsomal Triglyceride Transfer Protein Function.
Novel mutations in microsomal triglyceride transfer protein including maternal uniparental disomy in two patients with abetalipoproteinemia.
Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.
Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects.
The genetic basis of primary disorders of intestinal fat transport.
The hypobetalipoproteinemias.
The role of the microsomal triglygeride transfer protein in abetalipoproteinemia.
Update on the molecular biology of dyslipidemias.
Using genetically engineered mice to understand apolipoprotein-B deficiency syndromes in humans.
[An adult case of probable Bassen-Kornzweig syndrome, presenting resting tremor]
[Apolipoprotein B]
[Microsomal triglyceride transfer protein and abetalipoproteinemia]
Abnormalities, Multiple
Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases. A new variant of congenital adrenal hyperplasia.
Abortion, Spontaneous
Analysis of the EPHX1 113 polymorphism and GSTM1 homozygous null polymorphism and oral clefting associated with maternal smoking.
Effects of autoantibodies on the course of pregnancy and fetal growth.
Microsomal epoxide hydrolase polymorphism and risk of spontaneous abortion.
Abruptio Placentae
Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption.
Acidosis
Lysophosphatidylcholine metabolism in the rabbit heart. Characterization of metabolic pathways and partial purification of myocardial lysophospholipase-transacylase.
Regulation of lysophosphatidylcholine-metabolizing enzymes in isolated myocardial cells from rat heart.
The role of acid-base imbalance in statin-induced myotoxicity.
Acne Vulgaris
13-cis-retinoic acid stimulates in vitro mannose 6-phosphate hydrolysis and inhibits retinol esterification and benzo[a]pyrene hydroxylation by rat-liver microsomes.
Acute Kidney Injury
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation.
Pharmacokinetic changes of drugs in rat model of acute renal failure induced by uranyl nitrate: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes.
[Changes in hepatic microsomal cytochrome P-450 in glycerol rechallenged acute renal failure rats]
[Effects of the calcium-channel blocker diltiazem on gentamicin-induced nephrotoxicity in rats]
Addison Disease
Associated autoimmunity in Addison's disease.
Clinical profile and prognosis of Addison's disease in India.
[Diabetes mellitus type I, thyroid gland autoimmunity, thyroid gland function and HLA status]
[The incidence of the pituitary autoantibodies in Addison disease]
[Tubercular Addison's disease with high titers of microsomal thyroid antibodies and reduced thyroid function reserve]
Adenocarcinoma
Acyl specificity in triacylglycerol synthesis by mammary adenocarcinoma R3230AC in Fischer rats.
Associations between genetic polymorphisms of Phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma.
EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.
Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines.
Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma.
Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition.
Reduced expression of the low affinity nerve growth factor receptor in benign and malignant human prostate tissue and loss of expression in four human metastatic prostate tumor cell lines.
The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer.
Adenocarcinoma of Lung
Knockdown of microsomal glutathione S-transferase 1 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.
Adenoma
A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas.
A simple semiquantitative radiometric measurement of antithyroglobulin antibodies in human serum. Comparison with hemagglutination method.
Colorectal polyp type and the association with charred meat consumption, smoking, and microsomal epoxide hydrolase polymorphisms.
Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study.
High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens.
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome.
Levels of cytochrome P-450, steroidogenesis and microsomal and cytosolic epoxide hydrolases in normal human adrenal tissue and corresponding tumors.
Loss of microsomal antigen in follicular and papillary carcinoma of the thyroid. An immunofluorescence and electron-microscopic study.
Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas.
Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma.
Microsomal reductase activity in patients with thyroid neoplasms.
Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study.
Steroid 21-hydroxylase and 17 alpha-hydroxylase in microsomal fraction of functioning adrenocortical tumors.
Subcellular site and mechanism of synthesis of disaturated phosphatidylcholine in alveolar type II cell adenomas.
System review and metaanalysis of the relationships between five metabolic gene polymorphisms and colorectal adenoma risk.
Transmembrane orientation of palmitoyl-CoA: lysophosphatidylcholine acyltransferase in microsomes isolated from an alveolar type II cell adenoma and rat liver.
Two-year carcinogenicity study in rats with a nonnucleoside reverse transcriptase inhibitor.
[Enzymohistochemical and immunomorphological study of experimental thyroid gland carcinoma]
[The concentration of nucleic acids in the subcellular structures of the thyroid gland in several of its diseases]
Adenoma, Islet Cell
Lipid composition of glucose-stimulated pancreatic islets and insulin-secreting tumor cells.
Adrenal Hyperplasia, Congenital
Characterisation of CAH alleles with non-radioactive DNA single strand conformation polymorphism analysis of the CYP21 gene.
Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases. A new variant of congenital adrenal hyperplasia.
Adrenal Insufficiency
Mechanism of adrenal insufficiency following trauma and severe hemorrhage: role of hepatic 11beta-hydroxysteroid dehydrogenase.
Adrenocortical Carcinoma
Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinoma.
Levels of cytochrome P-450, steroidogenesis and microsomal and cytosolic epoxide hydrolases in normal human adrenal tissue and corresponding tumors.
Adrenogenital Syndrome
Steroid 21-hydroxylase and 17 alpha-hydroxylase in microsomal fraction of functioning adrenocortical tumors.
Adrenoleukodystrophy
Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.
Metabolic studies of adrenoleukodystrophy.
Agranulocytosis
Drug-protein conjugates--XIV. Mechanisms of formation of protein-arylating intermediates from amodiaquine, a myelotoxin and hepatotoxin in man.
The cytotoxicity of clozapine metabolites: implications for predicting clozapine-induced agranulocytosis.
Alopecia
Male-pattern baldness in men with X-linked recessive ichthyosis.
Alopecia Areata
Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.
Prevalence of thyroid diseases in patients with alopecia areata.
[Autoimmunity in alopecia areata. An assessment in 100 patients]
Alzheimer Disease
Decreased prostaglandin synthesis in postmortem cerebral cortex from patients with Alzheimer's disease.
Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease.
Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin.
[Investigation of changes in fluidity of brain membranes in mice bearing experimental Alzheimer's disease using spin labeling electron paramagnetic resonance].
[The incidence of the thyroid microsomal autoantibodies in Alzheimer disease.]
[Trends in nonsteroidal anti-inflammatory drug development and application]
Amyotrophic Lateral Sclerosis
Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE(2) production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
Anaphylaxis
The syndrome of thyroid autoimmunity and idiopathic chronic urticaria and angioedema presenting as anaphylaxis.
[Effect of glycine on liver cytochrome P-450 and severity of experimental food anaphylaxis]
Anemia
13C-Methacetin metabolism in patients with cirrhosis: relation to disease severity, haemoglobin content and oxygen supply.
Effects of oral contraceptive steroids (norethisterone/mestranol) on the activities of hepatic drug-metabolizing enzymes in iron-deficient anemic rats.
Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia.
Measles antibodies and autoantibodies in autoimmune disorders.
Anemia, Aplastic
Genetic polymorphisms of glutathione-S-transferase and microsomal epoxide hydrolase in egyptian acquired aplastic anemia patients.
The clinical relevance and prognostic significance of microsomal epoxide hydrolase gene polymorphisms and their susceptibility to acquired aplastic anemia: an Egyptian study.
Anemia, Hemolytic
Bullous pemphigoid after liver transplantation for liver failure.
Human spleen heme oxygenase and microsomal electron transport system component activity in normals and in patients with hemolytic anemia, idiopathic thrombocytopenic purpura, and lymphoproliferative disorders.
Long-term outcome of autoimmune hepatitis in children.
Anemia, Pernicious
65-70 kD protein identified by immunoblotting as the presumptive gastric microsomal autoantigen in pernicious anaemia.
Isolation of parietal cells from guinea-pig gastric mucosa and the immunological characterization of their antigenic structure.
The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H+/K(+)-ATPase (proton pump).
Anemia, Sickle Cell
Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia.
Anthracosis
[Gene variance in microsomal epoxide hydrolase and the susceptibility of coal workers' pneumoconiosis].
Antley-Bixler Syndrome Phenotype
P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes.
Aortic Aneurysm, Abdominal
Active smoking increases microsomal PGE2-synthase-1/PGE-receptor-4 axis in human abdominal aortic aneurysms.
Arbovirus Infections
[Behavior of microsomal mannosyl-transferases in cells carrying an arbovirus infection]
Arrhythmias, Cardiac
[Treatment of arrhythmia in patients with chronic ischemic heart disease using kinilentin combined with an inhibitor or inductor of microsomal oxidation]
Arthritis
Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation.
Antithyroid-antibody activity in the snyovial fluid of patients with various arthritides.
Dietary lipid and iron status modulate lipid peroxidation in rats with induced adjuvant arthritis.
Glucuronidation of R- and S-ketoprofen, acetaminophen, and diflunisal by liver microsomes of adjuvant-induced arthritic rats.
The effect of adjuvant-induced arthritis on rat liver microsomal phospholipid metabolism.
Arthritis, Experimental
Drug metabolism under pathological and abnormal physiological states in animals and man.
The effect of adjuvant-induced arthritis on rat liver microsomal phospholipid metabolism.
[Adjuvant arthritis. Its effect on the level of 3-chloro-4-benzyloxyphenylacetic acid and on the activity of the liver microsomal system]
[Influence of enzyme inducers and inhibitors of the metabolism of xenobiotics and of the coenzyme forms of vitamins B1 and B2 on the anti-inflammatory effect of voltaren]
Arthritis, Rheumatoid
A prospective evaluation of antithyroid antibody prevalence in 100 patients with rheumatoid arthritis.
Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis.
Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells.
Prostaglandin E2 synthesizing enzymes in rheumatoid arthritis B cells and the effects of B cell depleting therapy on enzyme expression.
Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy.
Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis.
[Seronegative hashitoxicosis in patient with rheumatoid arthritis]
[Thyroid autoantibodies in diabetes mellitus and rheumatoid arthritis]
arylsulfatase (type i) deficiency
Early diagnosis of recessive X-linked ichthyosis: elevation of cholesterol sulfate levels in placental sulfatase deficiency before the onset of skin symptoms.
[Microsomal sulfatase deficiency in X chromosome-linked ichthyosis]
Asbestosis
Biochemical mechanisms in asbestos toxicity.
Ascorbic Acid Deficiency
Ascorbic acid and hepatic drug metabolism.
Ascorbic acid deficiency and induction of hepatic microsomal hydroxylative enzymes by organochlorine pesticides.
Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats.
NADPH-dependent reduction of cytochrome P-450 in liver microsomes from vitamin C-deficient guinea pigs: effect of benzphetamine.
The effect of ascorbic acid deficiency on extrahepatic microsomal metabolism of drugs and carcinogens in the guinea pig.
The effect of certain vitamin deficiencies on hepatic drug metabolism.
The effect of protein quality and ascorbic acid deficiency stimulation of hepatic microsomal enzymes in guinea pigs.
Asthma
A rare case of Sjogren-Larsson syndrome with recurrent pneumonia and asthma.
EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis.
Gene polymorphism of xenobiotic detoxification in children with bronchial asthma.
Genetic architecture of transcript-level variation in humans.
Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma.
Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility.
IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.
Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma.
Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma.
Microsomal epoxide hydroxylase genotypes/diplotypes, traffic air pollution, and childhood asthma.
Optimization of substituted imidazobenzodiazepines as novel asthma treatments.
Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes.
[The function of 2 detoxifying body systems in workers of the petrochemical industry]
Asthma, Aspirin-Induced
Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations.
Astrocytoma
Cytotoxicity of alkyl-lysophospholipid derivatives and low-alkyl-cleavage enzyme activities in rat brain tumor cells.
Microsomal membrane proteome of low grade diffuse astrocytomas: Differentially expressed proteins and candidate surveillance biomarkers.
Atherosclerosis
Competitive inhibition of hepatic sterol 27-hydroxylase by sitosterol: decreased activity in sitosterolemia.
Decreased microsomal membrane fluidity in the development of cholesterol-induced atherosclerosis in the rabbit.
Effect of reticulo-endothelial blockade and stimulation on hepatic mitochondrial and microsomal lipids and atherosclerosis in cholesterol-fed cockerels.
Gene activation, apolipoprotein A-I/high density lipoprotein, atherosclerosis prevention and longevity.
Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation.
Inhibitors of the Microsomal Prostaglandin E(2) Synthase-1 as Alternative to Non Steroidal Anti-inflammatory Drugs (NSAIDs) - A Critical Review.
JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models.
MicroRNA-30c Mimic Mitigates Hypercholesterolemia and Atherosclerosis in Mice.
Microsomal enzyme induction, lipoproteins and atherosclerosis.
New Era of Lipid-Lowering Drugs.
Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase.
Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques.
Significance of various cholesterol, ester hydrolases in aorta.
The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial.
The possible role of Ca2+ on the activation of microsomal triglyceride transfer protein in rat hepatocytes.
[Biosynthesis and excretion of cholesterol in mice of line SWR with hereditary atherosclerosis and effects of multifunctional microsomal oxidase inducer on these processes]
[Change in the activity of the microsomal system of liver oxidation in rabbits in experimental atherosclerosis]
[Effect of the early postnatal induction of microsomal enzymes on their activity and the cholesterol content in the blood of adult mice from a hypercholesteremic line]
[Experimental myocardial infarction in atherosclerosis--various methods of pharmacological correction]
[Lipid peroxides and atherosclerosis. Hypothesis: the role of cholesterol and free-radical lipid peroxidation in altering cell membrane properties in hypercholesterolemia and atherosclerosis]
[Oxidation state of membrane phospholipids and activity of the microsomal system of cholesterol hydroxylation in the liver of animals during atherogenesis]
Autoimmune Diseases
Antibodies to liver/kidney microsome1 in chronic active hepatitis recognize specific forms of hepatic cytochrome P-450.
Autoantibodies to the thyroid microsomal/thyroid peroxidase antigen are polyclonal and directed to several distinct antigenic sites.
Expression of the microsomal antigen on the surface of continuously cultured rat thyroid cells is modulated by thyrotropin.
Immunologic parameters in premature follicular depletion: T and B lymphocytes, T-cell subpopulations, cutaneous reactivity, and serum immunoglobulin concentrations.
Incidence and significance of organ-specific autoimmune disorders (clinical, latent or only autoantibodies) in patients with vitiligo.
Non-organ specific autoantibodies associated with chronic C virus hepatitis.
Partially compensated hypoadrenalism presenting with persistent skin pigmentation.
Postpartum activation of autoimmunity: transient increase of total IgG levels in normal women and in women with autoimmune thyroiditis.
The effect of cyclosporine A on renal and hepatic microsomal mixed function oxidase systems in rats.
The effect of sulphydryl reagents on the human thyroid microsomal antigen.
[Chronic fatigue syndrome: immune dysfunction, role of pathogens and toxic agents and neurological and cardial changes]
[Investigation of autoimmunity markers during interferon alpha therapy of chronic hepatitis B and C - twenty years of experience].
[Thyroid microsomal autoantibodies in thyroid disease: their value as an antigenic marker]
[Thyroid peroxidase]
Avitaminosis
Hepatic peroxisome proliferation in vitamin A-deficient mice without a simultaneous increase in peroxisomal acyl-CoA oxidase activity.
Vitamin B-12 deficiency increases the specific activities of rat liver NADH- and NADPH-linked aquacobalamin reductase isozymes involved in coenzyme synthesis.
[Activity of enzymes participating in xenobiotic metabolism and the condition of microsomal membranes of rat liver in vitamin K deficiency]
Behcet Syndrome
Gastric parietal cell and thyroid autoantibodies in patients with Behcet's disease.
beta-Thalassemia
Antipyrin clearance in homozygous beta-thalassemia.
Biliary Atresia
Microsomal protein per gram of liver (MPPGL) in paediatric biliary atresia patients.
Blister
Ischemic loss of sarcolemmal dystrophin and spectrin: correlation with myocardial injury.
Bone Diseases
Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.
Bone Diseases, Metabolic
Antiopyrine half-life as a measure of hepatic enzyme induction: clinical applications in a chronic epileptic population.
Bowen's Disease
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Brain Edema
Phospholipid pool, lipid peroxidation, and superoxide dismutase activity under various types of oxidative stress of the brain and the effect of low-energy infrared laser irradiation.
Brain Injuries
Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population.
Protective Effects of Riboflavin and Selenium on Brain Microsomal Ca(2+)-ATPase and Oxidative Damage Caused by Glyceryl Trinitrate in a Rat Headache Model.
Brain Ischemia
[Membrane damage in brain subcellular structures in terminal states and in the postresuscitation period]
Brain Neoplasms
Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.
Identification of the putative brain tumor antigen BF7/GE2 as the (de)toxifying enzyme microsomal epoxide hydrolase.
Investigation of the Association between Genetic Polymorphism of Microsomal Epoxide Hydrolase and Primary Brain Tumor Incidence.
Phospholipid asymmetry in microsomal membranes of human brain tumors.
Sialic acid levels in various types of cancer.
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression.
Use of phenobarbital and high doses of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the treatment of brain tumor-bearing mice.
Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.
[ACNU delivery to malignant tumor tissue and serum--route of administration and combined use of phenobarbital]
[Effects of phenobarbital on the metabolism of ACNU in vivo]
Breast Neoplasms
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA.
4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.
A systematic approach to analysing gene-gene interactions: polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1, GSTT1, and GSTP1 loci and breast cancer risk.
Activation of brain estrogen receptors in mice lactating from mothers exposed to DDT.
Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane.
An Introduction to the Performance of Immunohistochemistry.
Antiestrogen binding sites in microsomal fractions of malignant and nonmalignant human breast tissues.
Breast cancer: role of polymorphisms in biotransformation enzymes.
Characterization of estrogen and antiestrogen binding to the cytosol and microsomes of breast tumors.
Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells.
CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes.
Diet and the epidemiology of human breast cancer.
Ethanol-induced oxidative stress and acetaldehyde formation in rat mammary tissue: potential factors involved in alcohol drinking promotion of breast cancer.
Expression and regulation of breast cancer resistance protein and multidrug resistance associated protein 2 in BALB/c mice.
Functional genomics based prioritization of potential nsSNPs in EPHX1, GSTT1, GSTM1 and GSTP1 genes for breast cancer susceptibility studies.
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands.
Immunochemical specificity of placental NADPH cytochrome c (P-450) reductase in neoplastic and non-neoplastic human tissue.
Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma.
Increased 3-hydroxy-3-methyl-glutaryl coenzyme A reductase activity in a virilizing adrenal carcinoma.
Influence of estrogen metabolism on proliferation of human breast cancer.
Interaction of gangliosides with the methyltransferase-I of microsomes from normal and neoplastic human mammary gland.
Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism.
Lipid-bound sugars in malignant human breast tumors. Partial characterization of mannosyl and glucosyl transferase activities.
Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma.
Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism.
Microsomal binding sites for antioestrogens in rat liver. Properties and detergent solubilization.
Microsomal binding sites for nonsteroidal anti-estrogens in MCF 7 human mammary carcinoma cells. Demonstration of high affinity and narrow specificity for basic ether derivatives of triphenylethylene.
Microsomal epoxide hydrolase expression as a predictor of tamoxifen response in primary breast cancer: a retrospective exploratory study with long-term follow-up.
Microsomal epoxide hydrolase expression in the endometrial uterine corpus is regulated by progesterone during the menstrual cycle.
Microsomal epoxide hydrolase variants are not associated with risk of breast cancer.
Proteolysis of human prolactin: resistance to cathepsin D and formation of a nonangiostatic, C-terminal 16K fragment by thrombin.
Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer.
Rat breast microsomal biotransformation of ethanol to acetaldehyde but not to free radicals: its potential role in the association between alcohol drinking and breast tumor promotion.
Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved.
Subcellular and extracellular localization of specific binding sites for triphenylethylene antiestrogens in human breast cancer.
Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17 beta-estradiol 4-hydroxylase.
Thyroid and other autoantibodies in British and Japanese women: an epidemiological study of breast cancer.
Time and dose-dependent modulation of phase 1 and phase 2 gene expression in response to treatment of MCF-7 cells with a natural anti-cancer agent.
Tobacco alkaloid derivatives as inhibitors of breast cancer aromatase.
Try113His and His139Arg polymorphisms in the microsomal epoxide hydrolase gene are not associated with risk of breast cancer.
[Biological effect of estrogen metabolites in human breast cancer]
[Biotransformation of phenazone and sulfadimidine as markers of liver metabolism of drug and xenobiotic oxidation and acetylation in women with breast cancer]
[Initial stages in the mechanism of protein glycosylation in human breast neoplasms]
Bronchitis
Air pollution and childhood bronchitis: Interaction with xenobiotic, immune regulatory and DNA repair genes.
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Bronchitis, Chronic
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children.
[The function of 2 detoxifying body systems in workers of the petrochemical industry]
Burkitt Lymphoma
Enhanced Ii expression after n-butyrate treatment of a P3HR-1 Burkitt's lymphoma subline which does not express HLA-D.
Burning Mouth Syndrome
Anemia, hematinic deficiencies, and hyperhomocysteinemia in serum gastric parietal cell antibody-positive burning mouth syndrome patients without serum thyroid autoantibodies.
Carcinogenesis
A microsomal butyrylesterase appearing in rat livers during development, regeneration, and carcinogenesis, and after phenobarbital treatment.
Alteration of microsomal and mitochondrial sites of metabolic control during chemical carcinogenesis.
Analysis of the EPHX1 113 polymorphism and GSTM1 homozygous null polymorphism and oral clefting associated with maternal smoking.
Association of Environmental Arsenic Exposure, Genetic Polymorphisms of Susceptible Genes, and Skin Cancers in Taiwan.
Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential.
Carcinogen activation by human uterine enzymes.
Catecholestrogens as mediators of carcinogenesis: correlation of aromatic hydroxylation of estradiol and its fluorinated analogs with tumor induction in Syrian hamsters.
Changes in carboxylesterase isoenzymes of rat liver microsomes during hepatocarcinogenesis.
Changes in microsomal enzyme activities during DAB carcinogenesis.
Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk.
Comparison of acyltransferase-mediated mutagenicity and nucleic acid binding of N-acetoxy-4-acetylaminobiphenyl by hepatic and bladder microsomes from rats and dogs.
Covalent binding of the carcinogen trichloroethylene to hepatic microsomal proteins and to exogenous DNA in vitro.
Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.
Effect of chronic estrogen treatment of Syrian hamsters on microsomal enzymes mediating formation of catecholestrogens and their redox cycling: implications for carcinogenesis.
Effect of cigarette smoke on mutagenic activation of environmental carcinogens by cytochrome P450 2A8 and inactivation by glucuronidation in hamster liver.
Effects of palm carotenoids in rat hepatic cytochrome P450-mediated benzo(a)pyrene metabolism.
Effects of selenium on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis and DNA adduct formation.
EPHX1 polymorphisms and the risk of lung cancer: a HuGE review.
Expression of rat microsomal epoxide hydrolase gene during liver chemical carcinogenesis.
Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility.
Hepatic drug metabolizing enzyme activity and tumorigenesis in mice following perinatal exposure to benzo(a)pyrene.
Hepatic metabolism and carcinogenesis. Its role in hepatoma and adenocarcinoma.
Hepatic microsomal N-glucuronidation and nucleic acid binding of N-hydroxy arylamines in relation to urinary bladder carcinogenesis.
Heterocyclic polycyclic aromatic hydrocarbon carcinogenesis: 7H-dibenzo[c,g]carbazole metabolism by microsomal enzymes from mouse and rat liver.
Heterogeneous nuclear ribonucleoproteins and their interactors are a major class of deregulated proteins in anaplastic astrocytoma: a grade III malignant glioma.
Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo.
Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.
Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital.
Immunofluorescence of phenobarbital inducible cytochrome P-450 in the hepatic lobule of normal and phenobarbital-treated rats.
In vitro metabolism and covalent binding of ethylbenzene to microsomal protein as a possible mechanism of ethylbenzene-induced mouse lung tumorigenesis.
In vitro screening of carcinogenesis inhibitors acting by inhibition of microsomal polycyclic aromatic hydrocarbon activation.
Inducibility of microsomal enzymes in normal and pre-cancerous lung tissue. Synergistic action of 5-6 benzoflavon or methyl-cholanthrene in radiation induced carcinogenesis.
Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.
Induction of microsomal epoxide hydrolase by sulfur amino acid deprivation via the pathway of C-Jun N-terminal kinase and its extracellular exposure during cell death.
Inhibition of microsomal metabolism and chemical oncogenesis in culture by naphthalene quinones.
Inhibitors of the Microsomal Prostaglandin E(2) Synthase-1 as Alternative to Non Steroidal Anti-inflammatory Drugs (NSAIDs) - A Critical Review.
Interaction of drugs and retinol.
Ketonitrosamines as metabolites of methyl-n-amylnitrosamine (MNAN) and its hydroxy derivatives in the rat.
Lack of association of EPHX1 gene polymorphisms with risk of hepatocellular carcinoma: a meta-analysis.
Localization of estrogen-induced DNA adducts and cytochrome P-450 activity at the site of renal carcinogenesis in the hamster kidney.
Low microsomal epoxide hydrolase expression is associated with bladder carcinogenesis and recurrence.
Mechanism of carcinogenesis with 1-aryl-3,3-dialkyltriazenes. Enzymatic dealkylation by rat liver microsomal fraction in vitro.
Microsomal aryl hydrocarbon hydroxylases: on their role in polycyclic hydrocarbon carcinogenesis and toxicity and the mechanism of enzyme induction.
Microsomal aspects of carcinogenesis and neoplasia.
Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer.
Microsomal epoxide hydrolase polymorphisms, cigarette smoking, and risk of colorectal cancer: The Fukuoka Colorectal Cancer Study.
Microsomal hydroxylases: induction and role in polycyclic hydrocarbon carcinogenesis and toxicity.
Microsomal hydroxylation of 2- and 4-fluoroestradiol to catechol metabolites and their conversion to methyl ethers: catechol estrogens as possible mediators of hormonal carcinogenesis.
Microsomal membrane alterations during acute ethionine toxicity and carcinogenesis.
Microsomal metabolism of picene.
Microsomal N-hydroxylase modification as a first step in carcinogenesis by arylamines [proceedings]
Modifications of 3'-methyl-4-dimethylaminoazobenzene carcinogenesis of rat liver and carcinogen metabolism by portacaval anastomosis.
Modifications of carcinogen metabolism in hepatic microsomes of suckling young by 3-methylcholanthrene or beta-naphthoflavone administered to lactating rats.
Monooxygenase system in Guerin’s carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice.
Polymorphisms of xenobiotic metabolizing genes in oropharyngeal carcinoma.
Putative EPHX1 Enzyme Activity Is Related with Risk of Lung and Upper Aerodigestive Tract Cancers: A Comprehensive Meta-Analysis.
Recent advances in metal carcinogenesis.
Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study.
Some biochemical properties of the preneoplastic antigen in rat liver hyperplastic nodules.
Species susceptibility to aflatoxin B1 carcinogenesis: comparative kinetics of microsomal biotransformation.
Stereochemistry of the major rodent liver microsomal metabolites of thecarcinogen dibenz[a,j]acridine.
Structure-activity relationships in polycyclic aromatic hydrocarbons: induction of microsomal aryl hydrocarbon hydroxylase and its possible importance in chemical carcinogenesis.
Studies on azo-dye carcinogenesis in rat liver. The effect of 4-dimethylamino-3'-methylazobenzene on the incorporation of [C]leucine into rat-liver microsomal protein.
Superoxide dismutase depletion and lipid peroxidation in rat liver microsomal membranes: correlation with liver carcinogenesis.
Suppressive effects of dietary curcumin on the increased activity of renal ornithine decarboxylase in mice treated with a renal carcinogen, ferric nitrilotriacetate.
Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene.
Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice.
The effect of modifiers of microsomal enzymes on chemical oncogenesis in cultures of C3H mouse cell lines.
The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters.
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis.
Weighted gene co-expression network analysis of pneumocytes under exposure to a carcinogenic dose of chloroprene.
[A study on the inherited susceptibility of chromosomal damage in peripheral blood lymphocytes among coke oven workers]
[Activity of 2 microsomal enzymes during the initial stage of liver carcinogenesis induced by 4-dimethylaminoazobenzene.]
[Disorders in the regulation of the activity of microsomal enzymes by lipids during chemical carcinogenesis in the liver]
[Effect of low doses of x-ray irradiation on the liver detoxication system in rats with transplanted Guerin's carcinoma].
[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
[Functional analysis of drug metabolizing enzymes using gene knockout animals]
[Hepatic mono-oxygenases]
[The interaction between microsomal epoxide hydrolase polymorphisms and indoor pollution in non small cell lung cancer]
[The relationship between the activity of microsomal enzymes and pulmonary carcinogenesis in mice]
Carcinoma
A simple semiquantitative radiometric measurement of antithyroglobulin antibodies in human serum. Comparison with hemagglutination method.
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Association of Activity Altering Genotypes - Tyr113His and His139Arg in Microsomal Epoxide Hydrolase Enzyme with Esophageal Squamous Cell Carcinoma.
Association of cell surface antigens with microsomal membrane fractions derived from Ehrlich ascites carcinoma cells.
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.
Characterization and significance of carbamyl phosphate phosphatase.
Characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human adrenal cortex.
Clinical enzymology: an autobiographical history.
Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells.
Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.
CYP1A1 activity in renal cell carcinoma and in adjacent normal renal tissue.
CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China.
EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.
Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China.
Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma.
Formation of 5,16-androstadien-3 beta-ol from pregnenolone in human testicular microsomes.
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Identification of protein disulfide isomerase and calreticulin as autoimmune antigens in LEC strain of rats.
In vitro effect of 16alpha-hydroxyprogesterone on the enzyme activities related to androgen production in human testes.
Increased 3-hydroxy-3-methyl-glutaryl coenzyme A reductase activity in a virilizing adrenal carcinoma.
Inhibition of human gastric carcinoma cell growth by treatment of N(3)-o-toluyl-fluorouracil as a precursor of 5-fluorouracil.
Interaction of human macrophage C-type lectin with O-linked N-acetylgalactosamine residues on mucin glycopeptides.
Levels of cytochrome P-450, steroidogenesis and microsomal and cytosolic epoxide hydrolases in normal human adrenal tissue and corresponding tumors.
Loss of microsomal antigen in follicular and papillary carcinoma of the thyroid. An immunofluorescence and electron-microscopic study.
Low microsomal epoxide hydrolase expression is associated with bladder carcinogenesis and recurrence.
Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas.
Metabolism of linoleic and arachidonic acids in VX2 carcinoma tissue: identification of monohydroxy octadecadienoic acids and monohydroxy eicosatetraenoic acids.
Microsomal binding sites for nonsteroidal anti-estrogens in MCF 7 human mammary carcinoma cells. Demonstration of high affinity and narrow specificity for basic ether derivatives of triphenylethylene.
Microsomal enzymes in patients with gastric carcinoma as determined by plasma half-life of antipyrine.
Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.
Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer.
Microsomal fatty acid desaturation and elongation in a human lung carcinoma grown in nude mice.
Mitochondrial and microsomal peripheral benzodiazepine receptors in human ovarian cancer xenografts.
Molecular basis of basal cell carcinoma: analysis of differential gene expression by differential display PCR and expression array.
Monoclonal antibody to a proximal nephrogenic renal antigen: immunohistochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinomas.
Monooxygenase system in Guerin’s carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Monooxygenase, epoxide hydrolase, and glutathione-S-transferase activities in human lung. Variation between groups of bronchogenic carcinoma and non-cancer patients and interindividual differences.
Occurrence of autoimmune antibodies to liver microsomal proteins in association with fulminant hepatitis in the LEC strain of rats.
Phospholipase D activity in human gastric carcinoma.
Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.
Polymorphisms of xenobiotic metabolizing genes in oropharyngeal carcinoma.
Protein kinase C activity in human gastric carcinoma.
Reduction of nitromin to nitrogen mustard: unscheduled DNA synthesis in aerobic or anaerobic rat hepatocytes, JB1, BL8 and Walker carcinoma cell lines.
Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines.
STUDIES ON THE SURFACE AND CYTOPLASMIC MEMBRANES OF EHRLICH ASCITES CARCINOMA CELLS. II. ALKALI-CATION-ACTIVATED ADENOSINE TRIPHOSPHATE HYDROLYSIS IN A MICROSOMAL MEMBRANE FRACTION.
The effect of inhibition of Ca2+-independent phospholipase A2 on chemotherapeutic-induced death and phospholipid profiles in renal cells.
The high-affinity binding of [3H]norharman ([3H]beta-carboline) to the ethanol-inducible cytochrome P450 2E1 in rat liver.
The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer.
Two-year carcinogenicity study in rats with a nonnucleoside reverse transcriptase inhibitor.
[Effect of liposomal antitumor preparation 5,6-benzocoumarin-5-uracil on intensity of free-radical processes in the liver microsomes and tumor cells of rats with transplanted Guerin's carcinoma]
[Effect of liposomal antitumor preparation 5-(5',6'-benzocoumarin-3')-methylaminouracil hydrobromide on cytochrome P-450 in the microsomal liver fraction of tumor bearing rats]
[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
[Transketolase activity and the TDP effect in tissues of animals with experimental tumors]
Carcinoma, Basal Cell
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Carcinoma, Ehrlich Tumor
Altered distribution of constitutive forms of microsomal cytochrome P-450 in tumor-bearing mouse liver.
Antitumor activity of sodium linoleate.
Biosynthesis of an O-alkyl analogue of phosphatidic acid and O-alkylglycerols via O-alkyl ketone intermediates by microsomal enzymes of Ehrlich ascites tumor.
Ca2+-dependent interaction of calcyclin with membrane.
Initiation of poly-N-acetyllactosamine chain biosynthesis occurs preferentially on complex multiantennary asparagine-linked oligosaccharides.
Macromolecular complexes produced by 1,3-propanesultone.
The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor.
Carcinoma, Embryonal
Induction of differentiation of embryonal carcinoma cells by retinol: possible mechanisms.
Microsomal aromatase in testicular tumour tissue: increased activity in choriocarcinoma compared to embryonal carcinoma.
Reverse transcriptase activity from human embryonal carcinoma cells NTera2D1.
Carcinoma, Hepatocellular
A MICROSOMAL DIFFERENCE BETWEEN NORMAL LIVER AND "MINIMAL-DEVIATION" HEPATOMA 5123 DETECTABLE BY ELECTRON SPIN RESONANCE.
A novel protocol for the subcellular fractionation of C3A hepatoma cells using sucrose density gradient centrifugation.
A real-time fluorescence assay for measuring N-dealkylation.
A role for Sp1 in the transcriptional regulation of hepatic triacylglycerol hydrolase in the mouse.
Abnormal membrane phospholipid content in subcellular fractions from the Morris 7777 hepatoma.
Abnormal microsomal cytochromes and electron transport in Morris hepatomas.
Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells.
Aldehyde dehydrogenase heterogeneity in rat hepatic cells.
An alternatively processed mRNA specific for gamma-glutamyl transpeptidase in human tissues.
ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1.
Arylamidases of rat liver and chemically induced hepatomas. 1. Subcellular distribution of L-leucine. 2. Naphthylamidase-active antigens.
Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities.
Cell surface expression and bile acid transport function of one topological form of m-epoxide hydrolase.
Changes in the glucose-6-phosphatase complex in hepatomas.
Characterization of microsomal methyl sterol demethylase in two Morris hepatomas.
Chemical, enzymatic, and cytochrome assays of microsomal fraction of hepatomas with different growth rates.
Comparative study on fucosylation of chicken liver and virus-induced hepatoma Mc-29.
Comparison of co-cultivation of V79 cells with rat hepatocytes and rat H4IIE hepatoma cells for studying nitrosamine-induced hprt gene mutations.
Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis.
Correlation of fatty acyl composition of mitochondrial and microsomal phospholipid with growth rate of rat hepatomas.
Covalent binding of the carcinogen trichloroethylene to hepatic microsomal proteins and to exogenous DNA in vitro.
Cytidine 5'-triphosphate-dependent dolichol kinase and dolichol phosphatase activities and levels of dolichyl phosphate in microsomal fractions from highly differentiated human hepatomas.
Cytochrome P-450 deficiency and resistance to t-butyl hydroperoxide of hepatoma microsomal lipid peroxidation.
delta9 Desaturase activity in normal mouse liver and hepatoma SS1K.
Detection of epoxide hydrolase in rat hepatoma cell lines and primary rat liver cells by immunoblotting.
Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review.
Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.
Diabetes mellitus and primary hepatocellular carcinoma.
Different properties of microsomal UDP-glucuronyltransferase in buffalo rat liver and a clonal strain of rat hepatoma cells derived from the same rat strain.
Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours.
Distribution of microsomal triglyceride transfer protein within sub-endoplasmic reticulum regions in human hepatoma cells.
Drug metabolism in the Novikoff hepatoma: evidence for a mixed function oxidase system and partial purification of cytochrome P-450 reductase.
Effect of interleukin-11 on the levels of mRNAs encoding heme oxygenase and haptoglobin in human HepG2 hepatoma cells.
Effect of Morris 7777 hepatoma on microsomal glucose-6-phosphatase latent activity.
Effect of nonspecific phospholipid transfer protein on cholesterol esterification in microsomes from Morris hepatomas.
Effects of 3-methylcholanthrene pretreatment on microsomal hydroxylation of 2-acetamidofluorene by various rat hepatomas.
Enhancing effect of a phorbol ester and of retinoic acid on glucocorticoid induction of chenodeoxycholate hydroxylation in hepatoma cultures.
Epoxide hydrolase: a marker for experimental hepatocarcinogenesis.
Eugenol cytotoxicity evaluated with continuous cell lines.
Evaluation of a human hepatoma cell line as a target cell in genetic toxicology.
Expression of microsomal and cytosolic epoxide hydrolases in cultured rat hepatocytes and hepatoma cell lines.
Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity.
Galactosyltransferase: multiple forms in serum of normal and hepatoma Mc-29 bearing chickens and from liver and hepatoma microsomal and plasma membrane preparations.
Glutathione-S-transferase and microsomal epoxide hydrolase polymorphism and viral-related hepatocellular carcinoma risk in India.
Halogenated biphenyls: molecular toxicology.
Haplotypes of Microsomal Epoxide Hydrolase and X-Ray Cross-Complementing Group 1 Genes in Indian Hepatocellular Carcinoma Patients.
Heat shock induction of heme oxygenase mRNA in human Hep 3B hepatoma cells.
Heme oxygenase is a positive acute-phase reactant in human Hep3B hepatoma cells.
Hepatic transcriptional up-regulator of the rat microsomal epoxide hydrolase gene.
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins.
Heterogeneity in the rate of benzo[a]pyrene metabolism in single cells: quantitation using flow cytometry.
Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics.
Immunoaffinity purification and partial amino acid sequence analysis of catechol-O-methyltransferase from pig liver.
Immunochemical comparison of human and rhesus monkey liver microsomal and the hepatocellular carcinoma-induced human serum epoxide hydrolases (preneoplastic antigens): basis for an enzyme-linked immunoabsorbent assay.
Immunochemical specificity of placental NADPH cytochrome c (P-450) reductase in neoplastic and non-neoplastic human tissue.
Immunochemical studies of microsomal membranes of rat preneoplastic and neoplastic hepatocytes.
Immunofluorescent localization of type II insulin-like growth factor receptor in rat liver and hepatoma cells.
Immunohistochemical assessment of human microsomal epoxide hydrolase in primary and secondary liver neoplasm: a quantitative approach.
Induction of cytochrome P-450 1A1 in human hepatoma HepG2 and lung carcinoma NCI-H322 cells by motorcycle exhaust particulate.
Induction of epoxide hydrolase in cultured rat hepatocytes and hepatoma cell lines.
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Morris hepatoma 7800 after intravenous injection of mevalonic acid.
Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters.
Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation.
Investigation of the rate-determining microsomal reaction of cholesterol biosynthesis from lanosterol in Morris hepatomas and liver.
Lack of association of EPHX1 gene polymorphisms with risk of hepatocellular carcinoma: a meta-analysis.
LINC00205 modulates the expression of EPHX1 through the inhibition of miR-184 in hepatocellular carcinoma as a ceRNA.
Lipid composition, physical state, and lipid peroxidation of tumor membranes.
Lipid peroxidation in cancer cells: chemical and physical studies.
Lipid peroxidation of the microsomal fraction and extracted microsomal lipids from DAB-induced hepatomas.
Lipoprotein profiles of hepatic cell lines at various stages of differentiation.
Long-term changes in mitochondrial outer membrane enzymes and microsomal enzymes involved in drug and heme metabolism during 2-acetylaminofluorene feeding.
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes.
Membrane alterations in cancer cells: the role of oxy radicals.
Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma.
Metabolic activation of chemicals to mutagenic carcinogens by human hepatoma microsomal extracts in Chinese hamster ovary cells (in vitro).
Metabolic characteristics and enflurane defluorination of cytochrome P450-dependent monooxygenases in human hepatocellular carcinoma.
Microsomal cytochrome P-450-linked monooxygenase systems and lipid composition of human hepatocellular carcinoma.
Microsomal N-demethylation and the effect of the hepatic carcinogen dimethylnitrosamine on amino acid incorporation into the proteins of rat livers and hepatomas.
Microsomal triglyceride transfer protein is essential for hepatic secretion of apoB-100 and apoB-48 but not triglyceride.
Monooxygenase, epoxide hydrolase, and glutathione-S-transferase activities in human lung. Variation between groups of bronchogenic carcinoma and non-cancer patients and interindividual differences.
Multiple forms of chicken liver and hepatoma Mc-29 microsomal and plasma-membrane sialyl and fucosyltransferases.
Occurrence of steroid glucuronyltransferases in a hepatoma.
Ornithine decarboxylase lability in 2 transplantable highly deviated rat hepatomas.
Oxy-radical metabolism and control of tumour growth.
Partial characterization of microsomal sialyltransferase from chicken liver and hepatoma Mc-29: I. Effect of nucleotides and metal ions.
Partial characterization of microsomal sialyltransferase from chicken liver and hepatoma Mc-29: II. Measurement of enzyme activities utilizing microsomal glycoproteins as exogenous acceptors.
Pattern of sialoglycoproteins obtained by chromatofocusing of chicken liver and hepatoma Mc-29 microsomal preparations labelled in vivo with 3H-leucine and N-acetyl-14C-mannosamine.
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
Phosphatidylserine biosynthesis in mitochondria from the Morris 7777 hepatoma.
Phospholipid content of mitochondrial and microsomal membranes from Morris hepatomas of varying growth rates.
Polymorphisms in xenobiotic metabolism-related genes in patients with hepatocellular carcinoma: a case-control study.
Polymorphisms of the gene for microsomal epoxide hydrolase and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a Caucasian population.
Preparation and properties of a Met-tRNAf binding factor from rat liver and rat hepatoma.
Proceedings: Activation and induction of microsomal UDPglucuronosyltransferases in rat liver and Morris hepatomas.
Prolonged inhibition of cholesterol synthesis by atorvastatin inhibits apo B-100 and triglyceride secretion from HepG2 cells.
Properties of aldehyde dehydrogenas from chemically-induced rat hepatomas and normal rat liver.
Properties of microsomal phospholipases in rat liver and hepatoma.
Prostaglandin biosynthetic capacity of hepatomas with different growth rates.
Protein turnover in microsomal subfractions of liver and Morris hepatomas 7800 and 9618A.
Proteomic Analysis Reveals that EPHX1 Contributes to 5-Fluorouracil Resistance in a Human Hepatocellular Carcinoma Cell Line.
Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly.
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver and Morris hepatomas 5123C, 9618A and 5123t.c.
Regulation of microsomal, xenobiotic epoxide hydrolase messenger RNA in persistent hepatocyte nodules and hepatomas induced by chemical carcinogens.
Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase.
Relationship between the microsomal epoxide hydrolase and the hepatocellular transport of bile acids and xenobiotics.
Reversible phosphorylation of 3-hydroxy-3-methylglutaryl CoA reductase in Morris hepatomas.
Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.
Role of lipid transfer proteins in the abnormal lipid content of Morris hepatoma mitochondria and microsomes.
Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator.
Selective fast degradation of cytochrome P-450 2E1 in serum-deprived hepatoma cells by a mechanism sensitive to inhibitors of vesicular transport.
Selective induction of microsomal 2-acetylaminofluorene N-hydroxylation by dietary 2-acetylaminofluorene in rats.
Serum epoxide hydrolase (preneoplastic antigen) in human and experimental liver injury.
Sesquiterpenoids Isolated from the Flower Buds of Tussilago farfara L. Inhibit Diacylglycerol Acyltransferase.
Sialidase of rat hepatomas: qualitative and quantitative comparison with rat liver sialidase.
Study of the in vitro bioactivation of albendazole in human liver microsomes and hepatoma cell lines.
Sulfhydryl group quantitation of hepatoma and liver microsomal fractions.
Superoxide dismutase content and microsomal lipid composition of tumours with different growth rates.
Superoxide dismutase depletion and lipid peroxidation in rat liver microsomal membranes: correlation with liver carcinogenesis.
Superoxide-dependent lipid peroxidation and vitamin E content of microsomes from hepatomas with different growth rates.
The acyl-CoA desaturases of microsomes from rat liver and the Morris 7777 hepatoma.
The anticancer enzyme DT diaphorase is induced selectively in liver during ascites hepatoma growth.
The composition and metabolism of microsomal and mitochondrial membrane lipids in the Morris 7777 hepatoma.
The expression of cytochrome P-450, epoxide hydrolase, and glutathione S-transferase in hepatocellular carcinoma.
The inhibition of microsomal triglyceride transfer protein activity in rat hepatoma cells promotes proteasomal and nonproteasomal degradation of apoprotein b100.
The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis.
The lipid composition of highly differentiated human hepatomas, with special reference to fatty acids.
The occurrence of carbonyl reduction in continuous cell lines emphasizes the essentiality of this metabolic pathway.
The role of delta-6- and delta-9-desaturase in the fatty acid metabolism of hepatomas with different growth rate.
The synthesis of sphingomyelin in the Morris hepatomas 7777 and 5123D is restricted to the plasma membrane.
Transcriptional and post-transcriptional regulation of the asialoglycoprotein receptor in normal and neoplastic rat liver.
Turnover of the plasma membrane proteins of hepatoma tissue culture cells.
Turnover of the plasma-membrane and microsomal proteins of rat liver containing primary hepatoma nodules.
Vitamin K uptake in hepatocytes and hepatoma cells.
Vitamin K-dependent carboxylase activity, prothrombin mRNA, and prothrombin production in two cultured rat hepatoma cell lines.
[Accelerated microsomal DNA synthesis under the influence of xenobiotics and chemical carcinogens]
[Differing microsomal monoxygenase activity in the cells of ascitic and solid forms of transplantable tumors]
[Effect of 5-fluorouracil and thiophosphamide on the activity and fractional content of phosphatases of Zajdela hepatoma]
[Enzymes metabolizing xenobiotics in spontaneous tumors in mice]
[EPHX1 Tyr113His polymorphism contributes to hepatocellular carcinoma risk: evidfnce from a meta-analysis].
[Photodynamic action of hypocrellin A on hepatoma cell mitochondria and microsomes]
[Presence of an acid p-nitrophenylphosphatse in the microsomal fraction of a transplantable hepatoma in rats]
[Purification of human microsomal epoxide hydrolase and study on its localization in hepatocellular carcinoma tissue]
[Study of the microsomal factors controlling protein synthesis in cell-free systems of liver and hepatoma]
[Subcellular particles in tumors. II. Analysis of mitochondrial and microsomal fractions in hepatoma HW by isopycnic centrifugation]
[The lipid composition of microsomal fractions in the liver and hepatoma]
Carcinoma, Intraductal, Noninfiltrating
Increased Breast Density Correlates with the Proliferation-Seeking Radiotracer (99m)Tc(V)-DMSA Uptake in Florid Epithelial Hyperplasia and in Mixed Ductal Carcinoma In Situ with Invasive Ductal Carcinoma but Not in Pure Invasive Ductal Carcinoma or in Mild Epithelial Hyperplasia.
Carcinoma, Medullary
[Enzymohistochemical and immunomorphological study of experimental thyroid gland carcinoma]
Carcinoma, Mucoepidermoid
Microsomal fatty acid desaturation and elongation in a human lung carcinoma grown in nude mice.
Carcinoma, Non-Small-Cell Lung
Genetic polymorphism and gene expression of microsomal epoxide hydrolase in non-small cell lung cancer.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
Carcinoma, Ovarian Epithelial
Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.
[Relation Between microsomal epoxide hydrolase polymorphism and susceptibility to ovarian epithelial cancer]
Carcinoma, Papillary
Loss of microsomal antigen in follicular and papillary carcinoma of the thyroid. An immunofluorescence and electron-microscopic study.
Carcinoma, Renal Cell
CYP1A1 activity in renal cell carcinoma and in adjacent normal renal tissue.
Estrogen 2- and 4-hydroxylase activity, catechol estrogen formation, and implications for estrogen carcinogenesis in the hamster kidney.
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Monoclonal antibody to a proximal nephrogenic renal antigen: immunohistochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinomas.
Carcinoma, Squamous Cell
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma.
Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells.
Molecular basis of basal cell carcinoma: analysis of differential gene expression by differential display PCR and expression array.
Monooxygenase, epoxide hydrolase, and glutathione-S-transferase activities in human lung. Variation between groups of bronchogenic carcinoma and non-cancer patients and interindividual differences.
Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.
The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer.
Carcinosarcoma
Decreased activities of liver microsomal drug-metabolizing enzymes in the rats bearing Walker carcinosarcoma.
Differential effects of Walker 256 carcinosarcoma cells growing subcutaneously, intramuscularly, or intraperitoneally on hepatic microsomal mixed-function oxygenase activity.
[Experimental data to substantiate the antitumor action of hydrazine sulfate]
Cardiomegaly
Effect of alcohol on the heart and cardiac metabolism.
Increased phospholipid methylation in the myocardium of hyperthyroid rats.
Cardiomyopathies
Abnormalities in heart membranes and myofibrils during bacterial infective cardiomyopathy in the rabbit.
Association of annexin A5 with Na+/Ca2+ exchanger and caveolin-3 in non-failing and failing human heart.
Biphasic changes in the sarcolemmal phosphatidylethanolamine N-methylation activity in catecholamine-induced cardiomyopathy.
[The status of the ethanol-oxidizing enzyme systems in fatal alcohol poisonings]
Cardiomyopathy, Alcoholic
Alcoholic cardiomyopathy. II. The inhibition of cardiac microsomal protein synthesis by acetaldehyde.
Cardiotoxicity
Biochemical pharmacology and DNA-drug interactions by Cl-958, a new antitumor intercalator derived from a series of substituted 2H-[1]benzothiopyrano[4,3,2-cd]indazoles.
Design, biochemical pharmacology, electrochemistry and tumour biology of anti-tumour anthrapyrazoles.
In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9-cd]pyrazol-6(2H)-ones (anthrapyrazoles).
Microsomal lipid peroxidation induced by adriamycin, epirubicin, daunorubicin and mitoxantrone: a comparative study.
Molecular and biochemical pharmacology of mitoxantrone.
[Effect of biological membrane stabilizing drugs (coenzyme Q10, dextran sulfate and reduced glutathione) on adriamycin (doxorubicin)-induced toxicity and microsomal lipid peroxidation in mice]
Cardiovascular Diseases
eNOSI4 and EPHX1 polymorphisms affect maternal susceptibility to preeclampsia: analysis of five polymorphisms predisposing to cardiovascular disease in 279 Caucasian and 241 African women.
Genetic polymorphisms and lipoprotein responses to diets.
Genotype at the P554L Variant of the Hexose-6 Phosphate Dehydrogenase Gene Is Associated with Carotid Intima-Medial Thickness.
Microsomal triglyceride transfer protein -164 T > C gene polymorphism and risk of cardiovascular disease: results from the EPIC-Potsdam case-cohort study.
The effect of ghee (clarified butter) on serum lipid levels and microsomal lipid peroxidation.
Cataplexy
Search for neuron-specific and nonneuron-specific antibodies in narcoleptic patients with and without HLA DQB1*0602.
Cataract
Glaucoma following congenital cataract surgery--the role of early surgery and posterior capsulotomy.
Rat lens prostaglandin biosynthesis during galactose-induced cataractogenesis.
Celiac Disease
Unusual occupational gastrointestinal and hepatic disorders.
Chagas Disease
Epitopes common to Trypanosoma cruzi and mammalian tissues are recognized by sera from Chagas' disease patients: prognosis value in Chagas disease.
Chemical and Drug Induced Liver Injury
Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity.
Drug-induced liver injury and microsomal arylamidase activity in needle biopsy of human liver.
Recurrent episodes of acute hepatitis associated with LKM-1 (cytochrome P450 2D6) antibodies in identical twin brothers.
Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
[Phosphatidylcholine-induced repair of damaged hepatocyte membranes in heliotrine poisoning]
[Tienilic acid-induced hepatitis associated with liver/kidney microsomal antibody (author's transl)]
Chloracne
Relationship of basic research in toxicology to environmental standard setting: the case of polybrominated biphenyls in Michigan.
Cholangitis, Sclerosing
Immunological liver diseases in children.
Organ and non-organ specific autoantibody titres and IgG levels as markers of disease activity: a longitudinal study in childhood autoimmune liver disease.
Significance of extractable nuclear antigens in childhood autoimmune liver disease.
Cholelithiasis
Hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and biliary lipid composition in man: relation to cholesterol gallstone disease and effects of cholic acid and chenodeoxycholic acid treatment.
Hepatic HMGCoA reductase in human cholelithiasis: effects of chenodeoxycholic and ursodeoxycholic acids.
Hepatic microsomal activities of cholesterol 7 alpha-hydroxylase and 3-hydroxy-3-methylglutaryl-CoA reductase in the prairie dog. An animal model for cholesterol gallstone disease.
Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease.
Normal antipyrine metabolism in patients with cholesterol cholelithiasis. Evidence that the disease is not due to generalized hepatic microsomal dysfunction.
Novel sterol 7 alpha-hydroxylase(s), microsomal 27-hydroxycholesterol 7 alpha-hydroxylase, in cholesterol gallstone disease and its etiological significance.
The effect of phenobarbital on biliary lipid metabolism and hepatic microsomal drug metabolism in patients with cholesterol cholelithiasis.
The plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man.
Cholera
GTP-dependent ADP-ribosylation of a 22 kDa protein in the endoplasmic reticulum membrane.
Induction of synthesis of bovine adrenocortical cytochromes P-450scc, P-45011 beta, P-450C21, and adrenodoxin by prostaglandins E2 and F2 alpha and cholera toxin.
Transient antibodies against homologous hepatic microsomal and mitochondrial antigens in a vervet immunized with standard cholera vaccine.
Cholestasis
Alteration of microsomal biotransformation in the liver in cholestasis.
Autoimmune hepatitis type-2 and Epstein-Barr virus infection in a toddler: art of facts or an artifact?
BCNU-induced quantitative and qualitative changes in hepatic cytochrome P-450 can be correlated with cholestasis.
Bile acids produce a generalized reduction of the catalytic activity of cytochromes P450 and other hepatic microsomal enzymes in vitro: relevance to drug metabolism in experimental cholestasis.
Caffeine demethylation measured by breath analysis in experimental liver injury in the rat.
Changes in microsomal phospholipid fatty acids composition in cholestatic rats.
Chemotherapy of larval echinococcosis with mebendazole: microsomal liver function and cholestasis as determinants of plasma drug level.
Cholestasis as an in vivo model for analysis of the induction of liver microsomal monooxygenases by sodium phenobarbital and 3-methylcholanthrene.
Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis.
Effect of cholestasis produced by bile duct ligation on hepatic heme and hemoprotein metabolism in rats.
Effect of subchronic cholestasis on microsomal mixed-function oxidases and the glutathione-conjugating enzyme system in rat liver.
Effects of bile duct ligation on hepatic expression of female-specific CYP2C12 in male and female rats.
Effects of bile duct obstruction and decompression on hepatic microsomal mixed function oxidase system in rats.
Effects of high taurocholate load on activities of hepatic alcohol metabolizing enzymes.
Effects of liver injury and cholestasis on microsomal enzyme activities and metabolism of halothane, enflurane and methoxyflurane in vivo in rats.
Hepatic adenine nucleotides and microsomal cholesterol 7 alpha-hydroxylase activity in the obstructed and freely draining lobes of the liver after selective bile duct obstruction.
Influence of liver metabolism on the actions of althesin and thiopentone.
Inhibition of NADPH-induced microsomal lipid peroxidation in the livers of cholestatic rats.
Liver metabolic zonation in rat biliary cirrhosis: distribution is reverse of that in toxic cirrhosis.
Liver microsomal bilirubin UDP-glucuronyltransferase disturbances in bile duct ligated rats.
Liver microsomal phospholipid fatty acids behavior and its relationship to bilirubin UDP-glucuronyltransferase activity in bile duct ligated rats.
Mechanism of cholestasis. 1. Effect of bile acids on microsomal cytochrome P-450 dependent biotransformation system in vitro.
Mechanism of cholestasis. 2. Effect of bile acids on the microsomal electron transfer system in vitro.
Mechanism of cholestasis. 3. Interaction of synthetic detergents with the microsomal cytochrome P-450 dependentbiotransformation system in vitro. A comparison between the effects of detergents, the effects of bile acids, and the findings in bile duct ligated rats.
Microsomal and peroxisomal fatty acid oxidation in bile duct ligated rats: a comparative study between liver and kidney.
Microsomal and peroxisomal fatty acid oxidation in liver of rats with bile duct ligation and two-thirds hepatectomy.
Microsomal biotransformation system in cholestasis.
Microsomal drug metabolism during alpha-naphthylisothiocyanate-induced cholestasis.
Microsomal function in biliary obstructed rats: effects of S-adenosylmethionine.
Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment.
Phenothiazine-induced cholestatic jaundice.
Prevention of lithocholate--induced cholestasis by cycloheximide, an inhibitor of protein synthesis.
Regulation of renal cytochrome P-450. Effects of two-thirds hepatectomy, cholestasis, biliary cirrhosis and post-necrotic cirrhosis on hepatic and renal microsomal enzymes.
Reversible bile acid changes in bile duct obstruction and its potential for hepatocellular injury.
Rhabdomyolysis in a patient taking simvastatin after addition of cyclosporine therapy.
Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans.
The hepatic microsomal mixed-function oxidase system in man: cofactor effects and the influence of cholestasis.
Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6.
[6,8-Dimethyl-2-piperidinomethyl-2,3-dihydrothiazolo[2,3-f]xanthine: a new inductor of the monooxygenase system inhibits experimental intrahepatic cholestasis in rats]
[Chemical structure of the endoplasmic reticulum and function of the microsomal biotransformation system of liver cells in experimental cholestasis in the rat]
[Drug-induced jaundice]
[Induction of liver microsomal monoxygenases in experimental cholestasis]
[Inhibition of the antioxidant protection, microsomal oxidation, and xenobiotic glucuroconjugation in rats with cholestasis and their regulation]
[Mechanism of inhibition of rat liver microsomal monooxygenases during the development of cholestasis]
[Metabolism of hypnotic and sedative drugs in cholestasis (author's transl)]
[Phospholipid composition of the hepatic microsomal membrane and its relationship to bilirubin UDP glucuronyltransferase in human cholestasis]
Cholestasis, Extrahepatic
[Increase of acetaminophen conjugation ability in experimental cholestasis]
Cholestasis, Intrahepatic
Effect of phenobarbital on hyperbilirubinemia, bile acid metabolism, and microsomal enzyme activity in chronic intrahepatic cholestasis of childhood.
Influence of drugs on bile acid excretion.
Intrahepatic cholestasis: a review of biochemical-pathological mechanisms.
Selective reduction of hepatic cytochrome P450 content in patients with intrahepatic cholestasis. A mechanism for impairment of microsomal drug oxidation.
Choline Deficiency
Biosynthesis of liver microsomal phosphatidyl cholines during the development of choline deficiency.
Effects of long-term choline deficiency on hepatic microsomal cytochrome P-450-mediated steroid and xenobiotic hydroxylases in the female rat.
Ethanolamine kinase activity and compositions of diacylglycerols, phosphatidylcholines and phosphatidylethanolamines in livers of choline-deficient rats.
Liver microsomal phosphatidyl choline biosynthesis in choline deficiency.
Phosphatidylethanolamine levels and regulation of phosphatidylethanolamine N-methyltransferase.
The effect of choline deficiency on the activity of a phosphatidylcholine-requiring enzyme: activity and properties of UDP-glucuronyltransferase in choline-deficient rats.
Chondrosarcoma
Incorporation of mannose 6-phosphate receptors into liposomes. Receptor topography and binding of alpha-mannosidase.
Chorioamnionitis
Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells.
Choriocarcinoma
Biochemistry and pharmacology of 7alpha-substituted androstenediones as aromatase inhibitors.
Biosynthesis and processing of placental alkaline phosphatase.
Microsomal aromatase in testicular tumour tissue: increased activity in choriocarcinoma compared to embryonal carcinoma.
Chronic Periodontitis
Biosynthesis of prostaglandin E2 and F2 alpha in gingiva of patients with chronic periodontitis.
Chronic Urticaria
Association between chronic urticaria and thyroid autoimmunity.
Association of chronic urticaria and angioedema with thyroid autoimmunity.
Correlation of serum antithyroid microsomal antibody and autologous serum skin test in patients with chronic idiopathic urticaria.
IgE antithyroid microsomal antibodies in a patient with chronic urticaria.
Steroid-resistant chronic urticaria associated with anti-thyroid microsomal antibodies in a nine-year-old boy.
Treatment of chronic urticaria with thyroxine in an euthyroid patient with thyroglobulin and microsomal antibodies.
Cleft Lip
Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice.
Cleft Palate
2,2',4,4',5,5'-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice.
Cocarcinogenesis
Benzo[a]pyrene uptake into rat liver microsomes: effects of adsorption of benzo[a]pyrene to asbestos and non-fibrous mineral particulates.
Colitis
Decreased drug penetration in inflamed tissue related to changed mucosal metabolism in experimental colitis.
Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis.
Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer.
Protective mucosal immunity mediated by epithelial CD1d and IL-10.
Colitis, Collagenous
Autoantibodies and immunoglobulins in collagenous colitis.
Colitis, Ulcerative
Leukocyte migration test in Crohn's disease, ulcerative colitis, and ankylosing spondylitis using Crohn's colon homogenate, mitochondrial, and microsomal fractions.
Colitis-Associated Neoplasms
Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer.
Colonic Neoplasms
Glycosides from the stem bark of Fraxinus sieboldiana.
In vitro metabolism of nitric oxide-donating aspirin: the effect of positional isomerism.
Microsomal epoxide hydrolase gene polymorphism and susceptibility to colon cancer.
Microsomal epoxide hydrolase polymorphisms are not associated with colon cancer risk.
Tumor microsomal metabolism of the food toxicant, benzo(a)pyrene, in Apc( Min ) mouse model of colon cancer.
Colorectal Neoplasms
15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.
5-Fluorouracil prodrug: role of anabolic and catabolic pathway modulation in therapy of colorectal cancer.
A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary.
Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population.
Diabetes mellitus and primary hepatocellular carcinoma.
Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study.
Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.
Glycosylation of the tandem repeat unit of the MUC2 polypeptide leading to the synthesis of the Tn antigen.
Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis.
Investigation of a Possible Relationship Between EPHX1 Gene Polymorphisms and Colorectal Cancer in Turkish Society.
Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas.
Microsomal epoxide hydrolase polymorphisms, cigarette smoking, and risk of colorectal cancer: The Fukuoka Colorectal Cancer Study.
Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population.
Molecular characterization of cellular proteins from colorectal tumors.
Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.
NQO1 and mEH exon 4 (mEH4) gene polymorphisms, smoking and colorectal cancer risk.
Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents.
Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression.
Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis.
Sialyltransferase activity and hepatic tumor growth in a nude mouse model of colorectal cancer metastases.
Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and Colorectal Cancer Risk.
Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer.
[Trends in nonsteroidal anti-inflammatory drug development and application]
Colorectal Neoplasms, Hereditary Nonpolyposis
Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.
Communicable Diseases
[Non-organ specific anticytoplasmic autoantibodies. Immunoserologic detection and diagnostic relevance]
Congenital Abnormalities
Application of kinetic polymerase chain reaction and molecular beacon assays to pooled analyses and high-throughput genotyping for candidate genes.
Differences in phenytoin biotransformation and susceptibility to congenital malformations: a review.
Genetic predisposition to phenytoin-induced birth defects.
Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
The Tyr113His polymorphism in exon 3 of the microsomal epoxide hydrolase gene is a risk factor for perinatal mortality.
Connective Tissue Diseases
Immunoblotting as a confirmatory test for antimitochondrial antibodies in primary biliary cirrhosis.
Coronary Disease
Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women.
High-density lipoproteins and hepatic microsomal enzyme induction in alcohol consumers.
Inverse relationship of serum LDL cholesterol and the LDL/HDL cholesterol ratio to liver microsomal enzyme induction in man.
Microsomal enzyme induction, lipoproteins and atherosclerosis.
Plasma high-density lipoproteins and liver lipids and proteins in man. Relation to hepatic histology and microsomal enzyme induction.
The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease.
[The status of the ethanol-oxidizing enzyme systems in fatal alcohol poisonings]
Coronary Occlusion
Alterations in heart membrane calcium transport during the development of ischemia-reperfusion injury.
Ischemia-induced alterations in myocardial (Na+ + K+)-ATPase and cardiac glycoside binding.
Craniofacial Abnormalities
Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations.
Crigler-Najjar Syndrome
The presence of a microsomal UDP-glucuronyl transferase for bilirubin in homozygous jaundiced Gunn rats and in the Crigler-Najjar syndrome.
Crohn Disease
Clinical pharmacokinetics of prednisone and prednisolone.
Genetic association between EPHX1 and Crohn's disease: population stratification, genotyping error, or random chance?
Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase.
Leucocyte migration studies in Crohn's disease using Crohn's colon homogenate and mitochondrial and microsomal fractions.
Leukocyte migration test in Crohn's disease, ulcerative colitis, and ankylosing spondylitis using Crohn's colon homogenate, mitochondrial, and microsomal fractions.
No genetic association between EPHX1 and Crohn's disease.
Cryoglobulinemia
Immunological disorders in chronic hepatitis C Egyptian patients.
Previous tuberculosis, hepatitis C virus and lichen planus. A report of 10 cases, a causal or casual link?
Cryptorchidism
Down-regulation of steroidogenic cytochrome P450XVII in cryptorchid rat testes.
Cushing Syndrome
Steroid 21-hydroxylase and 17 alpha-hydroxylase in microsomal fraction of functioning adrenocortical tumors.
Cystic Fibrosis
Calcium- and CaMKII-dependent chloride secretion induced by the microsomal Ca(2+)-ATPase inhibitor 2,5-di-(tert-butyl)-1,4-hydroquinone in cystic fibrosis pancreatic epithelial cells.
Effect of cystic fibrosis and non-cystic fibrosis plasma on 45Ca and 35SO4 uptake and retention by the small intestine at the cellular level in the guinea pig.
Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency.
Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes.
Properties of chloride-conductive pathways in rat kidney cortical and outer-medulla brush-border membranes--inhibition by anti-(cystic fibrosis transmembrane regulator) mAbs.
Properties of microsomal glycoprotein galactosyltransferase of cultured human fibroblasts in relation to cystic fibrosis.
[A new pathogenic hypothesis of mucoviscidosis: hyperactivity of microsomal glycosyl-transferases]
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Cysts
Characterisation of Phytophthora nicotianae zoospore and cyst membrane proteins
Dehydration
Association between Membrane Phase Properties and Dehydration Injury in Soybean Axes.
Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat.
Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene.
Effect of dehydration, food deprivation, saline and adrenalectomy on microsomal (Na + +K + )-dependent ATPase in the salivary glands and intestinal mucosa.
Effect of dehydration, starvation and sodium deprivation on microsomal ATPase in the kidney.
Enzymes converting D-3-hydroxyacyl-CoA to trans-2-enoyl-CoA. Microsomal and peroxisomal isoenzymes in rat liver.
Heterocyclic polycyclic aromatic hydrocarbon carcinogenesis: 7H-dibenzo[c,g]carbazole metabolism by microsomal enzymes from mouse and rat liver.
In vitro metabolism of diarylpyrazoles, a novel group of cannabinoid receptor ligands.
Involvement of Cytochrome P-450 in the Biosynthesis of Dhurrin in Sorghum bicolor (L.) Moench.
Metabolic activation of n-butyraldoxime by rat liver microsomal cytochrome P450. A requirement for the inhibition of aldehyde dehydrogenase.
Nitric oxide reduces hydrogen peroxide accumulation involved in water stress-induced subcellular anti-oxidant defense in maize plants.
P450-catalyzed in-chain desaturation of valproic acid: isoform selectivity and mechanism of formation of Delta 3-valproic acid generated by baculovirus-expressed CYP3A1.
Stability of diacylglycerol acyltransferase in dehydrated bovine muscle tissue.
Stereoselective formations of K-region and non-K-region epoxides in the metabolism of chrysene by rat liver microsomal cytochrome P-450 isozymes.
Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite.
Studies on the metabolism of haloperidol (HP): the role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HP.
[Mechanisms of aliphatic alcohols oxidation by enzymatic systems of the liver]
Depression, Postpartum
Maternal thyroid peroxidase antibodies during pregnancy: a marker of impaired child development?
Microsomal antibodies during gestation in relation to postpartum thyroid dysfunction and depression.
Dermatitis Herpetiformis
The prevalence of thyroid autoantibodies in dermatitis herpetiformis.
Thyroid abnormalities in dermatitis herpetiformis. Prevalence of clinical thyroid disease and thyroid autoantibodies.
Dermatitis, Allergic Contact
Subcellular fractions from dermis and epidermis in contact sensitization of guinea pigs to 1-chloro-2,4-dinitrobenzene.
Dermatitis, Atopic
[Study of liver function in babies with atopic dermatitis by using 13C-methacetin breath test]
Dermatitis, Contact
Contact sensitivity in vitro. The significance of microsomal fractions as antigens in contact sensitivity.
Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse.
Dermatomyositis
Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis.
Diabetes Mellitus
Antithyroid antibodies in Hispanic patients with type I diabetes mellitus. Prevalence and significance.
Effect of long-term anticonvulsant therapy on glucose metabolism in humans.
Effect of metformin on renal microsomal proteins, lipid peroxidation and antioxidant status in dexamethasone-induced type-2 diabetic mice.
Effect of the microsomal triglyceride transfer protein -493 G/T polymorphism and type 2 diabetes mellitus on LDL subfractions.
Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians.
Frequency of Hashimoto's thyroiditis in children with type 1 diabetes mellitus.
Lack of induction of serum gamma-glutamyltransferase in diabetes mellitus.
Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
Possible role of microsomal epoxide hydrolase gene polymorphism as a risk factor for developing insulin resistance and type 2 diabetes mellitus.
Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus.
Separate influences of insulin and hyperglycemia on hepatic drug metabolism in mice with genetic and chemically induced diabetes mellitus.
The effect of diabetes mellitus on aortic prostanoid synthesis and serum cholesterol levels in the rat fed a high cholesterol diet.
The effect of streptozotocin-induced diabetes mellitus on urinary excretion of sodium and renal Na+-K+-ATPase activity.
Thyroglobulin and microsomal antibodies in patients with insulin dependent diabetes mellitus and their relatives.
Thyroid autoantibodies in black and in white children and adolescents with type 1 diabetes mellitus and their first degree relatives.
Thyroid autoimmunity in type 2 (non-insulin-dependent) diabetic patients of Caucasoid, black and Mexican origin.
[Antitoxic function of the liver and the effect of zixorin in patients with diabetes mellitus]
[Evaluation of hepatic microsomal enzyme activity using C-l4-labeled aminopyrine breath test in patients with diabetes mellitus type 2 treated with tolbutamide]
[Systemic autoantibodies and their correction in patients with diabetic retinopathy in type 1 diabetes mellitus]
[Thyroglobulin and microsomal antibodies in diabetes mellitus in childhood (author's transl)]
[Thyroid autoantibodies in diabetes mellitus and rheumatoid arthritis]
Diabetes Mellitus, Experimental
Altered microsomal phospholipid composition in the streptozotocin diabetic rat.
Changes in the activity of NADH-oxidase in rat tissues during experimental diabetes.
Effect of experimental diabetes on the fatty acid composition, molecular species of phosphatidyl-choline and physical properties of hepatic microsomal membranes.
Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters.
The effect of alloxan diabetes on the activity of some mixed function oxidases in male rats.
[Interrelation of the processes of lipid peroxidation and hydroxylation in the liver microsomal fraction of white rats with alloxan diabetes]
[Oxidative processes and phospholipid metabolism in hepatocyte membranes during alloxan diabetes]
Diabetes Mellitus, Lipoatrophic
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Diabetes Mellitus, Type 1
A possible mechanism of insulin resistance in the rat adipose cell in streptozotocin-induced diabetes mellitus. Depletion of intracellular glucose transport systems.
Adrenal autoantibodies and Addison disease in insulin-dependent diabetes mellitus.
Autoantibodies in recent onset type-1 diabetic patients to a Mr 60K microsomal hepatic protein: new evidence for autoantibodies to the type-2 glucose transporter.
Effect of long-term anticonvulsant therapy on glucose metabolism in humans.
Epidemiology of insulin dependent diabetes before age 20 in Wisconsin, with particular reference to seasonality.
Frequency of Hashimoto's thyroiditis in children with type 1 diabetes mellitus.
Prevalence of islet cell and thyrogastric autoantibodies in Sudanese patients with type 1 diabetes.
Screening for thyroid disease in children with IDDM.
Thyroid peroxidase antibodies in children with autoimmune thyroiditis.
Thyroid, gastric, and adrenal autoimmunities associated with insulin-dependent diabetes mellitus.
Thyroid-stimulating immunoglobulins in insulin-dependent diabetes mellitus.
[Thyroglobulin and microsome autoantibodies and their clinical significance in adult type I diabetics]
[Thyroid hormone anomalies in patients with insulin-dependent diabetes mellitus and circulating antithyroid microsomal antibodies]
Diabetes Mellitus, Type 2
A common functional exon polymorphism in the microsomal triglyceride transfer protein gene is associated with type 2 diabetes, impaired glucose metabolism and insulin levels.
Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes.
Effect of the microsomal triglyceride transfer protein -493 G/T polymorphism and type 2 diabetes mellitus on LDL subfractions.
Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects.
Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians.
Messenger RNA levels of genes involved in dysregulation of postprandial lipoproteins in type 2 diabetes: the role of Niemann-Pick C1-like 1, ATP-binding cassette, transporters G5 and G8, and of microsomal triglyceride transfer protein.
Microsomal triglyceride transfer protein polymorphisms and lipoprotein levels in type 2 diabetes.
Plasma HDL cholesterol and blood glucose in non-insulin-dependent diabetics related to liver lipids and microsomal enzyme activity.
Possible role of microsomal epoxide hydrolase gene polymorphism as a risk factor for developing insulin resistance and type 2 diabetes mellitus.
Regulation of putative fatty acid transporters and Acyl-CoA synthetase in liver and adipose tissue in ob/ob mice.
Treatment of noninsulin-dependent diabetes mellitus with enzyme inducers.
[Determination of autoantibodies to pancreatic beta-cells, non-islet endocrine cells and fibroblasts in patients with newly detected diabetes mellitus]
[Humoral autoimmunity markers in autoimmune endocrine diseases]
Diabetes, Gestational
Autoantibodies in black women with class A1 or class GB diabetes mellitus.
Diabetic Nephropathies
Effects of vitamin E on microsomal Ca(2+) -ATPase activity and calcium levels in streptozotocin-induced diabetic rat kidney.
Diabetic Retinopathy
Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes.
[Systemic autoantibodies and their correction in patients with diabetic retinopathy in type 1 diabetes mellitus]
Digestive System Diseases
Serum gamma-glutamyl transferase activity in chronic renal failure during regular hemodialysis and after successful renal transplantation.
Diphtheria
Mutation induction by okadaic acid, a protein phosphatase inhibitor, in CHL cells, but not in S. typhimurium.
Vaccine-induced alterations in hepatic drug metabolism.
Disorder of Sex Development, 46,XY
Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases. A new variant of congenital adrenal hyperplasia.
DNA Repair-Deficiency Disorders
Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia.
Down Syndrome
Thyroid dysfunction in institutionalised Down's syndrome adults.
Drug-Related Side Effects and Adverse Reactions
Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions.
Decreases in phenytoin hydroxylation activities catalyzed by liver microsomal cytochrome P450 enzymes in phenytoin-treated rats.
Effect of four-day treatment with carbamazepine at different dose levels on microsomal enzyme induction, drug metabolism and drug toxicity.
Hepatic drug metabolism and adverse hepatic drug reactions.
Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital.
Immunofluorescence of phenobarbital inducible cytochrome P-450 in the hepatic lobule of normal and phenobarbital-treated rats.
Thalidomide teratogenesis: evidence for a toxic arene oxide metabolite.
Upper-airway obstruction and prolonged recovery from anesthesia following intranasal clotrimazole administration.
Duodenal Ulcer
[Assessment of microsomal enzyme function in liver of patients with duodenal ulcer treated with famotidine]
[Evaluation of microsomal enzyme function in the liver in patients with duodenal ulcer treated with famotidine]
[Evaluation of microsomal liver enzyme function in patients with duodenal ulcer treated with ranitidine]
[Liver microsomal enzyme function in patients with duodenal ulcer treated with cimetidine]
Dyslipidemias
A Small Molecule Inhibitor of Enterocytic Microsomal Triglyceride Transfer Protein; SLx-4090, Biochemical, Pharmacodynamic, Pharmacokinetic and Safety Profile.
Cholesterol: the good, the bad, and the ugly - therapeutic targets for the treatment of dyslipidemia.
Effect of microsomal triglyceride transfer protein gene polymorphism in the promoter region on dyslipidemia in type 2 diabetic subjects.
Emerging therapies for dyslipidemia: known knowns and known unknowns of MTP inhibitors.
Genetics for the Identification of Lipid Targets Beyond PCSK9.
Insights into the Novel Hydrolytic Mechanism of a Diethyl 2-Phenyl-2-(2-arylacetoxy)methyl Malonate Ester-Based Microsomal Triglyceride Transfer Protein (MTP) Inhibitor.
Intestinal rather than hepatic microsomal triglyceride transfer protein as a cause of postprandial dyslipidemia in diabetes.
JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, improves hyperglycemia and dyslipidemia independent of suppression of food intake in diabetic rats.
Potential Approaches to Ameliorate Hepatic Fat Accumulation Seen with MTP Inhibition.
PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease.
Toward an international consensus-Integrating lipoprotein apheresis and new lipid-lowering drugs.
[Diagnosis of Secondary Hyperlipidemia due to Diabetes].
Echinococcosis
Albendazole treatment of echinococcosis in humans: effects on microsomal metabolism and drug tolerance.
Chemotherapy of larval echinococcosis with mebendazole: microsomal liver function and cholestasis as determinants of plasma drug level.
Eczema
[Behavior of the liver microsomal detoxification systems in experimental dinitrochlorobenzene eczema]
Encephalomalacia
The influence of dietary fatty acids and vitamin E on plasma prostanoids and liver microsomal alkane production in broiler chickens with regard to nutritional encephalomalacia.
Encephalomyelitis
Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1? in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1? in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.
Endometrial Neoplasms
Carcinogen activation by human uterine enzymes.
Cholesterol esterification in human secretory endometrium and in endometrial cancer tissue. Demonstration of microsomal acyl-CoA-cholesterol acyl-transferase (ACAT) activity.
Studies on 17 beta-hydroxysteroid dehydrogenase in human endometrium and endometrial carcinoma. III. Partial purification and characterization of the microsomal enzyme.
Endometriosis
Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients.
The association of endometriosis risk and genetic polymorphisms involving dioxin detoxification enzymes: A systematic review.
Endotoxemia
Microsomal Ethanol-Oxidizing System: Success Over 50 Years and an Encouraging Future.
[The state of the microsomal oxidative system in the rat liver during fecal peritonitis]
Eosinophilia
Short-term inhalation toxicity of methanol, gasoline, and methanol/gasoline in the rat.
Epilepsy
ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients.
Antiopyrine half-life as a measure of hepatic enzyme induction: clinical applications in a chronic epileptic population.
Association between EPHX1 polymorphisms and carbamazepine metabolism in epilepsy: a meta-analysis.
Association of ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA, and BAG6 polymorphisms with the risk of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Chinese Han patients with epilepsy.
Death-associated protein kinase expression in human temporal lobe epilepsy.
Different EPHX1 methylation levels in promoter area between carbamazepine-resistant epilepsy group and carbamazepine-sensitive epilepsy group in Chinese population.
Effect of long-term anticonvulsant therapy on glucose metabolism in humans.
Effects of EPHX1 and CYP3A4*22 genetic polymorphisms on carbamazepine metabolism and drug response among Tunisian epileptic patients.
Effects of EPHX1, SCN1A and CYP3A4 genetic polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.
Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.
In vivo and in vitro correlation of microsomal epoxide hydrolase inhibition by progabide.
Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations.
Pharmacokinetic interactions with antiepileptic drugs.
Pharmacokinetics of radiotracers in human plasma during positron emission tomography.
Topiramate modulates hippocampus NMDA receptors via brain Ca(2+) homeostasis in pentylentetrazol-induced epilepsy of rats.
Epilepsy, Tonic-Clonic
Interactions with antiepileptic drugs.
Epiretinal Membrane
Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes.
Epstein-Barr Virus Infections
Autoimmune hepatitis type-2 and Epstein-Barr virus infection in a toddler: art of facts or an artifact?
Erythroblastosis, Fetal
[Effectiveness of a new Soviet drug Benzonal, inductor of microsomal enzymes of the liver, in the complex treatment of hemolytic disease of newborn]
Esophageal Neoplasms
Association between esophageal cancer risk and EPHX1 polymorphisms: a meta-analysis.
Association between microsomal epoxide hydrolase 1 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.
CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high- incidence area in north China.
EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.
EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis.
High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor.
Lack of association between EPHX1 polymorphism and esophageal cancer risk: evidence from meta-analysis.
Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk.
Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer.
Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India.
[Spermidine radioimmunoassay in monitor of precancerous lesions of esophagus]
Esophageal Squamous Cell Carcinoma
Association of Activity Altering Genotypes - Tyr113His and His139Arg in Microsomal Epoxide Hydrolase Enzyme with Esophageal Squamous Cell Carcinoma.
EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.
Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China.
Essential Hypertension
The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility.
Exfoliation Syndrome
Immunohistochemical analysis of microsomal glutathione S-transferase 1 and clusterin expression in lens epithelial cells of patients with pseudoexfoliation syndrome.
Quantitative analysis of SOD2, ALDH1A1 and MGST1 messenger ribonucleic acid in anterior lens epithelium of patients with pseudoexfoliation syndrome.
Exophthalmos
Immunologically mediated cytotoxicity against human eye muscle and thyroid cells in euthyroid and thyrotoxic Graves' ophthalmopathy.
Relationship of eye muscle antibodies with HLA phenotypes and thyroid-stimulating immunoglobulins in endocrine orbitopathy.
Role of thyrotropin receptor antibodies in the development of hyperthyroidism: follow-up studies on nine patients with Graves' disease.
exoribonuclease ii deficiency
Ribonucleases and neoplasia.
Familial Mediterranean Fever
Oxidative stress in the molecular mechanism of pathogenesis at different diseased states of organism in clinics and experiment.
Fanconi Anemia
Abnormal microsomal detoxification implicated in Fanconi anemia group C by interaction of the FAC protein with NADPH cytochrome P450 reductase.
Fascioliasis
Antihepatotoxic properties of uridine-diphosphoglucose in liver fluke infection. Experimental fascioliasis in the rat.
Characterization of the microsomal cytochrome P-450 species inhibited in rat liver in the course of fascioliasis.
Decrease in hepatic microsomal UDP-glucuronosyl-transferase activity in rats and cattle with fascioliasis: impaired in vitro glucuronidation of oxyclozanide.
Impaired in vitro metabolism of the flukicidal agent nitroxynil by hepatic microsomal cytochrome P-450 in bovine fascioliasis.
Incidence of a subclinical fascioliasis on antipyrine clearance and metabolite excretion in sheep.
Fatty Liver
Alcoholic liver injury: experimental models in rats and baboons.
Alloxan induced fatty liver degeneration in rat: its effect on the microsomal lipids.
Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion.
Anesthetic biotransformation and renal function in obese patients during and after methoxyflurane or halothane anesthesia.
Animal models of ethanol dependence and liver injury in rats and baboons.
Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with type II diabetes.
Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease.
Changes in hepatic microsomal triglyceride transfer protein and triglyceride in periparturient dairy cattle.
Correlation between MTP -493G>T polymorphism and non-alcoholic fatty liver disease risk: a meta-analysis.
Decreased microsomal triglyceride transfer protein activity contributes to initiation of alcoholic liver steatosis in rats.
Dietary egg white protein hydrolysate improves orotic acid-induced fatty liver in rats by promoting hepatic phospholipid synthesis and microsomal triglyceride transfer protein expression.
Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development.
Effect of betaine on the hepatic damage from orotic acid-induced fatty liver development in rats.
Effect of dietary composition and estradiol implants on hepatic microsomal mixed function oxidase and lipid deposition in growing chicks.
Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on fatty liver induced by carbon tetrachloride.
Effects of mineral and vitamin supplementation on the alcohol-induced fatty liver and microsomal induction.
Ethanol-related changes in liver microsomes and mitochondria from the monkey, Macaca fascicularis.
Etiology of fatty liver in dairy cattle: effects of nutritional and hormonal status on hepatic microsomal triglyceride transfer protein.
Etiopathogenesis of nonalcoholic steatohepatitis.
Expression and methylation of microsomal triglyceride transfer protein and acetyl-CoA carboxylase are associated with fatty liver syndrome in chicken.
Genes and nonalcoholic fatty liver disease.
Genes or environment to determine alcoholic liver disease and non-alcoholic fatty liver disease.
Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India.
Genetics of alcoholic liver disease and nonalcoholic fatty liver disease.
GLP-2 Dysregulates Hepatic Lipoprotein Metabolism, Inducing Fatty Liver and VLDL Overproduction in Male Hamsters and Mice.
Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon.
L-tryptophan alleviates fatty liver and modifies hepatic microsomal mixed function oxidase in laying hens.
Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients.
Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis.
Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis.
Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH.
Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism.
Membrane stabilising effects of natural polyphenols and flavonoids from Sempervivum tectorum on hepatic microsomal mixed-function oxidase system in hyperlipidemic rats.
MTP -493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients.
Non-Alcoholic Steatohepatitis Decreases Microsomal Liver Function in the Absence of Fibrosis.
Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment.
Novel Findings for the Development of Drug Therapy for Various Liver Diseases:Liver Microsomal Triglyceride Transfer Protein Activator May Be a Possible Therapeutic Agent in Non-alcoholic Steatohepatitis.
Organs related to glucose metabolism and aging in animal models.
Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very low density lipoprotein assembly.
Peroxisomal beta-oxidation and steatohepatitis.
Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis.
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Prevention of the acute ethanol-induced fatty liver by antihistamines and stimulants of hepatic microsomal enzyme activity.
Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing.
Retardation of microsomal protein synthesis in rat liver due to induction of Handler's experimental fatty liver.
Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets.
Subchronic toxicity of PCB 105 (2,3,3',4,4'-pentachlorobiphenyl) in rats.
[Alcoholic and non-alcoholic steatohepatitis]
[Effects of diispropyl 1, 3-dithiol-2-ylidene malonate (NKK-105) on the drug-metabolizing enzymes and fine structure of rat liver (author's transl)]
[Studies on drug metabolism in obese men and mice (author's transl)]
Fatty Liver, Alcoholic
Decreased microsomal triglyceride transfer protein activity contributes to initiation of alcoholic liver steatosis in rats.
Effect of ursodeoxycholic acid on prostaglandin metabolism and microsomal membranes in alcoholic fatty liver.
Hepatic alterations in rats fed ethanol at two levels of lipotropes.
Microsomal delta 9, delta 6 and delta 5 desaturase activities and liver membrane fatty acid profiles in alcohol-fed rats.
[Clinical aspects of alcohol induced liver injury (author's transl)]
[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
Fetal Growth Retardation
The prevalence of autoantibodies during third-trimester pregnancy complicated by hypertension or idiopathic fetal growth retardation.
Fetal Resorption
[Animal experiment studies of the modification of pregnancy by heterologous antibodies to placental antigens]
Fibromatosis, Aggressive
Estrogen and antiestrogen binding sites in desmoid tumors.
Folic Acid Deficiency
Effect of folate deficiency on microsomal drug metabolism and heme content in the intestinal mucosa of guinea pigs.
Gallstones
ACAT2 and human hepatic cholesterol metabolism: Identification of important gender-related differences in normolipidemic, non-obese Chinese patients.
Bile acid synthesis in man: assay of hepatic microsomal cholesterol 7 alpha-hydroxylase activity by isotope dilution-mass spectrometry.
Hepatic acyl-coenzyme A:cholesterol acyltransferase activity is decreased in patients with cholesterol gallstones.
Hepatic cholesterol and bile acid metabolism in subjects with gallstones: comparative effects of short erm feeding of chenodeoxycholic and ursodeoxycholic acid.
Hepatic cholesterol metabolism in cholesterol gallstone disease.
Hepatic microsomal activities of cholesterol 7 alpha-hydroxylase and 3-hydroxy-3-methylglutaryl-CoA reductase in the prairie dog. An animal model for cholesterol gallstone disease.
Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice.
Inactivation of hepatic microsomal triglyceride transfer protein protects mice from diet-induced gallstones.
Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease.
Lack of response to chenodeoxycholic acid in obese and non-obese patients. Role of cholesterol synthesis and possible response to ursodeoxycholic acid.
Modulation of cholesterol 7 alpha-hydroxylase activity by nonspecific lipid transfer protein in human liver--possibly altered regulation of its cytosolic level in patients with gallstones.
On the saturation of the cholesterol 7 alpha-hydroxylase in human liver microsomes.
Possible role of a defect in hepatic bilirubin glucuronidation in the initiation of cholesterol gallstones.
Treatment with the natural FXR agonist chenodeoxycholic acid reduces clearance of plasma LDL whilst decreasing circulating PCSK9, lipoprotein(a) and apolipoprotein C-III.
Gangliosidosis, GM1
Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain.
Gastritis
Autoantibodies in chronic gastritis.
Gastroenteritis
Unusual occupational gastrointestinal and hepatic disorders.
Gastroesophageal Reflux
Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma.
Gastrointestinal Diseases
Use of Nanovesicles from Orange Juice to Reverse Diet-Induced Gut Modifications in Diet-Induced Obese Mice.
Genetic Diseases, Inborn
Cell death and stress signaling in glycogen storage disease type I.
Characterisation of CAH alleles with non-radioactive DNA single strand conformation polymorphism analysis of the CYP21 gene.
Identification of two classes of lipid molecule binding sites on the microsomal triglyceride transfer protein.
The common P450 oxidoreductase variant A503V is not a modifier gene for 21-hydroxylase deficiency.
The role of the microsomal triglygeride transfer protein in abetalipoproteinemia.
Gilbert Disease
Effects of bucolome and related barbiturate derivatives on the displacement of bilirubin from plasma albumin in vivo and in vitro.
Gilbert's syndrome and drug metabolism.
Regulation of bilirubin glucuronide synthesis in primate (Macaca fascicularis) liver. Kinetic analysis of microsomal bilirubin uridine diphosphate glucuronyltransferase.
Glaucoma
The quality of optometrists' referral letters for glaucoma.
Glioblastoma
Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.
Glioma
Cytotoxicity of alkyl-lysophospholipid derivatives and low-alkyl-cleavage enzyme activities in rat brain tumor cells.
Evidence for a GTP-dependent increase in membrane permeability for calcium in NG108-15 microsomes.
Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line.
Heterogeneous nuclear ribonucleoproteins and their interactors are a major class of deregulated proteins in anaplastic astrocytoma: a grade III malignant glioma.
Identification of the putative brain tumor antigen BF7/GE2 as the (de)toxifying enzyme microsomal epoxide hydrolase.
Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation.
Involvement of tyrosine kinase in capacitative Ca2+ entry pathway in rat glioma C6 cells.
Is there a relationship between 3-hydroxy-3-methylglutaryl coenzyme a reductase activity and forebrain pathology in the PKU mouse?
Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin.
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.
Glomerulonephritis
Genetic variants of microsomal metabolism and susceptibility to hydrocarbon-associated glomerulonephritis.
Glossitis
Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity.
Glucose Intolerance
Dietary P(i) deprivation in rats affects liver cAMP, glycogen, key steps of gluconeogenesis and glucose production.
Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model.
JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses high fat diet-induced obesity and glucose intolerance in Sprague-Dawley rats.
Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of microsomal triglyceride transfer protein (MTP) in obese rats.
Up-regulation of liver glucose-6-phosphatase in rats fed with a P(i)-deficient diet.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Microsomal incubation test of potentially hemolytic drugs for glucose-6-phosphate dehydrogenase deficiency.
Glucosephosphate Dehydrogenase Deficiency
Microsomal incubation test of potentially hemolytic drugs for glucose-6-phosphate dehydrogenase deficiency.
glucuronosyltransferase deficiency
UDP-glucuronyltransferase-catalyzed deconjugation of bilirubin monoglucuronide.
glutathione synthase deficiency
Acetaminophen toxicity in lymphocytes heterozygous for glutathione synthetase deficiency.
Glutathione synthetase-deficient lymphocytes and acetaminophen toxicity.
Glycogen Storage Disease
A conformational model for the human liver microsomal glucose-6-phosphatase system: evidence from rapid kinetics and defects in glycogen storage disease type 1.
A direct evidence for defect in glucose-6-phosphate transport system in hepatic microsomal membrane of glycogen storage disease type IB.
Asymptomatic critical hypoglycaemia: a dangerous presentation of glycogen storage disease type Ib in infancy.
Cell death and stress signaling in glycogen storage disease type I.
Exon redefinition by a point mutation within exon 5 of the glucose-6-phosphatase gene is the major cause of glycogen storage disease type 1a in Japan.
Genomic structure of the human glucose 6-phosphate translocase gene and novel mutations in the gene of a Japanese patient with glycogen storage disease type Ib.
Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse.
Glucose-6-phosphatase mutation G188R confers an atypical glycogen storage disease type 1b phenotype.
Glycogen storage disease type 1a in Israel: biochemical, clinical, and mutational studies.
Glycogen storage disease type 1a in three siblings with the G270V mutation.
Glycogen storage disease type 1b: microsomal glucose-6-phosphatase system in two patients with different clinical findings.
Glycogen storage disease type I: diagnosis and phenotype/genotype correlation.
Glycogen storage disease type Ia (GSDIa) but not Glycogen storage disease type Ib (GSDIb) is associated to an increased risk of metabolic syndrome: possible role of microsomal glucose 6-phosphate accumulation.
Glycogen storage disease type Ib: a defect in the glucose-6-phosphate transport system in microsomal membrane (The Japan Society of Human Genetics Award lecture).
Glycogen storage disease type Ib: structural and mutational analysis of the microsomal glucose-6-phosphate transporter gene.
Homology modeling of the human microsomal glucose 6-phosphate transporter explains the mutations that cause the glycogen storage disease type Ib.
Identification of mutations in the gene for glucose-6-phosphatase, the enzyme deficient in glycogen storage disease type 1a.
Impaired chemotaxis and neutrophil (polymorphonuclear leukocyte) function in glycogenosis type IB.
Improved preparation of hepatic microsomes for in vitro diagnosis of inherited disorders of the glucose-6-phosphatase system.
Inactivation of the glucose 6-phosphate transporter causes glycogen storage disease type 1b.
Inhibition of microsomal glucose-6-phosphate transport in human neutrophils results in apoptosis: a potential explanation for neutrophil dysfunction in glycogen storage disease type 1b.
Is glycogen storage disease 1a associated with atherosclerosis?
Liver microsomal transport of glucose-6-phosphate, glucose, and phosphate in type 1 glycogen storage disease.
Molecular analysis of glycogen storage disease type Ib: identification of a prevalent mutation among Japanese patients and assignment of a putative glucose-6-phosphate translocase gene to chromosome 11.
Molecular diagnosis of type 1c glycogen storage disease.
Molecular genetics of type 1 glycogen storage disease.
Mutation spectrum of glycogen storage disease type Ia in Tunisia: implication for molecular diagnosis.
Mutation spectrum of the glucose-6-phosphatase gene and its implication in molecular diagnosis of Korean patients with glycogen storage disease type Ia.
NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic.
Ontogeny of the murine glucose-6-phosphatase system.
Proton MR spectroscopy of the lumbar spine in patients with glycogen storage disease type Ib.
Transmembrane topology of glucose-6-phosphatase.
Two new mutations in the glucose-6-phosphatase gene cause glycogen storage disease in Hungarian patients.
Type Ib glycogen storage disease is caused by a defect in the glucose-6-phosphate translocase of the microsomal glucose-6-phosphatase system.
Type Ib glycogenosis.
[Glycogenoses type 1b and 1c]
Glycogen Storage Disease Type I
Cell death and stress signaling in glycogen storage disease type I.
Glycogen storage disease type 1a in Israel: biochemical, clinical, and mutational studies.
Glycogen storage disease type 1a in three siblings with the G270V mutation.
Two new mutations in the glucose-6-phosphatase gene cause glycogen storage disease in Hungarian patients.
Goiter
A simple semiquantitative radiometric measurement of antithyroglobulin antibodies in human serum. Comparison with hemagglutination method.
Cellular immunity as a valuable factor for prognostic prediction in patients with Graves' disease under antithyroid drug therapy.
Childhood thyromegaly: recent developments.
Cytologic characterization of postiodization residual goiter in schoolchildren by fine needle biopsy.
Graves' disease and Turner's syndrome.
Hyperthyroidism due to Graves' disease and due to autonomous goiter.
Immunological features of endemic goiter.
Kentucky Appalachian goiter without iodine deficiency. Evidence for evanescent thyroiditis.
Mixed connective tissue disease associated with idiopathic portal hypertension and chronic thyroiditis.
Patients with endocrine ophthalmopathy not associated with overt thyroid disease have multiple thyroid immunological abnormalities.
Practical treatment with minimum maintenance dose of anti-thyroid drugs for prediction of remission in Graves' disease.
Prevalence of thyroid diseases in patients with alopecia areata.
Prevalence of thyroid microsomal and thyroglobulin autoantibodies in goitrous lesions.
Thyroid cancer yield in patients with Graves' disease selected for surgery on the basis of cold scintiscan defects.
Thyroid disease and high concentration of serum thyrotrophin in a population sample of women. A 4-year follow-up.
Transient postpartum hypothyroidism: fourteen cases with autoimmune thyroiditis.
Valuable predictive features of relapse of Graves' disease after antithyroid drug treatment.
[A case of Hypothyroid Graves' disease with extremely high titers of TSAb]
[A long-term follow-up study of patients with chronic lymphocytic thyroiditis--with special reference to histological findings]
[An immunoenzyme method of determining serum levels of anti-microsomal antibodies]
[Characteristics of the clinical picture, hormonal status and humoral immunity in older patients with diffuse toxic goiter]
[Cytologic differentiation between the autonomous and autoimmune type of diffuse hyperthyroid goiter: correlation with TSH receptor antibodies, microsomal antibodies and infiltrative ophthalmopathy]
[Diffuse toxic goiter associated with autoimmune thyroiditis]
[Humoral autoimmunity markers in autoimmune endocrine diseases]
[Immunological reactivity and the HLA system antigens in patients with autoimmune thyroiditis and nodular euthyroid goiter]
[Importance of thyroid diseases in internal medical hospital]
[Post-partum autoimmune thyroiditis in a patient presenting with Sheehan's syndrome]
[The concentration of nucleic acids in the subcellular structures of the thyroid gland in several of its diseases]
[Thyroid antibodies in autoimmune diseases of the thyroid and their dependence on the presence of autoantigens]
Goiter, Endemic
The relationship between autoimmune thyroid disease and iodine intake: a review.
[Antithyroid antibodies and endemic goiter]
Goiter, Nodular
Immunopathological findings and thyroid autoantibodies in thyroid autonomy.
Lack of response of peripheral blood mononuclear cells to thyroid microsomal antigen in nontoxic nodular goiters.
Microsomal reductase activity in patients with thyroid neoplasms.
[Systemic urticaria associated with autoimmune thyroiditis]
Granuloma
Alterations of hepatic microsomal enzymes in the early phase of murine schistosomiasis.
Graves Disease
Anterior pituitary cell antibodies detected in Hashimoto's thyroiditis and Graves' disease.
Anti-nuclear antibody, anti-DNA, and aCL in Graves' disease patients treated with propyluracil or methimazole.
Antibodies to the thyroid gland and to the thyrotrophin receptor in African and Indian thyrotoxic patients.
Carbimazole and the autoimmune response in Graves' disease.
Changes in serum autoantibodies to thyroid peroxidase during antithyroid drug therapy for Graves' disease.
Changes of circulating thyroid autoantibody levels during and after the therapy with methimazole in patients with Graves' disease.
Changes of serum anti-thyroid antibodies during and after pregnancy in autoimmune thyroid diseases.
Clinical significance of anti-TSH antibody in sera from patients with Graves' disease and other thyroid disorders.
Comparison of thyroperoxidase and microsomal antibody assays in sera from patients with Graves disease.
Correlation of microsomal antibodies with the intensity of the intrathyroidal autoimmune process in Graves' disease.
Correlation of orbital computed tomography and antibodies in patients with hyperthyroid Graves' disease.
Detection of autoantibodies to thyroid peroxidase in autoimmune thyroid diseases by micro-ELISA and immunoblotting.
Development of postpartum spontaneously resolving transient Graves' hyperthyroidism followed immediately by transient hypothyroidism.
Discordant changes in serum anti-TSH receptor antibody and antithyroid microsomal antibody during pregnancy in autoimmune thyroid diseases.
Effect of HLA-DR positive thyrocytes on in vitro thyroid autoantibody production.
Effect of thyrotropin-releasing hormone on serum thyroid hormones: a study in the patients with untreated and treated Graves' disease and subacute thyroiditis.
Enhanced expression of complement regulatory proteins on thyroid epithelial cells of Graves' disease.
Evaluation of TSH receptor antibody by 'natural in vivo human assay' in neonates born to mothers with Graves' disease.
Expression of the microsomal antigen on the surface of continuously cultured rat thyroid cells is modulated by thyrotropin.
Graves' disease and Hashimoto's thyroiditis: effects of high doses of antithyroid drugs on thyroid autoantibody levels.
Graves' disease and Turner's syndrome.
Hyperthyroidism due to Graves' disease and due to autonomous goiter.
IgG subclass distribution of thyroid autoantibodies: a 'fingerprint' of an individual's response to thyroglobulin and thyroid microsomal antigen.
Immunoelectron microscopic study of thyroid microsomal antigen.
Immunoglobulin A class fibroblast antibodies in patients with Graves' disease and pretibial myxedema.
Immunological disturbances in toxic multinodular goitre and active Graves' disease.
Immunological features of nonimmunogenic hyperthyroidism.
In vitro production of interferon-gamma by peripheral blood from patients with Graves' disease, Hashimoto's thyroiditis and rheumatoid arthritis.
Increased soluble interleukin 2 receptor levels in autoimmune thyroid disease.
Insoluble particulate antigen(s) in cell-mediated immunity of autoimmune thyroid disease.
Intrathyroidal cytokine gene expression profiles in autoimmune thyroiditis.
Measurement and clinical significance of thyroid microsomal and thyroglobulin antibodies by enzyme-linked immunosorbent assay.
Microsomal antigen-reactive lymphocyte lines and clones derived from thyroid tissue of patients with Graves' disease.
Peripheral blood T lymphocyte sensitization to thyroid microsomal antigen from patients with Graves' disease negative for circulating anti-thyroid microsomal antibodies.
Plasma membrane shedding and colloid vacuoles in hyperactive human thyroid tissue.
Prediction of post-partum Graves' thyrotoxicosis by measurement of thyroid stimulating antibody in early pregnancy.
Prevalence & significance of pancreatic islet cell & adrenal antibodies in patients with Graves' disease.
Retrospective reevaluation of the significance of thyroid microsomal antibody in the treatment of Graves' disease.
Significance of thyroid microsomal antibody in Graves' disease.
Similar effects of thionamide drugs and perchlorate on thyroid-stimulating immunoglobulins in Graves' disease: evidence against an immunosuppressive action of thionamide drugs.
T-lymphocyte subsets in pregnant women with Graves' disease.
The changes of serum titers of thyroid antibodies in patients of Graves' disease with hyperthyroidism after treatments with antithyroid drugs.
The IgG subclass distribution of thyroid autoantibodies.
The relationship of HLA-DR3 and outcome after antithyroid drugs to the IgG subclass distribution of thyroid autoantibodies in Graves' disease.
The significance of antithyroglobulin and antithyroidal microsomal antibodies in patients with hyperthyroidism due to Graves' disease treated with antithyroidal drugs.
Thyroid adenylate cyclase stimulating immunoglobulins in thyroid diseases.
Thyroid autoantigens and their relevance in the pathogenesis of thyroid autoimmunity.
Thyroid peroxidase antibodies in children with autoimmune thyroiditis.
[An immunoenzyme method of determining serum levels of anti-microsomal antibodies]
[Diagnostic value of thyroid antibodies]
[Humoral autoimmunity markers in autoimmune endocrine diseases]
[Laboratory diagnosis before onset and prediction of Graves' disease]
[Profile of autoimmune antibodies in idiopathic hypothyroidism and hypothyroidism following radio-iodine treatment in Basedow's disease: comparison with a group of normal subjects from the female population of Switzerland]
[The incidence of the pituitary autoantibodies in Graves' disease.]
[The presence of antithyroid antibodies in the blood serum of patients with diffuse toxic goiter before and during treatment]
Graves Ophthalmopathy
[Cytologic differentiation between the autonomous and autoimmune type of diffuse hyperthyroid goiter: correlation with TSH receptor antibodies, microsomal antibodies and infiltrative ophthalmopathy]
[Muscle antigens recognized with autoantibodies in patients with Graves' ophthalmopathy]
Gynecomastia
Studies on the interactions between drug and estrogen. II. On the inhibitory effect of 29 drugs reported to induce gynecomastia on the oxidation of estradiol at C-2 or C-17.
Hamartoma
Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas.
Hashimoto Disease
Detection of thyroid microsomal and thyroglobulin antibodies by new sensitive radioimmunoassay in Hashimoto's disease; comparison with conventional hemagglutination assay.
Hashimoto's disease in Turner's syndrome.
MICROSOMAL AND THYROGLOBULIN ANTIBODIES IN THYROID DISORDERS.
Postpartum thyrotoxicosis in a patient with Graves' disease. Association with low radioactive iodine uptake.
Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus.
Sclerosing lymphocytic lobulitis of the breast--evidence for an autoimmune pathogenesis.
[Diagnostic value of thyroid antibodies]
[Humoral autoimmunity markers in autoimmune endocrine diseases]
Head and Neck Neoplasms
Association between head and neck cancer and microsomal epoxide hydrolase genotypes.
CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer.
Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer.
Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer.
Hearing Loss, Sensorineural
Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.
Heart Defects, Congenital
The effect on congenital heart diseases of maternal EPHX1 polymorphisms modified by polycyclic aromatic hydrocarbons exposure.
Heart Failure
Canine cardiac digitalis receptors are preserved in congestive heart failure induced by rapid ventricular pacing.
Correlation between the demethylation rate of 14C-aminopyrine (breath-test) and haemodynamic parameters in congestive heart failure.
Effect of congestive heart failure on the intrinsic metabolic capacity of the liver in the dog.
Impairment of mitochondrial and sarcoplasmic reticular functions during the development of heart failure in cardiomyopathic (UM-X7.1) hamsters.
Role of sarcolemmal changes in cardiac pathophysiology.
The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury.
The effects of two new inotropic agents on microsomal liver function in patients with congestive heart failure.
Hepatic Encephalopathy
Liver failure and drug metabolism.
Hepatic Insufficiency
Development and testing of a bioartificial liver.
Hepatitis
A new antigen recognized by anti-liver-kidney-microsome antibody (LKMA).
Absence of anti-trifluoroacetate antibody after halothane anaesthesia in patients exhibiting no or mild liver damage.
Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.
Antibodies to liver/kidney microsome1 in chronic active hepatitis recognize specific forms of hepatic cytochrome P-450.
Antibody assays for the detection of patients sensitized to halothane.
Assessment of the (14C) aminopyrine breath test in liver disease.
Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2.
Autoantibodies and antigens in liver diseases--updated.
Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis.
Characterization of anti-liver kidney microsomal antibody in childhood autoimmune chronic active hepatitis: evidence for IgG1 subclass restriction, polyclonality and non cross-reactivity with hepatocyte surface antigens.
Chronic active hepatitis associated with liver-kidney microsomal antibody of an autoimmune type. Two familial cases.
Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.
Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis.
Correlation of induced drug metabolism with titer of duck hepatitis virus in chickens.
Cytochromes P450 and uridine triphosphate-glucuronosyltransferases: model autoantigens to study drug-induced, virus-induced, and autoimmune liver disease.
Detection of autoantibodies against M2, LKM-1, and SLA in liver diseases by standardized uniform ELISA-techniques.
Detection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitis.
Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians.
Development of thyroid autoimmunity after administration of recombinant human interferon-alpha 2b for chronic viral hepatitis.
Distinction between natural and pathological autoantibodies by immunoblotting and densitometric subtraction: liver-kidney microsomal antibody (LKM) positive sera identify multiple antigens in human liver tissue.
Effect of anti-basic liver protein antibody-induced liver injury on hepatic drug-metabolizing enzymes in C57 BL/6J mice.
Effect of silymarin (Carsil) on the microsomal glycoprotein and protein biosynthesis in liver of rats with experimental galactosamine hepatitis.
Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis.
Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis.
Evidence for expression in human liver of halothane-induced neoantigens recognized by antibodies in sera from patients with halothane hepatitis.
Factors affecting the expression of trifluoroacetylated liver microsomal protein neoantigens in rats treated with halothane.
FTIR spectroscopic and HPLC chromatographic studies of carbon tetrachloride induced acute hepatitis in rats: damage in liver phospholipid membrane.
Glutathione-S-transferase and microsomal epoxide hydrolase polymorphism and viral-related hepatocellular carcinoma risk in India.
Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase.
Haplotypes of Microsomal Epoxide Hydrolase and X-Ray Cross-Complementing Group 1 Genes in Indian Hepatocellular Carcinoma Patients.
Hepatic ?(9) and ?(6) desaturase activities during the recovery period following carbon tetrachloride poisoningdesaturase activities during the recovery period following carbon tetrachloride poisoning.
Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
Hepatic delta 9 and delta 6 desaturase activities during the recovery period following carbon tetrachloride poisoning.
Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase.
Identification by immunoblotting of three halothane-induced liver microsomal polypeptide antigens recognized by antibodies in sera from patients with halothane-associated hepatitis.
Identification of protein disulfide isomerase and calreticulin as autoimmune antigens in LEC strain of rats.
IgG subclass distribution of autoantibodies to glomerular basement membrane in Goodpasture's syndrome compared to other autoantibodies.
Immunoblotting as a confirmatory test for antimitochondrial antibodies in primary biliary cirrhosis.
Inhibition of microsomal lipid peroxidation and protein oxidation by extracts from plants used in bamun folk medicine (cameroon) against hepatitis.
Is autoimmune chronic active hepatitis a HCV-related disease?
Liver cell surface expression of the antigen reacting with liver-kidney microsomal antibody (LKM).
Long-term outcome of autoimmune hepatitis in children.
Low-titre auto-antibodies predict autoimmune disease during interferon-alpha treatment of chronic hepatitis C.
Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.
Mechanisms of halothane toxicity: novel insights.
Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane.
Microsomal pentobarbital hydroxylase activity in acute viral hepatitis.
Mitochondrial functions and content of microsomal and mitochondrial cytochromes in human cirrhosis.
Non-organ specific autoantibodies associated with chronic C virus hepatitis.
Occurrence of autoimmune antibodies to liver microsomal proteins associated with lethal hepatitis in LEC rats: effects of TJN-101 ((+)-(6S,7S,R-biar)- 5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11- methylenedioxy-6-dibenzo[a,c]cyclooctenol) on the development of hepatitis and the autoantibodies.
Occurrence of autoimmune antibodies to liver microsomal proteins in association with fulminant hepatitis in the LEC strain of rats.
Phenobarbital liver microsomal induction in MHV-3 viral hepatitis of the mouse.
Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes.
Progressive familial intrahepatic cholestasis type 4 in an Indian child: presentation, initial course and novel compound heterozygous mutation.
Recurrent episodes of acute hepatitis associated with LKM-1 (cytochrome P450 2D6) antibodies in identical twin brothers.
Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets.
Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72.
Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.
Stabilization of mitochondrial and microsomal function by polysaccharide of Ulva lactuca on D-Galactosamine induced hepatitis in rats.
The application of quantitative cytochemistry to study the acinar distribution of enzymatic activities in human liver biopsy sections.
The immunoelectron-microscopical demonstration of antibodies against endoplasmic reticulum (microsomes) in chronic aggressive hepatitis and liver cirrhosis.
The topography of trifluoroacetylated protein antigens in liver microsomal fractions from halothane treated rats.
Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9.
Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
Treatment of autoimmune chronic active hepatitis in childhood.
Uridine diphosphate glucoronosyl transferases, candidate antigens of liver-kidney microsomal antibodies in hepatitis delta virus-infected patients.
Viral load in samples from hepatitis C virus (HCV)-infected patients with various clinical conditions.
[Assessment of the status of microsomal and mitochondrial oxidation in rat liver tissue in tetracycline hepatitis]
[Chronic active hepatitis: recurrence after long-term immunosuppressive therapy in spite of normal liver histology]
[Complexed microsomal antigens in acute hepatitis B (author's transl)]
[Extrahepatic manifestations of hepatitis C virus infection]
[New protective effect of simvastatin in rats with experimental steatohepatitis]
[Non-organ specific anticytoplasmic autoantibodies. Immunoserologic detection and diagnostic relevance]
[Spondyloenchondrodysplasia with immune dysregulation: a case report and literature review].
[The assessment of liver microsomal oxidative capacity via caffeine and antipyrine elimination in patients with chronic active hepatitis: preliminary results]
[Tienilic acid-induced hepatitis associated with liver/kidney microsomal antibody (author's transl)]
Hepatitis A
Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A.
Hepatitis B
Expression of genes involved in lipogenesis is not increased in patients with HCV genotype 3 in human liver.
Hepatitis B spliced protein (HBSP) promotes the carcinogenic effects of benzo [alpha] pyrene by interacting with microsomal epoxide hydrolase and enhancing its hydrolysis activity.
Klinefelter's syndrome presenting with leg ulcers.
Microsomal Epoxide Hydrolase Polymorphisms and Haplotypes as Determinants of Hepatitis B Virusand Hepatitis C Virus-related Liver Disease in Indian Population.
Microsomal function in hepatitis B surface antigen healthy carriers: assessment of cytochrome P450 1A2 activity by the 14C-caffeine breath test.
Non-organ specific autoantibodies associated with chronic C virus hepatitis.
Polymorphisms of microsomal triglyceride transfer protein in different hepatitis B virus-infected patients.
Prevalence and significance of abdominal lymphadenopathy in patients with chronic liver disease: an ultrasound study.
[Chronic active hepatitis: recurrence after long-term immunosuppressive therapy in spite of normal liver histology]
[Complexed microsomal antigens in acute hepatitis B (author's transl)]
Hepatitis B, Chronic
Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study.
[Autoantibodies related to interferon therapy in chronic hepatitis B may affect the therapeutic response to interferon]
[Investigation of antinuclear antibodies in chronic hepatitis B patients].
Hepatitis C
A highly efficient and robust in vitro translation system for expression of picornavirus and hepatitis C virus RNA genomes.
A novel assay for detecting antibodies to cytochrome P4502D6, the molecular target of liver kidney microsomal antibody type 1.
A polymorphism in the microsomal triglyceride transfer protein can predict the response to antiviral therapy in Egyptian patients with chronic hepatitis C virus genotype 4 infection.
Analysis of hepatitis C virus genome in patients with autoimmune hepatitis type 2.
Anti-rat liver microsomal and cytosolic antibodies in hepatitis C virus infection.
Apolipoprotein-AII concentrations are associated with liver steatosis in patients with chronic hepatitis C.
Association between lipoprotein subfraction profile and the response to hepatitis C treatment in Japanese patients with genotype 1b.
Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A.
Autoimmune hepatitis type 2 and hepatitis C virus infection: study of HLA antigens.
Characterization of the liver cytosol antigen type 1 reacting with autoantibodies in chronic active hepatitis.
Clinical features and effect of antiviral therapy on anti-liver/kidney microsomal antibody type 1 positive chronic hepatitis C.
Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3.
Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians.
Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.
Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during alpha-interferon treatment.
Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection.
Evidence of a genetic basis for the different geographic occurrences of liver/kidney microsomal antibody type 1 in hepatitis C.
Genetic variation in the microsomal triglyceride transfer protein (-493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus.
Genotype 3 Infection: The Last Stand of Hepatitis C Virus.
Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP).
Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis.
Hepatitis C virus infection associated with liver-kidney microsomal antibody type 1 (LKM1) autoantibodies in children.
Hepatitis C virus-related chronic liver disease with autoantibodies to liver-kidney microsomes (LKM). Clinical characterization from idiopathic LKM-positive disorders.
Hepatotropic viruses and autoimmunity 1997.
Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease.
Immunoglobulin GM and KM allotypes and prevalence of anti-LKM1 autoantibodies in patients with hepatitis C virus infection.
Immunological disorders in chronic hepatitis C Egyptian patients.
Increased incidence of anti-LKM autoantibodies in a consecutive cohort of hepatitis C patients from central Greece.
Interferon therapy in liver/kidney microsomal antibody type 1-positive patients with chronic hepatitis C.
Klinefelter's syndrome presenting with leg ulcers.
Lichen planus, liver kidney microsomal (LKM1) antibodies and hepatitis C virus antibodies.
Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis.
Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane.
LKM3 autoantibodies in hepatitis C cirrhosis: a further phenomenon of the HCV-induced autoimmunity.
Low hepatitis C viremia levels in patients with anti-liver/kidney microsomal antibody type 1 positive chronic hepatitis.
Low prevalence of liver-kidney microsomal autoantibodies of type 1 (LKM1) in hepatitis C seropositive subjects on Crete, Greece.
Low-titre auto-antibodies predict autoimmune disease during interferon-alpha treatment of chronic hepatitis C.
Microsomal Epoxide Hydrolase Polymorphisms and Haplotypes as Determinants of Hepatitis B Virusand Hepatitis C Virus-related Liver Disease in Indian Population.
Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C.
MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus.
Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus infected patients is associated with the possession of HLA B51.
Non-organ specific autoantibodies associated with chronic C virus hepatitis.
Non-organ specific autoantibodies in children with chronic hepatitis C.
Prevalence of antibodies to hepatitis C and herpes simplex virus type 1 is not increased in children with liver kidney microsomal type 1 autoimmune hepatitis.
Prevalence of GBV-C/HGV-RNA, virus genotypes, and anti-E2 antibodies in autoimmune hepatitis.
Primary and secondary liver/kidney microsomal autoantibody response following infection with hepatitis C virus.
Study of the B cell response to cytochrome P450IID6 in sera from chronic hepatitis C patients.
The levels of monoamine neurotransmitters and measures of mental and emotional health in HCV patients treated with ledipasvir (LDV) and sofosbuvir (SOF) with or without ribavirin (RBV).
Thyroid dysfunction in Chinese hepatitis C patients: Prevalence and correlation with TPOAb and CXCL10.
Transient elastography as a noninvasive assessment tool for hepatopathies of different etiology in pediatric type 1 diabetes mellitus.
Treatment of autoimmune and extra-hepatic manifestations of HCV infection.
Two hepatitis C virus glycoprotein E2 products with different C termini.
Type 2 autoimmune hepatitis and hepatitis C virus infection.
[Primary and secondary autoimmunity in hepatology]
Hepatitis C, Chronic
A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens.
A polymorphism in the microsomal triglyceride transfer protein can predict the response to antiviral therapy in Egyptian patients with chronic hepatitis C virus genotype 4 infection.
Autoantibodies and hepatitis C virus genotypes in chronic hepatitis C patients in Estonia.
Clinical features and effect of antiviral therapy on anti-liver/kidney microsomal antibody type 1 positive chronic hepatitis C.
Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease.
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection.
Evidence of a genetic basis for the different geographic occurrences of liver/kidney microsomal antibody type 1 in hepatitis C.
Hepatitis C virus infection associated with liver-kidney microsomal antibody type 1 (LKM1) autoantibodies in children.
Heterogeneity of antigenic sites recognized by anti-liver/kidney microsomal antibody type I in autoimmune hepatitis and chronic hepatitis C.
Heterogeneity of liver-kidney microsomal autoantibodies in chronic hepatitis C and D virus infection.
High prevalence of thyroid autoantibodies in a prospective series of patients with chronic hepatitis C before interferon therapy.
Interferon and steroid treatment in patients with chronic hepatitis C and antinuclear or anti-liver-kidney microsomal antibodies.
Interferon therapy in liver/kidney microsomal antibody type 1-positive patients with chronic hepatitis C.
Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule.
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.
Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C.
MTP -493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients.
Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus infected patients is associated with the possession of HLA B51.
Non-organ specific autoantibodies associated with chronic C virus hepatitis.
Parameters of microsomal and cytosolic liver function but not of liver perfusion predict portal vein velocity in noncirrhotic patients with chronic hepatitis C.
Primary and secondary liver/kidney microsomal autoantibody response following infection with hepatitis C virus.
Recurrent episodes of acute hepatitis associated with LKM-1 (cytochrome P450 2D6) antibodies in identical twin brothers.
Steroid and interferon therapy in liver/kidney microsomal antibody-positive patients with chronic hepatitis C.
[Detection and the production mechanism of antinuclear antibodies (ANA) and anti-liver/kidney microsomal tpe 1 antibodies (anti-LKM1) in patients with chronic hepatitis C]
[Heterogeneity of antimicrosomal autoantibodies in chronic hepatitis C virus infection and delta hepatitis]
Hepatitis D
Detection and further characterization of a newly described microsomal autoantibody associated with chronic delta infection.
Hepatitis D, Chronic
Anti-GOR in hepatitis D: specific association with hepatitis C virus superinfection.
Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis.
Detection and further characterization of a newly described microsomal autoantibody associated with chronic delta infection.
Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D.
Hepatitis, Alcoholic
Aminopyrine N-demethylation: a prognostic test of liver function in patients with alcoholic liver disease.
Inhibition of hepatic drug metabolism by (+)-cyanidanol-3 (Catergen) in chronic alcoholic liver disease.
Non-organ specific autoantibodies associated with chronic C virus hepatitis.
Hepatitis, Autoimmune
A 12-year-old girl with antimitochondrial antibody-positive autoimmune hepatitis.
A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens.
A new antigen recognized by anti-liver-kidney-microsome antibody (LKMA).
A new epitope of CYP2D6 recognized by liver kidney microsomal autoantibody from japanese patients with autoimmune hepatitis.
A novel assay for detecting antibodies to cytochrome P4502D6, the molecular target of liver kidney microsomal antibody type 1.
Absence of LKM-1 antibody reactivity in autoimmune and hepatitis-C-related chronic liver disease in Sweden. Swedish Internal Medicine Liver club.
Analysis of hepatitis C virus genome in patients with autoimmune hepatitis type 2.
Anti-liver cytosolic antigen type 1 (LC1) antibodies in childhood autoimmune liver disease.
Anti-mitochondrial antibody positive autoimmune hepatitis triggered by EBV infection in a young girl.
Anti-peptide antibodies to the P4502D subfamily in rat, dog and man.
Anti-rat liver microsomal and cytosolic antibodies in hepatitis C virus infection.
Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2.
Autoantibodies in Autoimmune Hepatitis.
Autoantibodies to human cytosol: a marker of sporadic porphyria cutanea tarda.
Autoimmune hepatitis in childhood: a 20-year experience.
Autoimmune hepatitis type-2 and Epstein-Barr virus infection in a toddler: art of facts or an artifact?
Autoimmune hepatitis-specific antibodies against soluble liver antigen and liver cytosol type 1 in patients with chronic viral hepatitis.
Autoimmune hepatitis.
Characterization of anti-liver-kidney microsome antibody (anti-LKM1) from hepatitis C virus-positive and -negative sera.
Characterization of the liver cytosol antigen type 1 reacting with autoantibodies in chronic active hepatitis.
Clinical features and effect of antiviral therapy on anti-liver/kidney microsomal antibody type 1 positive chronic hepatitis C.
Cutting Edge Issues in Autoimmune Hepatitis.
Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease.
Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2.
Detection of anti-endoplasmic reticulum antibody-positive autoimmune hepatitis in children, using an ELISA technique.
Detection of anti-liver cytosol antibody type 1 (anti-LC1) by immunodiffusion, counterimmunoelectrophoresis and immunoblotting: comparison of different techniques.
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection.
Distinct epitopes on formiminotransferase cyclodeaminase induce autoimmune liver cytosol antibody type 1.
Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during alpha-interferon treatment.
Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection.
Evaluation of frequency of autoimmune hepatitis autoantibodies in children with type 1 diabetes.
Hepatitis C infection and autoimmunity.
Heterogeneity of antigenic sites recognized by anti-liver/kidney microsomal antibody type I in autoimmune hepatitis and chronic hepatitis C.
Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease.
Immunological cross-reactivity to multiple autoantigens in patients with liver kidney microsomal type 1 autoimmune hepatitis.
Immunological liver diseases in children.
Interferon therapy in LKM-1 positive patients with chronic hepatitis C: follow-up by a quantitative radioligand assay for CYP2D6 antibody detection.
Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?
Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule.
Liver-kidney microsomal antibody-positive autoimmune hepatitis in the United States.
Liver/kidney microsomal antibody type 1 and liver cytosol antibody type 1 concentrations in type 2 autoimmune hepatitis.
Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane.
LKM-1 sera from autoimmune hepatitis patients that recognize ERp57, carboxylesterase 1 and CYP2D6.
Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.
Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus infected patients is associated with the possession of HLA B51.
Organ and non-organ specific autoantibody titres and IgG levels as markers of disease activity: a longitudinal study in childhood autoimmune liver disease.
Organ-specific and non-organ-specific autoantibodies in children and young adults with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Pitfalls in the diagnosis of autoimmune hepatitis associated with liver and kidney microsomal proteins.
Polyclonal T-Cell Responses to Cytochrome P450IID6 Are Associated With Disease Activity in Autoimmune Hepatitis Type 2.
Prevalence of antibodies to hepatitis C and herpes simplex virus type 1 is not increased in children with liver kidney microsomal type 1 autoimmune hepatitis.
Prevalence of GBV-C/HGV-RNA, virus genotypes, and anti-E2 antibodies in autoimmune hepatitis.
Primary and secondary liver/kidney microsomal autoantibody response following infection with hepatitis C virus.
Recreational Exposure during Algal Bloom in Carrasco Beach, Uruguay: A Liver Failure Case Report.
Recurrent episodes of acute hepatitis associated with LKM-1 (cytochrome P450 2D6) antibodies in identical twin brothers.
Significance of extractable nuclear antigens in childhood autoimmune liver disease.
T cell receptor Vbeta chain restriction and preferred CDR3 motifs of liver-kidney microsomal antigen (LKM-1)-reactive T cells from autoimmune hepatitis patients.
Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases.
The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model.
Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9.
Type 1 and type 2 autoimmune hepatitis in adults share the same clinical phenotype.
Type 2 autoimmune hepatitis and hepatitis C virus infection.
Viruses and autoimmune liver disease.
[Fatal bleeding complications caused by Evans syndrome (autoimmune thrombocytopenia and hemolytic anemia) and type II autoimmune hepatitis in a 56-year-old patient]
[Heterogeneity of antimicrosomal autoantibodies in chronic hepatitis C virus infection and delta hepatitis]
[Primary and secondary autoimmunity in hepatology]
[Spondyloenchondrodysplasia with immune dysregulation: a case report and literature review].
Hepatitis, Chronic
A new antigen recognized by anti-liver-kidney-microsome antibody (LKMA).
Absence of LKM-1 antibody reactivity in autoimmune and hepatitis-C-related chronic liver disease in Sweden. Swedish Internal Medicine Liver club.
Antibodies to liver/kidney microsome1 in chronic active hepatitis recognize specific forms of hepatic cytochrome P-450.
Assessment of the (14C) aminopyrine breath test in liver disease.
Autoimmune hepatitis type 2 and hepatitis C virus infection: study of HLA antigens.
Characterization of anti-liver kidney microsomal antibody in childhood autoimmune chronic active hepatitis: evidence for IgG1 subclass restriction, polyclonality and non cross-reactivity with hepatocyte surface antigens.
Characterization of the microsomal antigen related to a subclass of active chronic hepatitis.
Chronic active hepatitis associated with liver-kidney microsomal antibody of an autoimmune type. Two familial cases.
Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.
Clinical significance of the trimethadione tolerance test in chronic hepatitis: a useful indicator of hepatic drug metabolizing capacity.
Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis.
Detection of autoantibodies against M2, LKM-1, and SLA in liver diseases by standardized uniform ELISA-techniques.
Distinction between natural and pathological autoantibodies by immunoblotting and densitometric subtraction: liver-kidney microsomal antibody (LKM) positive sera identify multiple antigens in human liver tissue.
IgG subclass distribution of autoantibodies to glomerular basement membrane in Goodpasture's syndrome compared to other autoantibodies.
Immunoblotting as a confirmatory test for antimitochondrial antibodies in primary biliary cirrhosis.
Interferon and prednisone therapy in chronic hepatitis C with non-organ-specific antibodies.
Interferon and steroid treatment in patients with chronic hepatitis C and antinuclear or anti-liver-kidney microsomal antibodies.
Is autoimmune chronic active hepatitis a HCV-related disease?
Liver cell surface expression of the antigen reacting with liver-kidney microsomal antibody (LKM).
Low hepatitis C viremia levels in patients with anti-liver/kidney microsomal antibody type 1 positive chronic hepatitis.
Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.
Microsomal antibodies in active chronic hepatitis and other disorders.
Non-organ specific autoantibodies associated with chronic C virus hepatitis.
Prevalence and significance of abdominal lymphadenopathy in patients with chronic liver disease: an ultrasound study.
Treatment of autoimmune chronic active hepatitis in childhood.
[Autoantibodies in chronic hepatitis C. Markers of autoimmunity or non-specific events?]
[Chronic active hepatitis: recurrence after long-term immunosuppressive therapy in spite of normal liver histology]
[Chronic hepatitis: interest of a classification based on the presence or the absence of HBs Ag, smooth muscle antibody and microsomal antibody (author's transl)]
[Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)]
[Complexed microsomal antigens in acute hepatitis B (author's transl)]
[Heterogeneity of antimicrosomal autoantibodies in chronic hepatitis C virus infection and delta hepatitis]
[Non-organ specific anticytoplasmic autoantibodies. Immunoserologic detection and diagnostic relevance]
[The assessment of liver microsomal oxidative capacity via caffeine and antipyrine elimination in patients with chronic active hepatitis: preliminary results]
[Tienilic acid-induced hepatitis associated with liver/kidney microsomal antibody (author's transl)]
Hepatomegaly
Age-related changes in the susceptibility to clofibric acid, a hypolipidemic agent, of male rat liver.
Biochemical, morphological and flow-cytometric evaluation of the effects of hexachlorobenzene on rat liver.
Characteristics and significance of D-tagatose-induced liver enlargement in rats: An interpretative review.
Comparative study of four hypolipidaemic agents on the activity of drug-metabolizing enzymes in rat liver microsomes.
Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells exposed to iprodione.
Diagnosis of type 1a and type 1c glycogen storage diseases in adults.
Effects of aging and phenobarbital on the rat liver microsomal drug-metabolizing system.
Effects of chronic administration of bromazepam on its blood level profile and on the hepatic microsomal drug-metabolizing enzymes in the rat.
Experimental studies on pharmacology, metabolism and toxicology with tiadenol-disulfoxide. Dissociation of lipid lowering effects and the induction of peroxisomal and microsomal drug-metabolizing enzymes.
Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPAR? and CAR/PXR.
Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.
Proceedings: Synthesis and metabolic stability of microsomal protein and enzymes metabolizing the hepatocarcinogen diethyl-nitrosamine during experimental hepatomegaly.
Recent update on the PPAR alpha-null mouse.
Responses of the liver to perfluorinated fatty acids with different carbon chain length in male and female mice:in relation to induction of hepatomegaly, peroxisomal beta-oxidation and microsomal 1-acylglycerophosphocholine acyltransferase.
Sex-related difference in the inductions by perfluoro-octanoic acid of peroxisomal beta-oxidation, microsomal 1-acylglycerophosphocholine acyltransferase and cytosolic long-chain acyl-CoA hydrolase in rat liver.
The influence of Propionibacterium acnes (Corynebacterium parvum) fractions on immune response in vivo.
The relationship among microsomal enzyme induction, liver weight, and histological change in cynomolgus monkey toxicology studies.
Toxicity of peroxisome proliferators.
Toxicological approach for elucidation of clobazam-induced hepatomegaly in male rats.
Toxicology of chloral hydrate in the mouse.
Weight-of-evidence versus strength-of-evidence in toxicologic hazard identification: Di(2-ethylhexyl)phthalate (DEHP).
[Changes in the hydroxylating function and structure of the hepatic endoplasmic reticulum of the rat as affected by long-term kordiamin administration]
Herpes Simplex
Altered kinetic properties of sialyl and galactosyl transferases associated with herpes simplex virus infection of GMK and BHK cells.
Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics.
Intracellular location, complex formation, and function of the transporter associated with antigen processing in yeast.
Prevalence of antibodies to hepatitis C and herpes simplex virus type 1 is not increased in children with liver kidney microsomal type 1 autoimmune hepatitis.
Herpes Zoster
3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in beef adrenal cortex.
Circulating auto-antibodies against the zona pellucida and thyroid microsomal antigen in women with premature ovarian failure.
Continuous adrenocorticotropin administration in hypopituitarism produces asynchronous increases of deoxycorticosterone and 11-deoxycortisol relative to other reduced zona fasciculata steroids.
Dose-dependent actions of spironolactone on the inner and outer zones of the guinea pig adrenal cortex.
Effects of age and adrenocorticotropin on microsomal enzymes in guinea pig adrenal inner and outer cortices.
Effects of cadmium in vitro on microsomal steroid metabolism in the inner and outer zones of the guinea pig adrenal cortex.
Effects of tocopherol depletion on the regional differences in adrenal microsomal lipid peroxidation and steroid metabolism.
Functional differences in cholesterol ester hydrolase and acyl-coenzyme-A/cholesterol acyltransferase between the outer and inner zones of the guinea pig adrenal cortex.
In vitro conversion of cholesterol into aldosterone and cortisol in different zones of the bovine adrenal cortex.
Localization of cytochrome P-450-linked mixed function oxidase and steroid hydroxylations within zones of bovine adrenocortices.
Monoclonal antibodies against rat adrenocortical cell antigens.
Regional distribution of microsomal drug and steroid metabolism in the guinea pig adrenal cortex.
Zonal differences in adrenocortical lipid peroxidation: role of alpha-tocopherol.
Zonation of the adrenal cortex. III. Distribution of cytochrome P-450 in the zona glomerulosa of the bovine adrenal cortex.
HIV Infections
Pharmacokinetic interaction of antimicrobial agents with levomethadon in drug-addicted AIDS patients.
Hoarseness
[Postgravid health care and laboratory tests]
Hodgkin Disease
Phenazone pharmacokinetics as an index of hepatic metabolic efficiency.
Homozygous Familial Hypercholesterolemia
Case report: The efficacy and safety of lomitapide in a homozygous familial hypercholesterolemic child.
Correction to: Lomitapide - a Microsomal Triglyceride Transfer Protein Inhibitor for Homozygous Familial Hypercholesterolemia.
Critical review of non-statin treatments for dyslipoproteinemia.
Dietary Intake during 56 Weeks of a Low-Fat Diet for Lomitapide Treatment in Japanese Patients with Homozygous Familial Hypercholesterolemia.
Efficacy and Safety of Lomitapide in Hypercholesterolemia.
Emerging low-density lipoprotein therapies: Microsomal triglyceride transfer protein inhibitors.
Evaluation of the effects of the weak CYP3A inhibitors atorvastatin and ethinyl estradiol/norgestimate on lomitapide pharmacokinetics in healthy subjects.
Homozygous Familial Hypercholesterolemia (HoFH) in Saudi Arabia and Two Cases of Lomitapide Use in a Real-World Setting.
In vivo regulation of human mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase. Decreased enzyme catalytic efficiency in familial hypercholesterolemia.
Inhibition of hepatic microsomal triglyceride transfer protein - a novel therapeutic option for treatment of homozygous familial hypercholesterolemia.
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia.
LDL cholesterol, statins and PCSK 9 inhibitors.
Lomitapide for the management of homozygous familial hypercholesterolemia.
Lomitapide for the treatment of hypertriglyceridemia.
Lomitapide-a Microsomal Triglyceride Transfer Protein Inhibitor for Homozygous Familial Hypercholesterolemia.
Long-term clinical results of microsomal triglyceride transfer protein inhibitor use in a patient with homozygous familial hypercholesterolemia.
Long-Term Efficacy and Safety of the Microsomal Triglyceride Transfer Protein Inhibitor Lomitapide in Patients With Homozygous Familial Hypercholesterolemia.
LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia: Rationale and design.
Management of familial hypercholesterolemia: a review of the recommendations from the national lipid association expert panel on familial hypercholesterolemia.
Management of homozygous familial hypercholesterolaemia in two brothers.
Management of homozygous familial hypercholesterolemia in real-world clinical practice: A report of 7 Italian patients treated in Rome with lomitapide and lipoprotein apheresis.
Modern Management of Familial Hypercholesterolemia.
MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion.
Review of the long-term safety of lomitapide: a microsomal triglycerides transfer protein inhibitor for treating homozygous familial hypercholesterolemia.
Targeting microsomal triglyceride transfer protein and lipoprotein assembly to treat homozygous familial hypercholesterolemia.
The Severe Hypercholesterolemia Phenotype: Clinical Diagnosis, Management, and Emerging Therapies.
Therapeutic options for homozygous familial hypercholesterolemia: the role of Lomitapide.
Treating homozygous familial hypercholesterolemia in a real-world setting: Experiences with lomitapide.
Use of microsomal triglyceride transfer protein inhibitors in patients with homozygous familial hypercholesterolemia: translating clinical trial experience into clinical practice.
What are we able to achieve today for our patients with homozygous familial hypercholesterolaemia, and what are the unmet needs?
Hookworm Infections
Hepatic microsomal cytochrome P450 system during experimental hookworm infection.
HTLV-I Infections
A high prevalence of human T-lymphotropic virus type I carriers in patients with antithyroid antibodies.
Hyperaldosteronism
Steroid 21-hydroxylase and 17 alpha-hydroxylase in microsomal fraction of functioning adrenocortical tumors.
Hypercholesterolemia
Competitive inhibition of hepatic sterol 27-hydroxylase by sitosterol: decreased activity in sitosterolemia.
Development of MEPS-UHPLC-MS/MS multistatin methods for clinical analysis.
Effect of dietary antioxidants on the susceptibility to hepatic microsomal lipid peroxidation in the rat.
Effects of hypercholesterolemia on the microsomal membrane fluidity of intimal-medial versus medial layers of swine aorta: implications for the pathogenesis of vasospasm.
Expression of mRNA of apolipoprotein E, apolipoprotein A-IV, and matricellular proteins in the myocardium and intensity of fibroplastic processes during experimental hypercholesterolemia.
Hepatic tissue sterol regulatory element binding protein 2 and low-density lipoprotein receptor in nephrotic syndrome.
Hypocholesterolemic action of pre-germinated brown rice in hepatoma-bearing rats.
Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia.
Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives.
Is there a role for the adrenals in the development of hypercholesterolemia in Zucker fatty rats?
Lomitapide, a microsomal triglyceride transfer protein inhibitor for the treatment of hypercholesterolemia.
Lomitapide.
Microsomal transfer protein (MTP) inhibition-a novel approach to the treatment of homozygous hypercholesterolemia.
miR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.
Modern Management of Familial Hypercholesterolemia.
Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia.
Severe hypertriglyceridemia with pancreatitis: thirteen years' treatment with lomitapide.
The effect of pravastatin on hepatic 3-hydroxy-3-methylglutaryl CoA reductase obtained from poloxamer 407-induced hyperlipidemic rats.
[Formation of mevalonic acid, sterols and bile acids from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in the liver of rabbits with experimental hypercholesterolemia]
[Heterozygous familial hypercholesterolemia].
[New agents for hypercholesterolemia].
Hyperemia
Effects of liver congestion on hepatic drug metabolism in the rat.
Hyperglycemia
Effect of diabetes on enzymes involved in rat hepatic corticosterone production.
Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones.
JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, improves hyperglycemia and dyslipidemia independent of suppression of food intake in diabetic rats.
Permanent diabetes without serological evidence of autoimmunity after transient neonatal diabetes.
Peroxyvanadium compounds inhibit glucose-6-phosphatase activity and glucagon-stimulated hepatic glucose output in the rat in vivo.
Separate influences of insulin and hyperglycemia on hepatic drug metabolism in mice with genetic and chemically induced diabetes mellitus.
Hyperhomocysteinemia
Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative atrophic glossitis patients.
Hyperinsulinism
Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney.
Comparison of the effect of hyperinsulinemia on acyl-CoA:cholesterol acyltransferase activity in the liver and intestine of the rat.
Increased fetal insulin receptors and changes in membrane fluidity and lipid composition.
Insulin degradation. XVIII. On the regulation of glutathione-insulin transhydrogenase in the hyperglycemic obese (ob/ob) mouse.
Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men.
Hyperlipidemias
A wild-type mouse-based model for the regression of inflammation in atherosclerosis.
Alcoholic liver injury: experimental models in rats and baboons.
Animal models of ethanol dependence and liver injury in rats and baboons.
Drug evaluation: The MTP inhibitor JTT-130 as a potential treatment for hyperlipidemia.
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes.
Effects of poloxamer 407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats: Impact of decreased expression of both CYP3A1/2 and microsomal epoxide hydrolase.
Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation.
Familial hypobetalipoproteinemia due to apolipoprotein B R463W mutation causes intestinal fat accumulation and low postprandial lipemia.
Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice.
Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon.
MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion.
Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review.
Microsomal ethanol-oxidizing system.
Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal ?-Barrel in Microsomal Triglyceride Transfer Protein Function.
Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies.
Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques.
Small RNA overcomes the challenges of therapeutic targeting of microsomal triglyceride transfer protein.
Supplementation of all trans retinoic acid ameliorates ethanol-induced endoplasmic reticulum stress.
The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (+/-)-halofantrine.
The environmental and genetic evidence for the association of hyperlipidemia and hypertension.
Hyperlipoproteinemia Type II
A functional polymorphism in the promoter region of the microsomal triglyceride transfer protein (MTP -493G/T) influences lipoprotein phenotype in familial hypercholesterolemia.
Current and future trends in the treatment of dyslipidemias.
Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin on urinary 6 beta-hydroxycortisol excretion: a preliminary study.
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia.
Looking into the crystal ball-upcoming drugs for dyslipidemia.
Microsomal Transfer Protein Inhibitors, New Approach for Treatment of Familial Hypercholesterolemia, Review of the Literature, Original Findings and Clinical Significance.
Recent developments in the treatment of familial hypercholesterolemia: a review of several new drug classes.
The role of microsomal triglyceride transfer protein inhibitors in the treatment of patients with familial hypercholesterolemia: risks, benefits, and management.
[New agents for hypercholesterolemia].
Hyperprolactinemia
New evidence for a direct effect of prolactin on rat adrenal steroidogenesis.
The effects of prolactin on rat testicular steroidogenic enzyme activities.
Hypersensitivity
A microsomal fraction of Cryptococcus neoformans induces lymphocyte blastogenesis in infected guinea pigs.
Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations.
Autoantibodies in Estonia and Sweden, populations with different responses to allergens.
Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.
Differential selectivity in carbamazepine-induced inactivation of cytochrome P450 enzymes in rat and human liver.
Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis.
Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity.
Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Kinetic parameters of lymphocyte microsomal epoxide hydrolase in carbamazepine hypersensitive patients. Assessment by radiometric HPLC.
Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites.
Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins.
Hypertension
Age-related depletion of linoleic acid desaturation in liver microsomes from young spontaneously hypertensive rats.
Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats.
Clinical features of end-stage renal failure in patients with essential hypertension.
Combined homozygous 21 hydroxylase with heterozygous P450 oxidoreductase mutation in a Saudi boy presented with hypertension.
Decreased myocardial Na+K+ATPase activity in rats with reduced renal mass-saline hypertension.
Demonstration of a ouabainlike plasma compound in hypertension prone and hypertension resistant rats.
Effect of sucrose addition to drinking water, that induces hypertension in the rats, on liver microsomal Delta9 and Delta5-desaturase activities.
Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.
Liver microsomal membrane fluidity and microsomal desaturase activities in adult spontaneously hypertensive rats.
Membrane abnormalities occur in vascular smooth muscle but not in non-vascular smooth muscle from rats with deoxycorticosterone-salt induced hypertension.
Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress.
Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population.
Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2's-hydroxy-3's-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors.
Myocardial Na,K-ATPase activity in rats with steroid and spontaneous hypertension.
Reversal of one-kidney, one-clip hypertension in rats. Effects on myocardial Na+, K(+)-ATPase, arterial Na(+)-K+ pump, arterial membrane potential, and plasma Na(+)-K+ pump inhibitory activity.
Role of cellular sodium and calcium metabolism in the pathogenesis of essential hypertension.
Single-Nucleotide Polymorphisms (SNPs) Both Associated with Hypertension and Contributing to Accelerated-Senescence Traits in OXYS Rats.
Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension.
The environmental and genetic evidence for the association of hyperlipidemia and hypertension.
The prevalence of autoantibodies during third-trimester pregnancy complicated by hypertension or idiopathic fetal growth retardation.
[A prospective study of antipyrine pharmacokinetics in pregnancy]
[Characteristics of calcium and sodium transport in the synaptosomes and subsynaptosomal structures of the brain of spontaneously hypertensive rats]
Hypertension, Portal
Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression?
Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.
Lipid changes in hepatic microsomes and its relationship to P-nitrophenol glucuronidation in an experimental model of portal hypertension.
Reversibility of secondary biliary fibrosis by biliodigestive anastomosis in the rat.
Structure-function relationship in secondary biliary cirrhosis in the rat. Stereologic and hemodynamic characterization of a model.
Ursodeoxycholate has no beneficial effect on liver function or histology in biliary cirrhosis in the rat.
Hypertension, Pulmonary
Can microsomal RNA be a biomarker in pulmonary hypertension secondary to bronchopulmonary dysplasia?
Hyperthyroidism
Altered plasma half-lives of antipyrine, propylthiouracil, and methimazole in thyroid dysfunction.
Amiodarone-induced thyroid dysfunction in a tertiary center in south Brazil.
Antithyroid microsomal autoantibodies and HLA-DR5 are associated with postpartum thyroid dysfunction: evidence supporting an autoimmune pathogenesis.
Biliary excretion of acetaminophen in diabetic and hyperthyroid rats.
Change of circulating thyroid autoantibody titers in Graves' hyperthyroidism after antithyroid drugs therapy.
Chemiluminescent and respiratory responses related to thyroid hormone-induced liver oxidative stress.
Clinical pharmacokinetics of prednisone and prednisolone.
Comparison of covalent binding from halothane metabolism in hepatic microsomes from phenobarbital-induced and hyperthyroid rats.
Correlation of orbital computed tomography and antibodies in patients with hyperthyroid Graves' disease.
Effect of hyperthyroidism on lipogenesis in brown adipose tissue of young rats.
Effect of hyperthyroidism on the in vitro metabolism and covalent binding of 1,1-dichloroethylene in rat liver microsomes.
Effect of thyroid dysfunction upon phospholipid composition and CDP-choline incorporation in mitochondria and microsomal fraction isolated from liver and brain of suckling rats.
Effect of thyroid hormones on microsomal fatty acid chain elongation synthesis in rat liver.
Effect of thyrotropin-releasing hormone on serum thyroid hormones: a study in the patients with untreated and treated Graves' disease and subacute thyroiditis.
Effects of neonatal hyperthyroidism on activity of cyclic AMP-dependent microsomal protein kinase.
Enhancement of lindane-induced liver oxidative stress and hepatotoxicity by thyroid hormone is reduced by gadolinium chloride.
Expression of the microsomal antigen on the surface of continuously cultured rat thyroid cells is modulated by thyrotropin.
Fatty-acid desaturation and microsomal lipid fatty-acid composition in experimental hyperthyroidism.
Hepatic conversion of amino-nitrogen to urea in thyroid diseases. II. A study in hyperthyroid patients.
Hepatic microsomal ethanol-oxidizing system (MEOS): increased activity following propylthiouracil administration.
Hyperthyroidism due to Graves' disease and due to autonomous goiter.
Hyperthyroidism following primary hypothyroidism in association with polyendocrine autoimmunity.
Immunological features of nonimmunogenic hyperthyroidism.
Induction of microsomal 1-acylglycerophosphocholine acyltransferase by peroxisome proliferators in rat kidney; co-induction with peroxisomal beta-oxidation.
Influence of hyperthyroidism on the activity of liver nitric oxide synthase in the rat.
Influence of hyperthyroidism on the uptake and binding of calcium by cardiac microsomal fractions and on mitochondrial structure.
Influence of hypo- and hyperthyroidism on rat liver glycerophospholipid metabolism.
Insulin-dependent diabetes mellitus in southern Chinese children: an overview.
Iodide induces thyroid autoimmunity in patients with endemic goitre: a randomised, double-blind, placebo-controlled trial.
Lipid composition of liver mitochondria and microsomes in hyperthyroid rats.
Liver microsomal parameters related to oxidative stress and antioxidant systems in hyperthyroid rats subjected to acute lindane treatment.
Manifestation of Hashimoto's encephalopathy years before onset of thyroid disease.
Organ-specific autoimmunity and genetic predisposition in interferon-treated HCV-related chronic hepatitis patients.
Patients with endocrine ophthalmopathy not associated with overt thyroid disease have multiple thyroid immunological abnormalities.
Prognostic significance of thyroid antibodies in hyperthyroid patients treated with antithyroid drugs.
Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goiter.
Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes.
Superoxide radical generation, NADPH oxidase activity, and cytochrome P-450 content of rat liver microsomal fractions in an experimental hyperthyroid state: relation to lipid peroxidation.
The changes of serum titers of thyroid antibodies in patients of Graves' disease with hyperthyroidism after treatments with antithyroid drugs.
The effect of dithiotreitol on thyroid peroxidase and microsomal antigen epitopes recognized by auto and monoclonal antibodies.
The effect of treatment with levothyroxine or iodine on thyroid size and thyroid growth stimulating immunoglobulins in endemic goitre patients.
The relationship between autoimmune thyroid disease and iodine intake: a review.
The significance of antithyroglobulin and antithyroidal microsomal antibodies in patients with hyperthyroidism due to Graves' disease treated with antithyroidal drugs.
Thioredoxin and glutaredoxin systems of rat liver cytosol are not influenced by thyroid dysfunction.
Thyroid disease is associated with an increased risk of breast cancer: a systematic review and meta-analysis.
Thyroid dysfunction in institutionalised Down's syndrome adults.
Thyroid function and autoimmune manifestations in insulin-dependent diabetes mellitus during and after pregnancy.
Thyroid hormone-induced changes in the hepatic monooxygenase system, heme oxygenase activity and epoxide hydrolase activity in adult male, female and immature rats.
Transient recurrence of hyperthyroidism after delivery in Graves' disease.
[Autoimmune thyroid disease and associated autoimmunity]
[Autoimmune thyroid pathology. Study and follow-up of pediatric case reports]
[Comparison of thiamazole pharmacokinetics in healthy individuals and patients with hyperthyroidism]
[Cytologic differentiation between the autonomous and autoimmune type of diffuse hyperthyroid goiter: correlation with TSH receptor antibodies, microsomal antibodies and infiltrative ophthalmopathy]
[Phenobarbital-induced changes in enzyme activities of the microsomal oxidative system in the liver of normal rats of different ages and in rats with hyperthyroidism]
[Seronegative hashitoxicosis in patient with rheumatoid arthritis]
[Serum levels of interleukin 6 (IL-6) and soluble IL-6 receptor (sIL-6R) in children and adolescents with Graves-Basedow disease]
[Thyroid autoantibodies in diabetes mellitus and rheumatoid arthritis]
Hypertriglyceridemia
Augmentation of Ca2+-induced microsomal triglyceride transfer protein activity by glucose supply enhances hypertriglyceridemia in vivo.
Diagnosis and treatment of severe hypertriglyceridemia.
Emerging approaches for the treatment of hypertriglyceridemia.
HMG-CoA reductase activity in the liver of rats with hereditary hypertriglyceridemia: effect of dietary fish oil.
Lipolytic enzymes as markers of induction and differentiation.
Lomitapide for the treatment of hypertriglyceridemia.
Severe hypertriglyceridemia with pancreatitis: thirteen years' treatment with lomitapide.
The possible role of Ca2+ on the activation of microsomal triglyceride transfer protein in rat hepatocytes.
Hypertrophy, Right Ventricular
The distribution of microsomal (Na+, K+)-ATPase in the rat heart and the effects of induced right ventricular hypertrophy and feeding with digitalis, sodium, and potassium.
Time-dependent alterations of myocardial microsomal yield and calcium accumulation in experimentally-induced right ventricular hypertrophy and failure.
Hypervitaminosis A
Microsomal enzyme inducers and hypervitaminosis A in rats.
Hypoalphalipoproteinemias
Microsomal enzyme inducers raise plasma high-density lipoprotein cholesterol levels in healthy control subjects but not in patients with primary hypoalphalipoproteinemia.
Hypobetalipoproteinemias
Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease.
Insights from human congenital disorders of intestinal lipid metabolism.
Mutations in MTP gene in abeta- and hypobeta-lipoproteinemia.
Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion.
Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects.
The genetic basis of primary disorders of intestinal fat transport.
Hypoglycemia
Effect of hypoglycemia on the brain free fatty acid level and the uptake of fatty acids by phospholipids.
Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis.
[ATPase activity of rat brain microsomal and synaptosomal fractions in insulin hypoglycemia and its treatment with glucose]
Hypokinesia
[Enzyme system of initiation and protection against lipid peroxidation in the liver and blood of rats with hypokinesia]
[The state of the monooxygenase enzymatic system of the rat liver in hypokinesia]
Hypopituitarism
Continuous adrenocorticotropin administration in hypopituitarism produces asynchronous increases of deoxycorticosterone and 11-deoxycortisol relative to other reduced zona fasciculata steroids.
Low sodium intake enhances sensitivity of 11-deoxycortisol and deoxycorticosterone to ACTH in ACTH-suppressed normal subjects.
Organ- and non-organ-specific auto-antibodies in children with hypopituitarism on growth hormone therapy.
Hypoprothrombinemias
Depression of liver microsomal vitamin K epoxide reductase activity associated with antibiotic-induced coagulopathy.
Hypothyroidism
A case of a false-positive anti-myeloperoxidase antibody ELISA in a patient with hypothyroidism.
A case of acetohexamide-induced hypoglycemia: the influence of hypothyroidism on the metabolism of acetohexamide.
Altered plasma half-lives of antipyrine, propylthiouracil, and methimazole in thyroid dysfunction.
Amnesic syndrome with bilateral mesial temporal lobe involvement in Hashimoto's encephalopathy.
Association between thyroid microsomal antibodies of subclass IgG-1 and hypothyroidism in autoimmune postpartum thyroiditis.
Atrophic, autoimmune thyroiditis in infancy. A case report.
Autoimmune endocrine disease induced by recombinant interferon-alpha therapy for chronic active type C hepatitis.
Autoimmune thyroid phenomena are not evidence for human lymphocyte antigen-genetic heterogeneity in insulin-dependent diabetes.
Carbimazole and autoantibody synthesis in Hashimoto's thyroiditis.
Comparison of triacylglycerol synthesis in rat brown and white adipocytes. Effects of hypothyroidism and streptozotocin-diabetes on enzyme activities and metabolic fluxes.
Development of postpartum spontaneously resolving transient Graves' hyperthyroidism followed immediately by transient hypothyroidism.
Discordant changes in serum anti-TSH receptor antibody and antithyroid microsomal antibody during pregnancy in autoimmune thyroid diseases.
Effect of neonatal hypothyroidism on the kinetic properties of Na+, K+ -ATPase from rat brain microsomes.
Effect of thyroid dysfunction upon phospholipid composition and CDP-choline incorporation in mitochondria and microsomal fraction isolated from liver and brain of suckling rats.
Effects of hypothyroidism and undernourishment on nuclear-cytoplasmic transport "in vitro" of cerebral RNA.
Expression of the microsomal antigen on the surface of continuously cultured rat thyroid cells is modulated by thyrotropin.
Factors affecting thyroid function after thyroidectomy for Graves' disease.
Fatty acid desaturation and microsomal lipid fatty acid composition in experimental hypothyroidism.
IgG subclass distribution and relative functional affinity of thyroid microsomal antibodies in postpartum thyroiditis.
Influence of hypo- and hyperthyroidism on rat liver glycerophospholipid metabolism.
Insulin-dependent diabetes mellitus in southern Chinese children: an overview.
Isolated right ventricular cardiomyopathy with autoimmune hypothyroidism: a rare association in an adolescent.
Life-threatening theophylline intoxication in a hypothyroid patient.
Macroamylasemia attributable to gluten-related amylase autoantibodies: a case report.
Management of the unexpected result: compensated hypothyroidism.
Measurement and clinical significance of thyroid microsomal and thyroglobulin antibodies by enzyme-linked immunosorbent assay.
MICROSOMAL AND THYROGLOBULIN ANTIBODIES IN THYROID DISORDERS.
Mixed connective tissue disease associated with idiopathic portal hypertension and chronic thyroiditis.
Natural history of thyroid function in diabetics with impaired thyroid reserve: a four year controlled study.
Organ-specific autoimmunity and genetic predisposition in interferon-treated HCV-related chronic hepatitis patients.
Patients with endocrine ophthalmopathy not associated with overt thyroid disease have multiple thyroid immunological abnormalities.
Postpartum thyroid disease.
Prediction of hypothyroidism after hemithyroidectomy: a biochemical and pathological analysis.
Prevalence and relevance of thyroid dysfunction in 1922 cholesterol screening participants.
Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus.
Recovery of the thyroid function in patients with atrophic hypothyroidism and blocking type TSH binding inhibitor immunoglobulin.
Recovery of thyroid function with a decreased titre of antimicrosomal antibody in a hypothyroid man with Hashimoto's thyroiditis.
Role of thyroid state on induction by ciprofibrate of laurate hydroxylase and peroxisomal enzymes in rat liver microsomes.
Serum thyroid autoantibodies as a risk factor for development of hypothyroidism after radioactive iodine therapy for single thyroid 'hot' nodule.
Spectrum of thyroid function in patient's remaining in remission after antithyroid drug therapy for thyrotoxicosis.
The incidence of occult thyroid disease associated with thyroid antibodies identified on routine autoantibody screening.
The influence of fasting and the thyroid state on the activity of thyroxine 5'-monodeiodinase in rat liver: a kinetic analysis of microsomal formation of triiodothyronine from thyroxine.
Thyroid control over biomembranes: VI. Lipids in liver mitochondria and microsomes of hypothyroid rats.
Thyroid disease and other autoimmune phenomena in a family study of primary Sjögren's syndrome.
Thyroid disease is associated with an increased risk of breast cancer: a systematic review and meta-analysis.
Thyroid dysfunction in institutionalised Down's syndrome adults.
Thyrotropin receptor antibodies in hypothyroid Graves' disease.
Transient hypothyroidism after delivery in autoimmune thyroiditis.
Transient postpartum hypothyroidism: fourteen cases with autoimmune thyroiditis.
[A case of Hashimoto's encephalopathy with a relapsing course related to menstrual cycle]
[A case of Hypothyroid Graves' disease with extremely high titers of TSAb]
[Antithyroid antibodies. Prevalence in primary hypothyroidism in Central Tunisia]
[Association of primary autoimmune hypothyroidism with Addison's anemia]
[Autoimmune haemolytic anaemia, thrombocytopenia and thyroiditis: an immunopathological triad (author's transl)]
[Diabetes mellitus type I, thyroid gland autoimmunity, thyroid gland function and HLA status]
[Diagnostic value of thyroid antibodies]
[Endocrine involvement in immunotherapy]
[Occurrence of TSH receptor antibodies and thyroid microsomal antibodies in Graves-Basedow disease]
[Postgravid health care and laboratory tests]
[Profile of autoimmune antibodies in idiopathic hypothyroidism and hypothyroidism following radio-iodine treatment in Basedow's disease: comparison with a group of normal subjects from the female population of Switzerland]
[Spontaneous Hashimoto-like thyroiditis in cats]
Hypoxia-Ischemia, Brain
Cerebral hypoxia-ischemia increases microsomal iron in newborn piglets.
Ichthyosis
Early diagnosis of recessive X-linked ichthyosis: elevation of cholesterol sulfate levels in placental sulfatase deficiency before the onset of skin symptoms.
Increased levels of DHEAS in serum of patients with X-linked ichthyosis.
Isolation and characterization of a steroid sulfatase cDNA clone: genomic deletions in patients with X-chromosome-linked ichthyosis.
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis.
Steroid sulfatase = aryl sulfatase C? Chromatographic and electrophoretic properties in extracts from placental microsomes and skin fibroblasts.
Stratum corneum lipids in disorders of cornification: increased cholesterol sulfate content of stratum corneum in recessive x-linked ichthyosis.
[Microsomal sulfatase deficiency in X chromosome-linked ichthyosis]
Ileus
[The detoxifying function of the liver in acute experimental intestinal obstruction]
Immune System Diseases
Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism.
[Fatal bleeding complications caused by Evans syndrome (autoimmune thrombocytopenia and hemolytic anemia) and type II autoimmune hepatitis in a 56-year-old patient]
Infections
A polymorphism in the microsomal triglyceride transfer protein can predict the response to antiviral therapy in Egyptian patients with chronic hepatitis C virus genotype 4 infection.
A study of autoimmune markers in hepatitis C infection.
A study of hepatic mitochondrial respiration and microsomal cytochrome P450 content in mice infected with the liver fluke Fasciola hepatica.
Alterations of hepatic microsomal enzymes in the early phase of murine schistosomiasis.
Altered hepatic microsomal drug-metabolizing enzyme activity resulting from experimental infection of rats with Trypanosoma b. brucei.
Anti-rat liver microsomal and cytosolic antibodies in hepatitis C virus infection.
Antihepatotoxic properties of uridine-diphosphoglucose in liver fluke infection. Experimental fascioliasis in the rat.
Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis.
Autoantibody appearance in cytomegalovirus-infected liver transplant recipients: correlation with antigenemia.
Autoantibody prevalence in children with liver disease due to chronic hepatitis C virus (HCV) infection.
Autoimmune mechanisms in chronic hepatitis B and delta virus infections.
Autoimmunity and extrahepatic manifestations in treatment-naïve children with chronic hepatitis C virus infection.
Chagas' disease: a clinical, parasitological, immunological, and pathological study in rabbits.
Characterization of anti liver kidney microsomal antibody associated with chronic HDV infection by immunoblotting.
Chronic hepatitis delta virus (HDV) infection.
Comparative Subcellular Proteomics Analysis of Susceptible and Near-isogenic Resistant Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV infection.
Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease.
Decrease in hepatic microsomal UDP-glucuronosyl-transferase activity in rats and cattle with fascioliasis: impaired in vitro glucuronidation of oxyclozanide.
Demonstration of species-specific and cross-reactive components of the adult microsomal antigens from Schistosoma mansoni and S. japonicum (MAMA and JAMA).
Different levels of Schistosoma mansoni infection increased the mutagenicity of benzo(a)pyrene, the activity of aryl hydrocarbon hydroxylase and the formation of hepatic microsomal hydrogen peroxide.
Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells.
Effect of experimental fasciolosis on antipyrine metabolism and clearance in water buffaloes.
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Effect of murine schistosomiasis on hepatic cytochrome P-450 and microsomal protein.
Effect of Plasmodium berghei infection and chloroquine on the hepatic drug metabolizing system of mice.
Effect of Plasmodium yoelii nigeriensis infection and chloroquine on the hepatic mixed function oxidase system of mice.
Effect of praziquantel treatment on the activities of some liver microsomal enzymes in mice infected with Schistosoma mansoni.
Effect of Schistosoma mansoni infection on the hepatic drug-metabolizing capacity of mice.
Effects of malarial infection on host microsomal drug-metabolizing enzymes.
Enhanced metabolic activation of chemical hepatocarcinogens in woodchucks infected with hepatitis B virus.
Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection.
Evidence of CD1d pathway of lipid antigen presentation in mouse primary lung epithelial cells and its up-regulation upon Mycobacterium bovis BCG infection.
Experimental ovine fasciolosis: antipyrine clearance as indicator of liver damage.
Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesis.
Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.
Fasciola hepatica: liver microsomal membrane functions in host rat.
Hepatic cytochrome P-450 system in experimental hepatosplenic schistosomiasis. Presence of an artifact in spectrophotometric analysis.
Hepatic microsomal alterations during Dipetalonema viteae infection in Mastomys natalensis.
Hepatic microsomal cytochrome P450 system during experimental hookworm infection.
Hepatic microsomal enzymes in S. mansoni infected mice: II. Effect of duration of infection and lindane administration on aminopyrine demethylase and aniline hydroxylase.
Hepatic microsomal enzymes in Schistosoma mansoni-infected mice: I. Effect of duration of infection and lindane administration on dimethylnitrosamine demethylases.
Hepatic microsomal protein and cytochrome P-450 in BALB/c mice infected with Leishmania.
Hepatitis C and hepatic steatosis.
Heterogeneity of liver-kidney microsomal autoantibodies in chronic hepatitis C and D virus infection.
Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease.
Human papillomavirus 13 in a Mexican Mayan community with multifocal epithelial hyperplasia: could saliva be involved in household transmission?
Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics.
Improved expression and characterization of Ca2+-ATPase and phospholamban in High-Five cells.
In vitro determination of carcinogenicity of sixty-four compounds using a bovine papillomavirus DNA-carrying C3H/10T(1/2) cell line.
Infection (Actinobacillus pleuropneumoniae)-mediated suppression of oxidative hepatic drug metabolism and cytochrome P4503A mRNA levels in pigs.
Influence of Vesicular-Arbuscular Mycorrhizal Fungi on the Response of Potato to Phosphorus Deficiency.
Isolation and partial characterization of plasma membranes from the livers of control and Streptococcus pneumoniae-infected rats.
Juvenile hormone (JH) esterase activity but not JH epoxide hydrolase activity is downregulated in larval Adoxophyes honmai following nucleopolyhedroviruses infection.
Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule.
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.
Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane.
Low B12 levels in chronic idiopathic urticaria.
Membrane glycoproteins and antigens induced by human cytomegalovirus.
Methimazole-mediated enhancement of albendazole oral bioavailability and anthelmintic effects against parenteral stages of Trichinella spiralis in mice: the influence of the dose-regime.
Modulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice.
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res.
O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
Participation of lipid peroxidation in the loss of hepatic drug-metabolizing activities in experimental fascioliasis in the rat.
Perinuclear localization of Na-K-Cl-cotransporter protein after human cytomegalovirus infection.
Polymorphisms of microsomal triglyceride transfer protein in different hepatitis B virus-infected patients.
Preserved cytosolic and synthetic liver function in jaundice of severe extrahepatic infection.
Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study.
Primary and secondary liver/kidney microsomal autoantibody response following infection with hepatitis C virus.
Status of hepatic glutathione-S-transferase(s) during Plasmodium berghei infection and chloroquine treatment in Mastomys natalensis.
Status of the microsomal mixed function oxidase system in the intestine, lungs and kidneys of hamsters during infection with Ancylostoma ceylanicum.
Studies of the hepatic mitochondrial and microsomal mixed-function oxidase system during Plasmodium yoelii infection and inducer treatment in Swiss albino mice.
Study of the B cell response to cytochrome P450IID6 in sera from chronic hepatitis C patients.
Suppression of the hepatic microsomal cytochrome P-450 dependent mixed function oxidase activities in golden hamster during Leishmania donovani infection.
Susceptibility to Helicobacter pylori infection: results of an epidemiological investigation among gastric cancer patients.
Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages.
The hepatic and duodenal activities of some drug metabolizing enzymes in chickens: influence of infection with Escherichia coli endotoxin and coccidiosis.
The influence of Propionibacterium acnes (Corynebacterium parvum) fractions on immune response in vivo.
The iron-responsive microsomal proteome of Aspergillus fumigatus.
The restoring effect of trifluralin and benznidazole on the abnormal fatty-acid pattern induced by Trypanosoma cruzi in the liver microsomes of infected mice.
TISSUE METABOLISM IN INFECTION. LIVER MICROSOMAL ENZYMES OF MICE AND GUINEA PIGS IN EXPERIMENTAL TUBERCULOSIS.
Vaccination of mice against Leishmania mexicana amazonensis with microsomal fraction associated with BCG.
[Activity of microsomal N-acetyl-glucosaminyl-transferases in animal carriers of a Myxovirus infection]
[Autoantibodies in chronic hepatitis C. Markers of autoimmunity or non-specific events?]
[Biosynthesis of glycoproteins in animals with a myxovirus infection. I. Study of liver and spleen microsomal glucosaminyl-transferases]
[Heterogeneity of antimicrosomal autoantibodies in chronic hepatitis C virus infection and delta hepatitis]
[Microsomal hydroxylating system of the mouse liver in toxic forms of influenza infection]
Infertility
Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.
Hashimoto's disease in Turner's syndrome.
Infertility, Male
Integrated Analysis of DNA Methylation and mRNA Expression Profiles to Identify Key Genes in Severe Oligozoospermia.
Inflammatory Bowel Diseases
Common polymorphisms in the microsomal epoxide hydrolase and N-acetyltransferase 2 genes in association with inflammatory bowel disease in the Danish population.
Influenza, Human
A nucleoprotein peptide of influenza A virus stimulates assembly of HLA-B27 class I heavy chains and beta 2-microglobulin translated in vitro.
In vitro synthesis of full-length influenza virus complementary RNA.
Inhibition of mouse liver sialidase by plant flavonoids.
Lack of effect of influenza vaccine on the pharmacokinetics of antipyrine, alprazolam, paracetamol (acetaminophen) and lorazepam.
Posttranslational translocation of influenza virus hemagglutinin across microsomal membranes.
The influenza hemagglutinin insertion signal is not cleaved and does not halt translocation when presented to the endoplasmic reticulum membrane as part of a translocating polypeptide.
Translocation of peptides through microsomal membranes is a rapid process and promotes assembly of HLA-B27 heavy chain and beta 2-microglobulin translated in vitro.
Uncoupling of translocation across microsomal membranes from biosynthesis of influenza virus hemagglutinin.
[Microsomal hydroxylating system of the mouse liver in toxic forms of influenza infection]
[NEUTRALIZATION OF INFLUENZA BY MICROSOMAL FRACTIONS OF GUINEA PIG LIVER.]
Insulin Resistance
(13C)-Methacetin breath test provides evidence of subclinical liver dysfunction linked to fat storage but not lifestyle.
Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.
Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in very low density lipoprotein assembly and secretion in the fructose-fed hamster.
Effect of long-term anticonvulsant therapy on glucose metabolism in humans.
Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects.
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Hepatitis C and insulin resistance: mutual interactions. A review.
Insulin-mediated glucose metabolism is related to liver structure and microsomal function.
Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis.
Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model.
Microsomal triglyceride transfer protein inhibition improves insulin sensitivity and reduces atherogenic risk in Zucker fatty rats.
Microsomal triglyceride transfer protein: does insulin resistance play a role in the regulation of chylomicron assembly?
Oleate-mediated stimulation of microsomal triglyceride transfer protein (MTP) gene promoter: implications for hepatic MTP overexpression in insulin resistance.
Possible role of microsomal epoxide hydrolase gene polymorphism as a risk factor for developing insulin resistance and type 2 diabetes mellitus.
Up-regulation of liver glucose-6-phosphatase in rats fed with a P(i)-deficient diet.
[Diagnosis of Secondary Hyperlipidemia due to Diabetes].
Insulinoma
Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.
Spontaneous secretion of thyroid autoantibodies by cultured peripheral blood lymphocytes from patients with Hashimoto's thyroiditis detected by micro-ELISA techniques.
Intellectual Disability
NADH cytochrome b5 reductase activity in lymphoid cell lines. Expression of the defect in epstein Barr virus transformed lymphoblastoid cell lines from patients with recessive congenital methemoglobinemia.
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Intestinal Neoplasms
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Intestinal Obstruction
The effect of intestinal obstruction on liver microsomal enzymes in rats.
[State of the microsomal oxidative system of the rat liver in acute intestinal obstruction]
Intestinal Volvulus
Dolichol kinase in Ascaris suum and Onchocerca volvulus.
Intraabdominal Infections
Increased hepatic microsomal adenosine triphosphatase activity secondary to intra-abdominal infection.
Intracranial Aneurysm
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.
Intussusception
Myoepithelial hamartoma causing small-bowel intussusception: a case report and literature review.
Iron Deficiencies
Effect of long term iron deficiency on the activities of hepatic and extra-hepatic drug metabolising enzymes in Fischer rats.
Quantitative proteomics of Arabidopsis shoot microsomal proteins reveals a cross-talk between excess zinc and iron deficiency.
Iron Overload
Chronic dietary iron overload in rats results in impaired calcium sequestration by hepatic mitochondria and microsomes [corrected]
Formation of liver microsomal MDA-protein adducts in mice with chronic dietary iron overload.
Hepatic lipid peroxidation in vivo in rats with chronic iron overload.
Hepatic microsomal function in rats with chronic dietary iron overload.
Iron toxicity and chelation therapy.
Lipid peroxidation and associated hepatic organelle dysfunction in iron overload.
Metal-induced hepatotoxicity.
Pathophysiology of iron toxicity.
Polyenylphosphatidylcholine opposes the increase of cytochrome P-4502E1 by ethanol and corrects its iron-induced decrease.
Ischemic Stroke
Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population.
Keloid
[Treatment of keloids and hypertrophic scars. Pilot study with intralesional Lipotalon injections]
Keratosis
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Keratosis, Seborrheic
Aminopeptidase M and dipeptidyl peptidase IV activity in epithelial skin tumors: a histochemical study.
Ketosis
Permanent diabetes without serological evidence of autoimmunity after transient neonatal diabetes.
Kidney Diseases
Drug metabolism under pathological and abnormal physiological states in animals and man.
Effects of n-3 and n-6 fatty acids on the activities and expression of hepatic antioxidant enzymes in autoimmune-prone NZBxNZW F1 mice.
Kidney Failure, Chronic
Antipyrine kinetics in Nigerian women in chronic renal failure.
Barbiturate and anticonvulsant treatment in relation to osteomalacia with haemodialysis and renal transplantation.
Changes of hepatic microsomal oxidative drug metabolizing enzymes in chronic renal failure (CRF) rats by partial nephrectomy.
Downregulation of Hepatic Carbonyl Reductase Type 1 in End-Stage Renal Disease.
Hepatic metabolism of aminopyrine in patients with chronic renal failure.
The plasma half-life of antipyrine in chromic uraemic and normal subjects.
Kwashiorkor
Antipyrine pharmacokinetics and D-glucaric excretion in kwashiorkor.
Laryngeal Neoplasms
Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk.
High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers.
Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.
Lecithin Cholesterol Acyltransferase Deficiency
Enzymic esterification of cholesterol in rat intestinal mucosa catalyzed by acyl-CoA: cholesterol acyltransferase.
Leiomyoma
Increased expression of type I 17beta-hydroxysteroid dehydrogenase enhances in situ production of estradiol in uterine leiomyoma.
Inhibition of in situ expression of aromatase P450 in leiomyoma of the uterus by leuprorelin acetate.
Suicide inactivation of aromatase in human placenta and uterine leiomyoma by 5 alpha-dihydronorethindrone, a metabolite of norethindrone, and its effect on steroid-producing enzymes.
Leishmaniasis
Changes in hepatic xenobiotic-metabolising enzymes in mouse liver following infection with Leishmania donovani.
Lipid peroxidation in hepatic microsomal membranes isolated from mice in health and in experimental leishmaniasis.
Leishmaniasis, Visceral
Aminothiazoles: Hit to lead development to identify antileishmanial agents.
Suppression of the hepatic microsomal cytochrome P-450 dependent mixed function oxidase activities in golden hamster during Leishmania donovani infection.
Leptospirosis
Alterations in specific activity of glucose-6-phosphatase in laboratory rats after leptospiral exposure followed by triiodothyronine administration.
Leukemia
125I-labeled cell surface as a marker in preparation of microsome fraction by gel filtration.
Analysis of the characteristics and expression profiles of coding and noncoding RNAs of human dental pulp stem cells in hypoxic conditions.
Colocalization of leukotriene C synthase and microsomal glutathione S-transferase elucidated by indirect immunofluorescence analysis.
Effects of advanced leukemia on hepatic drug-metabolizing activity in the mouse.
Emerging role of EPHX1 in chemoresistance of acute myeloid leukemia by regurlating drug-metabolizing enzymes and apoptotic signaling.
Increased gene expression in human promyeloid leukemia cells exposed to trans,trans-muconaldehyde, a hematotoxic benzene metabolite.
Leukotriene C synthetase, a special glutathione S-transferase: properties of the enzyme and inhibitor studies with special reference to the mode of action of U-60,257, a selective inhibitor of leukotriene synthesis.
Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity.
Microsomal activation and increased production of 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide (m-AMSA)-dependent, topoisomerase-associated DNA lesions in nuclei from human HL-60 leukemia cells.
Microsomal enzymes in patients with acute leukemia as determined by plasma half-life of antipyrine.
Myristoyl-CoA:protein N-myristoyltransferase activity in cancer cells. Purification and characterization of a cytosolic isoform from the murine leukemia cell line L1210.
Phenazone as a marker of liver-metabolic function in patients with acute leukemia.
Regulation of inositol 1,4,5-trisphosphate receptors in rat basophilic leukemia cells. I. Multiple conformational states of the receptor in a microsomal preparation.
Resolution and characterization of intracytoplasmic forms of reverse transcriptase from Rauscher leukemia virus-producing cells.
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.
Subcellular distribution of newly synthesized virus-specific polypeptides in Moloney murine leukemia virus infected cells.
The effect of alpha-interferon on the liver in a patient with hairy cell leukemia: light and electron microscopic studies.
The effect of phenobarbital on cyclophosphamide antitumor activity.
Leukemia L1210
125I-labeled cell surface as a marker in preparation of microsome fraction by gel filtration.
Leukemia, Hairy Cell
The effect of alpha-interferon on the liver in a patient with hairy cell leukemia: light and electron microscopic studies.
Leukemia, Lymphocytic, Chronic, B-Cell
A novel B-CLL specific nuclear protein (p44/46).
Altered expression of nuclear non-histone protein (p44/46) in different stages of B-chronic lymphocytic leukemia.
Leukemia, Myeloid
Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses.
Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry.
Leukemia, Myeloid, Acute
Association of Glutathione S-Transferase, EPHX, and p53 codon 72 Gene Polymorphisms with Adult Acute Myeloid Leukemia.
Emerging role of EPHX1 in chemoresistance of acute myeloid leukemia by regurlating drug-metabolizing enzymes and apoptotic signaling.
Enzyme kinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase.
EPHX1 rs1051740 T>C (Tyr113His) is strongly associated with acute myeloid leukemia and KMT2A rearrangements in early age.
Phenazone as a marker of liver-metabolic function in patients with acute leukemia.
Leukemic Infiltration
Hepatic drug clearance in children with leukemia: changes in clearance of model substrates during remission-induction therapy.
Leukoencephalopathies
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Leukopenia
Protective role of thiols in cyclophosphamide-induced urotoxicity and depression of hepatic drug metabolism.
Leydig Cell Tumor
Relation of membrane property of microsomes to androgen biosynthesis.
Lichen Planus
Lichen planus, liver kidney microsomal (LKM1) antibodies and hepatitis C virus antibodies.
[Extrahepatic manifestations of hepatitis C virus infection]
Lichen Planus, Oral
Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and antibody-negative erosive oral lichen planus patients with thyroid antibody positivity.
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus.
Modulation of serum anti-thyroglobulin and anti-thyroid microsomal autoantibody levels by levamisole in patients with oral lichen planus.
Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus.
Lipid Metabolism Disorders
Metformin improves lipid metabolism disorders through reducing the expression of microsomal triglyceride transfer protein in OLETF rats.
[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
Lipodystrophy
Myo-inositol action on gerbil intestine: reversal of a diet-induced lipodystrophy and change in microsomal lipase activity.
Liver Cirrhosis
A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers.
Dietary nucleotides correct plasma and liver microsomal fatty acid alterations in rats with liver cirrhosis induced by oral intake of thioacetamide.
Differential effects of hepatic cirrhosis on the intrinsic clearances of sorafenib and imatinib by CYPs in human liver.
Downregulation of the male-specific hepatic microsomal steroid 16 alpha-hydroxylase, cytochrome P-450UT-A, in rats with portal bypass. Relevance to estradiol accumulation and impaired drug metabolism in hepatic cirrhosis.
Effect of carbon tetrachloride--alcohol-induced liver fibrosis on microsomal mixed-function oxidases and the cytosolic glutathione-conjugating system in rat liver.
Effects of liver fibrosis on verapamil pharmacokinetics in rats.
Impaired androgen 16 alpha-hydroxylation in hepatic microsomes from carbon tetrachloride-cirrhotic male rats.
Inducibility of microsomal liver function may differentiate cirrhotic patients with maintained compared with severely compromised liver reserve.
Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis.
Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition.
The immunoelectron-microscopical demonstration of antibodies against endoplasmic reticulum (microsomes) in chronic aggressive hepatitis and liver cirrhosis.
Treatment of liver cirrhosis with microsomal enzyme-inducing compound in the rat.
[Non-organ specific anticytoplasmic autoantibodies. Immunoserologic detection and diagnostic relevance]
[Psychometric hepatic encephalopathy score normalization data for the Portuguese population].
[Time course of thioacetamide-induced changes in estrogen metabolism in the rat liver]
Liver Cirrhosis, Alcoholic
Assessment of the (14C) aminopyrine breath test in liver disease.
Decreased hepatic microsomal reserve in patients with cirrhosis. Studies using aminopyrine as model drug.
Hepatic ethanol elimination kinetics in patients with cirrhosis.
Hepatic [14C]aminopyrine demethylation capacity after portocaval shunting. Comparative study in patients with and without arterialization of portal vein.
Mitochondrial functions and content of microsomal and mitochondrial cytochromes in human cirrhosis.
Pericellular collagen in alcoholics with liver cirrhosis.
Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis.
The effect of alcoholic cirrhosis on the activities of microsomal aldrin epoxidase, 7-ethoxycoumarin O-de-ethylase and epoxide hydrolase, and on the concentrations of reduced glutathione in human liver.
The effect of alcoholic cirrhosis on the two kinetic components (high and low affinity) of the microsomal 0-deethylation of 7-ethoxycoumarin in human liver.
Liver Cirrhosis, Biliary
Assessment of the (14C) aminopyrine breath test in liver disease.
Detection of autoantibodies against M2, LKM-1, and SLA in liver diseases by standardized uniform ELISA-techniques.
IgG subclass distribution of autoantibodies to glomerular basement membrane in Goodpasture's syndrome compared to other autoantibodies.
Immunoblotting as a confirmatory test for antimitochondrial antibodies in primary biliary cirrhosis.
Prevalence and significance of abdominal lymphadenopathy in patients with chronic liver disease: an ultrasound study.
Regulation of renal cytochrome P-450. Effects of two-thirds hepatectomy, cholestasis, biliary cirrhosis and post-necrotic cirrhosis on hepatic and renal microsomal enzymes.
Serum antibodies to thymus epithelial cells in non-A, non-B and cryptogenic chronic liver disease.
The metabolism of 7-ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease.
Treatment of chronic type B hepatitis with recombinant alpha-interferon induces autoantibodies not specific for autoimmune chronic hepatitis.
Liver Diseases
13C-breath tests in the study of mitochondrial liver function.
A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins.
Activity and inducibility of hepatic microsomal enzymes in liver diseases.
Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny.
Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease.
ALCOHOL: its metabolism and interaction with nutrients.
Antipyrine clearance and metabolite excretion in Saudi patients with non-alcoholic chronic liver disease.
Antipyrine elimination and hepatic microsomal enzyme activity in patients with liver disease.
Association of Polymorphisms in Glutamate-Cysteine Ligase Catalytic Subunit and Microsomal Triglyceride Transfer Protein Genes with Nonalcoholic Fatty Liver Disease.
Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease.
Autoantibodies during alpha-interferon therapy for chronic hepatitis B.
Autoantibodies in chronic liver disease.
Autoimmune hepatitis in the Indian subcontinent: 7 years experience.
Autoimmune liver disease 2007.
Caffeine: a model compound for measuring liver function.
Correlation between MTP -493G>T polymorphism and non-alcoholic fatty liver disease risk: a meta-analysis.
Critical appraisal of (13) C breath tests for microsomal liver function: aminopyrine revisited.
Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease.
Detection of a microsomal antigen and its antibody in human liver diseases.
Detection of liver-kidney microsomal autoantibodies by radioimmunoassay and their relation to anti-mitochondrial antibodies in inflammatory liver diseases.
Differential effects of hepatic cirrhosis on the intrinsic clearances of sorafenib and imatinib by CYPs in human liver.
Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes.
Enhancement of hepatic drug metabolism by glutethimide in patients with liver disease.
Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease.
Immunological disorders in chronic hepatitis C Egyptian patients.
Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease.
Impaired liver function in stable renal allograft recipients.
Influence of liver disease and environmental factors on hepatic monooxygenase activity in vitro.
Inhibition of drug metabolism by cimetidine in man: dependence on pretreatment microsomal liver function.
Interferon therapy in liver/kidney microsomal antibody type 1-positive patients with chronic hepatitis C.
Intragraft iNOS induction during human liver allograft rejection depresses cytochrome p450 activity.
Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.
Lichen planus, liver kidney microsomal (LKM1) antibodies and hepatitis C virus antibodies.
Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis.
Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice.
Microsomal Epoxide Hydrolase Polymorphisms and Haplotypes as Determinants of Hepatitis B Virusand Hepatitis C Virus-related Liver Disease in Indian Population.
Microsomal triglyceride transfer protein and nonalcoholic fatty liver disease.
MTP -493G/T Polymorphism and Susceptibility to Nonalcoholic Fatty Liver Disease: A Meta-Analysis.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
New advances in the diagnosis of canine and feline liver and pancreatic disease.
Pediatric autoimmune liver diseases: the molecular basis of humoral and cellular immunity.
Phospholipid transmethylation and choline phosphotransferase in microsomal fraction of human diseased liver.
Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH?
Polymorphisms of microsomal epoxide hydrolase gene and severity of HCV-related liver disease.
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans.
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Previous tuberculosis, hepatitis C virus and lichen planus. A report of 10 cases, a causal or casual link?
Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes.
Quantitative analysis of hepatitis C virus activity in vivo in different groups of untreated patients.
Recurrent episodes of acute hepatitis associated with LKM-1 (cytochrome P450 2D6) antibodies in identical twin brothers.
Relationship between metabolic clearance rate of antipyrine and hepatic microsomal drug-oxidizing enzyme activities in humans without liver disease.
Salivary antipyrine kinetics in hepatic and renal disease and in patients on anticonvulsant therapy.
Seronegative autoimmune hepatitis in children: a single-center experience.
The aminopyrine breath test does not correlate with histologic disease severity in patients with cholestasis.
The association between SNPs rs1800591 and rs3816873 of the MTTP gene and nonalcoholic fatty liver disease: A meta-analysis.
The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model.
The metabolism of 7-ethoxycoumarin in human liver microsomes and the effect of primary biliary cirrhosis: implications for studies of drug metabolism in liver disease.
Treatment of autoimmune and extra-hepatic manifestations of HCV infection.
Treatment of autoimmune and extrahepatic manifestations of hepatitis C virus infection.
Treatment of chronic type B hepatitis with recombinant alpha-interferon induces autoantibodies not specific for autoimmune chronic hepatitis.
Trial and error investigational drug induced liver injury, a case series report.
Unusual occupational gastrointestinal and hepatic disorders.
Use of liver breath tests to assess severity of nonalcoholic Fatty liver disease.
[Changes of serum 3,5,3'-triiodothyronine (T3), thyroxine (T4), 3,3',5'-triiodothyronine (rT3) levels in patients with liver diseases. One marker for hepatic microsomal function]
[Enzymatic activity of microsomal hydroxylation in chronic liver diseases]
[Extrahepatic manifestations of hepatitis C virus infection]
[Immunofluorescent-optical demonstration of microsomal antibodies in chronic liver diseases]
[Lipid peroxidation markers in the exhaled breath and microsomal oxidation in patients with chronic diffuse liver diseases]
[Lipoprotein (a) in liver diseases. Correlation between low levels and liver function]
[Liver diseases with microsomal antibodies. Frequency, clinical and immunological findings and course observations (author's transl)]
[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
[Microsomal enzymes in chronic liver diseases]
[Microsomal oxidative foreign-substance degradation by the human liver. Oxidative foreign-substance degradation by microsomal fractions of the liver withdrawn by needle biopsy, illustrated on the example of coumarin-7-hydroxylase and 7-ethoxycoumarin hydroxylase in persons with healthy livers and various liver diseases]
[Non-organ specific anticytoplasmic autoantibodies. Immunoserologic detection and diagnostic relevance]
[Plasma levels of cytoplasmic, mitochondrial and microsomal enzymes in animals administered carbon-tetrachloride and in patients with various liver diseases]
[Primary and secondary autoimmunity in hepatology]
Liver Diseases, Alcoholic
Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 (CYP2E1) in the liver of rats chronically fed ethanol.
From alcohol toxicity to treatment.
Inhibition of hepatic drug metabolism by (+)-cyanidanol-3 (Catergen) in chronic alcoholic liver disease.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Nutritional and metabolic effects of alcoholism: their relationship with alcoholic liver disease.
Polymorphisms of the gene for microsomal epoxide hydrolase and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a Caucasian population.
Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system.
Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation.
Role of microsomal enzymes in development of alcoholic liver diseases.
[A retrospective study on the role of antibodies against soluble liver antigen (anti-SLA antibodies) and other autoantibodies in the diagnostics of autoimmune hepatitis]
[Vitamin A and the liver--current knowledge]
Liver Failure
Bullous pemphigoid after liver transplantation for liver failure.
Clinical pharmacokinetics of prednisone and prednisolone.
Profile of urinary bile acids in familial intrahepatic cholestasis with Coombs' negative haemolytic anaemia.
[Effect of sera from patients with liver failure on microsomal Na+, K+-ATPase activity of rat brain]
Liver Failure, Acute
Liver support systems: a 1978 perspective.
[The correction of disorders in the microsomal oxidation system of the liver in experimental acute liver failure]
Liver Neoplasms
A review of new approaches to assessing hepatic function in animals.
Altered lipid parameters in hepatic subcellular membrane fractions induced by fumonisin B1.
Association of reduction of AFB1-induced liver tumours by antioxidants with increased activity of microsomal enzymes.
Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells.
Immunohistochemical assessment of human microsomal epoxide hydrolase in primary and secondary liver neoplasm: a quantitative approach.
Inhibition of AFB1-induced liver cancer and induction of increased microsomal enzyme activity by dietary constituents.
Microsomal sphingomyelin accumulation in thioacetamide-injured regenerating rat liver: involvement of sphingomyelin synthase activity.
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Serum and liver glycylproline dipeptidyl aminopeptidase activity in rats with experimental hepatic cancer.
The impact of vitamins A,C,E, and selenium compound on prevention of liver cancer in rats.
Liver Neoplasms, Experimental
Analysis of the stearoyl-CoA desaturase system in the Morris hepatoma 7288C and 7288CTC.
Carbohydrate composition of rat hepatocyte nuclear membrane as compared to normal, Morris hepatoma 7800, and phenobarbital-induced microsomal membranes.
Comparative studies on the endogenous phosphorylation of microsomal membrane derived from Morris hepatoma, eight-day-old rats, and host livers in the presence of micromolar levels of Mg2+ ion.
Comparison of serine palmitoyltransferase in Morris hepatoma 7777 and rat liver.
Drug metabolism in the Novikoff hepatoma: evidence for a mixed function oxidase system and partial purification of cytochrome P-450 reductase.
Effect of assay temperature on the kinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver and Morris hepatoma 5123C.
Effect of nonspecific phospholipid transfer protein on cholesterol esterification in microsomes from Morris hepatomas.
Effects of phenobarbital and 3-methylcolanthrene treatment on microsomes of Morris hepatoma 3924-A, tumour-bearing and normal rat liver.
Electrophoretic analysis of microsomal smooth membrane proteins in rat liver and in Morris hepatoma 5123C.
Ethanol metabolism by a transplantable hepatocellular carcinoma. Role of microsomes and mitochondria.
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Morris hepatoma 7800 after intravenous injection of mevalonic acid.
Isolation and partial characterization of a cytochrome P-450 isoenzyme (cytochrome P-450tu) from mouse liver tumors.
Lipid peroxidation and lipid antioxidants in normal and tumor cells.
Microsomal cAMP-independent histone H1 kinase activity in plasmacytoma, Morris hepatoma and normal liver.
Mitochondrial and microsomal phospholipids of Morris hepatoma 7777.
Nonspecific lipid transfer proteins as probes of membrane structure and function.
O2-dependent lipid peroxidation does not affect the molecular order in hepatoma microsomes.
Restoration of hydroperoxide-dependent lipid peroxidation by 3-methylcholanthrene induction of cytochrome P-448 in hepatoma microsomes.
Lung Diseases
Microsomal epoxide hydrolase is not associated with COPD in a community-based sample.
Polymorphism in gene for microsomal epoxide hydrolase and lung disease.
Pulmonary disease and antipyrine clearance.
Lung Injury
Association of changes in lysophosphatidylcholine metabolism and in microsomal membrane lipid composition to the pulmonary injury induced by oleic acid.
Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites.
Metabolic sources of reactive oxygen metabolites during oxidant stress and ischemia with reperfusion.
Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.
Studies on the interaction of bleomycin A2 with rat lung microsomes. I. Characterization of factors which influence bleomycin-mediated DNA chain breakage.
The metabolic basis of 3-methylindole-induced pneumotoxicity.
[Protective effect of low concentration endothelin-1 on the reactive oxygen-induced inhibition of pulmonary surfactant lipid synthesis]
Lung Neoplasms
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers.
Alterations in the pulmonary microsomal cytochrome P-450 system after exposure of rats to silica.
Aromatic DNA adducts and number of lung cancer risk alleles in Map-Ta-Phut Industrial Estate workers and nearby residents.
Association between EPHX1 rs1051740 and lung cancer susceptibility: a meta-analysis.
Association between lung cancer and microsomal epoxide hydrolase genotypes.
Association between microsomal epoxide hydrolase 1 T113C polymorphism and susceptibility to lung cancer.
Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma.
Association of functionally important polymorphism of microsomal epoxide hydrolase gene (EPHX1) with lung cancer susceptibility.
Association of microsomal epoxide hydrolase polymorphisms and lung cancer risk.
Combined analysis of polymorphisms in glutathione S-transferase M1 and microsomal epoxide hydrolase in lung cancer patients.
Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancer.
EPHX1 A139G polymorphism and lung cancer risk: a meta-analysis.
EPHX1 gene polymorphisms and individual susceptibility to lung cancer.
EPHX1 polymorphisms and the risk of lung cancer: a HuGE review.
EPHX1 rs2234922 polymorphism and lung cancer susceptibility in Asian populations: a meta-analysis.
Functional polymorphisms of the microsomal epoxide hydrolase gene: A reappraisal on a early-onset lung cancer patients series.
Genetic analysis of microsomal epoxide hydrolase gene and its association with lung cancer risk.
Genetic polymorphism and gene expression of microsomal epoxide hydrolase in non-small cell lung cancer.
Genetic Polymorphism of Epoxide Hydrolase and GSTM1 in Lung Cancer Susceptibility of Korean Population.
Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients.
Genetic polymorphisms and lung cancer susceptibility: a review.
Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancer.
Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.
Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China.
Impact of epoxide hydrolase 1 polymorphisms on lung cancer susceptibility in asian populations.
Lung cancer risk in relation to genetic polymorphisms of microsomal epoxide hydrolase among African-Americans and Caucasians in Los Angeles County.
Lung cancer susceptibility in relation to combined polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1.
Microsomal epoxide hydrolase genotypes and chronic obstructive pulmonary disease in Japanese.
Microsomal epoxide hydrolase polymorphisms and lung cancer risk in non-Hispanic whites.
Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review.
Multiple analytical approaches reveal distinct gene-environment interactions in smokers and non smokers in lung cancer.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.
Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer.
Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer.
Polymorphisms in the microsomal epoxide hydrolase gene: role in lung cancer susceptibility and prognosis.
Pulmonary microsomal metabolism of benzo[a]pyrene following exposure of rats to silica.
Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer.
Quantitative membrane proteomics applying narrow range peptide isoelectric focusing for studies of small cell lung cancer resistance mechanisms.
Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation.
The association of microsomal epoxide hydrolase polymorphisms and lung cancer risk in African-Americans and Mexican-Americans.
The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer.
Variation of microsomal mixed function oxidase(s) and human lung cancer.
[Assessment of the functional state of microsomal enzymes in the liver in patients with small cell lung cancer treated with cytostatic drugs]
[The interaction between microsomal epoxide hydrolase polymorphisms and indoor pollution in non small cell lung cancer]
Lupus Erythematosus, Systemic
Cytochrome P-450 mediated metabolism in active murine systemic lupus erythematosus.
Distinction between natural and pathological autoantibodies by immunoblotting and densitometric subtraction: liver-kidney microsomal antibody (LKM) positive sera identify multiple antigens in human liver tissue.
Estrogen metabolism in the (New Zealand black x New Zealand white)F1 murine model of systemic lupus erythematosus.
Microsomal hydroxylation as measured by pentobarbital elimination in patients with idiopathic systemic lupus erythematosus.
Lymphadenopathy
Prevalence and significance of abdominal lymphadenopathy in patients with chronic liver disease: an ultrasound study.
Lymphatic Metastasis
Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.
Lymphoma
Alterations of drug-induced toxicity in the mouse lymphoma assay by a rat hepatic microsomal metabolizing system (S-9).
Bromodeoxyuridine resistance induced in mouse lymphoma cells by microsomal activation of dimethylnitrosamine.
Cell-free synthesis and membrane insertion of mouse H-2Dd histocompatibility antigen and beta 2-microglobulin.
Chimeric bovine-human growth hormone prepared by recombinant DNA technology: binding properties and biological activity.
Choline incorporation into phospholipids by microsomal fractions from L5178Y lymphoma.
Comparative study of in vitro and in vivo modulation of lactogenic and somatotropic receptors by native human growth hormone and its modified analog prepared by recombinant deoxyribonucleic acid technology.
Corticosteroids and phosphatidylcholine biosynthesis in microsomal fractions from L5178Y lymphoma.
Direct evidence that lactogenic hormones induce homodimerization of membrane-anchored prolactin receptor in intact Nb2-11C rat lymphoma cells.
Evidence that murine hematopoietic cell subset marker J11d is attached to a glycosyl-phosphatidylinositol membrane anchor.
Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas.
Human ovarian cancer, lymphoma spleen, and bovine milk GlcNAc:beta1,4Gal/GalNAc transferases: two molecular species in ovarian tumor and induction of GalNAcbeta1,4Glc synthesis by alpha-lactalbumin.
Protective role of vanadium in the survival of hosts during the growth of a transplantable murine lymphoma and its profound effects on the rates and patterns of biotransformation.
Role of vitamin D3 on the activity patterns of hepatic drug metabolizing enzymes in transplantable murine lymphoma.
Site-directed mutations of human growth hormone that selectively modify its lactogenic activity and binding properties.
The metabolism of N-acetyl-2-aminofluorene to a mutagen in L5178Y/TK+/-mouse lymphoma cells.
Two enzymes involved in the synthesis of O-linked oligosaccharides are localized on membranes of different densities in mouse lymphoma BW5147 cells.
Lymphoma, B-Cell
Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma.
Lymphoma, Large B-Cell, Diffuse
Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma.
Lymphoma, Non-Hodgkin
Alterations in hepatic heme and cytochrome P-450 metabolism in Murphy-Sturm lymphosarcoma-bearing rats. Implications for drug metabolism.
Metabolic gene variants and risk of non-Hodgkin's lymphoma.
Phenazone pharmacokinetics as an index of hepatic metabolic efficiency.
Lymphoproliferative Disorders
Human spleen heme oxygenase and microsomal electron transport system component activity in normals and in patients with hemolytic anemia, idiopathic thrombocytopenic purpura, and lymphoproliferative disorders.
Macular Degeneration
Genetic association of manganese superoxide dismutase with exudative age-related macular degeneration.
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy.
Malaria
Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay.
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Hepatic metabolism in severe falciparum malaria: caffeine clearance study.
Non-detergent sulphobetaines: a new class of mild solubilization agents for protein purification.
[Detection of a system of microsomal monooxygenases in the rodent malaria parasite Plasmodium berghei]
Malnutrition
Acute and chronic drug-induced hepatitis.
Alcohol and gastrointestinal cancer: pathogenic mechanisms.
Antipyrine pharmacokinetics and D-glucaric excretion in kwashiorkor.
Effect of chloramphenicol on hepatic mitochondrial and microsomal functions in protein-energy malnourishment.
Effect of protein and calorie malnutrition on drug metabolism in rat - in vitro.
Induction of microsomal drug metabolizing enzymes by oral contraceptives in protein-malnourished rats.
Influence of vitamin E and selenium on glutathione-dependent protection against microsomal lipid peroxidation.
Microsomal enzymes in malnutrition as determined by plasma half life of antipyrine.
Microsomal enzymes in malnutrition.
Rehabilitation of microsomal enzymes in malnourished rats: Comparison of parenteral versus oral refeeding.
The fetal somatotropic axis during long term maternal undernutrition in sheep: evidence for nutritional regulation in utero.
The role of dietary aflatoxin in the genesis of hepatocellular cancer in developing countries.
Undernutrition in the neonate: long-term effects upon mitochondrial and microsomal constituents of the rat hepatocyte.
Marek Disease
Marek's disease vaccination, with turkey herpesvirus, and enrofloxacin modulate the activities of hepatic microsomal enzymes in broiler chickens.
Massive Hepatic Necrosis
Increase of UDP-glucuronosyltransferase activities toward xenobiotics during the development of hereditary hepatitis in LEC rats.
Iproclozide fulminant hepatitis. Possible role of enzyme induction.
Occurrence of autoimmune antibodies to liver microsomal proteins in association with fulminant hepatitis in the LEC strain of rats.
Role of protein binding in cocaine-induced hepatic necrosis.
Serum thyroid hormone, triiodothyronine, thyroxine, and triiodothyronine/thyroxine ratio in patients with fulminant, acute, and chronic hepatitis.
Mastocytoma
Biosynthesis of glycosoaminoglycans by microsomal preparations from cultured mastocytoma cells.
Biosynthesis of heparin. Availability of glucosaminyl 3-O-sulfation sites.
Biosynthesis of heparin. Concerted action of late polymer-modification reactions.
Biosynthesis of heparin. Effects of n-butyrate on cultured mast cells.
Biosynthesis of heparin. Enzymatic sulfation of pentasaccharides.
Biosynthesis of heparin. Modulation of polysaccharide chain length in a cell-free system.
Biosynthesis of heparin. O-sulfation of D-glucuronic acid units.
Biosynthesis of heparin. O-sulfation of the antithrombin-binding region.
Biosynthesis of heparin. Relationship between the polymerization and sulphation processes.
Biosynthesis of heparin. Solubilization and partial characterization of N- and O-sulphotransferases.
Biosynthesis of heparin. Studies on the microsomal sulfation process.
Biosynthesis of heparin. The D-glucuronosyl- and N-acetyl-D-glucosaminyltransferase reactions and their relation to polymer modification.
Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides.
Colocalization of leukotriene C synthase and microsomal glutathione S-transferase elucidated by indirect immunofluorescence analysis.
Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases.
Primary structure of a mouse mastocytoma proteoglycan core protein.
Proteoglycans of microsomal fraction of mouse mastocytoma.
Relationship of sulfation to ongoing chondroitin polymerization during biosynthesis of chondroitin 4-sulfate by microsomal preparations from cultured mouse mastocytoma cells.
Simultaneous sulfation of endogenous chondroitin sulfate and chondroitin-derived oligosaccharides. Studies with separate 4-sulfating and 6-sulfating microsomal systems.
Substrate specificities of glycosyltransferases involved in formation of heparin precursor and E. coli K5 capsular polysaccharides.
Sulfation of chondroitin. Specificity, degree of sulfation, and detergent effects with 4-sulfating and 6-sulfating microsomal systems.
Measles
Measles antibodies and autoantibodies in autoimmune disorders.
Medulloblastoma
Maternal variation in EPHX1, a xenobiotic metabolism gene, is associated with childhood medulloblastoma: an exploratory case-parent triad study.
Melanoma
Action of trypsin and detergents on tyrosinase of normal and malignant melanocytes.
Assays for mammalian tyrosinase: a comparative study.
Human melanoma cells generate leukotrienes B4 and C4 from leukotriene A4.
Human melanomas of fibroblast and epithelial morphology differ widely in their ability to synthesize retinyl esters.
Isolation of the major component in white snakeroot that is toxic after microsomal activation: possible explanation of sporadic toxicity of white snakeroot plants and extracts.
Melanocyte-stimulating hormone (alpha-MSH) inhibits the growth of human malignant melanoma cells with the induction of phosphatidyl inositol and myo-inositol phosphate levels.
Microsomal activation of constituents of white snakeroot (Eupatorium rugosum Houtt) to form toxic products.
Properties of the nerve growth factor receptor. Relationship between receptor structure and affinity.
Structural toxicity relationship of 4-alkoxyphenols' cytotoxicity towards murine B16-F0 melanoma cell line.
Tyrosinase isoenzymes in mammalian melanocytes. 1. Biochemical characterization of two melanosomal tyrosinases from B16 mouse melanoma.
Melanoma, Experimental
Melanocyte stimulating hormone activation of tyrosinase in B16 mouse melanoma cells. Evidence for a differential induction of two distinct isoenzymes.
[Investigation of tyrosinase activity and phospholipid composition in Harding-Passey melanoma microsomal fraction]
Meningioma
Biochemical characterization of 17 beta-hydroxysteroid dehydrogenase in human meningioma.
Menopause, Premature
Partially compensated hypoadrenalism presenting with persistent skin pigmentation.
Mesothelioma, Malignant
Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.
Metabolic Diseases
Microsomal Triglyceride Transfer Protein: From Lipid Metabolism to Metabolic Diseases.
The role of epoxide hydrolases in health and disease.
Metabolic Syndrome
Analysis of alternative promoter usage in expression of HSD11B1 including the development of a transcript-specific quantitative real-time PCR method.
Energy-restricted Central-European diet stimulates liver microsomal function in obese postmenopausal women - a randomized nutritional trial with a comparison to energy-restricted Mediterranean diet.
Genetic variants of microsomal triglyceride transfer protein (MTTP) are associated with metabolic syndrome in schizophrenic patients treated with atypical antipsychotics.
Glycogen storage disease type Ia (GSDIa) but not Glycogen storage disease type Ib (GSDIb) is associated to an increased risk of metabolic syndrome: possible role of microsomal glucose 6-phosphate accumulation.
Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.
The influence of polymorphism of -493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress.
Methemoglobinemia
An investigation into the formation of tebufenozide's toxic aromatic amine metabolites in human in vitro hepatic microsomes.
Cytochrome b5 reductase: the roles of the recessive congenital methemoglobinemia mutants P144L, L148P, and R159*.
Heterologous expression of enzymopenic methemoglobinemia variants using a novel NADH:cytochrome c reductase fusion protein.
Metabolism of the arylamide herbicide propanil. I. Microsomal metabolism and in vitro methemoglobinemia.
Suppression of phenacetin-induced methemoglobinemia by diethyldithiocarbamate and carbon disulfide and its relation to phenacetin metabolism in mice.
[Induction of hepatic microsomal drug metabolizing enzymes and methemoglobinemia induced by local anesthetics]
microsomal epoxide hydrolase deficiency
Microsomal epoxide hydrolase deletion enhances tyrosine hydroxylase phosphorylation in mice after MPTP treatment.
Miosis
Preclinical toxicology studies with nizatidine, a new H2-receptor antagonist: acute, subchronic, and chronic toxicity evaluations.
Motor Neuron Disease
Xenobiotic metabolism in motor neuron disease.
Mouth Neoplasms
Lack of Association of EPHX1 Genotypes and Haplotypes with Oral Cancer in South Indians.
Multifocal epithelial hyperplasia: A potentially precancerous disease? (Review).
Mucopolysaccharidoses
Specific inhibition of human beta-D-glucuronidase and alpha-L-iduronidase by a trihydroxy pipecolic acid of plant origin.
Multiple Sclerosis
Circulating autoantibodies in multiple sclerosis.
Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite.
Partial purification of MS specific brain antigens.
Muscular Dystrophies
Preclinical increase in activity of muscle microsomal trypsin-like protease in murine muscular dystrophy, C57BL/10-mdx.
Sarocoplasmic reticulum. VI. Microsomal Ca2+ transport in genetic muscular dystrophy of mice.
Muscular Dystrophy, Duchenne
Muscle ribosome detachment factor. Does it have a role in the pathogenesis of Duchenne muscular dystrophy?
Therapeutic effect of camostat mesilate on Duchenne muscular dystrophy in mdx mice.
Myasthenia Gravis
Clinical and immunological associations in myasthenia gravis. 1: Autoantibodies.
Myasthenic Syndromes, Congenital
Unusual association of insulin-dependent diabetes mellitus with congenital myasthenia gravis and autoimmune thyroid disease.
Myelodysplastic Syndromes
Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes.
Myocardial Infarction
Clinical enzymology: an autobiographical history.
Microsomal epoxide hydrolase genotype and risk of myocardial infarction.
Pharmacology, electrophysiology, and pharmacokinetics of mexiletine.
[Changes in fatty acid composition and lipid peroxidation activity in microsomal membranes of the liver in experimental myocardial infarct]
[Experimental myocardial infarction in atherosclerosis--various methods of pharmacological correction]
[Functioning of the monooxygenase system of the liver in experimental myocardial infarct]
Myocardial Ischemia
Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease.
Hydrogen sulfide modulates sub-cellular susceptibility to oxidative stress induced by myocardial ischemic reperfusion injury.
Lack of effect of methylprednisolone on lysosomal and microsomal enzymes after two hours of well-defined canine myocardial ischemia.
Regulation of lysophosphatidylcholine-metabolizing enzymes in isolated myocardial cells from rat heart.
[Activity of microsomal oxidation and biochemical characteristics of the sympathico-adrenal system in myocardial ischemia in rats]
[Oxidative stress and hepatic monooxygenase function in patients with coronary heart disease before and after cardiac surgery]
[Treatment of arrhythmia in patients with chronic ischemic heart disease using kinilentin combined with an inhibitor or inductor of microsomal oxidation]
Myoma
[Diagnosis of thyroid function in uterine myomatosis]
Myositis
[Experimental myositis produced by injection of the microsomal fraction]
Myxedema
L-thyroxine therapy induces a fall of thyroid microsomal and thyroglobulin antibodies in idiopathic myxedema and in hypothyroid, but not in euthyroid Hashimoto's thyroiditis.
Thyroid autoantigens and their relevance in the pathogenesis of thyroid autoimmunity.
nadph-hemoprotein reductase deficiency
P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes.
Neoplasm Metastasis
Epithelioid hemangioendothelioma of the mandibular gingiva: A rare case of metastasis 4 years after radical excision and literature review.
Immunohistochemical assessment of human microsomal epoxide hydrolase in primary and secondary liver neoplasm: a quantitative approach.
Inhibitory effect of a biscoclaurine alkaloid, cepharanthin, on lung metastasis of Lewis lung carcinoma.
Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.
Neoplasms
15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.
3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase expression in rat and characterization of the testis isoform.
A Multi-step Virtual Screening Protocol for the Identification of Novel Non-acidic Microsomal Prostaglandin?E2 Synthase-1 (mPGES-1) Inhibitors.
A phylogenetic analysis identifies heterogeneity among hepatocellular carcinomas.
A unique highly oxygenated pyrano[4,3-c][2]benzopyran-1,6-dione derivative with antioxidant and cytotoxic activities from the fungus Phellinus igniarius.
Abnormal membrane phospholipid content in subcellular fractions from the Morris 7777 hepatoma.
Accelerated elimination of pimonidazole following microsomal enzyme induction in mice: a possible approach to reduced neurotoxicity of the pimonidazole-etanidazole combination.
Activation of calcium oscillations by thapsigargin in parotid acinar cells.
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.
Acylation of cholesterol by microsomal enzymes from mouse preputial gland tumors.
Adrenal microsomal C19-steroid 5alpha-reductase activity in the Snell transplantable rat adrenocortical tumour 494 and the effect of oestradiol, testosterone propionate and adrenocorticotrophin in intact and gonadectomized rats.
Aetiology of jaagsiekte: transmission by means of subcellular fractions and evidence for the involvement of a retrovirus.
Alcohol-related diseases and carcinogenesis.
Alterations in hepatic heme and cytochrome P-450 metabolism in Murphy-Sturm lymphosarcoma-bearing rats. Implications for drug metabolism.
Alterations of hepatic delta-aminolevulinic acid synthetase, heme oxygenase, microsomal cytochrome content and drug metabolism in rats bearing ascitic tumors AH 13, AH 66 and AH 414 and a 3-methylcholanthrene induced tumor.
Altered distribution of constitutive forms of microsomal cytochrome P-450 in tumor-bearing mouse liver.
Analogues of hexamethylmelamine. The anti-neoplastic activity of derivatives with enhanced water solubility.
Antiestrogen binding sites in microsomal fractions of malignant and nonmalignant human breast tissues.
Antihyperlipidaemic effect of triterpenic acid-enriched fraction from Cyclocarya paliurus leaves in hyperlipidaemic rats.
Antileukotactic properties of tumor cells.
Antitumor activity of sodium linoleate.
Antitumor agents. II. Effect of 5-fluorouracil and cyclophosphamide on immunological parameters and liver microsomes of tumor-bearing rats.
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Application of a microsomal drug activation system in a human tumor cloning assay.
Aryl hydrocarbon hydroxylase and its components in human lung microsomes.
Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events.
Association between head and neck cancer and microsomal epoxide hydrolase genotypes.
Association of Activity Altering Genotypes - Tyr113His and His139Arg in Microsomal Epoxide Hydrolase Enzyme with Esophageal Squamous Cell Carcinoma.
Association of microsomal epoxide hydrolase exon 3 Tyr113His and exon 4 His139Arg polymorphisms with gastric cancer in India.
Association of reduction of AFB1-induced liver tumours by antioxidants with increased activity of microsomal enzymes.
Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.
Bioactive Properties of Tynanthus panurensis (Bureau) Sanwith Bark Extract, the Amazonian "Clavo Huasca".
Biological markers as an aid in the clinical management of patients with liver metastases.
Biosynthesis of an O-alkyl analogue of phosphatidic acid and O-alkylglycerols via O-alkyl ketone intermediates by microsomal enzymes of Ehrlich ascites tumor.
Biosynthesis of heparin. 3. Formation of a sulfated glycosaminoglycan with a microsomal preparation from mast cell tumors.
Ca2+-dependent interaction of calcyclin with membrane.
cADP-ribose/ryanodine channel/Ca2+-release signal transduction pathway in mesangial cells.
Carbohydrate processing of thyrotropin differs from that of free alpha-subunit and total glycoproteins in microsomal subfractions of mouse pituitary tumor.
Carbon tetrachloride promoted malondialdehyde formation in liver microsomal and nuclear preparations from Sprague Dawley or Osborne Mendel male rats.
Changes in GTP-dependent fusion and ras-related proteins in membranes from rat hepatocellular carcinomas.
Characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human adrenal cortex.
Characterization of an extracellular matrix-degrading protease derived from a highly metastatic tumor cell line.
Characterization of microsomal methyl sterol demethylase in two Morris hepatomas.
Characterization of peripheral benzodiazepine receptors in rat prostatic adenocarcinoma.
Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride.
Chemopreventive effect of Ginkgo biloba extract against benzo(a)pyrene-induced forestomach carcinogenesis in mice: amelioration of doxorubicin cardiotoxicity.
Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.
Combined cancer chemotherapy with cyclophoshamide and an inducer of microsomal drug-metabolizing enzymes (cytochrome P-450) in tumor-bearing rats.
Common precursor molecule as origin for the ectopic-hormone-producing-tumour syndrome.
Comparative in vitro cytotoxicity of cyclophosphamide, its major active metabolites and the new oxazaphosphorine ASTA Z 7557 (INN mafosfamide).
Comparative studies on estrogen receptors between a pregnancy-dependent mouse mammary tumor (TPDMT-4) and related autonomous tumors.
Comparison of enzyme phenotypes in human bladder tumours and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder. A combined histochemical and immunohistochemical approach.
Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.
Covalent binding of carbon tetrachloride reactive metabolites to liver microsomal and nuclear lipid and phospholipid classes from Sprague Dawley and osborne Mendel male rats.
COX-2 Limits Prostanoid Production in Activated HUVECs and Is a Source of PGH2 for Transcellular Metabolism to PGE2 by Tumor Cells.
Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.
CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes.
Cytidine 5'-triphosphate-dependent dolichol kinase and dolichol phosphatase activities and levels of dolichyl phosphate in microsomal fractions from highly differentiated human hepatomas.
Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats.
Decrease in the activity of hepatic microsomal drug-metabolizing enzymes in tumor-bearing nude mice.
Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2.
Deep proteogenomic investigations elucidate the NRF2 antioxidant mechanism as a major driving mechanism of lung adenocarcinoma in Asia.
Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity.
Demonstration of the transferrin receptor in human breast cancer tissue. Potential marker for identifying dividing cells.
Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases.
Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors.
Developmental expression of human microsomal epoxide hydrolase.
Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumors.
Dietary ellagic acid reduces the esophageal microsomal metabolism of methylbenzylnitrosamine.
Dietary lipotropes, hepatic microsomal mixed-function oxidase activities, and in vivo covalent binding of aflatoxin B1 in rats.
Different sensitivity of two Walker 256 carcinoma lines to cyclophosphamide: correlation with drug distribution, biotransformation and macromolecule binding.
Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.
Differential effects of Walker 256 carcinosarcoma cells growing subcutaneously, intramuscularly, or intraperitoneally on hepatic microsomal mixed-function oxygenase activity.
Differentially expressed proteins in malignant and benign adrenocortical tumors.
Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer.
Discovery of pyridone-based histone deacetylase inhibitors: approaches for metabolic stability.
Displacement by tamoxifen of the estradiol-estrogen receptor binding: a functional assay for breast cancer studies.
Distribution of microsomal antigen in various types of thyroid tumour.
Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours.
DNA polymerases from intracisternal A-type particles on the mouse plasmacytoma MPC 11.
Does dienogest influence the inflammatory response of endometriotic cells? A systematic review.
Downregulation of apoptosis-related genes in keloid tissues.
Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital.
Dual role of fibroblasts in tumor cell growth.
Effect of a hepatic activation system on the antiproliferative activity of hexamethylmelamine against human tumor cell lines.
Effect of a zinc-deficient diet on lipid peroxidation in liver and tumor subcellular membranes.
Effect of different levels of omega-3 and omega-6 fatty acids on azoxymethane-induced colon carcinogenesis in F344 rats.
Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancer.
Effect of nonspecific phospholipid transfer protein on cholesterol esterification in microsomes from Morris hepatomas.
Effect of phenobarbital and other liver monooxygenase modifiers on dimethylnitrosamine-induced alkylation of rat liver macromolecules.
Effect of pretreatment with phenobarbital or SKF 525A on the toxicity and antitumor activity of lomustine.
Effect of strain differences and tumor presence on microsomal drug metabolism in the guinea pig: brief communication.
Effects of chemical inducers on human microsomal epoxide hydrolase in primary hepatocyte cultures.
Effects of dieldrin, diet, and bedding on enzyme function and tumor incidence in livers of male CF-1 mice.
Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats.
Effects of dietary fat on hepatic microsomal metabolism of 1,2-dimethylhydrazine.
Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat.
Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.
Effects of partial hepatectomy and dietary phenobarbital on liver and mammary tumorigenesis by two N-hydroxy-N-acylaminobiphenyls in female CD rats.
Effects of phenobarbital and 3-methylcolanthrene treatment on microsomes of Morris hepatoma 3924-A, tumour-bearing and normal rat liver.
Effects of phenobarbital, pregnenolone-16alpha-carbonitrile, and propylthiouracil on thyroid follicular cell proliferation.
Effects of selenium on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis and DNA adduct formation.
Effects of the antitumor agents from various natural sources on drug-metabolizing system, phagocytic activity and complement system in sarcoma 180-bearing mice.
EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.
Ehrlich's ascites fluid adsorbed over protein A containing Staphylococcus aureus Cowan I produces inhibition of tumor growth.
Elevated concentrations of mitochondrial peripheral benzodiazepine receptors in ovarian tumors.
Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase.
Enantioselective cytotoxic activity of bromine-substituted analogues of ifosfamide. A microsomal implication.
Enhanced cancer growth in mice administered daily human-equivalent doses of some H1-antihistamines: predictive in vitro correlates.
Enhanced drug-metabolizing capacity within liver adjacent to human and rat liver tumors.
Enhancement of acyl coenzyme A:retinol acyltransferase in rat liver and mammary tumor tissue by retinyl acetate and its competitive inhibition by N-(4-hydroxyphenyl) retinamide.
Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients.
Enzymology of mitomycin C metabolic activation in tumour tissue. Characterization of a novel mitochondrial reductase.
EPHX1 gene polymorphisms and individual susceptibility to lung cancer.
Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study.
Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype.
Esophageal microsomal metabolism of N-nitrosomethylbenzylamine in the zinc-deficient rat.
Estrogen and antiestrogen binding sites in desmoid tumors.
Estrogen synthesizing rare malignant Brenner tumor of the ovary with the presence of progesterone and androgen receptors in the absence of estrogen receptors.
Ethanol metabolism by a transplantable hepatocellular carcinoma. Role of microsomes and mitochondria.
Ethoxyresorufin O-deethylase activity in intact human cells.
Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma.
Evoked effects of PGE2 and PGA2 on lipid fluidity and Ca2+-stimulated ATPase of Walker-256 tumor microsomal membranes.
Experiments aiming at demonstrating microsomal drug metabolism in the tumor tissue.
Expression of class I and II human leukocyte antigens by thyrocytes and lymphocytic infiltration on human thyroid tumors. An immunofluorescence study.
Expression of cytochrome P-450(17) alpha, 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase, and steroid 5 alpha-reductase in rat H540 Leydig tumor cells.
Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines.
Expression of xenobiotic metabolizing enzymes in breast cancer.
Functional polymorphisms of the microsomal epoxide hydrolase gene: A reappraisal on a early-onset lung cancer patients series.
Further studies on effects of a small intestinal microsomal fraction upon transplantable tumors.
Further studies on the potential contribution of acetaldehyde accumulation and oxidative stress in rat mammary tissue in the alcohol drinking promotion of breast cancer.
gamma-Glutamyl carboxylase activity in experimental tumor tissues: a biochemical basis for vitamin K dependence of cancer procoagulant.
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis.
Gene expression analysis for predicting gemcitabine sensitivity in pancreatic cancer patients.
Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review.
Genes and nonalcoholic fatty liver disease.
Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1.
Genetic polymorphism and cancer risk.
Genetic polymorphism and gene expression of microsomal epoxide hydrolase in non-small cell lung cancer.
Genetic polymorphisms in chronic obstructive pulmonary disease.
Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India.
Genetically lowered microsomal epoxide hydrolase activity and tobacco-related cancer in 47,000 individuals.
Genetics of alcoholic liver disease and nonalcoholic fatty liver disease.
Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency.
Glutathione S-transferase expression in the human testis and testicular germ cell neoplasia.
Glutathione S-transferase isoenzymes in human renal carcinoma demonstrated by immunohistochemistry.
Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate.
Glutathione-S-transferase and microsomal epoxide hydrolase polymorphism and viral-related hepatocellular carcinoma risk in India.
Growth inhibition and prostaglandin metabolism in the R3230AC mammary adenocarcinoma by reduced glutathione.
Growth-related lipid peroxidation in tumour microsomal membranes and mitochondria.
Haplotypes of Microsomal Epoxide Hydrolase and X-Ray Cross-Complementing Group 1 Genes in Indian Hepatocellular Carcinoma Patients.
Heat-stimulated nitroreductive bioactivation of the 2-nitroimidazole benznidazole in vitro.
Hepatic metabolism and carcinogenesis. Its role in hepatoma and adenocarcinoma.
Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis.
Heterogeneous nuclear ribonucleoproteins and their interactors are a major class of deregulated proteins in anaplastic astrocytoma: a grade III malignant glioma.
Hexachlorobenzene is a tumor co-carcinogen and induces alterations in insulin-growth factors signaling pathway in the rat mammary gland.
High dietary level of synthetic vitamin E on lipid peroxidation, membrane fatty acid composition and cytotoxicity in breast cancer xenograft and in mouse host tissue.
High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers.
Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin.
Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression.
Human melanomas of fibroblast and epithelial morphology differ widely in their ability to synthesize retinyl esters.
Human ovarian cancer, lymphoma spleen, and bovine milk GlcNAc:beta1,4Gal/GalNAc transferases: two molecular species in ovarian tumor and induction of GalNAcbeta1,4Glc synthesis by alpha-lactalbumin.
Hydride transfer stereospecificity of rat liver aldehyde dehydrogenases.
Hypomethylation and hypoexpression of human CYP2E1 gene in lung tumors.
Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.
Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells.
Immunohistochemical assessment of human microsomal epoxide hydrolase in primary and secondary liver neoplasm: a quantitative approach.
Immunological identification of a common precursor to arginine vasopressin and neurophysin II synthesized by in vitro translation of bovine hypothalamic mRNA.
In vitro biosynthesis of human renin and identification of plasma inactive renin as an activation intermediate.
In vitro cytostatic activity of 8-substituted and tricyclic analogues of acyclovir.
In vitro Metabolism of Phenstatin: Potential Pharmacological Consequences.
In vitro prostaglandin H synthase- and monooxygenase-mediated binding of aflatoxin B1 to DNA in guinea-pig tissue microsomes.
In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue.
In vivo effect of chemically induced fibrosarcoma on copper metabolism of liver in mice.
In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome.
Incorporation of 35SO4 into endogenous heparin by a microsomal fraction from mast cell tumors.
Increased estrogen sulfation of estradiol 17beta-D-glucuronide in metastatic tumor rat livers.
Increased phospholipase D activity in human breast cancer.
Indole-3-propionic acid, a melatonin-related molecule, protects hepatic microsomal membranes from iron-induced oxidative damage: relevance to cancer reduction.
Induction of a novel Ca2+-dependent chymotrypsin-like serine protease by tumor promoters in rat livers.
Induction of colon tumors in 1,2-dimethylhydrazine-resistant Lobund Wistar rats by methylazoxymethanol acetate.
Induction of somatogenic receptors in livers of hypersomatotropic rats.
Influence of estrogen metabolism on proliferation of human breast cancer.
Influence of tumor microsomal fraction on sensory nerve regeneration.
Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesis.
Inhibition of Leydig tumor cell steroidogenesis by 10-propargylestr-4-ene-3,17-dione, an irreversible aromatase inhibitor.
Inhibition of tumour promotion in mouse skin by extracts of rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia), unique South African herbal teas.
Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, on the growth of human ovarian cancers.
Inhibitory effects of diallyl sulfide on the metabolism and tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung.
Initiation of poly-N-acetyllactosamine chain biosynthesis occurs preferentially on complex multiantennary asparagine-linked oligosaccharides.
Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy.
Insulin binding by normal and neoplastic colon tissue.
Insulin-like growth factor-I receptor expression and localization in benign and malignant rat mammary tumors.
Intervention of transplantable human mammary carcinoma MX-1 chemotherapy with dietary menhaden oil in athymic mice: increased therapeutic effects and decreased toxicity of cyclophosphamide.
Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer.
Intracellular mechanisms underlying lipid accumulation (white opaque substance) in gastric epithelial neoplasms: A pilot study of expression profiles of lipid-metabolism-associated genes.
Intrathecal administration of 4-hydroperoxycyclophosphamide in rhesus monkeys.
Investigation of the rate-determining microsomal reaction of cholesterol biosynthesis from lanosterol in Morris hepatomas and liver.
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors.
Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes.
Isosexual precocious pseudopuberty secondary to a feminizing adrenal tumor.
Kinetic modeling of beta-chloroprene metabolism: I. In vitro rates in liver and lung tissue fractions from mice, rats, hamsters, and humans.
Knockdown of microsomal glutathione S-transferase 1 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.
Levels of cytochrome P-450, steroidogenesis and microsomal and cytosolic epoxide hydrolases in normal human adrenal tissue and corresponding tumors.
Ligands of the antiestrogen binding site block endothelial cell proliferation reversibly.
LINC00205 modulates the expression of EPHX1 through the inhibition of miR-184 in hepatocellular carcinoma as a ceRNA.
Lipid composition of glucose-stimulated pancreatic islets and insulin-secreting tumor cells.
Lipid peroxidation of the microsomal fraction and extracted microsomal lipids from DAB-induced hepatomas.
Liver metabolic disruption induced after a single exposure to PCB126 in rats.
Localization of microsomal epoxide hydrolase in normal and neoplastic human kidney.
Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors.
Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.
Low microsomal epoxide hydrolase expression is associated with bladder carcinogenesis and recurrence.
Lung cancer susceptibility in relation to combined polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1.
Macromolecular complexes produced by 1,3-propanesultone.
Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas.
Mechanism of the abnormal vitamin K-dependent gamma-carboxylation process in human hepatocellular carcinomas.
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.
Mechanistic study on liver tumor promoting effects of flutamide in rats.
Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity.
Membrane proteins in human skin tumors.
Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.
Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin.
Metabolism of dimethylnitrosamine to mutagenic intermediates by kidney microsomal enzymes and correlation with reported host susceptibility to kidney tumors.
Microsomal aromatase in testicular tumour tissue: increased activity in choriocarcinoma compared to embryonal carcinoma.
Microsomal aspects of carcinogenesis and neoplasia.
Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer.
Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease.
Microsomal epoxide hydrolase expression as a predictor of tamoxifen response in primary breast cancer: a retrospective exploratory study with long-term follow-up.
Microsomal Epoxide Hydrolase Polymorphisms and Haplotypes as Determinants of Hepatitis B Virusand Hepatitis C Virus-related Liver Disease in Indian Population.
Microsomal fatty acid desaturation and elongation in a human lung carcinoma grown in nude mice.
Microsomal metabolites of the aryl hydrocarbon hydroxylase and tumour inhibitor 7,8-benzoflavone.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Microsomal reductase activity in patients with thyroid neoplasms.
Microsomal synthesis of the ether analogs of triacylglycerols. Acyl CoA:alkylacylglycerol and acyl CoA:alk-i-enylacylglycerol acyltransferases in tumors and liver.
Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease.
Mitochondrial and microsomal peripheral benzodiazepine receptors in human ovarian cancer xenografts.
Mitochondrial and microsomal phospholipids of Morris hepatoma 7777.
Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.
Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2's-hydroxy-3's-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors.
Modulation of peripheral benzodiazepine receptor density by testosterone in Dunning G prostatic adenocarcinoma.
Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism.
Monoclonal antibody recognizing a determinant on type 2 chain blood group A and B oligosaccharides detects oncodevelopmental changes in azoxymethane-induced rat colon tumors and human colon cancer cell lines.
Monooxygenase system in Guerin’s carcinoma of rats under conditions of ?-3 polyunsaturated fatty acids administration.
Monooxygenase, epoxide hydrolase, and glutathione-S-transferase activities in human lung. Variation between groups of bronchogenic carcinoma and non-cancer patients and interindividual differences.
Mouse liver tumors and microsomal enzyme-inducing drugs: experimental and clinical perspectives with phenobarbital.
mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer.
New actinomycin D analogues as superior chemotherapeutic agents against primary and advanced colon tumors and colon xenografts in nude mice.
Nitric Oxide and PGE-2 Cross-Talk in EGFR-Driven Epithelial Tumor Cells.
Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment.
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses.
O-Glycosylation and cellular differentiation in a subpopulation of mucin-secreting HT-29 cell line.
Optimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazole.
Oxidative biotransformation of benzo(a)pyrene by human lung microsomal fractions prepared from surgical specimens.
Particular cytochrome P-450-dependent steroid metabolism: a new class of mouse liver tumor markers.
Peripheral benzodiazepine receptors in androgen sensitive dunning rat prostatic adenocarcinoma.
PGE2 and PGA2 affect the allosteric properties and the activities of calmodulin-dependent guanylate cyclase and Ca2+-stimulated ATPase of Walker-256 tumour microsomal membranes.
Pharmacokinetics of 5-fluorouracil in mutant Nagase analbuminemic rats: faster metabolism of 5-fluorouracil via CYP1A.
Phenobarbital does not promote hepatic tumorigenesis in a twenty-six-week bioassay in p53 heterozygous mice.
Phenobarbital, beta-naphthoflavone, clofibrate, and pregnenolone-16alpha-carbonitrile do not affect hepatic thyroid hormone UDP-glucuronosyl transferase activity, and thyroid gland function in mice.
Photoaffinity labeling of peripheral benzodiazepine receptors in R-3327 Dunning prostatic tumors.
Physiological effects of cabbage with reference to its potential as a dietary cancer-inhibitor and its use in ancient medicine.
Polychlorinated terphenyls (PCTs) use, levels and biological effects.
Polymorphic enzymes of xenobiotic metabolism as modulators of acquired P53 mutations in bladder cancer.
Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia.
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Possible role of riboflavin deficiency in epithelial neoplasia. 3. Induction of microsomal aryl hydrocarbon hydroxylase.
Processing of placental peptide hormones synthesized in lysates containing membranes derived from tunicamycin-treated ascites tumor cells.
Profiling the progression of cancer: separation of microsomal proteins in MCF10 breast epithelial cell lines using nonporous chromatophoresis.
Prolactin binding components in prostatic cancer tissue specimens obtained by TURP.
Prostaglandin concentrations and prostaglandin synthetase activity in N-nitrosomethylurea-induced rat mammary adenocarcinoma.
Protective role of vanadium in the survival of hosts during the growth of a transplantable murine lymphoma and its profound effects on the rates and patterns of biotransformation.
Protein kinase C activity in human gastric carcinoma.
Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes.
Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells.
Purification and characterization of a lysosomal form and a variant form of beta-glucuronidase from the rat basophil leukaemia tumour.
Putative EPHX1 Enzyme Activity Is Related with Risk of Lung and Upper Aerodigestive Tract Cancers: A Comprehensive Meta-Analysis.
Quantitative assessment of the influence of EPHX1 gene polymorphisms and cancer risk: a meta-analysis with 94,213 subjects.
Rat ventral prostate microsomal biotransformation of ethanol to acetaldehyde and 1-hydroxyethyl radicals: its potential contribution to prostate tumor promotion.
Receptors characterization of intraperitoneally N-nitroso-N-methylurea-induced mammary tumors in rats.
Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice.
Reduction of dihydrodiol dehydrogenase expression in resected hepatocellular carcinoma.
Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet.
Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes.
Regulation of cardiovascular biology by microsomal epoxide hydrolase.
Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase.
Regulation of Human Microsomal Prostaglandin E Synthase-1 by IL-1? requires a Distal Enhancer Element with a Unique Role for C/EBP?
Relation of membrane property of microsomes to androgen biosynthesis.
Relationship between the microsomal epoxide hydrolase and the hepatocellular transport of bile acids and xenobiotics.
Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells.
Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3? and ?-catenin pathway in A549 cell line.
Reversal of cytochrome P-4501A1 and P-450-EF expression in MCA-C3H/10T1/2 cell-derived tumors as compared to cultured cells.
Riboflavin.
Ribonucleases and neoplasia.
Role of beta-carotene on the changes in activity patterns and levels of biotransforming enzymes in transplantable murine lymphoma.
Role of lipid transfer proteins in the abnormal lipid content of Morris hepatoma mitochondria and microsomes.
Role of metabolism in effects of diflubenzuron on growth of B16 melanomas in mice.
Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study.
Ruthenium red-insensitive calcium transport in ascites-sarcoma 180/TG cells.
Shikimic acid and quinic acid are not mutagenic in the Ames assay.
Skin and salivary gland carcinogenicity of 7,12-dimethylbenz[a]anthracene is equivalent in the presence or absence of aryl hydrocarbon receptor.
Small bowel extracts in the inhibition of tumour growth.
Some biochemical properties of human breast tumor sialyltransferase.
Species differences in enzymes controlling reactive epoxides.
Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin.
Stauntoside B inhibits macrophage activation by inhibiting NF-?B and ERK MAPK signalling.
Steroid 21-hydroxylase and 17 alpha-hydroxylase in microsomal fraction of functioning adrenocortical tumors.
Steroid metabolism in normal mammary gland and in the dimethylbenzanthracene-induced mammary tumor of rats.
Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.
Studies of the effects of treatment with 5-flourouracil alone and in combination with either cyclophosphamide, methotrexate, or methyl-CCNU on hepatic drug-metabolizing enzymes in murine L1210 leukemia.
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Studies on lipid peroxidation in normal and tumour tissues. The Novikoff rat liver tumour.
Studies on the mode of action for thyroid gland tumor promotion in rats by phenobarbital.
Study of relationship between allogeneic transplantability of tumors and their effects on drug-metabolizing system in rats.
Subcellular and extracellular localization of specific binding sites for triphenylethylene antiestrogens in human breast cancer.
Subcellular localization of sialic acid in human brain tumors.
Superoxide dismutase content and microsomal lipid composition of tumours with different growth rates.
Symposium overview: the role of genetic polymorphism and repair deficiencies in environmental disease.
Synthesis and antitumor activity of 6-trifluoromethylcyclophosphamide and related compounds.
Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase.
Synthesis of vitamin K-dependent proteins by cultured human tumor cells.
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression.
The effect of a pituitary mammotropic tumor on hepatic microsomal drug metabolism in the rat.
The enzymology of doxorubicin quinone reduction in tumour tissue.
The essential role of microsomal deacetylase activity in the metabolic activation, DNA-(deoxyguanosin-8-yl)-2-aminofluorene adduct formation and initiation of liver tumors by N-hydroxy-2-acetylaminofluorene in the livers of infant male B6C3F1 mice.
The lipid composition of highly differentiated human hepatomas, with special reference to fatty acids.
The mode of action of cytotoxic and antitumor 1-nitroacridines. II. In vivo enzyme-mediated covalent binding of a 1-nitroacridine derivative, Ledakrin or Nitracrine, with dna and other macromolecules of mammalian or bacterial cells.
The possible roles of membrane organization in the activity of androgen biosynthetic enzymes associated with normal or tumorous mouse Leydig cell microsomes.
The relationship between metabolism, DNA binding, and carcinogenicity of 15,16-dihydro-11-methylcyclopenta(alpha)phenanthren-17-one in the presence of a microsomal enzyme inhibitor.
The relationship of the cyclic nucleotide system to inhibition of hepatic drug metabolism in Walker 256 carcinoma-bearing rats.
The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor.
The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
The role of delta-6- and delta-9-desaturase in the fatty acid metabolism of hepatomas with different growth rate.
The role of epoxide hydrolase Y113H gene variant in pancreatic diseases.
The role of epoxide hydrolases in health and disease.
The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.
The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: implications for thyroid gland neoplasia.
The utilization of in vitro mutagenesis techniques to explain strain, age and sex related differences in dimethylnitrosamine tumor susceptibilities in mice.
Tin-protoporphyrin inhibits heme oxygenase and prevents the decline in hepatic heme and cytochrome P-450 contents produced in nude mice by tumor transplantation.
Tissue and species specificity of the microsomal metabolism of N-nitrosomethylbenzylamine.
Transfer of tyrosinase to melanosomes in Harding-Passey mouse melanoma.
Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats.
Tumor microsomal metabolism of the food toxicant, benzo(a)pyrene, in Apc( Min ) mouse model of colon cancer.
Tumor promoter-stimulated translocation of glucose transport system in mouse embryo fibroblast Swiss 3T3 cell.
Use of a transgenic mouse model to identify markers of human lung tumors.
Visibility of phospholipids in 31P NMR spectra of human breast tumours in vivo.
Wax ester synthesis in the mouse preputial gland tumour.
Weight-of-evidence versus strength-of-evidence in toxicologic hazard identification: Di(2-ethylhexyl)phthalate (DEHP).
Xanthones as inhibitors of microsomal lipid peroxidation and TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs).
Xenobiotic metabolizing enzymes in genetically and chemically initiated mouse liver tumors.
Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole.
[A new styrene dimer derivative from Litsea greenmaniana].
[Activity of 5-alpha- and 5-beta-steroid reductases in subcellular liver structures from rats bearing Walker carcinosarcoma]
[Autoantibodies to steroid-producing ovarian cells in cancer patients]
[Cellular mechanisms of induction of apoptosis in human erythroleukaemic K562 cells line treated by quinoline-N-oxide derivatives]
[Changes in phospholipid composition in rat liver microsomes and mitochondria under chemical carcinogenesis]
[Chemical constituents of stems and branches of Adina polycephala]
[Cytochrome P-450 and aryl hydroxylase activity in cells of a long-term transplantable tumor]
[Differing microsomal monoxygenase activity in the cells of ascitic and solid forms of transplantable tumors]
[Effect of liposomal antitumor preparation 5,6-benzocoumarin-5-uracil on intensity of free-radical processes in the liver microsomes and tumor cells of rats with transplanted Guerin's carcinoma]
[Effect of liposomal antitumor preparation 5-(5',6'-benzocoumarin-3')-methylaminouracil hydrobromide on cytochrome P-450 in the microsomal liver fraction of tumor bearing rats]
[Effect of low doses of x-ray irradiation on the liver detoxication system in rats with transplanted Guerin's carcinoma].
[Effect of microsomal fraction of transplantable neoplasm on regeneration of sensory nerves]
[Effect of pregnenolone-16 -carbonitrile on microsomal enzyme activity and hepatic ultrastructure in a rat bearing a Walker tumor]
[Effect of thyroid hormones on the modulation of genetic expression of liver cytosolic malic enzyme, in rats poisoned with hexachlorobenzene]
[Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
[Genetic features during chronic obstructive pulmonary disease]
[Genetics risk factors in chronic obstructive pulmonary disease]
[Metabolism and distribution of phosphatidylcholine in membranes of normal and tumor cells]
[Microsomal monooxygenases of the liver in mice with transplanted tumors]
[Microsomal N-acetyl-glucosaminyl-transferases activity in BALB/c mice infected with mouse mammary tumor virus (M-MTV) (author's transl)]
[Non-anthraquinones constituents from the roots of Knoxia valerianoides].
[Rat microsomal glutathione S-transferase 1 alters cytotoxic effects of chlorambucil on PC-3, K562, HepG2 and P388D1 cell lines]
[Relation Between microsomal epoxide hydrolase polymorphism and susceptibility to ovarian epithelial cancer]
[Subcellular particles in tumors. II. Analysis of mitochondrial and microsomal fractions in hepatoma HW by isopycnic centrifugation]
[The clinical significance of aberrant HLA-DR antigen expression on thyrocytes]
[The induction of Guerin's carcinoma cytochrome p450 hydroxylase activity by retinoids].
[The role of pyridine nucleotide cofactors in the reaction of microsomal N-demethylation under normal conditions and in tumor pathology]
Neoplasms, Germ Cell and Embryonal
Glutathione S-transferase expression in the human testis and testicular germ cell neoplasia.
Nephritis, Hereditary
Antithyroid and antiadrenal autoantibodies in antiglomerular basement membrane disease, thin basement membrane disease and Alport syndrome.
Asymptomatic autoimmune thyroiditis and thyroid dysfunction in Alport's syndrome. A report of three families.
Nephrolithiasis
[Lipid peroxidation and Ca-dependent ATPase activity in the microsomal fraction of renal tissue in patients with nephrolithiasis and chronic pyelonephritis]
Nervous System Diseases
Circulating autoantibodies in multiple sclerosis.
Elucidation of plasma protein binding, blood partitioning, permeability, CYP phenotyping and CYP inhibition studies of Withanone using validated UPLC method: An active constituent of neuroprotective herb Ashwagandha.
Neuralgia
Ellagic acid enhances the antinociceptive action of carbamazepine in the acetic acid writhing test with mice.
Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test.
Neuroblastoma
Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1.
Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines.
Effects of neuropathic and non-neuropathic isomers of tricresyl phosphate and their microsomal activation on the production of axon-like processes by differentiating mouse N2a neuroblastoma cells.
Evidence for a GTP-dependent increase in membrane permeability for calcium in NG108-15 microsomes.
Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules.
Prostaglandin synthesis in homogenates of cultured neuroblastoma cells.
Neurocutaneous Syndromes
Clinical, biochemical and molecular genetic characteristics of 19 patients with the Sjögren-Larsson syndrome.
Defective metabolism of leukotriene B4 in the Sjögren-Larsson syndrome.
MRI and 1H-MRS findings of three patients with Sjögren-Larsson syndrome.
[Sjögren-Larsson syndrome: a novel mutation in a Moroccan child]
Neuroinflammatory Diseases
Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
Neurotoxicity Syndromes
Interaction between smoking and glutathione S-transferase polymorphisms in solvent-induced chronic toxic encephalopathy.
[The role of smoking and metabolic enzyme polymorphisms in the organic solvent induced chronic encephalopathy].
Newcastle Disease
Translation and membrane insertion of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus.
Non-alcoholic Fatty Liver Disease
(13C)-Methacetin breath test provides evidence of subclinical liver dysfunction linked to fat storage but not lifestyle.
Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease.
Association of Polymorphisms in Glutamate-Cysteine Ligase Catalytic Subunit and Microsomal Triglyceride Transfer Protein Genes with Nonalcoholic Fatty Liver Disease.
Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease.
Correlation between MTP -493G>T polymorphism and non-alcoholic fatty liver disease risk: a meta-analysis.
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease.
Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review.
Genes and nonalcoholic fatty liver disease.
Genetic polymorphisms in non-alcoholic fatty liver disease: Interleukin-6-174G/C polymorphism is associated with non-alcoholic steatohepatitis.
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.
Impact of cholesterol metabolism and the LXRalpha-SREBP-1c pathway on nonalcoholic fatty liver disease.
Induction of microsomal triglyceride transfer protein expression is a candidate mechanism by which ezetimibe therapy might exert beneficial effects in patients with nonalcoholic steatohepatitis.
Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model.
Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis.
Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease.
Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice.
Microsomal triglyceride transfer protein and nonalcoholic fatty liver disease.
Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease.
MTP -493G/T Polymorphism and Susceptibility to Nonalcoholic Fatty Liver Disease: A Meta-Analysis.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Nonalcoholic steatohepatitis (NASH) in ob/ob mice treated with yo jyo hen shi ko (YHK): effects on peroxisome proliferator-activated receptors (PPARs) and microsomal triglyceride transfer protein (MTP).
Pathogenesis and significance of hepatitis C virus steatosis: an update on survival strategy of a successful pathogen.
Plasma free choline is a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis: A multi-center validation study.
Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH?
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans.
Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell.
Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes.
Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.
Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease.
The association between SNPs rs1800591 and rs3816873 of the MTTP gene and nonalcoholic fatty liver disease: A meta-analysis.
The role of ¹³C-methacetin breath test for the non-invasive evaluation of nonalcoholic fatty liver disease.
Obesity
A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes.
Altered activity of cytochrome P450 in alcoholic fatty liver exposed to ischemia/reperfusion.
Biologic activity of dirlotapide, a novel microsomal triglyceride transfer protein inhibitor, for weight loss in obese dogs.
Cardiac expression of microsomal triglyceride transfer protein is increased in obesity and serves to attenuate cardiac triglyceride accumulation.
Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila.
Changes in microsomal activity in alcoholism and obesity.
Effect of genetic obesity and experimental diabetes on hepatic microsomal mixed function oxidase activities.
Hepatic cholesterol metabolism in obesity: activity of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Human Resistin Stimulates Hepatic Overproduction of Atherogenic ApoB-Containing Lipoprotein Particles by Enhancing ApoB Stability and Impairing Intracellular Insulin Signaling.
Impact of Obesity on Ovotoxicity Induced by 7,12-dimethylbenz[a]anthracene in Mice.
Insulin degradation. XVIII. On the regulation of glutathione-insulin transhydrogenase in the hyperglycemic obese (ob/ob) mouse.
JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses high fat diet-induced obesity and glucose intolerance in Sprague-Dawley rats.
Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of microsomal triglyceride transfer protein (MTP) in obese rats.
Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis activation.
Mice subjected to aP2-Cre mediated ablation of microsomal triglyceride transfer protein are resistant to high fat diet induced obesity.
Obesity alters the ovarian proteomic response to zearalenone exposure†.
Obesity as a risk factor for drug-induced organ injury. VI. Increased hepatic P450 concentration and microsomal ethanol oxidizing activity in the obese overfed rat.
Octreotide promotes weight loss via suppression of intestinal MTP and apoB48 expression in diet-induced obesity rats.
PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease.
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice.
Progressive obesity alters ovarian insulin, phosphatidylinositol-3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by phosphoramide mustard in mice†.
Regulation of putative fatty acid transporters and Acyl-CoA synthetase in liver and adipose tissue in ob/ob mice.
Obesity, Abdominal
Genetic determinants of obesity and related vascular diseases.
Molecular screening of the microsomal triglyceride transfer protein: association between polymorphisms and both abdominal obesity and plasma apolipoprotein B concentration.
Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men.
Obesity, Maternal
Maternal obesity alters feto-placental cytochrome P4501A1 activity.
Optic Atrophy, Hereditary, Leber
Genetic variants of TP53 and EPHX1 in Leber's hereditary optic neuropathy and their relationship to age at onset.
Optic Nerve Diseases
Genetic variants of TP53 and EPHX1 in Leber's hereditary optic neuropathy and their relationship to age at onset.
Oral Submucous Fibrosis
High incidence of autoantibodies in Taiwanese patients with oral submucous fibrosis.
Oropharyngeal Neoplasms
High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers.
Osteoarthritis
Antithyroid-antibody activity in the snyovial fluid of patients with various arthritides.
Osteomalacia
Pathophysiology behind anticonvulsant osteomalacia.
The plasma half-life of antipyrine in chromic uraemic and normal subjects.
Osteomyelitis
[The state of the microsomal oxidative system in the liver of rats with acute osteomyelitis of the mandible]
Osteoporosis, Postmenopausal
Interactions between drugs and vitamins at advanced age.
Osteosarcoma
Immunohistochemical Expression of COX-2, mPGES and EP2 Receptor in Normal and Reactive Canine Bone and in Canine Osteosarcoma.
Purification and biochemical characterization of a virus-specific reverse transcriptase from human osteosarcoma tissue.
Ovarian Neoplasms
Association between EPHX1 polymorphism rs1051740 and the risk of ovarian cancer: a meta-analysis.
mEH Tyr113His polymorphism and the risk of ovarian cancer development.
Microsomal epoxide hydrolase polymorphism and susceptibility to ovarian cancer.
Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer.
Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma.
Mitochondrial and microsomal peripheral benzodiazepine receptors in human ovarian cancer xenografts.
Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Proteins associated with Cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels.
Shotgun glycopeptide capture approach coupled with mass spectrometry for comprehensive glycoproteomics.
The microsomal epoxide hydrolase Tyr113His polymorphism: association with risk of ovarian cancer.
Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.
Pancreatic Diseases
The role of epoxide hydrolase Y113H gene variant in pancreatic diseases.
Pancreatic Neoplasms
Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers.
MGST1, a new soldier of NRF2 in the battle against ferroptotic death.
Pancreatitis
c-Src regulates cargo transit via the Golgi in pancreatic acinar cells.
Glutathione S-transferase activity in the liver in acute pancreatitis at various terms of disease and during treatment with inducers.
Severe hypertriglyceridemia with pancreatitis: thirteen years' treatment with lomitapide.
Unusual occupational gastrointestinal and hepatic disorders.
Zymogen activation in a reconstituted pancreatic acinar cell system.
Pancreatitis, Chronic
Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.
Pancytopenia
Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.
Papilloma
Human papillomavirus detection in histologic samples of multifocal epithelial hyperplasia: a novel demographic presentation.
Paralysis
Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation.
Cell-free synthesis of functional human epidermal growth factor receptor: Investigation of ligand-independent dimerization in Sf21 microsomal membranes using non-canonical amino acids.
Effect of exogenous pyruvate on acrylamide neuropathy in rats.
Effect of thymectomy on zoxazolamine paralysis and metabolism in untreated and (PCN) pregnenolone-16alpha-carbonitril- or ACTH-pretreated rats.
Effects of mixed-function oxidase modifiers on neurotoxicity of acrylamide in rats.
Inhibitory effect of propylthiouracil-induced hypothyroidism in rat on oxidative drug metabolism.
Structure-activity relations for methylenedioxyphenyl and related compounds on hepatic microsomal enzyme function, as measured by prolongation of hexobarbital narcosis and zoxazolamine paralysis in mice.
Thiram-induced disturbance of microsomal phospholipid bioformation and phospholipid fatty acid pattern.
Paraparesis, Spastic
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
Parasitemia
Chagas' disease: a clinical, parasitological, immunological, and pathological study in rabbits.
Effect of Plasmodium berghei infection and chloroquine on the hepatic drug metabolizing system of mice.
Parkinson Disease
Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes.
Cytochrome P450-dependent metabolism of l-deprenyl in monkey (Cercopithecus aethiops) and C57BL/6 mouse brain microsomal preparations.
Employing in vitro metabolism to guide design of F-labelled PET probes of novel ?-synuclein binding bifunctional compounds.
Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease.
GSTM1 and mEPHX polymorphisms in Parkinson's disease and age of onset.
In vitro confirmation of selegiline N-oxidation by flavin-containing monooxygenase in rat microsome using LC-ESI MS.
l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes.
Parkinsonian Disorders
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse liver preparations.
Peptic Ulcer
Blood group activities in water-soluble glycoproteins and in microsomal fractions of gastric mucosa in peptic ulcer and gastric cancer patients.
Unusual occupational gastrointestinal and hepatic disorders.
[The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions]
Peritonitis
Effect of bile on liver function tests in experimental E. coli peritonitis in the rat.
Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity.
[Clinical and experimental research on the drug-metabolizing function of the liver in peritonitis]
[The state of the microsomal oxidative system in the rat liver during fecal peritonitis]
Persistent Infection
Microsomal autoantibodies in chronic infection with the HBsAg associated delta (delta) agent.
Polymorphisms of microsomal triglyceride transfer protein in different hepatitis B virus-infected patients.
Pharyngeal Neoplasms
CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study.
Pharyngitis
Upper-airway obstruction and prolonged recovery from anesthesia following intranasal clotrimazole administration.
Pheochromocytoma
Identification of inositol 1,4,5-trisphosphate binding in human pheochromocytoma.
phosphatidylcholine-sterol o-acyltransferase deficiency
Enzymic esterification of cholesterol in rat intestinal mucosa catalyzed by acyl-CoA: cholesterol acyltransferase.
Photosensitivity Disorders
Acridine orange-mediated photodamage of microsomal- and lysosomal fractions.
Destruction of microsomal cytochrome P-450 by reactive oxygen species generated during photosensitization of hematoporphyrin derivative.
Role of active oxygen species in the photodestruction of microsomal cytochrome P-450 and associated monooxygenases by hematoporphyrin derivative in rats.
Studies on the nature of in vitro and in vivo photosensitization reactions by psoralens and porphyrins.
[Photosensitization of mitochondrial and microsomal enzymes by hematoporphyrin derivative in vitro]
Pituitary ACTH Hypersecretion
Steroid 21-hydroxylase and 17 alpha-hydroxylase in microsomal fraction of functioning adrenocortical tumors.
Pituitary Neoplasms
A neuroendocrine-specific protein localized to the endoplasmic reticulum by distal degradation.
Carbohydrate processing of thyrotropin differs from that of free alpha-subunit and total glycoproteins in microsomal subfractions of mouse pituitary tumor.
Thyroid-stimulating hormone subunit processing and combination in microsomal subfractions of mouse pituitary tumor.
Plasmacytoma
Analogues of hexamethylmelamine. The anti-neoplastic activity of derivatives with enhanced water solubility.
Correlation of the effect of feeding upon the cell cycle distribution profiles of MPC-11 cells with the relative appearance of [3H]-choline labeled material in microsomal subfractions and other cell fractions.
DNA polymerases from intracisternal A-type particles on the mouse plasmacytoma MPC 11.
Effect of a zinc-deficient diet on mitochondrial and microsomal lipid composition in TEPC-183 plasmacytoma.
Microsomal cAMP-independent histone H1 kinase activity in plasmacytoma, Morris hepatoma and normal liver.
Purification and characterization of a specific histone H1 protein kinase from mouse plasmacytoma.
Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma.
The isolation of microsomal subfractions of mouse plasmacytoma cells: the effect of salt concentration during nitrogen cavitation.
Ultrastructure and polysome content of the microsomal subfractions of mouse plasmacytoma cells.
Pleural Effusion
Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole.
Pneumatosis Cystoides Intestinalis
Unusual occupational gastrointestinal and hepatic disorders.
Pneumococcal Infections
Effects of pneumococcal infection on rat liver microsomal enzymes and lipogenesis by isolated hepatocytes.
Pneumoconiosis
[Gene variance in microsomal epoxide hydrolase and the susceptibility of coal workers' pneumoconiosis].
Pneumonia
Antipyrine clearance in pneumonia.
Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children.
[Changes in the content and activity of liver and lung microsomal enzymes in experimental pneumonia and their possible correction]
Polycystic Kidney Diseases
Inhibition of catalase and epoxide hydrolase by the renal cystogen 2-amino-4,5-diphenylthiazole and its metabolites.
Polycystic Kidney, Autosomal Recessive
Inhibition of catalase and epoxide hydrolase by the renal cystogen 2-amino-4,5-diphenylthiazole and its metabolites.
Polycystic Ovary Syndrome
Quantitative Methylation Level of the EPHX1 Promoter in Peripheral Blood DNA Is Associated with Polycystic Ovary Syndrome.
Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are associated with polycystic ovary syndrome.
Polycythemia
Nickel induction of microsomal heme oxygenase activity in rodents.
Polyendocrinopathies, Autoimmune
Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
[Autoimmune polyendocrinopathies. Pathogenic hypotheses]
Polymyositis
Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis.
[Non-organ specific anticytoplasmic autoantibodies. Immunoserologic detection and diagnostic relevance]
Porphyria Cutanea Tarda
Hepatic arachidonic acid metabolism is disrupted after hexachlorobenzene treatment.
Unusual occupational gastrointestinal and hepatic disorders.
Porphyria, Acute Intermittent
Melatonin reduces rat hepatic macromolecular damage due to oxidative stress caused by delta-aminolevulinic acid.
Porphyrias
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.
Changes in some intestinal enzyme activities in experimental hexachlorobenzene-induced porphyria and modifying effects of diet.
Chemically induced porphyria: increased microsomal heme turnover after treatment with allylisopropylacetamide.
Distinction between octachlorostyrene and hexachlorobenzene in their potentials to induce ethoxyphenoxazone deethylase and cause porphyria in rats and mice.
Genetic variation of iron-induced uroporphyria in mice.
Hepatic alteration of tryptophan metabolism in an acute porphyria model Its relation with gluconeogenic blockage.
Hepatic arachidonic acid metabolism is disrupted after hexachlorobenzene treatment.
Hexachlorobenzene as a persistent organic pollutant: Toxicity and molecular mechanism of action.
Hexachlorobenzene triggers apoptosis in rat thyroid follicular cells.
Hexachlorobenzene-induced porphyria in Japanese quail: changes in microsomal enzymes.
Melatonin reduces rat hepatic macromolecular damage due to oxidative stress caused by delta-aminolevulinic acid.
Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity.
Modulation by iron of hepatic microsomal and nuclear cytochrome P450, and cytosolic glutathione S-transferase and peroxidase in C57BL/10ScSn mice induced with polychlorinated biphenyls (Aroclor 1254).
Porphyrin biosynthesis. Enhancement of the fractional catabolic rate of microsomal haem in chemically induced porphyria.
Relationship of basic research in toxicology to environmental standard setting: the case of polybrominated biphenyls in Michigan.
The biological effects of polybrominated biphenyls in avian species.
The role of contaminants in hexachlorobenzene toxicity.
Unusual occupational gastrointestinal and hepatic disorders.
[Behaviour of the hepatic glutathione (GSH) in the rat in continuous administration of hexachlorobenzene (HCB) (author's transl)]
[Effect of thyroid hormones on the modulation of genetic expression of liver cytosolic malic enzyme, in rats poisoned with hexachlorobenzene]
[Induction of mixed microsomal oxidase in experimental hexachlorobenzene porphyria in rabbits]
[Porphyria symptoms and microsomal enzyme activity in rat liver following administration of hexachlorobenzene]
Postpartum Thyroiditis
Association between thyroid microsomal antibodies of subclass IgG-1 and hypothyroidism in autoimmune postpartum thyroiditis.
IgG subclass distribution and relative functional affinity of thyroid microsomal antibodies in postpartum thyroiditis.
Thyroid function and autoimmune manifestations in insulin-dependent diabetes mellitus during and after pregnancy.
[Post-partum autoimmune thyroiditis in a patient presenting with Sheehan's syndrome]
Pre-Eclampsia
A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia.
Association of Four Missense SNPs with Preeclampsia in Saudi Women.
Association of microsomal epoxide hydrolase gene polymorphism and pre-eclampsia in Turkish women.
Comparison of ex vivo inhibitory effect between 2-hydroxyestradiol and its 17-sulfate on rat hepatic microsomal lipid peroxidation.
Complement fixing antibody against solubilized placental microsomal fraction in pre-eclampsia sera.
Dimethyl acetals, an indirect marker of the endogenous antioxidant plasmalogen level, are reduced in blood lipids of Sudanese pre-eclamptic subjects whose background diet is high in carbohydrate.
eNOSI4 and EPHX1 polymorphisms affect maternal susceptibility to preeclampsia: analysis of five polymorphisms predisposing to cardiovascular disease in 279 Caucasian and 241 African women.
Oxidative stress-related genes (EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis.
PP057. ENOSI4 and EPHX1 polymorphisms affect maternal susceptibility topreeclampsia - Analysis of five polymorphisms predisposing tocardiovascular disease in 279 caucasian and 241 african women.
Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Altered expression of nuclear non-histone protein (p44/46) in different stages of B-chronic lymphocytic leukemia.
Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia.
Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children.
Primary Ovarian Insufficiency
Circulating auto-antibodies against the zona pellucida and thyroid microsomal antigen in women with premature ovarian failure.
prostaglandin-e synthase deficiency
The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.
Prostatic Hyperplasia
Acid phosphatase in the lysosomal and microsomal fractions of human prostatic epithelium.
Estradiol/androgen receptors during aging: microsomal distribution in human benign prostatic hypertrophy.
Low-affinity nerve growth factor receptors (p75LNGFR) in human prostate tissue: stromal localisation.
Prostatic cancer/benign prostatic hypertrophy. Subcellular distribution of estradiol/androgen receptors.
Reduced expression of the low affinity nerve growth factor receptor in benign and malignant human prostate tissue and loss of expression in four human metastatic prostate tumor cell lines.
Prostatic Neoplasms
Androgen-sensitive microsomal signaling networks coupled to the proliferation and differentiation of human prostate cancer cells.
Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.
Cytochrome P4501A1 and microsomal epoxide hydrolase gene polymorphisms: gene-environment interaction and risk of prostate cancer.
Inhibition of aromatase (P450Arom) by some 1-(benzofuran-2-ylmethyl)imidazoles.
Inhibition of CHOP accentuates the apoptotic effect of ?-mangostin from the mangosteen fruit (Garcinia mangostana) in 22Rv1 prostate cancer cells.
Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids.
Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer.
Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.
Microsomal epoxide hydrolase gene polymorphisms and susceptibility to prostate cancer: A systematic review.
Microsomal epoxide hydrolase polymorphisms, cigarette smoking and prostate cancer risk in the Slovak population.
Pharmacokinetics-pharmacodynamics and antitumor activity of mercaptoacetamide-based histone deacetylase inhibitors.
Polymorphisms in polycyclic aromatic hydrocarbon metabolism and conjugation genes, interactions with smoking and prostate cancer risk.
Prolactin binding components in prostatic cancer tissue specimens obtained by TURP.
Prostatic cancer/benign prostatic hypertrophy. Subcellular distribution of estradiol/androgen receptors.
Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research.
Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells.
Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.
Zinc and cadmium analysis in human prostate neoplasms.
Protein Deficiency
A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.
Effect of cross-fostering rats at birth on the normal supply of essential fatty acids during protein deficiency.
Effect of protein deficiency on the hepatic microsomal mixed function oxidase. III-Influence on aflatoxin B1 metabolism and epoxide hydrase activity.
Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system. 3.
Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system. I. Effect on substrate interaction with cytochrome P-450.
Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizng enzyme system. II. Effect of enzyme kinetics and electron transport system.
Effects of protein deficiency on uridine diphosphate glucuronyltransferase activity and phospholipid composition of rat liver microsomal fraction.
Influence of protein deficiency on the inhibition of hepatic microsomal detoxication by methyl mercury in two rat strains.
Myocardial effects and pharmacokinetics of digoxin and ouabain in protein-deficient guinea pigs.
Pharmacokinetics of theophylline in protein-calorie malnutrition.
Protein deficiency in pregnant rats causes decreased levels of plasma somatomedin and its carrier protein associated with reduced plasma levels of placental lactogen and hepatic lactogenic receptor number.
The combined effects of protein deficiency and chronic ethanol administration on rat ethanol metabolism.
The effect of protein deficiency and microsomal enzyme induction by DDT and phenobarbitone on the acute toxicity of chloroform and a pyrrolizidine alkaloid, retrorsine.
The phospholipid-dependence of uridine diphosphate glucuronyltransferase. Effect of protein deficiency on the phospholipid composition and enzyme activity of rat liver microsomal fraction.
Protein-Energy Malnutrition
Nutrition-related alterations in liver microsomal testosterone hydroxylases.
Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes.
Prevention of c-Jun/activator protein-1 activation and microsomal epoxide hydrolase induction in the rat liver by cysteine during protein-calorie malnutrition.
Proteinuria
Proteinuria in autoimmune thyroid disease.
Relationship between microtubules and Golgi apparatus in hepatocytes: a quantitative study during experimental nephrosis.
[A prospective study of antipyrine pharmacokinetics in pregnancy]
Psoriasis
Aryl hydrocarbon hydroxylase, epoxide hydrolase, and benzo[a]-pyrene metabolism in human epidermis: comparative studies in normal subjects and patients with psoriasis.
Cyclosporine A metabolism by cytochrome P-450III occurs in microsomes from rat liver but not from normal epidermis or psoriatic lesions.
Decreased epidermal aryl hydrocarbon hydroxylase and localized pustular psoriasis.
Effects of antipsoriatic therapies on hepatic microsomal enzyme activity in patients with psoriasis.
Generalised tissue abnormality of aryl hydrocarbon hydroxylase in psoriasis.
Prevalence of autoantibodies in patients of psoriasis.
Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population.
The effects of retinoids and terbinafine on the human hepatic microsomal metabolism of cyclosporin.
Pulmonary Adenomatosis, Ovine
Aetiology of jaagsiekte: transmission by means of subcellular fractions and evidence for the involvement of a retrovirus.
Pulmonary Disease, Chronic Obstructive
A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population.
Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study.
Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema.
Association between polymorphisms of microsomal epoxide hydrolase and COPD: results from meta-analyses.
Association of Functional Variants of Phase I and II Genes with Chronic Obstructive Pulmonary Disease in a Serbian Population.
Combined analysis of EPHX1, GSTP1, GSTM1 and GSTT1 gene polymorphisms in relation to chronic obstructive pulmonary disease risk and lung function impairment.
Correlation of EPHX1, GSTP1, GSTM1, and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic obstructive pulmonary disease.
Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung.
Detection of polymorphisms at exons 3 (Tyr113-->His) and 4 (His139-->Arg) of the microsomal epoxide hydrolase gene using fluorescence PCR method combined with melting curves analysis.
Effect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes.
EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis.
EPHX1 Y113H polymorphism is associated with increased risk of chronic obstructive pulmonary disease in Kazakhstan population.
Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining.
Exploring the interaction among EPHX1, GSTP1, SERPINE2, and TGFB1 contributing to the quantitative traits of chronic obstructive pulmonary disease in Chinese Han population.
Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease.
Genetic association analysis of COPD candidate genes with bronchodilator responsiveness.
Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1.
Genetic associations with hypoxemia and pulmonary arterial pressure in COPD.
Genetic determinants of emphysema distribution in the national emphysema treatment trial.
Genetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD.
Genetic polymorphisms in chronic obstructive pulmonary disease.
Genetic polymorphisms of GSTP1 and mEPHX correlate with oxidative stress markers and lung function in COPD.
Genetic susceptibility to chronic obstructive pulmonary disease in Koreans: combined analysis of polymorphic genotypes for microsomal epoxide hydrolase and glutathione S-transferase M1 and T1.
Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD.
Genetic variations in detoxification enzymes and HIF-1? in Japanese patients with COPD.
Genetics of COPD.
Glutathione S-transferase and microsomal epoxide hydrolase gene polymorphisms and risk of chronic obstructive pulmonary disease in Slovak population.
IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.
Lack of association between glutathione S-transferase P1 polymorphism and COPD in Koreans.
Microsomal epoxide hydrolase gene polymorphisms and risk of chronic obstructive pulmonary disease: A comprehensive meta-analysis.
Microsomal Epoxide Hydrolase Gene Polymorphisms and Susceptibility to Chronic Obstructive Pulmonary Disease in Tunisian Population.
Microsomal epoxide hydrolase genotypes and chronic obstructive pulmonary disease in Japanese.
Microsomal epoxide hydrolase is not associated with COPD in a community-based sample.
Oxidative Stress and Genetic Variants of Xenobiotic-Metabolising Enzymes Associated with COPD Development and Severity in Serbian Adults.
Polymorphic variation in surfactant protein B is associated with COPD exacerbations.
Polymorphism of microsomal epoxide hydrolase is associated with chronic obstructive pulmonary disease and bronchodilator response.
Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD.
Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility.
Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population.
Relationship between polymorphisms of genes encoding microsomal epoxide hydrolase and glutathione S-transferase P1 and chronic obstructive pulmonary disease.
Special issue on carbon monoxide and exhaled biomarkers in human disease.
Susceptibility genes for rapid decline of lung function in the lung health study.
Update in chronic obstructive pulmonary disease: role of antioxidant and metabolizing gene polymorphisms.
[Association between polymorphisms in the microsomal epoxide hydrolase (mEH) gene and chronic obstructive pulmonary disease]
[Genetic features during chronic obstructive pulmonary disease]
[Genetic risk factors for chronic obstructive pulmonary disease (COPD)]
[Genetics risk factors in chronic obstructive pulmonary disease]
[Microsomal epoxide hydrolase gene polymorphism and susceptibility to chronic obstructive pulmonary disease in Han nationality of North China]
[Role of genetic factors in the development of COPD]
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
[Study on the relationship between EPHX1 gene polymorphism and antioxidant capacity in patients with chronic obstructive pulmonary disease].
Pulmonary Fibrosis
Effect of bleomycin-induced fibrosis on pulmonary metabolism of selected xenobiotics.
Purpura, Thrombocytopenic, Idiopathic
Human spleen heme oxygenase and microsomal electron transport system component activity in normals and in patients with hemolytic anemia, idiopathic thrombocytopenic purpura, and lymphoproliferative disorders.
Pyelonephritis
[Disorders of the processes of protein biosynthesis and a decrease in the content of cytochromes P-450 and b5 in the microsomal fraction of rat kidney in the dynamics of development of acute pyelonephritis]
[Lipid peroxidation and Ca-dependent ATPase activity in the microsomal fraction of renal tissue in patients with nephrolithiasis and chronic pyelonephritis]
Renal Insufficiency
Clinical pharmacokinetics of prednisone and prednisolone.
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation.
Effects of methylguanidine on sodium and organic ion transport.
Hepatic microsomal oxidative N-demethylation in rats with renal failure [proceedings]
Involvement of endogenous prostaglandin E2 in tubular epithelial regeneration through inhibition of apoptosis and epithelial-mesenchymal transition in cisplatin-induced rat renal lesions.
Renal disease and drug metabolism: an overview.
Salivary antipyrine kinetics in hepatic and renal disease and in patients on anticonvulsant therapy.
Reperfusion Injury
Cytochrome P450 and myocardial ischemia: potential pharmacological implication for cardioprotection.
Effects of normothermic hepatic ischemia-reperfusion injury on the in vivo, isolated perfused liver, and microsomal disposition of chlorzoxazone, a cytochrome P450 2E1 probe, in rats.
Hydrogen sulfide modulates sub-cellular susceptibility to oxidative stress induced by myocardial ischemic reperfusion injury.
Respiratory Insufficiency
Cimetidine inhibits the in vitro N-demethylation of methadone.
Respiratory Tract Diseases
[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]
Reye Syndrome
Effect of acetylsalicylic acid on fatty acid omega-hydroxylation in rat liver.
Reye's syndrome: preservation of mitochondrial enzymes in brain and muscle compared with liver.
Rhabdomyolysis
Rhabdomyolysis in a patient taking simvastatin after addition of cyclosporine therapy.
Rheumatic Diseases
Immunoblotting as a confirmatory test for antimitochondrial antibodies in primary biliary cirrhosis.
Riboflavin Deficiency
Effect of riboflavin deficiency on liver microsomal enzyme system and lipid peroxidation in male rats.
Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat.
Lipid metabolism in riboflavin-deficient rats. 2. Mitochondrial fatty acid oxidation and the microsomal desaturation pathway.
Possible role of riboflavin deficiency in epithelial neoplasia. 3. Induction of microsomal aryl hydrocarbon hydroxylase.
Riboflavin.
[Effect of thiamine and riboflavin derivatives on the activity of xenobiotic-metabolizing enzyme and on the pharmacologic effect of analgesics]
Rickets
Mutation of the CYP2R1 Vitamin D 25-Hydroxylase in a Saudi Arabian Family with Severe Vitamin D Deficiency.
Rubella
Autoimmunity in congenital rubella syndrome.
Sarcoma
Biosynthesis of plasmalogens by the microsomal fraction of fischer R-3259 sarcoma. Influence of specific 2-acyl chains on the desaturation of 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine.
Ruthenium red-insensitive calcium transport in ascites-sarcoma 180/TG cells.
Two step purification of human and murine leukotriene C4 synthase.
[Differing microsomal monoxygenase activity in the cells of ascitic and solid forms of transplantable tumors]
Sarcoma 180
Effects of the antitumor agents from various natural sources on drug-metabolizing system, phagocytic activity and complement system in sarcoma 180-bearing mice.
The influence of Propionibacterium acnes (Corynebacterium parvum) fractions on immune response in vivo.
Sarcoma, Avian
NUCLEOTIDE SEQUENCE INVESTIGATIONS IN MICROSOMAL RIBONUCLEIC ACIDS OF NORMAL AND ROUS SARCOMA VIRUS-INFECTED TISSUES.
[Virus-specific double-stranded RNA in the composition of the microsomal RNA of Rous sarcoma cells]
Schistosomiasis
Activity of liver microsomal enzymes during the chronic phase of murine schistosomiasis.
Alterations of hepatic microsomal enzymes in the early phase of murine schistosomiasis.
Effect of murine schistosomiasis on hepatic cytochrome P-450 and microsomal protein.
Ethanol challenge in non-alcoholic patients with schistosomiasis.
Hepatic cytochrome P-450 system in experimental hepatosplenic schistosomiasis. Presence of an artifact in spectrophotometric analysis.
The pharmacokinetics of antipyrine in patients with graded severity of schistosomiasis.
Schistosomiasis mansoni
Different levels of Schistosoma mansoni infection increased the mutagenicity of benzo(a)pyrene, the activity of aryl hydrocarbon hydroxylase and the formation of hepatic microsomal hydrogen peroxide.
Hepatic cytochrome P-450 system in experimental hepatosplenic schistosomiasis. Presence of an artifact in spectrophotometric analysis.
Scleroderma, Diffuse
Autoantibody to gp50, a glycoprotein shared in common between fibroblasts and lymphocytes, in progressive systemic sclerosis.
Scrapie
Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems.
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res.
Prion removal by nanofiltration under different experimental conditions.
Prion-removal capacity of chromatographic and ethanol precipitation steps used in the production of albumin and immunoglobulins.
Scrapie prion liposomes and rods exhibit target sizes of 55,000 Da.
TSE clearance during plasma products separation process by Gradiflow(TM).
Scurvy
The absence of an inhibitory effect of metyrapone (2-methyl-1,2-di (3-pyridyl) propan-1-one) on hepatic microsomal hydroxylation in scurvy.
Seizures
Anticonvulsant activity of enzyme inhibitors in rats.
Antiepileptic drugs and hormonal contraceptives in adolescent women with epilepsy.
Correlation between effects of acute acetazolamide administration to mice on electroshock seizure threshold and maximal electroshock seizure pattern, and on carbonic anhydrase activity in subcellular fractions of brain.
Different EPHX1 methylation levels in promoter area between carbamazepine-resistant epilepsy group and carbamazepine-sensitive epilepsy group in Chinese population.
Effects of SKF525A, phenobarbital, fasting, and carnitine on the anticonvulsant activity and neurotoxicity of valproate in mice.
Evidence for increased activity of mouse brain fatty acid cyclooxygenase following drug-induced convulsions.
Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.
Picrotoxin-induced convulsions alters rat brain microsomal membrane structural properties.
Selenium and topiramate modulates brain microsomal oxidative stress values, Ca2+-ATPase activity, and EEG records in pentylentetrazol-induced seizures in rats.
Synthesis of arachidonoyl coenzyme A and docosahexaenoyl coenzyme A in synaptic plasma membranes of cerebrum and microsomes of cerebrum, cerebellum, and brain stem of rat brain.
Topiramate and vitamin e modulate the electroencephalographic records, brain microsomal and blood antioxidant redox system in pentylentetrazol-induced seizure of rats.
[Evaluation of monitoring the efficacy of phenobarbital as an anticonvulsant agents using the fluorescence-polarization immunoassay]
[Liver extract effect on liver microsomal system and on an experimental model of intoxication]
[Na, K-ATP-ase and acetylcholinesterase activity of the membrane structures of the rat brain and spinal cord during the seizure process]
[Role of calcium ions in the evolution of the anticonvulsant effect of taurine]
Seminoma
Glutathione S-transferase expression in the human testis and testicular germ cell neoplasia.
Sepsis
An increase in exhaled CO concentration in systemic inflammation/sepsis.
Calcium content in liver and heart and its intracellular distribution in liver during endotoxicosis and sepsis in rats.
Changes in inositol 1,4,5-triphosphate binding in microsomal fractions from the rat liver during sepsis.
Changes of adenosine triphosphate-dependent calcium uptake in microsomal fractions of rat liver during sepsis.
Effect of endotoxicosis and sepsis on intracellular calcium homeostasis in rat liver. Mitochondrial and microsomal calcium uptake.
In vivo regulation of acyl-CoA synthetase mRNA and activity by endotoxin and cytokines.
Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia.
Nitric oxide mediates hepatic cytochrome P450 dysfunction induced by endotoxin.
Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats.
The effect of sepsis during parenteral nutrition on hepatic microsomal function in rats.
Urinary excretion of 3-methylhistidine: an assessment of muscle protein catabolism in adult normal subjects and during malnutrition, sepsis, and skeletal trauma.
Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis.
Severe Combined Immunodeficiency
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
Sialadenitis
[The sources of active forms of oxygen in the normal oral tissues and in pathology]
Silicosis
Alterations in the pulmonary microsomal cytochrome P-450 system after exposure of rats to silica.
Pulmonary microsomal metabolism of benzo[a]pyrene following exposure of rats to silica.
[Biochemical investigations of the silicosis problem; enzyme inhibition by silicic acid in the case of microsomal glucose-6-phosphatase.]
Sjogren's Syndrome
Rheumatic Manifestations in Autoimmune Liver Disease.
Sjogren-Larsson Syndrome
Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.
Clinical, biochemical and molecular genetic characteristics of 19 patients with the Sjögren-Larsson syndrome.
Defective metabolism of leukotriene B4 in the Sjögren-Larsson syndrome.
Enzymatic diagnosis of Sjögren-Larsson syndrome using electrospray ionization mass spectrometry.
Microsomal fatty aldehyde dehydrogenase catalyzes the oxidation of aliphatic aldehyde derived from ether glycerolipid catabolism: implications for Sjögren-Larsson syndrome.
Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal.
MRI and 1H-MRS findings of three patients with Sjögren-Larsson syndrome.
Novel and recurrent ALDH3A2 mutations in Italian patients with Sjögren-Larsson syndrome.
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome.
[Sjögren-Larsson syndrome: a novel mutation in a Moroccan child]
Skin Diseases
Review: genetics of steroid sulphatase deficiency and X-linked ichthyosis.
[Effect of microsomal monooxygenase inductor zixoryn on clinico-immunologic indicators in allergologic patients]
[Role of polymorphous genes of xenobiotic biotransformation system in pathogenesis of occupational allergic dermatoses].
Skin Neoplasms
Association of Environmental Arsenic Exposure, Genetic Polymorphisms of Susceptible Genes, and Skin Cancers in Taiwan.
Small Cell Lung Carcinoma
Combined analysis of polymorphisms in glutathione S-transferase M1 and microsomal epoxide hydrolase in lung cancer patients.
[Assessment of the functional state of microsomal enzymes in the liver in patients with small cell lung cancer treated with cytostatic drugs]
[The interaction between microsomal epoxide hydrolase polymorphisms and indoor pollution in non small cell lung cancer]
Spinal Cord Injuries
Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation.
Neuroprotective Effects of Hypothermia Following Spinal Cord Injury in Rats: Comparative Study Between Epidural Hypothermia and Systemic Hypothermia.
Spondylitis, Ankylosing
Antithyroid-antibody activity in the snyovial fluid of patients with various arthritides.
Leukocyte migration test in Crohn's disease, ulcerative colitis, and ankylosing spondylitis using Crohn's colon homogenate, mitochondrial, and microsomal fractions.
Squamous Cell Carcinoma of Head and Neck
Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.
Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma.
Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.
Starvation
A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment.
Abnormal expression of glucose-6-phosphatase in preterm infants.
Accumulation of phenols and catechols in isolated mouse hepatocytes in starvation or after pretreatment with acetone.
Acute renal failure due to acetaminophen ingestion: a case report and review of the literature.
Adipose-tissue Mg2+-dependent phosphatidate phosphohydrolase. Control of activity and subcellular distribution in vitro and in vivo.
Characteristics of peroxisome proliferation: co-induction of peroxisomal fatty acid oxidation-related enzymes with microsomal laurate hydroxylase.
Characterization of fatty acid desaturase activity in rat lung microsomes.
Cytochrome P-450 and free radical generation in rat liver microsomes under the influence of prostaglandin E1.
Dietary control of the chain elongation of palmityl-CoA in rat liver microsomes.
Effect of dehydration, starvation and sodium deprivation on microsomal ATPase in the kidney.
Effect of diabetes, starvation, ethanol and isoniazid on rat liver microsomal 12 alpha-hydroxylase activity involved in bile acid biosynthesis.
Effect of ethanol on the microsomal glutathione S-transferase activity in glutathione-depleted rat liver.
Effect of prostaglandin F2 alpha on free radical generation, glutathione content and microsomal oxidase activities in rat liver microsomes induced either by ethanol or acetone.
Effect of short term starvation on disposition kinetics of chloramphenicol in goats.
Effects of starvation on liver microsomal P450 activity in juvenile Pleuronectes americanus.
Effects of starvation on microsomal cytochrome P-450 and laurate-omega-hydroxylation of rat kidney and liver.
Impaired calcium sequestration activity in liver microsomes from fasted rats.
Influence of starvation and hepatic microsomal enzyme induction on the mobilization of DDT residues in rats.
Influence of starvation and total protein deprivation on cardiac mRNA levels.
Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine palmitoyltransferase-I.
Microsomal proteins and hemoproteins: enhancement of phenobarbital induction by prevention of breakdown due to starvation.
Modulation of rat liver peroxisomal and microsomal fatty acid oxidation by starvation.
Purification and characterization of 7 alpha-hydroxy-4-cholesten-3-one 12 alpha-hydroxylase.
Starvation effect on rat kidney peroxisomal and microsomal fatty acid oxidation. A comparative study between liver and kidney.
The activities of lipoprotein lipase and of enzymes involved in triacylglycerol synthesis in rat adipose tissue. Effects of starvation, dietary modification and of corticotropin injection.
The effect of starvation on the kinetics of drug oxidation by hepatic microsomal enzymes from male and female rats.
The effect of thioacetamide on rat liver plasma membrane enzymes and its potentiation by fasting.
The regulation by gender, strain, dose, and feeding status of the induction of multiple forms of cytochrome P450 isozymes in rat hepatic microsomes by 2,4,5,2',4',5'-hexachlorobiphenyl.
Xenobiotic biotransformation in the rainbow trout liver and kidney during starvation.
[Activities of 3-hydroxyl-3-methylglutaryl-CoA reductase and acetyl-CoA carboxylase and the rate of mevalonic acid, squalene, sterol and fatty acid biosynthesis from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in rat liver: effects of Triton WR 1339, starvation and cholesterol diet]
[The effect of starvation on mast cell functional activity and on the content of microsomal cytochromes in the liver]
Status Epilepticus
Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier.
Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake.
Steatorrhea
Persistence of the intestinal defect in abetalipoproteinaemia after liver transplantation.
steroid 17alpha-monooxygenase deficiency
Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility.
Successful Delivery in 17,20-Lyase Deficiency.
The genetic and functional basis of isolated 17,20-lyase deficiency.
steroid 21-monooxygenase deficiency
The common P450 oxidoreductase variant A503V is not a modifier gene for 21-hydroxylase deficiency.
steryl-sulfatase deficiency
Hydrolysis of deoxycorticosterone-21-yl sulphate and dehydroepiandrosterone sulphate by microsomal preparations of human placentae: evidence for a common enzyme.
Review: genetics of steroid sulphatase deficiency and X-linked ichthyosis.
Stevens-Johnson Syndrome
Association of ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA, and BAG6 polymorphisms with the risk of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Chinese Han patients with epilepsy.
Stomach Neoplasms
Association of microsomal epoxide hydrolase exon 3 Tyr113His and exon 4 His139Arg polymorphisms with gastric cancer in India.
Blood group activities in water-soluble glycoproteins and in microsomal fractions of gastric mucosa in peptic ulcer and gastric cancer patients.
Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean.
Differential protein phosphorylation in human gastric adenocarcinomas.
Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesis.
Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines.
Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis.
Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition.
Stomach Ulcer
Differential protein phosphorylation in human gastric adenocarcinomas.
Drug therapy in the neonatal foal.
Effect of melatonin on secreted and induced matrix metalloproteinase-9 and -2 activity during prevention of indomethacin-induced gastric ulcer.
Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers.
[A method for stimulating the protective mechanisms of the gastric mucosa in peptic ulcer]
Stomatitis, Aphthous
Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive and -negative recurrent aphthous stomatitis patients with anti-thyroid antibody positivity.
Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis.
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus.
Serum thyroid autoantibodies are not associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in patients with Behcet's disease.
Stroke
Variables in human liver microsome preparation: impact on the kinetics of l-alpha-acetylmethadol (LAAM) n-demethylation and dextromethorphan O-demethylation.
Stupor
Effects of a new fluorinated macrolide (P-0501A) and other erythromycins on drug metabolizing enzymes in rat liver.
Hormonal environment and age influencing the activity of flumecinol, a synthetic enzyme inducer.
Pharmacological responses to pentobarbital in different strains of mice.
Structure-activity relations for methylenedioxyphenyl and related compounds on hepatic microsomal enzyme function, as measured by prolongation of hexobarbital narcosis and zoxazolamine paralysis in mice.
[Comparative studies of enzyme-inducing ability of phenobarbital, methylphenobarbital, glutethimide and their N-substituted morphoalkylic derivatives]
Superinfection
Isolation and characterization of an EBV superinfection-enhanced, host-cell-coded, 53,000-dalton protein.
Tachycardia
Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle.
Testicular Neoplasms
Microsomal aromatase in testicular tumour tissue: increased activity in choriocarcinoma compared to embryonal carcinoma.
Tetanus
Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus.
Vaccine-induced alterations in hepatic drug metabolism.
Thiamine Deficiency
Hepatic drug metabolism and lipid peroxidation in thiamine deficient rats.
[Transketolase activity and the TDP effect in tissues of animals with experimental tumors]
Thyroid Diseases
A high prevalence of human T-lymphotropic virus type I carriers in patients with antithyroid antibodies.
A simple semiquantitative radiometric measurement of antithyroglobulin antibodies in human serum. Comparison with hemagglutination method.
Absence of cross-reactivity to myeloperoxidase of anti-thyroid microsomal antibodies in patients with autoimmune thyroid diseases.
Anti-thyroid microsomal antibody in synovial fluid as a revealing feature of seronegative autoimmune thyroiditis.
Anti-thyroid peroxidase antibody in patients with autoimmune thyroid disease: possible identity with anti-microsomal antibody.
Antibodies against denatured and reduced thyroid microsomal antigen in autoimmune thyroid disease.
Antibodies to membrane antigens in autoimmune thyroid disease.
Autoimmune thyroid phenomena are not evidence for human lymphocyte antigen-genetic heterogeneity in insulin-dependent diabetes.
Binding of thyroid microsomes by lymphocytes from patients with thyroid disease and normal subjects.
CD4 cells from patients with autoimmune thyroid disease secrete interferon gamma after stimulation by thyroid microsomal antigen; CD8 cells suppress this secretion.
Chronic angio-oedema of the tongue associated with pernicious anaemia and Hashimoto's thyroiditis.
Clinical evaluation of a hemagglutination method for microsomal and thyroglobulin antibodies in autoimmune thyroid disease.
Comparison of measurements of in vitro production of antithyroid microsomal antibody versus antithyroid peroxidase antibody.
Comparison of serum thyroid microsomal and thyroid peroxidase autoantibodies in thyroid diseases.
Detection of autoantibodies to thyroid peroxidase in autoimmune thyroid diseases by micro-ELISA and immunoblotting.
Detection of microsomal and thyroglobulin antibodies in autoimmune thyroid diseases: evaluation of two methods.
Development of thyroid autoimmunity after administration of recombinant human interferon-alpha 2b for chronic viral hepatitis.
Differential autoantibody responses to thyroid peroxidase in patients with Graves' disease and Hashimoto's thyroiditis.
Discordant changes in serum anti-TSH receptor antibody and antithyroid microsomal antibody during pregnancy in autoimmune thyroid diseases.
Effect of antithyroid autoantibodies on pancreatic islet-cell function.
Effect of HLA-DR positive thyrocytes on in vitro thyroid autoantibody production.
Effects of deglycosylation of human thyroperoxidase on its enzymatic activity and immunoreactivity.
Enzymatic deglycosylation of porcine thyroid peroxidase: effects on catalytic activity and immunoreactivity.
Identification of a thyroid microsomal antigen by Western blot and immunoprecipitation.
Improved ELISA for thyroid microsomal auto-antibodies. Comparison with haemagglutination and immunofluorescent techniques.
Incidence, predictability, and pathogenesis of amiodarone-induced thyrotoxicosis and hypothyroidism.
Induction of thyroid autoantibody production: synergistic effect of B cell mitogen combined with T cell mitogen.
Interaction of highly purified thyroid peroxidase with anti-microsomal antibodies in autoimmune thyroid diseases.
Iodine in autoimmune thyroiditis.
Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase.
Mapping of a linear autoantigenic epitope within the human thyroid peroxidase using recombinant DNA techniques.
Measles antibodies and autoantibodies in autoimmune disorders.
Measurement of circulating thyroid microsomal antibodies by the tanned red cell haemagglutination technique: its usefulness in the diagnosis of autoimmune thyroid diseases.
Patients with endocrine ophthalmopathy not associated with overt thyroid disease have multiple thyroid immunological abnormalities.
Performance of two agglutination techniques in the detection of thyroid antibodies and assessment of their clinical significance.
Peripheral blood T lymphocyte sensitization to thyroid microsomal antigen from patients with Graves' disease negative for circulating anti-thyroid microsomal antibodies.
Post-partum thyroiditis can be painful.
Postpartum thyroid dysfunction in Mid Glamorgan.
Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus.
Prevalence of antithyroid microsomal antibody in thyroid patients of endemic goitre area.
Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases.
Reduced activation of suppressor T lymphocytes by specific antigens in autoimmune thyroid disease.
Serum antibodies reactive with eye muscle membrane antigens are detected in patients with nonspecific orbital inflammation.
Structural and functional aspects of thyroid peroxidase.
Studies of the effect of suppressor T lymphocytes on the induction of antithyroid microsomal antibody-secreting cells in autoimmune thyroid disease.
Studies with purified human thyroid peroxidase and thyroid microsomal autoantibodies.
Surface markers and function of circulating thyroid autoantibody-producing cells.
T cell regulation of thyroglobulin autoantibody IgG subclasses in Hashimoto's thyroiditis.
Thyroid autoantibodies in black and in white children and adolescents with type 1 diabetes mellitus and their first degree relatives.
Thyroid microsomal antigen in Graves' thyroid is not different from that in normal thyroid.
Thyroid microsomal/thyroid peroxidase autoantibodies show discrete patterns of cross-reactivity to myeloperoxidase, lactoperoxidase and horseradish peroxidase.
Thyroid peroxidase and the induction of autoimmune thyroid disease.
Thyroid peroxidase and thyroid microsomal autoantibodies.
Thyroid-stimulating immunoglobulins in insulin-dependent diabetes mellitus.
TSH receptor antibody-associated thyroid dysfunction following subacute thyroiditis.
Use of recombinant epitopes to study the heterogeneous nature of the autoantibodies against thyroid peroxidase in autoimmune thyroid disease.
[An immunoenzyme method for determining autoantibodies to the microsomal antigens of human thyrocytes]
[Antigenic relation between thyroid peroxidase and the microsomal antigen implicated in auto-immune diseases of the thyroid]
[Detection of anti-thyroid plasma membrane antibody in patients with various thyroid diseases by solid phase enzyme-immunoassay]
[Diagnostic value of thyroid antibodies]
[Level of neopterin in blood serum in selected thyroid diseases]
[Systemic urticaria associated with autoimmune thyroiditis]
[The significance of microsomal antibodies, thyroglobulin antibodies, thyrotropin receptor antibodies in the diagnosis of thyroid diseases]
[Thyroid antibodies in autoimmune diseases of the thyroid and their dependence on the presence of autoantigens]
[Thyroid microsomal autoantibodies in thyroid disease: their value as an antigenic marker]
[Value of the detection of antithyroid antibodies in thyroid pathology]
Thyroid Neoplasms
Characterization of the thyroid microsomal antigen, and its relationship to thyroid peroxidase, using monoclonal antibodies.
Common precursor molecule as origin for the ectopic-hormone-producing-tumour syndrome.
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.
Identification of procalcitonin in a rat medullary thyroid carcinoma cell line.
Measurement and clinical significance of thyroid microsomal and thyroglobulin antibodies by enzyme-linked immunosorbent assay.
MICROSOMAL AND THYROGLOBULIN ANTIBODIES IN THYROID DISORDERS.
Microsomal reductase activity in patients with thyroid neoplasms.
Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB).
Rat pre-prosomatostatin. Structure and processing by microsomal membranes.
Serum albumin and antibodies in the diagnosis of thyroid cancer.
Serum autoantibodies and thyroid lymphocytic infiltration in endemic goitre.
Thyroid autoantibodies in thyroid cancer: incidence and relationship with tumour outcome.
Thyroid disease is associated with an increased risk of breast cancer: a systematic review and meta-analysis.
Thyroid Nodule
Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids.
Immunological features of nonimmunogenic hyperthyroidism.
Thyroiditis
A case of acetohexamide-induced hypoglycemia: the influence of hypothyroidism on the metabolism of acetohexamide.
A simple semiquantitative radiometric measurement of antithyroglobulin antibodies in human serum. Comparison with hemagglutination method.
Age-related changes of thyroid function and immunologic abnormalities in patients with hyperthyroidism due to Graves' disease.
Anterior pituitary cell antibodies detected in Hashimoto's thyroiditis and Graves' disease.
Antibodies to human thyroid peroxidase in autoimmune thyroid disease: studies with a cloned recombinant complementary deoxyribonucleic acid epitope.
Antithyroid microsomal autoantibodies and HLA-DR5 are associated with postpartum thyroid dysfunction: evidence supporting an autoimmune pathogenesis.
Carbimazole and autoantibody synthesis in Hashimoto's thyroiditis.
Clinical evaluation of a hemagglutination method for microsomal and thyroglobulin antibodies in autoimmune thyroid disease.
Comparison of autoantibodies level in thyroid autoimmune diseases estimated by different methods.
Detection of autoantibodies to thyroid peroxidase in autoimmune thyroid diseases by micro-ELISA and immunoblotting.
Expression of the microsomal antigen on the surface of continuously cultured rat thyroid cells is modulated by thyrotropin.
Frequency of Hashimoto's thyroiditis in children with type 1 diabetes mellitus.
Graves' disease and Hashimoto's thyroiditis: effects of high doses of antithyroid drugs on thyroid autoantibody levels.
Hashimoto's thyroiditis and papillary carcinoma in an adolescent girl: A case report.
Helicobacter pylori infection is markedly increased in patients with autoimmune atrophic thyroiditis.
High prevalence of thyroid autoantibodies in a prospective series of patients with chronic hepatitis C before interferon therapy.
Hypothyroidism and goiter in a patient during treatment with interleukin-2.
Imatinib-induced thyroiditis in Philadelphia chromosome-positive chronic myeloid leukemia.
Intrathyroidal T cell clones from patients with autoimmune thyroid disease.
L-thyroxine therapy induces a fall of thyroid microsomal and thyroglobulin antibodies in idiopathic myxedema and in hypothyroid, but not in euthyroid Hashimoto's thyroiditis.
Lack of association between Hashimoto's thyroiditis and SD-locus HLA antigens.
Localized primary amyloid tumor of the thyroid developing in the course of Hashimoto's thyroiditis.
Measurement and clinical significance of thyroid microsomal and thyroglobulin antibodies by enzyme-linked immunosorbent assay.
Mixed connective tissue disease associated with idiopathic portal hypertension and chronic thyroiditis.
Myasthenia gravis, pernicious anemia, and Hashimoto's thyroiditis.
Performance of two agglutination techniques in the detection of thyroid antibodies and assessment of their clinical significance.
Possible induction of Graves' disease and painless thyroiditis by gonadotropin-releasing hormone analogues.
Prediction of thyroid hormone supplementation after thyroid lobectomy.
Rifampin-Induced Hypothyroidism without Underlying Thyroid Disease.
Serum thyroglobulin concentration as an indicator for assessing thyroid stimulation in patients with Graves' disease during antithyroid drug therapy.
The association between thyroid echogenicity and thyroid function in pediatric and adolescent Hashimoto's thyroiditis.
The IgG subclass distribution of thyroid autoantibodies.
Thyroid antibodies in thyroid diseases.
Thyroid autoantigens and their relevance in the pathogenesis of thyroid autoimmunity.
Thyroid peroxidase and the induction of autoimmune thyroid disease.
Thyrotropin receptor antibodies in hypothyroid Graves' disease.
Thyroxine, methimazole, and thyroid microsomal autoantibody titres in hypothyroid Hashimoto's thyroiditis.
Virus-induced thyroiditis.
[A case of Hashimoto's encephalopathy with a relapsing course related to menstrual cycle]
[A long-term follow-up study of patients with chronic lymphocytic thyroiditis--with special reference to histological findings]
[Autoimmune thyroid pathology. Study and follow-up of pediatric case reports]
[Chronic lymphocytic autoimmune thyroiditis: a commonly occurring thyroid disease]
[Effect of moxibustion on the antibody-dependent cell-mediated cytotoxicity activity in peripheral blood of patients with Hashimoto's thyroiditis]
[Extrahepatic manifestations of hepatitis C virus infection]
[Leucocyte migration inhibition test in diabetes mellitus (author's transl)]
[Seronegative hashitoxicosis in patient with rheumatoid arthritis]
[Subclinical hypothyroidism: a diagnostic and therapeutic approach in primary care]
[The clinical serological tests in chronic thyroiditis: the importance of measurement of anti-thyroid microsomal antibodies (author's transl)]
Thyroiditis, Autoimmune
Anti-thyroid microsomal antibody in synovial fluid as a revealing feature of seronegative autoimmune thyroiditis.
Asymptomatic autoimmune thyroiditis and thyroid dysfunction in Alport's syndrome. A report of three families.
Changes of serum anti-thyroid antibodies during and after pregnancy in autoimmune thyroid diseases.
Different aetiologies in post-partum thyroiditis?
Free thyroxin index and direct measurements of free thyroxin compared for evaluating postpartum autoimmune thyroid dysfunction.
Hemoglobin, iron, and vitamin B12 deficiencies and high blood homocysteine levels in patients with anti-thyroid autoantibodies.
HLA-A, B and DR antigens in patients with gonadal dysgenesis.
Improving iodine nutritional status and increasing prevalence of autoimmune thyroiditis in children.
Isolation of thyroid peroxidase and lack of autoantibodies to the enzyme in dogs with autoimmune thyroid disease.
Multiple pulmonary hyalinizing granulomas associated with systemic idiopathic fibrosis.
Postpartum activation of autoimmunity: transient increase of total IgG levels in normal women and in women with autoimmune thyroiditis.
Restricted heterogeneity and T cell dependence of human thyroid autoantibody immunoglobulin G subclasses.
The effect of thyroxine on spontaneous thyroiditis in BB/W rats.
Thyroid autoimmunity in children and adolescents with Type 1 diabetes mellitus.
Thyroid diseases in a school population with thyromegaly.
Thyroid peroxidase antibodies in children with autoimmune thyroiditis.
[Antibodies to the thyroid microsomal antigen in children and adolescents subjected to radiation exposure as a result of the accident at the Chernobyl Atomic Electric Power Station]
[Thyroid gland antibodies. Methods and clinical significance]
Thyroiditis, Subacute
Measurement and clinical significance of thyroid microsomal and thyroglobulin antibodies by enzyme-linked immunosorbent assay.
[Diagnostic value of thyroid antibodies]
Thyrotoxicosis
Aggravation of thyrotoxicosis in early pregnancy and after delivery in Graves' disease.
Five patients with painless thyroiditis simultaneously developed in a nursery school.
Presence of the organ-specific 'microsomal' autoantigen on the surface of human thyroid cells in culture: its involvement in complement-mediated cytotoxicity.
[Postgravid health care and laboratory tests]
Toxocariasis
[Investigation of the presence of autoantibodies in patients with toxocariasis]
Tremor
The pharmacology of N-carbamoyl-2-(2,6-dichlorophenyl)acetamidine hydrochloride (LON-954) a new tremorogenic agent.
[Postgravid health care and laboratory tests]
Trigeminal Neuralgia
Ellagic acid enhances the antinociceptive action of carbamazepine in the acetic acid writhing test with mice.
Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test.
Triple Negative Breast Neoplasms
Piperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast Cancer.
Trypanosomiasis
Hepatic microsomal alterations during chronic trypanosomiasis in the field vole, Microtus montanus.
Tuberculosis
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.
Bifunctional T-cell-derived cytokines for the diagnosis of tuberculosis and treatment monitoring.
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
Design, synthesis and biological evaluation of indole-2-carboxamides, a promising class of anti-tuberculosis agents.
Drug metabolism in experimental tuberculosis: I. Changes in hepatic and pulmonary monooxygenase activities due to infection.
Effect of cord factor, a toxic glycolipid from Mycobacterium tuberculosis, on mouse liver drug metabolizing enzymes.
Oxidative stress in the molecular mechanism of pathogenesis at different diseased states of organism in clinics and experiment.
Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.
The effect of adjuvant-induced arthritis on rat liver microsomal phospholipid metabolism.
TISSUE METABOLISM IN INFECTION. LIVER MICROSOMAL ENZYMES OF MICE AND GUINEA PIGS IN EXPERIMENTAL TUBERCULOSIS.
[Effect of antitubercular preparations on the isoform composition of cytochrome P-450 of rat liver microsomes]
Turner Syndrome
Hashimoto's disease in Turner's syndrome.
Typhoid Fever
[Effect of inducers and inhibitors of mixed function oxidases on body resistance to endotoxins of gram-negative bacteria]
unspecific monooxygenase deficiency
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
Uremia
Effect of uremia on rates of ethanol disappearance from the blood and on the activities of the ethanol-oxidizing enzymes.
Enzyme induction in the uremic liver.
Expression of hepatic microsomal cytochrome P450s as altered by uremia.
The effects of acute and chronic uremia in rats on their hepatic microsomal enzyme activity.
Urinary Bladder Neoplasms
Co2+ is able to substitute for Mn2+ in some exogenous and endogenous galactosyltransferase reactions.
Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk.
Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India.
Global Identification and Differential Distribution Analysis of Glycans in Subcellular Fractions of Bladder Cells.
Urticaria
Association between chronic urticaria and thyroid autoimmunity.
Correlation of serum antithyroid microsomal antibody and autologous serum skin test in patients with chronic idiopathic urticaria.
Steroid-resistant chronic urticaria associated with anti-thyroid microsomal antibodies in a nine-year-old boy.
Vaccinia
Inhibitory and noninhibitory monoclonal antibodies to human cytochrome P450 2E1.
Vascular Diseases
Gene activation, apolipoprotein A-I/high density lipoprotein, atherosclerosis prevention and longevity.
Plasma high-density lipoproteins and hepatic microsomal enzyme induction. Relation to histological changes in the liver.
Vascular System Injuries
Vitamins E and A in vascular diseases.
Vesicular Stomatitis
Cell-free fatty acylation of microsomal integrated and detergent-solubilized glycoprotein of vesicular stomatitis virus.
Translation of vesicular stomatitis and Sindbis virus mRNAs in cell-free extracts of Aedes albopictus cells.
Viremia
Interferon therapy in liver/kidney microsomal antibody type 1-positive patients with chronic hepatitis C.
Low hepatitis C viremia levels in patients with anti-liver/kidney microsomal antibody type 1 positive chronic hepatitis.
Quantitative analysis of hepatitis C virus activity in vivo in different groups of untreated patients.
Virus Diseases
A novel assay for detecting antibodies to cytochrome P4502D6, the molecular target of liver kidney microsomal antibody type 1.
Anti-rat liver microsomal and cytosolic antibodies in hepatitis C virus infection.
Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection.
Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A.
Changes in microsomal protein synthesis caused by in vivo virus infection.
Clinical enzymology: an autobiographical history.
Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection.
Establishment of a novel radioligand assay using eukaryotically expressed cytochrome P4502D6 for the measurement of liver kidney microsomal type 1 antibody in patients with autoimmune hepatitis and hepatitis C virus infection.
Hepatitis C virus infection associated with liver-kidney microsomal antibody type 1 (LKM1) autoantibodies in children.
Hepatitis C virus-related chronic liver disease with autoantibodies to liver-kidney microsomes (LKM). Clinical characterization from idiopathic LKM-positive disorders.
Heterogeneity of liver-kidney microsomal autoantibodies in chronic hepatitis C and D virus infection.
Interferon therapy in liver/kidney microsomal antibody type 1-positive patients with chronic hepatitis C.
Liver kidney microsomal type 1 antibodies reduce the CYP2D6 activity in patients with chronic hepatitis C virus infection.
Low hepatitis C viremia levels in patients with anti-liver/kidney microsomal antibody type 1 positive chronic hepatitis.
Modulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice.
Non-organ specific autoantibodies associated with chronic C virus hepatitis.
Non-organ specific autoantibodies in children with chronic hepatitis C.
Recurrent episodes of acute hepatitis associated with LKM-1 (cytochrome P450 2D6) antibodies in identical twin brothers.
Viral stimulation of choline phosphotransferase in spleen microsomes.
Vitamin A Deficiency
Effect of vitamin A deficiency on hepatic microsomal and colon mucosal mixed function oxidase. IV--Influence on aflatoxin B1 metabolism, ethylmorphine and epoxide hydrase activity.
Effect of vitamin A on rat hepatic mixed-function oxidases, glutathione transferase activity and generations of oxygen radicals.
Lipid peroxidation and benzo[a]pyrene activation to mutagenic metabolites: in vivo influence of vitamins A, E and C and glutathione in both dietary vitamin A sufficiency and deficiency.
Restoration of cytochrome P450 2C11 in vitamin A-deficient rat liver by exogenous androgen.
Suppression of the constitutive microsomal cytochrome P450 2C11 in male rat liver during dietary vitamin A deficiency.
Synthesis of retinyl phosphate mannose and dolichyl phosphate mannose from endogenous and exogenous retinyl phosphate and dolichyl phosphate in microsomal fraction. Specific decrease in endogenous retinyl phosphate mannose synthesis in vitamin A deficiency.
The differential effects of chemical carcinogens on vitamin A status and on microsomal drug metabolism in normal and vitamin A-deficient rats.
[Lipid peroxidation in the rat liver in mild forms of vitamin A deficiency]
[Vitamin A and microsomal membranes: the effect of retinol deficiency on lipid microviscosity and phospholipid turnover in rat liver microsomes]
Vitamin D Deficiency
Loss of seizure control due to anticonvulsant-induced hypocalcemia.
Mutation of the CYP2R1 Vitamin D 25-Hydroxylase in a Saudi Arabian Family with Severe Vitamin D Deficiency.
Pathophysiology behind anticonvulsant osteomalacia.
Vitamin E Deficiency
Alteration of brain and liver microsomal polyunsaturated fatty acids following dietary vitamin E deficiency.
Effects of selenium and vitamin E deficiencies in lambs on hepatic microsomal hemoproteins and mitochondrial respiration.
Effects of vitamin E deficiency on hepatic microsomal cytochrome P450 and phase II enzymes in male and female rats.
Influence of vitamin E and nitrogen dioxide on lipid peroxidation in rat lung and liver microsomes.
The dependence on vitamin E and selenium of drug demethylation in rat liver microsomal fractions.
Vitamin E, membrane order, and antioxidant behavior in lung microsomes and reconstituted lipid vesicles.
Vitamin K Deficiency
Phenytoin, hemorrhage, skeletal defects and vitamin K in the newborn.
[Activity of enzymes participating in xenobiotic metabolism and the condition of microsomal membranes of rat liver in vitamin K deficiency]
Vitiligo
Autoimmunity in vitiligo: relationship with HLA, Gm and Km polymorphisms.
Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies.
Incidence and significance of organ-specific autoimmune disorders (clinical, latent or only autoantibodies) in patients with vitiligo.
Increased incidence of antismooth muscle antibody in Korean vitiligo patients.
Organ-specific autoantibodies in vitiligo patients and their relatives.
Warts
Enhancement of bleomycin-mediated DNA damage by epidermal microsomal enzymes.
Whooping Cough
Depression of hepatic drug-metabolizing enzyme activity by B. pertussis vaccination.
Depression of hepatic mixed-function oxidase activity by B. pertussis in splenectomized and athymic nude mice.
Muscarinic acetylcholine receptors in the sino-atrial node and right atrium of bovine heart.
Rapid activation of phosphatidate phosphohydrolase in mesangial cells by lipid A.
Thrombin-induced prostacyclin biosynthesis in human endothelium: role of guanine nucleotide regulatory proteins in stimulus/coupling responses.
Trypanosoma cruzi: immune response in mice immunized with parasite antigens.
Vaccine-induced alterations in hepatic drug metabolism.
Xanthomatosis
Competitive inhibition of bile acid synthesis by endogenous cholestanol and sitosterol in sitosterolemia with xanthomatosis. Effect on cholesterol 7 alpha-hydroxylase.
Xanthomatosis, Cerebrotendinous
Biosynthesis of bile acids in cerebrotendinous xanthomatosis. Relationship of bile acid pool sizes and synthesis rates to hydroxylations at C-12, C-25, and C-26.
Transformation of 4-cholesten-3-one and 7 alpha-hydroxy-4-cholesten-3-one into cholestanol and bile acids in cerebrotendinous xanthomatosis.