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4.1.2.13: fructose-bisphosphate aldolase

This is an abbreviated version!
For detailed information about fructose-bisphosphate aldolase, go to the full flat file.

Word Map on EC 4.1.2.13

Reaction

D-fructose 1,6-bisphosphate
=
glycerone phosphate
 +
D-glyceraldehyde 3-phosphate

Synonyms

1,6-Diphosphofructose aldolase, 37 kDa major allergen, 41 kDa antigen, ALD, ALDC, aldoA, Aldob, aldolase, aldolase A, aldolase B, aldolase C, aldolase, fructose diphosphate, ALDP, bifunctional fructose-1,6-bisphosphate aldolase/phosphatase, Brain-type aldolase, Ca-FBA-II, CE1, CE2, class I Fba, class I fructose 1,6-bisphosphate aldolase, class I fructose bisphosphate aldolase, class I fructose-1,6-bisphosphate aldolase, class I muscle fructose bis-phosphate aldolase, class II aldolase, class II FBA, class II FBP aldolase, class II fructose 1,6-bisphosphate aldolase, class II fructose bisphosphate aldolase, class II fructose-1,6-bisphosphate aldolase, class IIa fructose 1,6-bisphosphate aldolase, class IIb fructose 1,6-bisphosphate aldolase, ClassII FBP-aldolase, CoFBA1, CoFBA2, CoFBA3, CoFBA4, D-fructose-1,6-bisphosphate aldolase, D-fructose-1,6-bisphosphate D-glyceraldehyde-3-P-lyase, D-fructose-6-phosphate aldolase, Diphosphofructose aldolase, DLF, EC 4.1.2.7, F1,6-P2 aldolase, F1,6P2 aldolase, F16BP aldolase, FBA, FBA class II, FBA-II, Fba1, Fba1p, Fba2, FBA7, FbaA, FbaB, FbaC, FBAld, FbaP, FBP aldolase, FBP aldolase/phosphatase, FBP-aldolase, FBPA, FBPA I, FBPA-1, FBPA/P, FDP aldolase, FPA, Fru-1,6-P2 aldolase, Fru-P2A, Fructoaldolase, fructose 1,6 bisphosphate aldolase, fructose 1,6-bisphosphatase/aldolase, Fructose 1,6-bisphosphate aldolase, fructose 1,6-bisphosphate aldolase/phosphatase, Fructose 1,6-diphosphate aldolase, Fructose 1-monophosphate aldolase, Fructose 1-phosphate aldolase, fructose bis-phosphate aldolase, Fructose bisphosphate aldolase, Fructose diphosphate aldolase, fructose-1,6-biphosphate aldolase, fructose-1,6-bisphosphate (FBP) aldolase/phosphatase, fructose-1,6-bisphosphate aldolase, fructose-1,6-bisphosphate aldolase A, fructose-1,6-bisphosphate aldolase B, fructose-1,6-bisphosphate aldolase class II, fructose-1,6-bisphosphate aldolase/phosphatase, fructose-1,6-bisphosphate muscle aldolase, Fructose-1,6-bisphosphate triosephosphate-lyase, fructose-bisphosphate aldolase, fructose-bisphosphate aldolase A, FSA, fuculose aldolase, heat-induced protein 44, HIP44, IgE-binding allergen, ketose 1-phosphate aldolase, Leishmania aldolase, Liver-type aldolase, MGA3_01355, MJ0400-His6, More, MtFBA, Muscle-type aldolase, Ov-fba-1, OvFBPA-1, Pcal_0111, Phosphofructoaldolase, SMALDO, SSO0286, STK_03180, TgALD1, Tneu_0133, TnFBPAP, Tt-FBPA, zerebrin II, zymohexase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.13 fructose-bisphosphate aldolase

KI Value

KI Value on EC 4.1.2.13 - fructose-bisphosphate aldolase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0017 - 0.23
(2E)-1-(4-nitrophenyl)-2-[(4-nitrophenyl)methylidene]hydrazine
0.11
([3-hydroxy-2-oxo-4-[(phosphonomethoxy)methyl]pyridin-1(2H)-yl]methyl)phosphonic acid
-
at pH 7.5 and 25°C
0.014
([3-hydroxy-2-oxo-4-[2-(phosphonooxy)ethyl]pyridin-1(2H)-yl]methyl)phosphonic acid
-
at pH 7.5 and 25°C
0.09
([3-hydroxy-4-[(1R)-1-hydroxy-2-(phosphonooxy)ethyl]-2-oxopyridin-1(2H)-yl]methyl)phosphonic acid
-
at pH 7.5 and 25°C
0.01
([3-hydroxy-4-[(1S)-1-hydroxy-2-(phosphonooxy)ethyl]-2-oxopyridin-1(2H)-yl]methyl)phosphonic acid
-
at pH 7.5 and 25°C
0.015
([4,5-dihydroxy-6-[2-(phosphonooxy)ethyl]pyridin-3-yl]methyl)phosphonic acid
-
at pH 7.5 and 25°C
0.125
1-hydroxy-2-naphthaldehyde 6-phosphate
wild-type enzyme
0.9
2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl dihydrogen phosphate
-
at pH 7.5 and 25°C
0.000234 - 0.067
2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl phosphate
2.3
2-hydroxy-2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl dihydrogen phosphate
-
at pH 7.5 and 25°C
0.1
2-oxo-2-[(phenylsulfonyl)amino]ethyl phosphate
-
-
0.35
2-[(methylsulfonyl)amino]-2-oxoethyl phosphate
-
-
0.00067 - 0.37
2-[(trihydroxyphosphoranyl)oxy]acetohydrazide
0.00017 - 2.5
2-[hydroxy(3-hydroxypropyl)amino]-2-oxoethyl dihydrogen phosphate
0.000185 - 0.4
2-[hydroxy(4-hydroxybutyl)amino]-2-oxoethyl dihydrogen phosphate
0.000013 - 0.264
3-[hydroxy[(phosphonooxy)acetyl]amino]propyl dihydrogen phosphate
0.00012 - 0.85
4-[hydroxy[(phosphonooxy)acetyl]amino]butyl hexanoate
0.1824 - 0.1934
5-chloro-8-hydroxyquinoline
0.0233
5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate
-
-
0.096
8-hydroxyquinoline-2-carboxylic acid
3.1
ADP
-
pH 7.5, 30°C
7.5
AMP
-
pH 7.5, 30°C
0.38
D-erythrose 4-phosphate
-
-
2 - 22
D-fructose 1,6-bisphosphate
0.06 - 0.17
D-glucitol 1,6-bisphosphate
0.0073 - 0.4
D-mannitol 1,6-bisphosphate
0.12 - 0.59
D-ribulose 1,5-bisphosphate
0.13 - 1.7
dihydroxyacetone phosphate
0.045
hexitol-1,6-bisphosphate
-
-
0.0033
N'-hydroxy-2-[(trihydroxyphosphoranyl)oxy]ethanimidamide
-
-
0.001
N-hydroxy-2-[(trihydroxyphosphoranyl)oxy]acetamide
-
-
0.028
naphthalene-2,6-bisphosphate
-
-
0.00028 - 0.013
naphthyl 2,6-bisphosphate
0.00023 - 0.00118
phosphate
0.00001 - 0.001
phosphoglycolo hydroxamic acid
0.0023
phosphoglycolo-amidoxime
-
-
0.00034
phosphoglycolo-hydrazide
-
-
0.0024
Phosphoglycolohydroxamate
-
at pH 7.5 and 25°C, in the absence of Zn2+
2.2
ribose 5-phosphate
-
pH 7.5, 30°C
0.001
tagatose 1,6-bisphosphate
-
at pH 7.5 and 25°C
1.2
[(3-hydroxy-2-oxopyridin-1(2H)-yl)methyl]phosphonic acid
-
at pH 7.5 and 25°C
0.81
[2-(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)ethyl]phosphonic acid
-
at pH 7.5 and 25°C
0.97
[[(3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)methoxy]methyl]phosphonic acid
-
at pH 7.5 and 25°C
0.8
[[3-hydroxy-2-oxo-4-(2-phosphonoethyl)pyridin-1(2H)-yl]methyl]phosphonic acid
-
at pH 7.5 and 25°C