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Literature summary for 2.5.1.16 extracted from

  • Shirahata, A.; Takahashi, N.; Beppu, T.; Hosoda, H.; Samejima, K.
    Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues (1993), Biochem. Pharmacol., 45, 1897-1903.
    View publication on PubMed
Search for more literature for 2.5.1.16

Inhibitors

Inhibitors Comment Organism Structure
exo-2-aminonorbornane potent and selective, 98% inhibition at 0.1 mM in the presence of 1 mM of putrescine Rattus norvegicus
trans-4-Methylcyclohexylamine potent and selective, 98% inhibition at 0.1 mM in the presence of 1 mM of putrescine, in vitro. In vivo, intraperitoneal administration causes effective decrease in spermidine content in prostate, and oral administration causes 28%, 21% and 33% decrease in spermidine content in prostate, liver and kidney, respectively Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Rattus norvegicus
-
 5'-methylthioadenosine + spermidine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
prostate gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?
S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?