6.1.1.6: lysine-tRNA ligase

This is an abbreviated version!
For detailed information about lysine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.6

6.1.1.6

synthetases

aminoacylation

lysylation

anticodon

aarss

isoacceptors

diadenosine

aspartyl-trna

gagpol

tetraphosphate

trnalys3

prors

valrs

leurs

arginyl-trna

isoleucyl-trna

glnrs

atp-ppi

anticodon-binding

prolyl-trna

multi-trna

asprs

diagnostics

pharmacology

medicine

drug development

synthesis

Reaction

Synonyms

Ap4A synthase, BBA_03037, class 1 lysyl tRNA synthetase, class I LysRS, class I lysyl-tRNA synthetase, class II lysyl-tRNA synthetase, cyto-LysRS, cytoKARS, cytoplasmic lysyl-tRNA synthetase, FOSTERSO_4045, GsLysRS, hKRS, KARS, KRS, KRS-1, L-Lysine-transfer RNA ligase, lysine aminoacyl-tRNA synthetase, Lysine translase, Lysine--tRNA ligase, Lysine-tRNA synthetase, LysRS, LysRS-I, LysRS-II, LysRS1, LysRS2, lysS, lysS2, LysU, LysX, lysyl tRNA synthetase, Lysyl-transfer ribonucleate synthetase, Lysyl-transfer RNA synthetase, Lysyl-tRNA synthetase, lysylphosphatidylglycerol biosynthesis bifunctional protein, mito-LysRS, mitochondrial lysyl-tRNA synthetase, mitoKARS, More, Msk1p, MSMEG_3796, MSMEG_6094, MSMEI_3707, MXAN_4731, PF3D7_1350100, PfKRS, preMsk1p, Synthetase, lysyl-transfer ribonucleate, tRK1

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.6 lysine-tRNA ligase

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Results	in table
10	Activating Compound
51219	AA Sequence
7	Application
1	CAS Registry Number
47	Cloned(Commentary)
56	Cofactor
13	Crystallization (Commentary)
181	Disease/ Diagnostics
6	Expression
58	General Information
1	General Stability
9	IC50 Value
64	Inhibitors
3	kcat/KM [mM/s]
44	Ki Value [mM]
138	KM Value [mM]
53	Localization
27	Metals/Ions
38	Molecular Weight [Da]
64	Natural Substrates/ Products (Substrates)
728	Organism
4	Pathway
173	PDB ID
15	pH Optimum
1	pH Range
1	pH Stability
2	pI Value
9	Posttranslational Modification
99	Protein Variants
46	Purification (Commentary)
13	Reaction
46	Reaction Type
170	Reference
52	Source Tissue
15	Specific Activity [micromol/min/mg]
4	Storage Stability
251	Substrates and Products (Substrate)
32	Subunits
474	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
130	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 6.1.1.6 - lysine-tRNA ligase

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AMP

Rattus norvegicus

stimulation of diadenosine 5',5'''-P1,P4-tetraphosphate synthetase activity

500

aspartyl-tRNA synthetase

Homo sapiens

Q15046

EC 6.1.1.12, AspRS, from the multi-synthetase complex. HKRS and hKRSDELTA60 are differentially stimulated by

690704

Diphosphatase

2 entries

dithiothreitol

Escherichia coli

activates 30fold the aminoacylation raection

649906

epidermal growth factor receptor

Homo sapiens

Q15046

activation of LysRS by epidermal growth factor receptor (EGFR)

745950

syntenin-1

Homo sapiens

Q15046

tandem PDZ protein, regulates KRS activity, adaptor modulating the activity of KRS. A point mutation in the PDZ2 domain of syntenin-1 abrogates interaction with KRS

693871

translation elongation factor 1alpha

Homo sapiens

Q15046

EF1alpha, hKRSDELTA60 binds to EF1alpha and is stimulated by EF1alpha in vitro

690704

additional information

3 entries