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Literature summary for 6.1.1.6 extracted from

  • Soell, D.; Becker, H.D.; Plateau, P.; Blanquet, S.; Ibba, M.
    Context-dependent anticodon recognition by class I lysyl-tRNA synthetases (2000), Proc. Natl. Acad. Sci. USA, 97, 14224-14228.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpresssion of His-tagged enzyme in Escherichia coli Helicobacter pylori

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00033
-
tRNALysGUU
-
Borreliella burgdorferi
0.0004
-
tRNALysUUU
-
Borreliella burgdorferi
0.00056
-
tRNALysCUU
-
Borreliella burgdorferi
0.0015
-
tRNALysUUUmodified
-
Borreliella burgdorferi
0.0018
-
tRNALysUGU
-
Borreliella burgdorferi
0.0028
-
tRNALysUUC
-
Borreliella burgdorferi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-lysine + tRNALys Helicobacter pylori
-
AMP + L-lysyl-tRNALys + diphosphate
-
?
ATP + L-lysine + tRNALys Methanococcus maripaludis
-
AMP + L-lysyl-tRNALys + diphosphate
-
?
ATP + L-lysine + tRNALys Borreliella burgdorferi
-
AMP + L-lysyl-tRNALys + diphosphate
-
?
additional information Helicobacter pylori phylogenetic comparison ?
-
?
additional information Methanococcus maripaludis phylogenetic comparison ?
-
?
additional information Borreliella burgdorferi phylogenetic comparison ?
-
?

Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi
-
recombinant purified bacterial class I enzyme
-
Helicobacter pylori
-
gene lysS, class II enzyme
-
Methanococcus maripaludis
-
recombinant purified archaeal class I enzyme
-

Purification (Commentary)

Purification (Comment) Organism
recombinant from overexpressing Escherichia coli Helicobacter pylori

Reaction

Reaction Comment Organism Reaction ID
ATP + L-lysine + tRNALys = AMP + diphosphate + L-lysyl-tRNALys bases N73, U35 and U36 play an important role in tRNA substrate recognition Borreliella burgdorferi

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Helicobacter pylori

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-lysine + tRNALys
-
Helicobacter pylori AMP + L-lysyl-tRNALys + diphosphate
-
?
ATP + L-lysine + tRNALys
-
Methanococcus maripaludis AMP + L-lysyl-tRNALys + diphosphate
-
?
ATP + L-lysine + tRNALys
-
Borreliella burgdorferi AMP + L-lysyl-tRNALys + diphosphate
-
?
ATP + L-lysine + tRNALys tRNA substrate from Escherichia coli, bases N73, and U36 play an important role in tRNA substrate recognition Methanococcus maripaludis AMP + L-lysyl-tRNALys + diphosphate
-
?
ATP + L-lysine + tRNALys tRNA substrate from Escherichia coli, bases U35 and U36 play an important role in tRNA substrate recognition Helicobacter pylori AMP + L-lysyl-tRNALys + diphosphate
-
?
ATP + L-lysine + tRNALysCUU anticodon variant tRNA substrate from Escherichia coli Borreliella burgdorferi AMP + L-lysyl-tRNALysCUU + diphosphate
-
?
ATP + L-lysine + tRNALysGUU anticodon variant tRNA substrate from Escherichia coli Borreliella burgdorferi AMP + L-lysyl-tRNALysGUU + diphosphate
-
?
ATP + L-lysine + tRNALysUGU anticodon variant tRNA substrate from Escherichia coli Borreliella burgdorferi AMP + L-lysyl-tRNALysUGU + diphosphate
-
?
ATP + L-lysine + tRNALysUUC anticodon variant tRNA substrate from Escherichia coli Borreliella burgdorferi AMP + L-lysyl-tRNALysUUC + diphosphate
-
?
ATP + L-lysine + tRNALysUUU anticodon variant tRNA substrate from Escherichia coli Borreliella burgdorferi AMP + L-lysyl-tRNALysUUU + diphosphate
-
?
ATP + L-lysine + tRNALysUUUmodified anticodon variant tRNA substrate from Escherichia coli, t6 modification of base A37 Borreliella burgdorferi AMP + L-lysyl-tRNALysUUUmodified + diphosphate
-
?
additional information phylogenetic comparison Helicobacter pylori ?
-
?
additional information phylogenetic comparison Methanococcus maripaludis ?
-
?
additional information phylogenetic comparison Borreliella burgdorferi ?
-
?

Synonyms

Synonyms Comment Organism
L-Lysine-transfer RNA ligase
-
Helicobacter pylori
L-Lysine-transfer RNA ligase
-
Methanococcus maripaludis
L-Lysine-transfer RNA ligase
-
Borreliella burgdorferi
Lysine translase
-
Helicobacter pylori
Lysine translase
-
Methanococcus maripaludis
Lysine translase
-
Borreliella burgdorferi
Lysine--tRNA ligase
-
Helicobacter pylori
Lysine--tRNA ligase
-
Methanococcus maripaludis
Lysine--tRNA ligase
-
Borreliella burgdorferi
Lysine-tRNA synthetase
-
Helicobacter pylori
Lysine-tRNA synthetase
-
Methanococcus maripaludis
Lysine-tRNA synthetase
-
Borreliella burgdorferi
LysRS
-
Helicobacter pylori
LysRS
-
Methanococcus maripaludis
LysRS
-
Borreliella burgdorferi
Lysyl-transfer ribonucleate synthetase
-
Helicobacter pylori
Lysyl-transfer ribonucleate synthetase
-
Methanococcus maripaludis
Lysyl-transfer ribonucleate synthetase
-
Borreliella burgdorferi
Lysyl-transfer RNA synthetase
-
Helicobacter pylori
Lysyl-transfer RNA synthetase
-
Methanococcus maripaludis
Lysyl-transfer RNA synthetase
-
Borreliella burgdorferi
Lysyl-tRNA synthetase
-
Helicobacter pylori
Lysyl-tRNA synthetase
-
Methanococcus maripaludis
Lysyl-tRNA synthetase
-
Borreliella burgdorferi
Synthetase, lysyl-transfer ribonucleate
-
Helicobacter pylori
Synthetase, lysyl-transfer ribonucleate
-
Methanococcus maripaludis
Synthetase, lysyl-transfer ribonucleate
-
Borreliella burgdorferi

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00018
-
tRNALysUUC
-
Borreliella burgdorferi
0.0004
-
tRNALysUGU
-
Borreliella burgdorferi
0.0095
-
tRNALysUUU
-
Borreliella burgdorferi
0.0095
-
tRNALysGUU
-
Borreliella burgdorferi
0.014
-
tRNALysCUU
-
Borreliella burgdorferi
0.12
-
tRNALysUUUmodified
-
Borreliella burgdorferi

Cofactor

Cofactor Comment Organism Structure
ATP
-
Helicobacter pylori
ATP
-
Methanococcus maripaludis
ATP
-
Borreliella burgdorferi