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Information on EC 2.3.1.258 - N-terminal methionine Nalpha-acetyltransferase NatE

for references in articles please use BRENDA:EC2.3.1.258
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IUBMB Comments
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis. It may also play a role in membrane targeting and gene silencing. NatE is found in all eukaryotic organisms and plays an important role in chromosome resolution and segregation. It specifically targets N-terminal L-methionine residues attached to Lys, Val, Ala, Tyr, Phe, Leu, Ser, and Thr. There is some substrate overlap with EC 2.3.1.256, N-terminal methionine Nalpha-acetyltransferase NatC. In addition, the acetylation of Met followed by small residues such as Ser, Thr, Ala, or Val suggests a kinetic competition between NatE and EC 3.4.11.18, methionyl aminopeptidase. The enzyme also has the activity of EC 2.3.1.48, histone acetyltransferase, and autoacetylates several of its own lysine residues.
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Word Map
  • 2.3.1.258
  • co-translational
  • chromatid
  • auxiliary
  • overload
  • acetylome
  • metazoan
  • substrate-specific
  • cohesin
  • congenic
  • nt-acetylation
  • ribosome-associated
  • medicine
The enzyme appears in viruses and cellular organisms
Synonyms
naa50, naa50/san, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + an N-terminal-L-methionyl-L-alanyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-alanyl-[protein] + CoA
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(1)
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acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA
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acetyl-CoA + an N-terminal-L-methionyl-L-lysyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-lysyl-[protein] + CoA
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(5)
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acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalany-[protein] + CoA
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(7)
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acetyl-CoA + an N-terminal-L-methionyl-L-seryl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-seryl-[protein] + CoA
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(2)
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acetyl-CoA + an N-terminal-L-methionyl-L-threonyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-threonyl-[protein] + CoA
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(4)
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acetyl-CoA + an N-terminal-L-methionyl-L-tyrosyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA
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(8)
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acetyl-CoA + an N-terminal-L-methionyl-L-valyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-valyl-[protein] + CoA
show the reaction diagram
(3)
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PATHWAY SOURCE
PATHWAYS
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