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Literature summary for 3.3.2.9 extracted from

  • Oesch, F.
    Purification and specificity of a human microsomal epoxide hydratase (1974), Biochem. J., 139, 77-88.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
1-(2-cyanophenyl)-imidazole 2 mM, stimulates Cavia porcellus
1-(2-cyanophenyl)-imidazole 2 mM, stimulates Homo sapiens
1-(2-cyanophenyl)-imidazole 2 mM, stimulates Rattus norvegicus
1-(2-Isopropylphenyl)-imidazole 2 mM, stimulates Cavia porcellus
1-(2-Isopropylphenyl)-imidazole 2 mM, stimulates Homo sapiens
1-(2-Isopropylphenyl)-imidazole 2 mM, stimulates Rattus norvegicus
ethanol 2.7 M, stimulates Cavia porcellus
ethanol 2.7 M, stimulates Homo sapiens
ethanol 2.7 M, stimulates Rattus norvegicus
Metyrapone 2 mM, stimulates Cavia porcellus
Metyrapone 2 mM, stimulates Homo sapiens
Metyrapone 2 mM, stimulates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,1-diphenyloxirane
-
Cavia porcellus
1,1-diphenyloxirane
-
Homo sapiens
1,1-diphenyloxirane
-
Rattus norvegicus
1-isopropyl-1-phenyloxirane
-
Cavia porcellus
1-isopropyl-1-phenyloxirane
-
Homo sapiens
1-isopropyl-1-phenyloxirane
-
Rattus norvegicus
1-methyl-1-phenyloxirane
-
Cavia porcellus
1-methyl-1-phenyloxirane
-
Homo sapiens
1-methyl-1-phenyloxirane
-
Rattus norvegicus
1-methylcyclohexene oxide
-
Cavia porcellus
1-methylcyclohexene oxide
-
Homo sapiens
3,3,3-trichloropropene oxide
-
Cavia porcellus
3,3,3-trichloropropene oxide
-
Homo sapiens
3,3,3-trichloropropene oxide
-
Rattus norvegicus
3,3,3-trifluoropropene oxide
-
Cavia porcellus
3,3,3-trifluoropropene oxide
-
Homo sapiens
3,3,3-trifluoropropene oxide
-
Rattus norvegicus
3,3-dimethylbutene oxide
-
Cavia porcellus
3,3-dimethylbutene oxide
-
Homo sapiens
3,3-dimethylbutene oxide
-
Rattus norvegicus
3-methylbutene 1,2-oxide
-
Cavia porcellus
3-methylbutene 1,2-oxide
-
Homo sapiens
3-methylbutene 1,2-oxide
-
Rattus norvegicus
3-methylcyclohexene oxide
-
Cavia porcellus
3-methylcyclohexene oxide
-
Homo sapiens
3-methylcyclohexene oxide
-
Rattus norvegicus
3-phenylpropene 1,2-oxide
-
Cavia porcellus
3-phenylpropene 1,2-oxide
-
Homo sapiens
3-phenylpropene 1,2-oxide
-
Rattus norvegicus
cis-2-methyl-1-phenyloxirane
-
Cavia porcellus
cis-2-methyl-1-phenyloxirane
-
Homo sapiens
cis-2-methyl-1-phenyloxirane
-
Rattus norvegicus
cis-stilbene oxide
-
Cavia porcellus
cis-stilbene oxide
-
Homo sapiens
cis-stilbene oxide
-
Rattus norvegicus
Cyclohexene oxide
-
Cavia porcellus
Cyclohexene oxide
-
Homo sapiens
Cyclohexene oxide
-
Rattus norvegicus
indene 1,2-oxide
-
Cavia porcellus
indene 1,2-oxide
-
Homo sapiens
indene 1,2-oxide
-
Rattus norvegicus
m-bromostyrene oxide
-
Cavia porcellus
m-bromostyrene oxide
-
Homo sapiens
m-bromostyrene oxide
-
Rattus norvegicus
m-nitrostyrene oxide
-
Cavia porcellus
m-nitrostyrene oxide
-
Homo sapiens
m-nitrostyrene oxide
-
Rattus norvegicus
methyl-p-epoxymethylbenzoate
-
Cavia porcellus
methyl-p-epoxymethylbenzoate
-
Homo sapiens
methyl-p-epoxymethylbenzoate
-
Rattus norvegicus
n-octene 1,2-oxide
-
Cavia porcellus
n-octene 1,2-oxide
-
Homo sapiens
n-octene 1,2-oxide
-
Rattus norvegicus
naphthalene 1,2-oxide
-
Cavia porcellus
naphthalene 1,2-oxide
-
Homo sapiens
naphthalene 1,2-oxide
-
Rattus norvegicus
p-bromostyrene oxide
-
Cavia porcellus
p-bromostyrene oxide
-
Homo sapiens
p-bromostyrene oxide
-
Rattus norvegicus
p-chlorophenyl 2,3-epoxypropyl ether
-
Cavia porcellus
p-chlorophenyl 2,3-epoxypropyl ether
-
Homo sapiens
p-chlorophenyl 2,3-epoxypropyl ether
-
Rattus norvegicus
p-nitrostyrene oxide
-
Cavia porcellus
p-nitrostyrene oxide
-
Homo sapiens
p-nitrostyrene oxide
-
Rattus norvegicus
p-phenylstyrene oxide
-
Cavia porcellus
p-phenylstyrene oxide
-
Homo sapiens
p-phenylstyrene oxide
-
Rattus norvegicus
propene oxide
-
Cavia porcellus
propene oxide
-
Homo sapiens
propene oxide
-
Rattus norvegicus
styrene oxide
-
Cavia porcellus
styrene oxide
-
Homo sapiens
styrene oxide
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Cavia porcellus
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Cavia porcellus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.118
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methyl-1-phenyloxirane + H2O
-
Homo sapiens ?
-
?
cyclohexene oxide + H2O
-
Homo sapiens ?
-
?
indene 1,2-oxide + H2O
-
Homo sapiens ?
-
?
styrene oxide + H2O
-
Cavia porcellus styrene glycol
-
?
styrene oxide + H2O
-
Homo sapiens styrene glycol
-
?
styrene oxide + H2O
-
Rattus norvegicus styrene glycol
-
?