6.1.1.6: lysine-tRNA ligase

This is an abbreviated version!
For detailed information about lysine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.6

Reaction

ATP
+
L-lysine
+
tRNALys
=
AMP
+
diphosphate
+
L-lysyl-tRNALys

Synonyms

Lysyl-tRNA synthetase, Synthetase, lysyl-transfer ribonucleate, Lysyl-transfer ribonucleate synthetase, Lysyl-transfer RNA synthetase, L-Lysine-transfer RNA ligase, Lysine-tRNA synthetase, Lysine translase, More, Lysine--tRNA ligase, LysRS, LysRS-I, LysRS-II, LysRS2, LysRS1, class II lysyl-tRNA synthetase, class I lysyl-tRNA synthetase, lysine aminoacyl-tRNA synthetase, LysU, class 1 lysyl tRNA synthetase, mito-LysRS, cyto-LysRS, KRS-1, hKRS, GsLysRS, KARS, mitoKARS, cytoKARS, KRS, tRK1, class I LysRS, lysyl tRNA synthetase, LysX, cytoplasmic lysyl-tRNA synthetase, BBA_03037, PF3D7_1350100, PfKRS, lysS, MSMEG_6094, MSMEG_3796, lysS2, MSMEI_3707, lysylphosphatidylglycerol biosynthesis bifunctional protein, Ap4A synthase, MXAN_4731, mitochondrial lysyl-tRNA synthetase, preMsk1p, Msk1p, FOSTERSO_4045

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.6 lysine-tRNA ligase

Temperature Stability

Temperature Stability on EC 6.1.1.6 - lysine-tRNA ligase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40
-
5 min, 80% loss of activity
50
-
stable below, pH 8.0, 5 h
60
-
after 4 h complete loss of aminoacylation activity, 3 min, stable in presence of all substrates except lysine
70
-
0.5 min, stable in presence of all substrates except lysine
additional information
-
24 S complex lysyl-tRNA synthetase activity is more resistant to thermal inactivation than the 6S free lysyl-tRNA synthetase activity at 30°C, 37°C and 43°C