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EC 2.3.1.295 Details
EC number
2.3.1.295
Accepted name
mycoketide-CoA synthase
Reaction
a medium-chain acyl-CoA + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH + 22 H+ = a mycoketide-CoA + 10 CO2 + 10 CoA + 22 NADP+ + 11 H2O
Other name(s)
pks12 (gene name)
Systematic name
malonyl-CoA/(S)-methylmalonyl-CoA:heptanoyl-CoA malonyltransferase (mycoketide-CoA-forming)
Comment
The enzyme, found in mycobacteria, is involved in the synthesis of β-D-mannosyl phosphomycoketides. It is a very large polyketide synthase that contains two complete sets of FAS-like fatty acid synthase modules. It binds an acyl-CoA with 5-9 carbons as a starter unit, and extends it by five rounds of alternative additions of malonyl-CoA and methylmalonyl-CoA extender units. Depending on the starter unit, the enzyme forms mycoketide-CoAs of different lengths.
History
created 2019
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992