6.1.1.14: glycine-tRNA ligase
This is an abbreviated version!
For detailed information about glycine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.14
-
6.1.1.14
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cord
-
glycinergic
-
postsynaptic
-
strychnine
-
alpha1
-
synthetases
-
synapses
-
ligand-gated
-
aminoacyl-trna
-
homomeric
-
gabaars
-
neurotransmission
-
electrophysiological
-
aminoacylation
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charcot-marie-tooth
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strychnine-sensitive
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gephyrin
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patch-clamp
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hyperekplexia
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presynaptic
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heteromeric
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startle
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pentameric
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gabaergic
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extrasynaptic
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picrotoxin
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glycylation
-
glycine-induced
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single-channel
-
glycine-activated
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cys-loop
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anticodon
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mipscs
-
subunit-specific
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bicuculline
-
glycine-gated
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outside-out
-
subunit-containing
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alars
-
two-electrode
-
alpha2beta
-
mesolimbic
-
pore-lining
-
hisrs
-
glycine-mediated
-
accumbal
-
gabaar-mediated
-
molecular biology
-
medicine
- 6.1.1.14
- cord
-
glycinergic
-
postsynaptic
- strychnine
- alpha1
- synthetases
-
synapses
-
ligand-gated
- aminoacyl-trna
-
homomeric
-
gabaars
-
neurotransmission
-
electrophysiological
- aminoacylation
- charcot-marie-tooth
-
strychnine-sensitive
-
gephyrin
-
patch-clamp
- hyperekplexia
-
presynaptic
-
heteromeric
-
startle
-
pentameric
-
gabaergic
-
extrasynaptic
- picrotoxin
-
glycylation
-
glycine-induced
-
single-channel
-
glycine-activated
-
cys-loop
-
anticodon
-
mipscs
-
subunit-specific
- bicuculline
-
glycine-gated
-
outside-out
-
subunit-containing
- alars
-
two-electrode
-
alpha2beta
-
mesolimbic
-
pore-lining
- hisrs
-
glycine-mediated
-
accumbal
-
gabaar-mediated
- molecular biology
- medicine
Reaction
Synonyms
Glycyl-tRNA synthetase, Synthetase, glycyl-transfer ribonucleate, Glycyl-transfer ribonucleate synthetase, Glycyl-transfer RNA synthetase, Glycyl-transfer ribonucleic acid synthetase, Glycyl translase, GlyRS, More, Glycine--tRNA ligase, GARS, glycyl-tRNA synthetase 1, GRS1, GlyRS2, GlyRS1, glycyl tRNA synthetase
ECTree
6.1.1.14 glycine-tRNA ligaseAdvanced search results
results (
results (Results
in table
73392
30
109
44
37
157
Natural Substrates Products
Natural Substrates Products on EC 6.1.1.14 - glycine-tRNA ligase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + glycine + tRNAGly
?
-
insertion of glycine into proteins
-
-
?
ATP + glycine + tRNAGly
?
-
insertion of glycine into proteins
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
enzyme mutations with reduced enzyme activity cause distal spinal muscular atrophy type V or Charcot-Marie-Tooth type 2D, i.e. dSMAV/CMT2D
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
GlyRS allelic variants are causally associated with the Charcot-Marie-Tooth disease, the most common genetic disorder of the peripheral nervous system
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
GlyRS mutations cause Charcot-Marie-Tooth peripheral neuropathies, at least 10 different mutant alleles, overview
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
GlyRS mutations cause Charcot-Marie-Tooth peripheral neuropathies, the most common heritable disease of the peripheral nervous system, overview
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
mutations in the enzyme cause Charcot-Marie-Tooth disease type 2D, CMT2D, and distal spinal muscular atrophy type V, dSMA-V, axonal neuropathies characterized by a phenotype that is more severe in the upper extremities, in most cases, mutant GARS protein mislocalizes in neuronal cells
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
enzyme mutation Nmf249 causes Charcot-Marie-Tooth peripheral neuropathy type 2D, overview
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
Saccharomyces cerevisiae ATCC 204508
-
-
-
?
ATP + glycine + tRNAGly
AMP + diphosphate + glycyl-tRNAGly
-
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
enzyme plays an important role in transcription termination by affecting 3'-end formation
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
additional information
?
-
-
participates in peptidoglycan synthesis
-
-
?
additional information
?
-
-
participates in peptidoglycan synthesis
-
-
?
additional information
?
-
-
in a side reaction the enzyme also synthesizes dinucleoside polyphosphates, which probably participate in regulation of cell function
-
-
?
