Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

EC 2.3.1.297 Details
EC number
2.3.1.297
Accepted name
very-long-chain ceramide synthase
Reaction
a very-long-chain fatty acyl-CoA + a sphingoid base = a very-long-chain ceramide + CoA
Other name(s)
sphingoid base N-very-long-chain fatty acyl-CoA transferase, mammalian ceramide synthase 2, CERS3 (gene name), LASS3 (gene name), LAG1 (gene name), LAC1 (gene name), LOH1 (gene name), LOH3 (gene name)
Systematic name
very-long-chain fatty acyl-CoA:sphingoid base N-acyltransferase
Comment
This entry describes ceramide synthase enzymes that are specific for very-long-chain fatty acyl-CoA substrates. The two isoforms from yeast and the plant LOH1 and LOH3 isoforms transfer 24:0 and 26:0 acyl chains preferentially and use phytosphingosine as the preferred sphingoid base. The mammalian CERS2 isoform is specific for acyl donors of 20-26 carbons, which can be saturated or unsaturated. The mammalian CERS3 isoform catalyses this activity, but has a broader substrate range and also catalyses the activity of EC 2.3.1.298, ultra-long-chain ceramide synthase. Both mammalian enzymes can use multiple sphingoid bases, including sphinganine, sphingosine, and phytosphingosine.
History
created 2019
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992