6.1.1.6: lysine-tRNA ligase

This is an abbreviated version!
For detailed information about lysine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.6

Reaction

ATP
+
L-lysine
+
tRNALys
=
AMP
+
diphosphate
+
L-lysyl-tRNALys

Synonyms

Lysyl-tRNA synthetase, Synthetase, lysyl-transfer ribonucleate, Lysyl-transfer ribonucleate synthetase, Lysyl-transfer RNA synthetase, L-Lysine-transfer RNA ligase, Lysine-tRNA synthetase, Lysine translase, More, Lysine--tRNA ligase, LysRS, LysRS-I, LysRS-II, LysRS2, LysRS1, class II lysyl-tRNA synthetase, class I lysyl-tRNA synthetase, lysine aminoacyl-tRNA synthetase, LysU, class 1 lysyl tRNA synthetase, mito-LysRS, cyto-LysRS, KRS-1, hKRS, GsLysRS, KARS, mitoKARS, cytoKARS, KRS, tRK1, class I LysRS, lysyl tRNA synthetase, LysX, cytoplasmic lysyl-tRNA synthetase, BBA_03037, PF3D7_1350100, PfKRS, lysS, MSMEG_6094, MSMEG_3796, lysS2, MSMEI_3707, lysylphosphatidylglycerol biosynthesis bifunctional protein, Ap4A synthase, MXAN_4731, mitochondrial lysyl-tRNA synthetase, preMsk1p, Msk1p, FOSTERSO_4045

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.6 lysine-tRNA ligase

KM Value

KM Value on EC 6.1.1.6 - lysine-tRNA ligase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
2-Chloroadenosine 5'-triphosphate
-
aminoacylation
1.5
AMP
-
5',5'''-P1,P4-tetraphosphate formation
0.00015 - 9.5
ATP
0.002 - 0.0043
Borellia burgdorferi tRNALys
-
0.0039 - 0.0063
Escherichia coli G2.U71 tRNA
-
0.0015 - 0.0019
Escherichia coli wild type tRNA
-
0.2
Formycin 5'-triphosphate
-
aminoacylation
0.003 - 0.0117
human tRNALys3
-
0.0025 - 0.0236
L-Lys
0.0013 - 8.1
L-lysine
0.0024 - 0.0047
Lys
0.000007 - 0.0057
tRNALys
0.00057
tRNALys from rat liver
-
-
-
0.00056 - 1.4
tRNALysCUU
-
0.00033 - 1.5
tRNALysGUU
-
0.0078
tRNALysU35C
-
human mutant tRNALys, 30°C
-
0.0095
tRNALysU36A
-
human mutant tRNALys, 30°C
-
0.0037
tRNALysU36C
-
human mutant tRNALys, 30°C
-
0.0018
tRNALysUGU
-
-
-
0.0028
tRNALysUUC
-
-
-
0.0004 - 5.1
tRNALysUUU
-
0.0015
tRNALysUUUmodified
-
-
-
0.00145
tRNATyrCUA
-
-
-
0.002 - 0.0028
yeast tRNALys
-
additional information
additional information
-