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Literature summary for 3.3.2.9 extracted from

  • Guengerich, F.P.
    Epoxide hydratase: properties and metabolic roles (1982), Rev. Biochem. Toxicol., 4, 5-30.
No PubMed abstract available

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.35
-
trans-beta-ethylstyrene oxide
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Cavia porcellus
-
-
microsome
-
Mus musculus
-
-
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-
microsome
-
Bos taurus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
-
Mus musculus
additional information
-
-
Homo sapiens
additional information
-
enzyme aggregates in absence of amphipathic detergents Rattus norvegicus
49000
-
x * 49000, SDS-PAGE Homo sapiens
49000
-
x * 49000, SDS-PAGE Rattus norvegicus
58000
-
x * 58000, SDS-PAGE Homo sapiens
130000
-
gel filtration Mus musculus
130000
-
gel filtration Homo sapiens
600000
-
enzyme aggregate formed in absence of amphiphathic detergents, gel filtration Rattus norvegicus
800000
-
enzyme aggregate formed in absence of amphiphathic detergents, equilibrium sedimentation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cavia porcellus enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation ?
-
?
additional information Mus musculus enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation ?
-
?
additional information Homo sapiens enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation ?
-
?
additional information Rattus norvegicus enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Cavia porcellus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Cavia porcellus
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(exo)-2,3-epoxynorbornane + H2O
-
Rattus norvegicus ?
-
?
1,2-epoxybutane + H2O
-
Rattus norvegicus 2-hydroxy-n-butanol
-
?
2,3-epoxypropyl-p-methoxyphenyl ether + H2O
-
Rattus norvegicus ?
-
?
2,3-epoxypropyl-p-methoxyphenyl ether + H2O
-
Rattus norvegicus 3-(3-methoxyphenoxy)propane-1,2-diol
-
?
2-bromoethylene oxide + H2O
-
Rattus norvegicus ?
-
?
2-chloroethylene oxide + H2O
-
Homo sapiens ?
-
?
2-chloroethylene oxide + H2O
-
Rattus norvegicus ?
-
?
3,3,3-trichloropropylene oxide + H2O
-
Rattus norvegicus ?
-
?
3-methylcholanthrene 11,12-oxide + H2O
-
Homo sapiens ?
-
?
3-methylcholanthrene 11,12-oxide + H2O
-
Rattus norvegicus ?
-
?
4-chlorophenyl 2,3-epoxypropyl ether + H2O
-
Cavia porcellus ?
-
?
4-chlorophenyl 2,3-epoxypropyl ether + H2O
-
Rattus norvegicus ?
-
?
4-vinylcyclohexene dioxide + H2O low activity Rattus norvegicus ?
-
?
7-methylbenzanthracene-5,6-oxide + H2O
-
Rattus norvegicus ?
-
?
benzoanthracene 5,6-oxide + H2O
-
Homo sapiens ?
-
?
benzoanthracene 5,6-oxide + H2O
-
Rattus norvegicus ?
-
?
benzopyrene 4,5-oxide + H2O
-
Cavia porcellus (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 4,5-oxide + H2O
-
Mus musculus (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 4,5-oxide + H2O
-
Homo sapiens (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 4,5-oxide + H2O
-
Rattus norvegicus (-)benzopyrene 4,5-dihydrodiol
-
?
benzopyrene 7,8-oxide + H2O
-
Homo sapiens ?
-
?
benzopyrene 7,8-oxide + H2O
-
Rattus norvegicus ?
-
?
benzopyrene 9,10-oxide + H2O
-
Rattus norvegicus ?
-
?
butadiene monoxide + H2O low activity Rattus norvegicus ?
-
?
cyclododecene-1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
cyclohexene-1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
dibenzanthracene 5,6-oxide + H2O
-
Homo sapiens ?
-
?
dibenzanthracene 5,6-oxide + H2O
-
Rattus norvegicus ?
-
?
dl-1,3-butadiene diepoxide + H2O low activity Rattus norvegicus ?
-
?
epibromhydrin + H2O
-
Rattus norvegicus ?
-
?
epichlorhydrin + H2O
-
Rattus norvegicus 3-chloro-1,2-propanediol
-
?
epifluorohydrin + H2O
-
Rattus norvegicus ?
-
?
glycidyl methacrylate + H2O low activity Rattus norvegicus ?
-
?
additional information enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation Cavia porcellus ?
-
?
additional information enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation Mus musculus ?
-
?
additional information enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation Homo sapiens ?
-
?
additional information enzyme is induced by a number of xenobiotics, the enzyme is thought to play a detoxifying role by preventing epoxides from reacting irreversibly with critical cellular macromolecules. Some evidence exists to support the hypothesis that microsomal epoxide hydrolase is closely associated with at least certain forms of cytochrome P-450, such association may influence the functional role of the microsomal epoxide hydrolase in the various pathways of bioactivation Rattus norvegicus ?
-
?
naphthalene-1,2-oxide + H2O
-
Cavia porcellus ?
-
?
naphthalene-1,2-oxide + H2O
-
Homo sapiens ?
-
?
naphthalene-1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
octene 1,2-oxide + H2O
-
Homo sapiens ?
-
?
octene 1,2-oxide + H2O
-
Rattus norvegicus ?
-
?
p-nitrostyrene 7,8-oxide + H2O
-
Homo sapiens ?
-
?
p-nitrostyrene 7,8-oxide + H2O
-
Rattus norvegicus ?
-
?
phenanthrene-9,10-oxide + H2O
-
Mus musculus ?
-
?
phenanthrene-9,10-oxide + H2O
-
Homo sapiens ?
-
?
phenanthrene-9,10-oxide + H2O
-
Rattus norvegicus ?
-
?
propylene oxide + H2O low activity Rattus norvegicus ?
-
?
styrene 7,8-oxide + H2O
-
Homo sapiens styrene glycol
-
?
styrene 7,8-oxide + H2O
-
Rattus norvegicus styrene glycol
-
?
trans-ethyl styrene oxide + H2O
-
Mus musculus ?
-
?

Subunits

Subunits Comment Organism
?
-
Cavia porcellus
?
-
Mus musculus
? x * 58000, SDS-PAGE Homo sapiens
? x * 49000, SDS-PAGE Homo sapiens
? x * 49000, SDS-PAGE Rattus norvegicus