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Information on EC 2.3.1.180 - beta-ketoacyl-[acyl-carrier-protein] synthase III

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IUBMB Comments
Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41 (beta-ketoacyl-ACP synthase I) and EC 2.3.1.179 (beta-ketoacyl-ACP synthase II), this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer . In addition to the above reaction, the enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent . The enzyme is responsible for initiating both straight- and branched-chain fatty-acid biosynthesis , with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism [2,5]. For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4-C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA [4,5].
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
kas iii, mtfabh, kasiii, beta-ketoacyl-acyl carrier protein synthase iii, beta-ketoacyl-acyl carrier protein (acp) synthase iii, beta-ketoacyl-acp synthase iii, ecfabh, acetoacetyl-acp synthase, 3-ketoacyl-acp synthase iii, 3-ketoacyl-acyl carrier protein synthase iii, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2
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