6.1.1.14: glycine-tRNA ligase

This is an abbreviated version!
For detailed information about glycine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.14

Reaction

ATP
+
glycine
+
tRNAGly
=
AMP
+
diphosphate
+
glycyl-tRNAGly

Synonyms

Glycyl-tRNA synthetase, Synthetase, glycyl-transfer ribonucleate, Glycyl-transfer ribonucleate synthetase, Glycyl-transfer RNA synthetase, Glycyl-transfer ribonucleic acid synthetase, Glycyl translase, GlyRS, More, Glycine--tRNA ligase, GARS, glycyl-tRNA synthetase 1, GRS1, GlyRS2, GlyRS1, glycyl tRNA synthetase

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.14 glycine-tRNA ligase

Inhibitors

Inhibitors on EC 6.1.1.14 - glycine-tRNA ligase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5'-adenylylimidodiphosphate
-
i.e. AMPPNP, a nonsubstrate ATP analogue, competitive inhibition
5,5'-dithiobis(2-nitrobenzoate)
-
-
adenylylmethylenediphosphate
-
i.e. AMPPCP, a nonsubstrate ATP analogue, competitive inhibition
alpha,beta-methyleneadenosine 5'-diphosphate
-
i.e. AMPCPP, a nonsubstrate ATP analogue, competitive inhibition
Aminoethyl-AMP
-
-
glycyl sulfamoyl adenosine
-
-
Inorganic sulfide
-
activity is restored by addition of glutathione, cysteine or cysteamine
-
KCl
-
inhibits acylation of yeast tRNA, little effect on acylation of homologous tRNAGly
Nalidixic acid
-
-
novobiocin
-
-
Oxolinic acid
-
-
p-chloromercuribenzoate
p-chloromercuriphenylsulfonic acid
-
activity is not restored by treatment with 2-mercaptoethanol
phosphate
spermine
-
-
additional information
-
reversible denaturation by urea or guanidine-HCl, wild-type enzyme and N-terminally truncated mutant both dissociate to monomers and exhibit a cooperative transition at higher denaturant concentration, wild-type unfolds by a multistate process and 2 parallel state unfoldings, which are absent in the truncated mutant
-