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EC 2.3.1.284 Details
EC number
2.3.1.284
Accepted name
3′-(hydroxy)phthioceranyl-2′-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
Reaction
3 3′-(hydroxy)phthioceranyl-2′-palmitoyl(stearoyl)-2-O-sulfo-α,α-trehalose = 3,6,6′-tris-(hydroxy)phthioceranyl-2-palmitoyl(stearoyl)-2′-sulfo-α-alpha-trehalose + 2 2′-palmitoyl/stearoyl-2-O-sulfo-α,α-trehalose
Other name(s)
chp1 (gene name)
Systematic name
3′-(hydroxy)phthioceranyl-2′-palmitoyl(stearoyl)-2-O-sulfo-α,α-trehalose:3′-(hydroxy)phthioceranyl-2′-palmitoyl(stearoyl)-2-O-sulfo-α,α-trehalose 6,6′-di(hydroxy)phthioceranyltransferase
Comment
The enzyme, present in mycobacteria, catalyses the ultimate step in the biosynthesis of mycobacterial sulfolipids. It catalyses two successive transfers of a (hydroxy)phthioceranyl group from two diacylated intermediates to third diacylated intermediate, generating the tetraacylated sulfolipid.
History
created 2019
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992