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5'-methyl,5'-deoxymethylthioadenosine + putrescine
?
putrescine + (methyl-14C)-S-adenosylmethioninamine
spermidine + ?
-
-
-
?
putrescine + S-5'-deoxyadenosyl-(5')-3-methylthiopropylamine
spermidine + ?
-
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
S-5'-deoxyadenosyl-5'-3-butylthiopropylamine + 1,4-diaminobutane
?
-
-
-
?
S-5'-deoxyadenosyl-5'-3-ethylthiopropylamine + 1,4-diaminobutane
?
S-5'-deoxyadenosyl-5'-3-propylthiopropylamine + 1,4-diaminobutane
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,3-diaminopropane
?
-
weak substrate
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diamino-2-butene
5'-methylthioadenosine + N-3-aminopropyl-1,4-diamino-2-butene
-
-
in a lower yield than with the natural combination
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diamino-2-butene
?
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diamino-2-butene
N-3-aminopropyl-1,4-diamino-2-butene + 5'-methylthioadenosine
-
-
forms with a low yield
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,6-diaminohexane
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1-methyl-1,4-butanediamine
?
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 2,2-difluoro-1,4-diaminobutane
?
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 2-chloro-1,4-diaminobutane
?
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 2-hydroxy-1,4 butanediamine
?
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 2-methyl-1,4-diaminobutane
?
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + spermidine
5'-methylthioadenosine + spermine
S-adenosyl-(5')-3-methylthiopropylamine + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-3-butylthio-1-propylamine + 1,4-diaminobutane
?
-
prostate enzyme
-
?
S-adenosyl-3-carboxymethylthio-1-propylamine + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-3-ethylthio-1-propylamine + 1,4-diaminobutane
?
S-adenosyl-3-methylthio-1-propylamine + 1,3-diaminopentane
?
-
poor substrate
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
S-adenosyl-3-propylthio-1-propylamine + 1,4-diaminobutane
?
S-adenosyl-3-thiopropylamine sulfone + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-3-thiopropylamine sulfoxide + 1,4-diaminobutane
?
S-adenosyl-5',1-methyl-3-methylthiopropylamine + 1,4-diaminobutane
?
S-adenosyl-L-ethionine + 1,4-diaminobutane
?
S-adenosyl-L-homocysteine sulfone + 1,4-diaminobutane
?
S-adenosyl-L-methionine + 1,4-diaminobutane
?
S-adenosylmethioninamine + putrescine
5'-methylthioadenosine + spermidine
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
S-adenosylmethioninamine + putrescine
spermidine + 5'-methylthioadenosine
spermidine + S-adenosylmethioninamine
spermine + 5'-methylthioadenosine
in contrast to mammalian spermidine synthases, spermidine can replace to some extent putrescine as the aminopropyl acceptor
-
?
additional information
?
-
5'-methyl,5'-deoxymethylthioadenosine + putrescine

?
low activity
-
?
5'-methyl,5'-deoxymethylthioadenosine + putrescine
?
low activity
-
?
putrescine + S-adenosylmethioninamine

spermidine + 5'-methylthioadenosine
-
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
ir
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
-
?
putrescine + S-adenosylmethioninamine
spermidine + 5'-methylthioadenosine
-
-
?
S-5'-deoxyadenosyl-5'-3-ethylthiopropylamine + 1,4-diaminobutane

?
-
-
-
?
S-5'-deoxyadenosyl-5'-3-ethylthiopropylamine + 1,4-diaminobutane
?
-
-
-
?
S-5'-deoxyadenosyl-5'-3-propylthiopropylamine + 1,4-diaminobutane

?
-
-
-
?
S-5'-deoxyadenosyl-5'-3-propylthiopropylamine + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine

S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane

5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
derivatives of 1,4-diaminobutane are substrates too. Substitution of 1,4-diaminobutane in the immediate vicinity of an amino group produces weak substrates, whereas substituents in the 2-position are tolerated
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
analogues of decarboxylated S-adenosylmethionine act as propylamine donors
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
the reaction is linear from 1 to 10 nmol of spermidine
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
ir
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
+ H+
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
linear at least up to 6 nmol of spermidine formed, linearity not maintained in the absence of DTT
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
the enzyme transfers only the aminopropyl group, not an aminoethyl or aminobutyl groups
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
sulfonium analogs must carry the aminopropyl group to qualify as a substrate
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
analogues of decarboxylated S-adenosylmethionine act as propylamine donors
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
synthetic diamines are substrates too
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
the enzyme transfers only the aminopropyl group, not an aminoethyl or aminobutyl groups
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
sulfonium analogs must carry the aminopropyl group to qualify as a substrate
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
analogues of decarboxylated S-adenosylmethionine act as propylamine donors
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
linear at least up to 6 nmol of spermidine formed, linearity not maintained in the absence of DTT
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,6-diaminohexane

?
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,6-diaminohexane
?
-
1% the reaction rate than with 1,4-diaminobutane
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,6-diaminohexane
?
-
-
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + spermidine

5'-methylthioadenosine + spermine
-
at a reduced rate
-
?
S-adenosyl-(5')-3-methylthio-1-propylamine + spermidine
5'-methylthioadenosine + spermine
-
at a reduced rate
the reaction rate is slower than with 1,4-diaminobutane
?
S-adenosyl-(5')-3-methylthio-1-propylamine + spermidine
5'-methylthioadenosine + spermine
-
weak substrate
-
?
S-adenosyl-3-ethylthio-1-propylamine + 1,4-diaminobutane

?
-
-
-
?
S-adenosyl-3-ethylthio-1-propylamine + 1,4-diaminobutane
?
-
prostate enzyme
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane

5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
i.e. S-adenosylmethioninamine or decarboxylated S-adenosylmethionine + putrescine, involved in polyamine biosynthetic pathway
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane

5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
6% the reaction rate than with 1,4-diaminobutane
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
-
aminopropylcadaverine
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
cadaverine
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
20 times less active than 1,4-diaminobutane at the same concentration
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
20 times less active than 1,4-diaminobutane at the same concentration
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
weak substrate
-
?
S-adenosyl-3-propylthio-1-propylamine + 1,4-diaminobutane

?
-
-
-
?
S-adenosyl-3-propylthio-1-propylamine + 1,4-diaminobutane
?
-
prostate enzyme
-
?
S-adenosyl-3-thiopropylamine sulfoxide + 1,4-diaminobutane

?
-
-
-
?
S-adenosyl-3-thiopropylamine sulfoxide + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-3-thiopropylamine sulfoxide + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-5',1-methyl-3-methylthiopropylamine + 1,4-diaminobutane

?
-
brain enzyme
-
?
S-adenosyl-5',1-methyl-3-methylthiopropylamine + 1,4-diaminobutane
?
-
prostate enzyme
-
?
S-adenosyl-L-ethionine + 1,4-diaminobutane

?
-
-
-
?
S-adenosyl-L-ethionine + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-L-ethionine + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-L-homocysteine sulfone + 1,4-diaminobutane

?
-
-
-
?
S-adenosyl-L-homocysteine sulfone + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-L-homocysteine sulfone + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-L-methionine + 1,4-diaminobutane

?
-
-
-
?
S-adenosyl-L-methionine + 1,4-diaminobutane
?
-
-
-
?
S-adenosyl-L-methionine + 1,4-diaminobutane
?
-
-
-
?
S-adenosylmethioninamine + putrescine

5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine

5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
PAPTs are essential for bacterial cell viability
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
the enzyme is highly specific for putrescine
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
polyamine biosynthetic enzyme
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
functional ACL5 and SPMS are independently involved in apple fruit development and cell growth
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
Val149, Ser161, Ala205, and Val235 are involved in the S-adenosylmethioninamine binding
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
spermidine plays an important role in the activation of the eukaryotic translation initiation factor and cell proliferation
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
the enzyme shows a relatively low substrate specificity for putrescine
-
?
S-adenosylmethioninamine + putrescine

S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine

spermidine + 5'-methylthioadenosine
low activity
-
?
S-adenosylmethioninamine + putrescine
spermidine + 5'-methylthioadenosine
low activity
-
?
additional information

?
-
-
using yeast two-hybrid assays, spermidine synthase2 is identified as a specific 10A06 interactor. 10A06 is a cyst nematode (Heterodera glycines) secretory protein able to infect Arabidopsis thaliana, that is secreted as an effector into the developing syncytia during early plant parasitism
-
?
additional information
?
-
amine substrate specificity, overview
-
?
additional information
?
-
-
amine substrate specificity, overview
-
?
additional information
?
-
amine substrate specificity, overview
-
?
additional information
?
-
-
amine substrate specificity, overview
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
additional information
?
-
-
using yeast two-hybrid assays, spermidine synthase2 is identified as a specific 10A06 interactor. 10A06 is a cyst nematode (Heterodera glycines) secretory protein able to infect Arabidopsis thaliana, that is secreted as an effector into the developing syncytia during early plant parasitism
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine

S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl 3-(methylthio)propylamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane

5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
i.e. S-adenosylmethioninamine or decarboxylated S-adenosylmethionine + putrescine, involved in polyamine biosynthetic pathway
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
5'-methylthioadenosine + spermidine
-
-
-
-
?
S-adenosylmethioninamine + putrescine

5'-S-methyl-5'-thioadenosine + spermidine
-
PAPTs are essential for bacterial cell viability
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
polyamine biosynthetic enzyme
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
functional ACL5 and SPMS are independently involved in apple fruit development and cell growth
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
spermidine plays an important role in the activation of the eukaryotic translation initiation factor and cell proliferation
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
-
?
S-adenosylmethioninamine + putrescine
5'-S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine

S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
?
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,5-Diaminopentane
-
weak, competitive
1,6-diaminohexane
-
23% inhibition
1-Aminooxy-3-aminopropane
1H-benzimidazol-5-yl(4-[(2Z)-3-phenylprop-2-en-1-yl]piperazin-1-yl)methanone
-
identified by a five-step structure-based virtual screening procedure as a binder to spermidine synthase active site. Binds reversibly to the active site and partially competes with binding of methylthioadenosine
2-phenyl-1,2-thiazol-3(2H)-one
-
2-[(6-amino-5,9-dihydro-4H-purin-8-yl)sulfanyl]acetamide
-
identified by a five-step structure-based virtual screening procedure as a binder to spermidine synthase active site. Binds reversibly to the active site and competes with binding of methylthioadenosine
2H-1,4-benzothiazin-3-amine
-
4-methylenecyclohexylamine
-
-
5'-deoxy-5'-methylthioadenosine
5'-deoxy-5'-methylthiotubercidine
5-(1H-benzimidazol-2-yl)pentan-1-amine
-
identified by a five-step structure-based virtual screening procedure as a binder to spermidine synthase active site. Binds reversibly to the active site
5-[(4-methylbenzyl)oxy]quinazolin-2-amine
-
agmatine
-
89% inhibition at 0.1 mM and 61% inhibition at 1 mM
alpha,omega-Diamines
-
with 3 carbon atoms, at 0.25 mM, not at 2.5 mM substrate concentration
arginine
-
98% inhibition at 0.01 mM, 95% inhibition at 0.1 mM and 84% inhibition at 1 mM
benzimidazol-(2-yl)pentan-1-amine
-
bis-cyclohexylammonium sulfate
-
in vitro, 0.2 mM provokes strong decrease in cellular spermidine content, inhibition in cell growth, decrease in DNA synthesis, alterations in cell morphology, disorganization of microfilaments and changes in microtubule network structure, impairs the rate of microtubule reappearance after disruption with colchicine, alterations are prevented with spermidine addition
CGC-11038
-
polyamine analogue
CGC-11098
-
polyamine analogue
CGC-11099
-
polyamine analogue
CGC-11108
-
polyamine analogue
CGC-11114
-
polyamine analogue
CGC-11121
-
polyamine analogue
CGC-11122
-
polyamine analogue
CGC-11144
-
polyamine analogue
CGC-11150
-
polyamine analogue
CGC-11157
-
polyamine analogue
CGC-11158
-
polyamine analogue
CGC-11159
-
polyamine analogue
CGC-11160
-
polyamine analogue
CGC-11172
-
polyamine analogue
CGC-11175
-
polyamine analogue
CGC-11207
-
polyamine analogue
CGC-11211
-
polyamine analogue
CGC-11217
-
polyamine analogue
CGC-11226
-
polyamine analogue
CGC-11227
-
polyamine analogue
CGC-11231
-
polyamine analogue
CGC-11235
-
polyamine analogue
CGC-11237
-
polyamine analogue
CGC-11239
-
polyamine analogue
CGC-11241
-
polyamine analogue
deaminated analogs of decarboxy-S-adenosyl-(5')-3-methylthiopropylamine
-
competitive inhibition with 1,4-diaminobutane and non-competitive with decarboxy-S-adenosyl-(5')-3-methylthiopropylamine
decarboxylated S-adenosylhomocysteine
Dicyclohexylamine
poor inhibition
DTNB
-
potent inhibition, activity is restored to more than 95% with 0.1 mM DTT
exo-2-aminonorbornane
-
potent and selective, 98% inhibition at 0.1 mM in the presence of 1 mM of putrescine
Homospermidine
-
95% inhibition at 0.01 mM, 92% inhibition at 0.1 mM and 30% inhibition at 1 mM
methyl (2E)-2-(4-hydroxy-3-methoxybenzylidene)hydrazinecarbimidothioate
-
identified by a five-step structure-based virtual screening procedure as a binder to spermidine synthase active site. Binds reversibly to the active site and partially competes with binding of methylthioadenosine
N,N'-Bis-(2-aminoethyl)propane-1,3-diamine
-
strong, 52% inhibition
N-methyl-6-(piperidin-1-yl)hexan-1-amine
-
identified by a five-step structure-based virtual screening procedure as a binder to spermidine synthase active site. Binds reversibly to the active site
N-methyl-N-phenyl-2,3-dihydro-1,4-benzodioxine-2-carboxamide
-
N-[2-(phenylsulfanyl)ethyl]-1H-benzotriazole-5-carboxamide
-
identified by a five-step structure-based virtual screening procedure as a binder to spermidine synthase active site. Binds reversibly to the active site and partially competes with binding of methylthioadenosine
quinolin-8-yl piperidine-1-carboxylate
-
S-5'-Deoxyadenosyl(5')-2-ethylthioethylamine
-
uncompetitive with S-adenosyl-3-methylthio-1-propylamine at high concentrations but competitive with S-5'-deoxyadenosyl-5'-3-ethylthiopropylamine
S-5'-Deoxyadenosyl(5')-2-methylthioethylamine
S-5'-Deoxyadenosyl(5')-2-thioethylamine
-
weak
S-5'-Deoxyadenosyl(5')-3-butylthiopropylamine
-
weak
S-5'-deoxyadenosyl(5')-3-thiopropylamine
-
weak
S-5'-Deoxyadenosyl(5')-4-methylthiobutylamine
-
weak
S-5'-Deoxyadenosyl(5')-4-thiobutylamine
-
uncompetitive with S-Adenosyl-3-methylthio-1-propylamine
S-Adenosyl(5')-2-methylthioethylamine
-
-
S-Adenosyl(5')-3-methylthiopropanol
-
kinetics
S-adenosyl-(5')-3-methylthio-1-propylamine
S-Adenosyl-1,8-diamino-3-methylthiooctane
-
less efficient than the thioether
S-adenosyl-1,8-diamino-3-thio-octane
S-Adenosyl-1,8-diamino-3-thiooctane
S-Adenosyl-3-thiopropylamine sulfone
-
-
S-Adenosyl-4-methylthiobutyric acid
-
-
S-adenosyl-L-ethionine
-
-
S-Adenosyl-L-homocysteine sulfone
-
-
S-Inosyl(5')-3-methylthiopropylamine
-
not S-inosyl(5')-3-methylthiopropanol
S-Tubercidinylmethionine
-
-
spermine
-
99% inhibition at 0.1 mM and 90% inhibition at 1 mM
Substrate and product analogues
-
overview
-
sulfhydryl reagents
-
W strain
Sulfoxide and sulfone derivatives of decarboxylated S-adenosyl-L-homocysteine
-
-
-
trans-4-ethyl-cyclohexylamine
-
-
trans-4-hydroxycyclohexylamine
-
-
trans-4-Methylcyclohexylamine
triethylenetetramine
-
39% inhibition
1,3-diaminopropane

-
34% inhibition
1,3-diaminopropane
-
96% inhibition at 0.01 mM and 100% inhibition at 0.1 mM
1-Aminooxy-3-aminopropane

-
brain enzyme, specific, no inhibition of spermine synthase, reversible, competitive with 1,4-diaminobutane
1-Aminooxy-3-aminopropane
poor inhibition
2-mercaptoethylamine

poor inhibition
2-mercaptoethylamine
-
competitive with 1,4-diaminobutane, reversible, its removal restores the enzyme activity, the amino group is necessary to inhibit the enzyme
4-methylcyclohexylamine

-
-
4-methylcyclohexylamine
-
-
5'-deoxy-5'-methylthioadenosine

-
weak
5'-deoxy-5'-methylthioadenosine
-
above 0.05 mM
5'-deoxy-5'-methylthiotubercidine

-
weak
5'-deoxy-5'-methylthiotubercidine
-
-
5'-ethylthioadenosine

-
-
5'-ethylthioadenosine
-
-
5'-ethylthioadenosine
-
strong
5'-ethylthioadenosine
-
-
5'-methylthioadenosine

-
-
5'-methylthioadenosine
-
non-competitive, mixed type inhibition
5'-methylthioadenosine
-
weak inhibition
5'-methylthioadenosine
-
W strain
5'-methylthioadenosine
-
-
5'-methylthioadenosine
feedback inhibition
5'-methylthioadenosine
-
-
5'-methylthioadenosine
-
strong
5'-methylthioadenosine
-
-
5'-methylthioadenosine
-
weak inhibition
5'-methylthioadenosine
-
83% inhibition at 0.01 mM and 22% inhibition at 1 mM
5'-methylthiotubercidin

-
in vivo and in vitro, strong
5'-methylthiotubercidin
-
-
5-amino-1-pentene

50% inhibition at 6.5 microM
cadaverine

-
26-39% inhibition
cadaverine
-
77% inhibition at 0.01 mM and 22% inhibition at 1 mM
Cyclohexylamine

-
strong
Cyclohexylamine
-
IC50 2.4 +/- 0.7 microM
Cyclohexylamine
-
potent inhibition, reduces the rate of spermidine synthesis by more than 90% at 0.1 mM
Cyclohexylamine
50% inhibition at 19.7 microM
Cyclohexylamine
-
potent inhibition, reduces the rate of spermidine synthesis by more than 90% at 0.1 mM
Cyclohexylamine
-
potent inhibition, reduces the rate of spermidine synthesis by more than 90% at 0.1 mM
Cyclohexylamine
-
50% inhibition at 0.0081 mM, competitive with 1,4-diaminobutane
Cyclohexylamine
-
in vitro, 50% inhibition at 0.015 mM, competitive with 1,4-diaminobutane
decarboxylated S-adenosylhomocysteine

active site binding structure, overview
decarboxylated S-adenosylhomocysteine
-
-
decarboxylated S-adenosylhomocysteine
-
-
n-butylamine

-
specific inhibitor of the enzyme in vivo and in vitro
N-ethylmaleimide

-
-
N-ethylmaleimide
-
potent inhibition
p-hydroxymercuribenzoate

-
2-mercaptoethanol restores activity
p-hydroxymercuribenzoate
-
-
S-5'-Deoxyadenosyl(5')-2-methylthioethylamine

-
prostate
S-5'-Deoxyadenosyl(5')-2-methylthioethylamine
-
the most potent inhibitor, competitive with decarboxylated S-adenosylmethionine and S-5'-deoxyadenosyl-(5')-3-ethylthiopropylamine
S-adenosyl-(5')-3-methylthio-1-propylamine

-
at concentrations above 0.05 mM
S-adenosyl-(5')-3-methylthio-1-propylamine
-
competitive substrate inhibition
S-adenosyl-(5')-3-methylthio-1-propylamine
-
complete inhibition at 0.080 mM
S-adenosyl-1,8-diamino-3-thio-octane

-
S-adenosyl-1,8-diamino-3-thio-octane
-
S-Adenosyl-1,8-diamino-3-thiooctane

-
transition-state analogue, potent inhibition
S-Adenosyl-1,8-diamino-3-thiooctane
-
competitive with 1,4-diaminobutane, potent inhibition, stronger than dicyclohexylamine in vitro, but not in vivo, at concentrations of S-adenosyl-3-methylthio-1-propylamine and 1,4-diaminobutane higher than those normally present in vivo. At concentration of substrates that approximate in vivo conditions, more than 20fold stronger inhibition
S-Adenosyl-1,8-diamino-3-thiooctane
-
competitive with 1,4-diaminobutane, potent inhibition, stronger than dicyclohexylamine in vitro, but not in vivo, at concentrations of S-adenosyl-3-methylthio-1-propylamine and 1,4-diaminobutane higher than those normally present in vivo. At concentration of substrates that approximate in vivo conditions, more than 20fold stronger inhibition
S-Adenosyl-1,8-diamino-3-thiooctane
-
prostate
S-Adenosyl-1,8-diamino-3-thiooctane
-
specific and more potent inhibitor than the corresponding fully-charged methyl sulfonium salt; transition-state analogue, potent inhibition
S-Adenosyl-1,8-diamino-3-thiooctane
-
competitive with 1,4-diaminobutane, potent inhibition, stronger than dicyclohexylamine in vitro, but not in vivo, at concentrations of S-adenosyl-3-methylthio-1-propylamine and 1,4-diaminobutane higher than those normally present in vivo. At concentration of substrates that approximate in vivo conditions, more than 20fold stronger inhibition
S-Adenosyl-1,8-diamino-3-thiooctane
-
competitive with 1,4-diaminobutane, potent inhibition, stronger than dicyclohexylamine in vitro, but not in vivo, at concentrations of S-adenosyl-3-methylthio-1-propylamine and 1,4-diaminobutane higher than those normally present in vivo. At concentration of substrates that approximate in vivo conditions, more than 20fold stronger inhibition
S-Adenosyl-1,8-diamino-3-thiooctane
-
50% inhibition at 0.0025 mM
S-Adenosyl-1,8-diamino-3-thiooctane
-
IC50 of 0.0002 mM
S-Adenosyl-1,8-diamino-3-thiooctane
-
S-Adenosyl-1,8-diamino-3-thiooctane
-
potent, 50% inhibition at 0.025 mM
S-adenosyl-L-methionine

-
above 0.01 mM
S-adenosyl-L-methionine
-
-
spermidine

-
not competitive, mixed type inhibition
spermidine
-
product inhibition at physiological concentrations
trans-4-Methylcyclohexylamine

-
IC50 7.2 microM
trans-4-Methylcyclohexylamine
IC50 1.4 microM
trans-4-Methylcyclohexylamine
-
i.e. 4MCHA, binding structure
trans-4-Methylcyclohexylamine
-
potent and selective, 98% inhibition at 0.1 mM in the presence of 1 mM of putrescine, in vitro. In vivo, intraperitoneal administration causes effective decrease in spermidine content in prostate, and oral administration causes 28%, 21% and 33% decrease in spermidine content in prostate, liver and kidney, respectively
trans-4-Methylcyclohexylamine
-
-
trans-4-Methylcyclohexylamine
-
in vitro and in vivo inhibition, reduces the spermidine and spermine content in rat tissue after oral application, quantification, overview
trans-4-Methylcyclohexylamine
-
potent, 50% inhibition at 0.0017 mM, competitive with 1,4-diaminobutane
trans-4-Methylcyclohexylamine
-
additional information

-
inhibition by end products of reaction; no inhibition by phenylhydrazine, semicarbazide, sodium borohydride, NaCN, KCl, NH4Cl, MgCl2, CaCl2, NaNO3, Na2SO4, Na2HPO4
-
additional information
-
inhibition by end products of reaction; no inhibition by carbonyl binding reagents
-
additional information
-
no inhibition by 1,4-diaminobutane
-
additional information
-
no inhibition by 1,4-diaminobutane
-
additional information
-
inhibitory potency of diverse polyamine analogues on the polyamine biosynthesis in wild-type strain and strains overexpressing polyamine biosynthetic enzymes, EC50 values, overview
-
additional information
not inhibitory: S-adenosylmethioninamine concentrations up to 150 microM
-
additional information
-
not inhibitory: S-adenosylmethioninamine concentrations up to 150 microM
-
additional information
-
polyamines
-
additional information
-
S-adenosyl-L-homocysteine
-
additional information
-
no inhibition by 2-mercaptoethanol at 0.1 to 1 mM
-
additional information
-
no inhibition by putrescine up to 10 mM
-
additional information
-
not inhibitory: 4,4-dimethylcyclohexylamine
-
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