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EC 2.3.1.16 Details
EC number
2.3.1.16
Accepted name
acetyl-CoA C-acyltransferase
Reaction
acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA (overall reaction);;(1a) [acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine + acetyl-CoA = 3-oxoacyl-CoA + [acetyl-CoA C-acyltransferase]-L-cysteine;;(1b) acyl-CoA + [acetyl-CoA C-acyltransferase]-L-cysteine = [acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine + CoA
Other name(s)
β-ketothiolase,
3-ketoacyl-CoA thiolase,
KAT,
β-ketoacyl coenzyme A thiolase,
β-ketoacyl-CoA thiolase,
β-ketoadipyl coenzyme A thiolase,
β-ketoadipyl-CoA thiolase,
3-ketoacyl CoA thiolase,
3-ketoacyl coenzyme A thiolase,
3-ketoacyl thiolase,
3-ketothiolase,
3-oxoacyl-CoA thiolase,
3-oxoacyl-coenzyme A thiolase,
6-oxoacyl-CoA thiolase,
acetoacetyl-CoA β-ketothiolase,
acetyl-CoA acyltransferase,
ketoacyl-CoA acyltransferase,
ketoacyl-coenzyme A thiolase,
long-chain 3-oxoacyl-CoA thiolase,
oxoacyl-coenzyme A thiolase,
pro-3-ketoacyl-CoA thiolase,
thiolase I,
type I thiolase,
2-methylacetoacetyl-CoA thiolase [misleading]
Systematic name
acyl-CoA:acetyl-CoA C-acyltransferase
CAS registry number
9029-97-4
Comment
The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid β-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9, acetyl-CoA C-acetyltransferase.
History
created 1961, modified 2019
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992