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EC 2.3.1.180 Details
EC number
2.3.1.180
Accepted name
β-ketoacyl-[acyl-carrier-protein] synthase III
Reaction
acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2
Other name(s)
3-oxoacyl:ACP synthase III, 3-ketoacyl-acyl carrier protein synthase III, KASIII, KAS III, FabH, β-ketoacyl-acyl carrier protein synthase III, β-ketoacyl-ACP synthase III, β-ketoacyl (acyl carrier protein) synthase III, acetyl-CoA:malonyl-[acyl-carrier-protein] C-acyltransferase
Systematic name
acetyl-CoA:malonyl-[acyl-carrier protein] C-acyltransferase
CAS registry number
1048646-78-1
Comment
The enzyme is responsible for initiating straight-chain fatty acid biosynthesis by the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41, β-ketoacyl-[acyl-carrier-protein] synthase I, and EC 2.3.1.179, β-ketoacyl-[acyl-carrier-protein] synthase II, this enzyme specifically uses short-chain acyl-CoA thioesters (preferably acetyl-CoA) rather than acyl-[acp] as its substrate [1]. The enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent [1]. The enzymes from some organisms (e.g. the Gram-positive bacterium Streptococcus pneumoniae) can accept branched-chain acyl-CoAs in addition to acetyl-CoA [5] (cf. EC 2.3.1.300, branched-chain β-ketoacyl-[acyl-carrier-protein] synthase).
History
created 2006, modified 2021
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992