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Literature summary for 6.1.1.14 extracted from

  • Deng, X.; Qin, X.; Chen, L.; Jia, Q.; Zhang, Y.; Zhang, Z.; Lei, D.; Ren, G.; Zhou, Z.; Wang, Z.; Li, Q.; Xie, W.
    Large conformational changes of insertion 3 in human glycyl-tRNA synthetase (hGlyRS) during catalysis (2016), J. Biol. Chem., 291, 5740-5752 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.14

Crystallization (Commentary)

Crystallization (Comment) Organism
apo form of full-length E71G mutant and tRNA-bound mutant complex E71G/C157R, vapor diffusion method, using 13-15% (w/v) PEG 6000, 0.1 M sodium citrate buffer (pH 5.5), and 0.1 M NaCl Homo sapiens

Protein Variants

Protein Variants Comment Organism
C157R the activity of the mutant enzyme is 62% of wild type Homo sapiens
E71G the mutant shows slightly elevated aminoacylation activity over wild type Homo sapiens
E71G/C157R the activity of the mutant enzyme is 20% of wild type Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + glycine + tRNAGly Homo sapiens
-
 AMP + diphosphate + glycyl-tRNAGly
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P41250
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycine + tRNAGly
-
 Homo sapiens AMP + diphosphate + glycyl-tRNAGly
-
 ?

Synonyms

Synonyms Comment Organism
Glycyl-tRNA synthetase
-
 Homo sapiens
GlyRS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens