6.1.1.6: lysine-tRNA ligase

This is an abbreviated version!
For detailed information about lysine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.6

Reaction

ATP
+
L-lysine
+
tRNALys
=
AMP
+
diphosphate
+
L-lysyl-tRNALys

Synonyms

Lysyl-tRNA synthetase, Synthetase, lysyl-transfer ribonucleate, Lysyl-transfer ribonucleate synthetase, Lysyl-transfer RNA synthetase, L-Lysine-transfer RNA ligase, Lysine-tRNA synthetase, Lysine translase, More, Lysine--tRNA ligase, LysRS, LysRS-I, LysRS-II, LysRS2, LysRS1, class II lysyl-tRNA synthetase, class I lysyl-tRNA synthetase, lysine aminoacyl-tRNA synthetase, LysU, class 1 lysyl tRNA synthetase, mito-LysRS, cyto-LysRS, KRS-1, hKRS, GsLysRS, KARS, mitoKARS, cytoKARS, KRS, tRK1, class I LysRS, lysyl tRNA synthetase, LysX, cytoplasmic lysyl-tRNA synthetase, BBA_03037, PF3D7_1350100, PfKRS, lysS, MSMEG_6094, MSMEG_3796, lysS2, MSMEI_3707, lysylphosphatidylglycerol biosynthesis bifunctional protein, Ap4A synthase, MXAN_4731, mitochondrial lysyl-tRNA synthetase, preMsk1p, Msk1p, FOSTERSO_4045

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.6 lysine-tRNA ligase

Substrates Products

Substrates Products on EC 6.1.1.6 - lysine-tRNA ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-chloroadenosine 5'-triphosphate + lysine + tRNALys
2-chloroadenosine 5'-monophosphate + Lys-tRNALys + diphosphate
show the reaction diagram
-
-
-
-
?
AMP + ATP
diadenosine 5',5''-P1,P4-tetraphosphate + ?
show the reaction diagram
-
-
-
?
AMP + diphosphate + L-arginyl-tRNALys
ATP + L-arginine + tRNALys
show the reaction diagram
-
-
-
-
r
AMP + diphosphate + L-lysyl-tRNALys
ATP + L-lysine + tRNALys
show the reaction diagram
-
-
-
-
r
AMP + diphosphate + L-methionyl-tRNALys
ATP + L-methionine + tRNALys
show the reaction diagram
-
-
-
-
r
AMP + L-threonyl-tRNALys + diphosphate
ATP + L-threonine + tRNALys
show the reaction diagram
-
-
-
-
r
ATP + 4-aminobutanoate + tRNALys
AMP + 4-aminobutyryl-tRNALys + diphosphate
show the reaction diagram
-
-
-
?
ATP + ATP
diadenosine 5',5''-P1,P3-triphosphate + ?
show the reaction diagram
-
-
-
-
?
ATP + ATP
diadenosine 5',5''-P1,P4-tetraphosphate + diphosphate
show the reaction diagram
ATP + D-lysine + tRNALys
AMP + D-lysyl-tRNALys + diphosphate
show the reaction diagram
-
-
-
?
ATP + L-alanine + tRNALys
AMP + L-alanyl-tRNALys + diphosphate
show the reaction diagram
-
264000fold lower activity than with L-lysine, deacylation of the mischarged tRNALys, addition of 2 mM L-lysine abolishes the reaction
-
r
ATP + L-arginine + tRNALys
AMP + L-arginyl-tRNALys + diphosphate
show the reaction diagram
ATP + L-cysteine + tRNALys
AMP + L-cysteinyl-tRNALys + diphosphate
show the reaction diagram
-
750000fold lower activity than with L-lysine, deacylation of the mischarged tRNALys, addition of 2 mM L-lysine abolishes the reaction
-
r
ATP + L-glutamate + tRNALys
AMP + L-glutamyl-tRNALys + diphosphate
show the reaction diagram
-
low activity
-
?
ATP + L-leucine + tRNALys
AMP + L-leucyl-tRNALys + diphosphate
show the reaction diagram
-
132000fold lower activity than with L-lysine, addition of 2 mM L-lysine abolishes the reaction
-
r
ATP + L-lysinamide + tRNALys
AMP + L-aminolysyl-tRNALys + diphosphate
show the reaction diagram
-
low activity
-
?
ATP + L-lysine
?
show the reaction diagram
-
a small fraction of lysine is converted to lysine lactam in absence or presence of tRNALys
-
?
ATP + L-lysine + Borellia burgdorferi tRNALys
AMP + diphosphate + L-lysyl-tRNALys
show the reaction diagram
ATP + L-lysine + Escherichia coli G2.U71 tRNA
?
show the reaction diagram
ATP + L-lysine + Escherichia coli G2.U71 tRNALys
AMP + diphosphate + L-lysyl-tRNALys
show the reaction diagram
ATP + L-lysine + Escherichia coli tRNALys
AMP + diphosphate + L-lysyl-tRNALys
show the reaction diagram
-
-
-
-
r
ATP + L-lysine + Escherichia coli tRNALys CNBr-treated
AMP + diphosphate + L-lysyl-tRNALys CNBr-treated
show the reaction diagram
-
-
-
-
r
ATP + L-lysine + Escherichia coli wild type tRNA
?
show the reaction diagram
ATP + L-lysine + Escherichia coli wild type tRNALys
AMP + diphosphate + L-lysyl-tRNALys
show the reaction diagram
ATP + L-lysine + human tRNALys3
AMP + diphosphate + L-lysyl-tRNALys3
show the reaction diagram
-
-
-
-
?
ATP + L-lysine + Methanococcus maripaludis tRNALys
AMP + diphosphate + L-lysyl-tRNALys
show the reaction diagram
-
-
-
-
r
ATP + L-lysine + Methanococcus maripaludis tRNALys CNBr-treated
AMP + diphosphate + L-lysyl-tRNALys CNBr-treated
show the reaction diagram
-
-
-
-
r
ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
show the reaction diagram
ATP + L-lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
show the reaction diagram
ATP + L-lysine + tRNALys from rat liver
AMP + diphosphate + L-lysyl-tRNALys
show the reaction diagram
-
-
-
-
?
ATP + L-lysine + tRNALysCUU
AMP + L-lysyl-tRNALysCUU + diphosphate
show the reaction diagram
ATP + L-lysine + tRNALysGUU
AMP + L-lysyl-tRNALysGUU + diphosphate
show the reaction diagram
ATP + L-lysine + tRNALysUCU
AMP + L-lysyl-tRNALysUCU + diphosphate
show the reaction diagram
-
-
-
-
?
ATP + L-lysine + tRNALysUGU
AMP + L-lysyl-tRNALysUGU + diphosphate
show the reaction diagram
ATP + L-lysine + tRNALysUUC
AMP + L-lysyl-tRNALysUUC + diphosphate
show the reaction diagram
ATP + L-lysine + tRNALysUUG
AMP + L-lysyl-tRNALysUUG + diphosphate
show the reaction diagram
-
-
-
-
?
ATP + L-lysine + tRNALysUUU
AMP + L-lysyl-tRNALysUUU + diphosphate
show the reaction diagram
ATP + L-lysine + tRNALysUUUmodified
AMP + L-lysyl-tRNALysUUUmodified + diphosphate
show the reaction diagram
-
anticodon variant tRNA substrate from Escherichia coli, t6 modification of base A37
-
?
ATP + L-lysine + tRNATyrCUA
AMP + L-lysyl-tRNATyrCUA + diphosphate
show the reaction diagram
-
has a weak activity to tRNATyrCUA with L-lysine
-
-
?
ATP + L-lysine + yeast tRNALys
AMP + diphosphate + L-lysyl-tRNALys
show the reaction diagram
-
-
-
-
?
ATP + L-lysine amide + tRNALys
AMP + L-amino-lysyl-tRNALys + diphosphate
show the reaction diagram
-
-
-
r
ATP + L-lysine ethyl ester + tRNALys
AMP + ethyl-L-lysyl-tRNALys + diphosphate
show the reaction diagram
ATP + L-lysine hydroxamate + tRNALys
AMP + L-lysine hydroxamoyl-tRNALys + diphosphate
show the reaction diagram
ATP + L-lysine methyl ester + tRNALys
AMP + methyl-L-lysyl-tRNALys + diphosphate
show the reaction diagram
ATP + L-methionine + tRNALys
AMP + L-methionyl-tRNALys + diphosphate
show the reaction diagram
-
32000fold lower activity than with L-lysine, addition of 2 mM L-lysine abolishes the reaction
-
r
ATP + L-ornithine
?
show the reaction diagram
-
L-ornithine is converted to ornithine lactam in absence or presence of tRNALys
-
?
ATP + L-serine + tRNALys
AMP + L-seryl-tRNALys + diphosphate
show the reaction diagram
-
562000fold lower activity than with L-lysine, deacylation of the mischarged tRNALys, addition of 2 mM L-lysine abolishes the reaction
-
r
ATP + L-threonine + tRNALys
AMP + L-threonyl-tRNALys + diphosphate
show the reaction diagram
-
16000fold lower activity than with L-lysine, addition of 2 mM L-lysine abolishes the reaction
-
r
ATP + lysine + tRNALys
?
show the reaction diagram
-
primary role is the translation of genetic information into protein structure
-
-
?
ATP + lysine + tRNALys
AMP + L-lysyl-tRNALys + diphosphate
show the reaction diagram
ATP + lysine + tRNALys,3'-59mer
AMP + L-lysyl-tRNALys, 3'-59mer + diphosphate
show the reaction diagram
-
human tRNALys mutant
-
?
ATP + lysine + tRNALysU35A
AMP + L-lysyl-tRNALysU35A + diphosphate
show the reaction diagram
-
human tRNALys mutant, from in vitro translation, very low activity
-
?
ATP + lysine + tRNALysU35C
AMP + L-lysyl-tRNALysU35C + diphosphate
show the reaction diagram
-
human tRNALys mutant, from in vitro translation, 153fold decreased activity compared to the wild-type
-
?
ATP + lysine + tRNALysU36A
AMP + L-lysyl-tRNALysU36A + diphosphate
show the reaction diagram
-
human tRNALys mutant, from in vitro translation, 182fold decreased activity compared to the wild-type
-
?
ATP + lysine + tRNALysU36C
AMP + L-lysyl-tRNALysU36C + diphosphate
show the reaction diagram
-
human tRNALys mutant, from in vitro translation, 11fold decreased activity compared to the wild-type
-
?
ATP + ornithine + tRNALys
AMP + ornithyl-tRNALys + diphosphate
show the reaction diagram
dATP + lysine + tRNALys
dAMP + L-lysyl-tRNALys + diphosphate
show the reaction diagram
-
-
-
-
?
formycin 5'-triphosphate + L-lysine + tRNALys
formycin 5'-monophosphate + diphosphate + L-lysyl-tRNALys
show the reaction diagram
-
-
-
-
?
additional information
?
-