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EC 2.3.1.309 Details
EC number
2.3.1.309
Accepted name
[β-tubulin]-L-lysine N-acetyltransferase
Reaction
acetyl-CoA + a [β-tubulin]-L-lysine = CoA + a [β-tubulin]-N6-acetyl-L-lysine
Other name(s)
San, NatE, NAA50 (gene name)
Systematic name
acetyl-CoA:[β-tubulin]-L-lysine N6-acetyltransferase
Comment
The enzyme acetylates L-lysine at position 252 of β-tubulin, which is located at the interface of α/β-tubulin heterodimers and interacts with the phosphate group of the α-tubulin-bound GTP. The acetylation is thought to attenuate tubulin incorporation into microtubules. The enzyme catalysing this activity (NAA50) also catalyses the acetylation of certain N-terminal methionyl residues. That activity is classified as EC 2.3.1.258, N-terminal methionine Nα-acetyltransferase NatE. cf. EC 2.3.1.108, α-tubulin N-acetyltransferase.
History
created 2022
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992