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6.1.1.14: glycine-tRNA ligase

This is an abbreviated version!
For detailed information about glycine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.14

Reaction

ATP
+
glycine
 +
tRNAGly
=
AMP
 +
diphosphate
 +
glycyl-tRNAGly

Synonyms

GARS, Glycine--tRNA ligase, Glycyl translase, glycyl tRNA synthetase, Glycyl-transfer ribonucleate synthetase, Glycyl-transfer ribonucleic acid synthetase, Glycyl-transfer RNA synthetase, Glycyl-tRNA synthetase, glycyl-tRNA synthetase 1, GlyRS, GlyRS1, GlyRS2, GRS1, More, Synthetase, glycyl-transfer ribonucleate

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.14 glycine-tRNA ligase

General Information

General Information on EC 6.1.1.14 - glycine-tRNA ligase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
the essential enzyme for protein synthesis also plays a critical role in neddylation by specifically binding to NEDD8 and enhancing neddylation. The enzyme preferentially binds and protects Ubc12N8 and E, and regulates cell cycle progression
physiological function
-
glycyl-tRNA synthetase specifically binds to the poliovirus internal ribosome entry site to activate translation initiation