6.1.1.6: lysine-tRNA ligase
This is an abbreviated version!
For detailed information about lysine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.6
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6.1.1.6
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synthetases
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aminoacylation
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lysylation
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anticodon
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aarss
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isoacceptors
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diadenosine
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aspartyl-trna
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gagpol
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tetraphosphate
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trnalys3
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prors
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valrs
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leurs
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arginyl-trna
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isoleucyl-trna
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glnrs
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atp-ppi
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anticodon-binding
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prolyl-trna
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multi-trna
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asprs
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diagnostics
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pharmacology
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medicine
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drug development
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synthesis
- 6.1.1.6
- synthetases
- aminoacylation
- lysylation
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anticodon
-
aarss
-
isoacceptors
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diadenosine
- aspartyl-trna
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gagpol
- tetraphosphate
- trnalys3
- prors
- valrs
- leurs
- arginyl-trna
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isoleucyl-trna
- glnrs
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atp-ppi
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anticodon-binding
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prolyl-trna
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multi-trna
- asprs
- diagnostics
- pharmacology
- medicine
- drug development
- synthesis
Reaction
Synonyms
Ap4A synthase, BBA_03037, class 1 lysyl tRNA synthetase, class I LysRS, class I lysyl-tRNA synthetase, class II lysyl-tRNA synthetase, cyto-LysRS, cytoKARS, cytoplasmic lysyl-tRNA synthetase, FOSTERSO_4045, GsLysRS, hKRS, KARS, KRS, KRS-1, L-Lysine-transfer RNA ligase, lysine aminoacyl-tRNA synthetase, Lysine translase, Lysine--tRNA ligase, Lysine-tRNA synthetase, LysRS, LysRS-I, LysRS-II, LysRS1, LysRS2, lysS, lysS2, LysU, LysX, lysyl tRNA synthetase, Lysyl-transfer ribonucleate synthetase, Lysyl-transfer RNA synthetase, Lysyl-tRNA synthetase, lysylphosphatidylglycerol biosynthesis bifunctional protein, mito-LysRS, mitochondrial lysyl-tRNA synthetase, mitoKARS, More, Msk1p, MSMEG_3796, MSMEG_6094, MSMEI_3707, MXAN_4731, PF3D7_1350100, PfKRS, preMsk1p, Synthetase, lysyl-transfer ribonucleate, tRK1
ECTree
6.1.1.6 lysine-tRNA ligaseAdvanced search results
results (
results (KM Value
KM Value on EC 6.1.1.6 - lysine-tRNA ligase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.038
ATP
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aminoacylation reaction, recombinant mutant W332F, pH 8.0, 37°C
0.043
ATP
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aminoacylation reaction, recombinant wild-type enzyme, pH 8.0, 37°C
0.049
ATP
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aminoacylation reaction, recombinant mutant W314F, pH 8.0, 37°C
0.066
ATP
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aminoacylation reaction, recombinant mutant W314F/W332F, pH 8.0, 37°C
0.002
Borellia burgdorferi tRNALys
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recombinant enzyme, pH 7.2, 37°C
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0.0039
Escherichia coli G2.U71 tRNA
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recombinant enzyme, pH 7.2, 37°C
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0.0015
Escherichia coli wild type tRNA
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recombinant enzyme, pH 7.2, 37°C
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0.0066
L-lysine
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at 25°C, in 250 mM KCl, 100 mM HEPES, pH 7.5, 10 mM dithiothreitol, 10 mM MgCl2, 0.05 mg/ml bovine serum albumin
0.009
L-lysine
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ATP-diphosphate exchange reaction, recombinant wild-type enzyme and mutant W314F/W332F, pH 8.0, 37°C
0.01
L-lysine
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ATP-diphosphate exchange reaction, recombinant mutant W314F, pH 8.0, 37°C
0.016
L-lysine
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aminoacylation reaction, recombinant wild-type enzyme, pH 8.0, 37°C
0.017
L-lysine
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aminoacylation reaction, recombinant mutants W314F and W314F/W332F, pH 8.0, 37°C
0.018
L-lysine
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ATP-diphosphate exchange reaction, recombinant mutant W332F, pH 8.0, 37°C
0.022
L-lysine
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aminoacylation reaction, recombinant mutant W332F, pH 8.0, 37°C
0.023
L-lysine
recombinant T7-tagged enzyme, pH 8.0, 30°C
0.16
L-lysine
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wild type enzyme, in 100 mM HEPES (pH 7.2), 30 mM KCl, 10 mM MgCl2, at 37°C
0.2 - 1
L-lysine
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mutant enzyme A233S, in 100 mM HEPES (pH 7.2), 30 mM KCl, 10 mM MgCl2, at 37°C
3.9
L-lysine
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mutant enzyme G469A, in 100 mM HEPES (pH 7.2), 30 mM KCl, 10 mM MgCl2, at 37°C
8.1
L-lysine
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ATP-diphosphate exchange reaction, recombinant mutant Y271F, pH 8.0, 37°C
0.00074
tRNALys
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at 25°C, in 250 mM KCl, 100 mM HEPES, pH 7.5, 10 mM dithiothreitol, 10 mM MgCl2, 0.05 mg/ml bovine serum albumin
0.0034
tRNALys
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human wild-type tRNALys, 30°C, wild-type and N-terminally truncated mutant enzymes
1.4
tRNALysCUU
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wild type enzyme, at 37°C in 100 mM HEPES (pH 7.2), 25 mM KCl, 10 mM MgCl2, 4 mM dithiothreitol, and 5 mM ATP
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1.5
tRNALysGUU
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wild type enzyme, at 37°C in 100 mM HEPES (pH 7.2), 25 mM KCl, 10 mM MgCl2, 4 mM dithiothreitol, and 5 mM ATP
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0.87
tRNALysUUU
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wild type enzyme, at 37°C in 100 mM HEPES (pH 7.2), 25 mM KCl, 10 mM MgCl2, 4 mM dithiothreitol, and 5 mM ATP
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additional information
additional information
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Km values of ATP analogues in ATP-diphosphate exchange
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additional information
additional information
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binding kinetics of acceptor stem and anticodon domains of the tRNALys
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additional information
additional information
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Km-values of tRNALys variants
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