Literature summary for 2.5.1.16 extracted from

Sprenger, J.; Svensson, B.; Halander, J.; Carey, J.; Persson, L.; Al-Karadaghi, S.
Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design (2015), Acta Crystallogr. Sect. D, 71, 484-493.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21 (lambdaDE3) Rosetta Oxford cells	Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with S-methyl-5'-thioadenosine and putrescine or inhibitors, hanging drop vapor diffusion method, using 0.1 M MES buffer pH 5.6, 0.1 M ammonium sulfate, 27% (w/v) PEG 3350	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
4-methylaniline	-	Plasmodium falciparum
benzimidazol-(2-yl)pentan-1-amine	-	Plasmodium falciparum
S-adenosyl-1,8-diamino-3-thio-octane	-	Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl 3-(methylthio)propylamine + putrescine	Plasmodium falciparum	-	S-methyl-5'-thioadenosine + spermidine	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q8II73	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-affinity column chromatography	Plasmodium falciparum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl 3-(methylthio)propylamine + putrescine	-	Plasmodium falciparum	S-methyl-5'-thioadenosine + spermidine	-	?

Synonyms

Synonyms	Comment	Organism
SPDS	-	Plasmodium falciparum

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Release 2023.1 (January 2023)