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4.1.2.13: fructose-bisphosphate aldolase

This is an abbreviated version!
For detailed information about fructose-bisphosphate aldolase, go to the full flat file.

Word Map on EC 4.1.2.13

Reaction

D-fructose 1,6-bisphosphate
=
glycerone phosphate
 +
D-glyceraldehyde 3-phosphate

Synonyms

1,6-Diphosphofructose aldolase, 37 kDa major allergen, 41 kDa antigen, ALD, ALDC, aldoA, Aldob, aldolase, aldolase A, aldolase B, aldolase C, aldolase, fructose diphosphate, ALDP, bifunctional fructose-1,6-bisphosphate aldolase/phosphatase, Brain-type aldolase, Ca-FBA-II, CE1, CE2, class I Fba, class I fructose 1,6-bisphosphate aldolase, class I fructose bisphosphate aldolase, class I fructose-1,6-bisphosphate aldolase, class I muscle fructose bis-phosphate aldolase, class II aldolase, class II FBA, class II FBP aldolase, class II fructose 1,6-bisphosphate aldolase, class II fructose bisphosphate aldolase, class II fructose-1,6-bisphosphate aldolase, class IIa fructose 1,6-bisphosphate aldolase, class IIb fructose 1,6-bisphosphate aldolase, ClassII FBP-aldolase, CoFBA1, CoFBA2, CoFBA3, CoFBA4, D-fructose-1,6-bisphosphate aldolase, D-fructose-1,6-bisphosphate D-glyceraldehyde-3-P-lyase, D-fructose-6-phosphate aldolase, Diphosphofructose aldolase, DLF, EC 4.1.2.7, F1,6-P2 aldolase, F1,6P2 aldolase, F16BP aldolase, FBA, FBA class II, FBA-II, Fba1, Fba1p, Fba2, FBA7, FbaA, FbaB, FbaC, FBAld, FbaP, FBP aldolase, FBP aldolase/phosphatase, FBP-aldolase, FBPA, FBPA I, FBPA-1, FBPA/P, FDP aldolase, FPA, Fru-1,6-P2 aldolase, Fru-P2A, Fructoaldolase, fructose 1,6 bisphosphate aldolase, fructose 1,6-bisphosphatase/aldolase, Fructose 1,6-bisphosphate aldolase, fructose 1,6-bisphosphate aldolase/phosphatase, Fructose 1,6-diphosphate aldolase, Fructose 1-monophosphate aldolase, Fructose 1-phosphate aldolase, fructose bis-phosphate aldolase, Fructose bisphosphate aldolase, Fructose diphosphate aldolase, fructose-1,6-biphosphate aldolase, fructose-1,6-bisphosphate (FBP) aldolase/phosphatase, fructose-1,6-bisphosphate aldolase, fructose-1,6-bisphosphate aldolase A, fructose-1,6-bisphosphate aldolase B, fructose-1,6-bisphosphate aldolase class II, fructose-1,6-bisphosphate aldolase/phosphatase, fructose-1,6-bisphosphate muscle aldolase, Fructose-1,6-bisphosphate triosephosphate-lyase, fructose-bisphosphate aldolase, fructose-bisphosphate aldolase A, FSA, fuculose aldolase, heat-induced protein 44, HIP44, IgE-binding allergen, ketose 1-phosphate aldolase, Leishmania aldolase, Liver-type aldolase, MGA3_01355, MJ0400-His6, More, MtFBA, Muscle-type aldolase, Ov-fba-1, OvFBPA-1, Pcal_0111, Phosphofructoaldolase, SMALDO, SSO0286, STK_03180, TgALD1, Tneu_0133, TnFBPAP, Tt-FBPA, zerebrin II, zymohexase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.13 fructose-bisphosphate aldolase

Substrates Products

Substrates Products on EC 4.1.2.13 - fructose-bisphosphate aldolase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 acetaldehyde
5-deoxy-D-threo-2-pentulose
show the reaction diagram
2 butyraldehyde
5,6,7-trideoxy-D-threo-2-heptulose
show the reaction diagram
2 D-glyceraldehyde
D-fructose
show the reaction diagram
-
-
yield 60%
-
?
2 pentanaldehyde
5,6,7,8-tetradeoxy-D-threo-2-octulose
show the reaction diagram
2 propionaldehyde
5,6-dideoxy-D-threo-2-hexulose
show the reaction diagram
5-fluoro-5-deoxy-D-ribulose 1-phosphate
fluoroacetaldehyde + dihydroxyacetone phosphate
show the reaction diagram
-
-
-
-
r
D-fructose 1,6-bisphosphate
dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram
D-fructose 1,6-bisphosphate
dihydroxyacetone phosphate + glyceraldehyde 3-phosphate
show the reaction diagram
aldolase is involved in the metabolism of fructose, converting fructose 1-phosphate to dihydroxyacetone phosphate and glyceraldehyde
-
-
r
D-fructose 1,6-bisphosphate
dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
show the reaction diagram
-
-
-
-
?
D-fructose 1,6-bisphosphate
glycerone phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram
D-fructose 1,6-bisphosphate + H2O
glycerone phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram
D-Fructose 1-phosphate
Glycerone phosphate + D-glyceraldehyde
show the reaction diagram
D-fructose 6-phosphate
D-glyceraldehyde 3-phosphate + dihydroxypropanone
show the reaction diagram
-
-
-
r
D-fructose-1,6-bisphosphate
dihydroxyacetone phosphate + glyceraldehyde-3-phosphate
show the reaction diagram
D-fructose-1,6-bisphosphate
glyceraldehyde-3-phosphate + dihydroxyacetone phosphate
show the reaction diagram
-
-
-
-
r
D-glyceraldehyde 3-phosphate + glycerone phosphate
tagatose-1,6-bisphosphate
show the reaction diagram
D-Xylulose 1-phosphate
?
show the reaction diagram
-
110% of the activity with fructose 1,6-diphosphate
-
-
?
dihydroxyacetone + phenyl [(2R)-1-oxopropan-2-yl]carbamate
phenyl [(2R,3R,4S)-3,4,6-trihydroxy-5-oxohexan-2-yl]carbamate
show the reaction diagram
-
i.e. (S)-N-Cbz-alaninal,substrate only for mutant A129S/A165G
aldol adduct is a key intermediates for the expedient synthesis of the pyrrolidine type iminocyclitol, 2,5-imino-1,2,5-trideoxy-D-mannitol
-
?
dihydroxyacetone + phenyl [(2S)-1-oxopropan-2-yl]carbamate
phenyl [(2S,3R,4S)-3,4,6-trihydroxy-5-oxohexan-2-yl]carbamate
show the reaction diagram
-
i.e. (S)-N-Cbz-alaninal, substrate only for mutant A129S/A165G
aldol adduct is a key intermediates for the expedient synthesis of the pyrrolidine type iminocyclitol, 2,5-imino-1,2,5-trideoxy-D-glucitol
-
?
dihydroxyacetone phosphate
?
show the reaction diagram
dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
D-fructose 1,6-bisphosphate
show the reaction diagram
Glycerone phosphate + D-glyceraldehyde
Fructose 1-phosphate
show the reaction diagram
-
-
-
?
Glycerone phosphate + D-glyceraldehyde 3-phosphate
D-Fructose 1,6-bisphosphate
show the reaction diagram
hydroxyacetone + phenoxyacetaldehyde
?
show the reaction diagram
-
substrate only for mutant A129S/A165G
-
-
?
hydroxyacetone + phenyl (2-oxoethyl)carbamate
?
show the reaction diagram
-
substrate only for mutant A129S/A165G
-
-
?
hydroxyacetone + phenyl (3-oxopropyl)carbamate
?
show the reaction diagram
-
substrate only for mutant A129S/A165G
-
-
?
hydroxyacetone + phenyl [(2R)-1-oxopropan-2-yl]carbamate
phenyl [(2R,3R,4S)-3,4-dihydroxy-5-oxohexan-2-yl]carbamate
show the reaction diagram
-
substrate only for mutant A129S/A165G
-
-
?
hydroxyacetone + phenyl [(2S)-1-oxopropan-2-yl]carbamate
phenyl [(2S,3R,4S)-3,4-dihydroxy-5-oxohexan-2-yl]carbamate
show the reaction diagram
-
substrate only for mutant A129S/A165G
-
-
?
L-glyceraldehyde
L-sorbose
show the reaction diagram
-
-
yield 28%
-
?
L-glyceraldehyde 3-phosphate + butanone
(2S,3S)-2,3-dihydroxy-5-oxoheptyl phosphate
show the reaction diagram
-
-
-
?
L-glyceraldehyde 3-phosphate + cyclopentane
(2S,3S)-2,3-dihydroxy-3-(2-oxocyclopentyl)propylphosphate
show the reaction diagram
-
-
-
?
L-glyceraldehyde 3-phosphate + ethanol
2-deoxy-5-O-phosphono-L-threo-pentose
show the reaction diagram
-
-
-
?
L-glyceraldehyde 3-phosphate + propanone
1,3-dideoxy-6-O-phosphono-L-threo-hex-2-ulose
show the reaction diagram
-
-
-
?
propanal + dihydroxyacetone phosphate
?
show the reaction diagram
-
-
-
?
sedoheptulose 1,7-bis-phosphate
?
show the reaction diagram
-
-
-
-
?
sedoheptulose 1,7-bis-phosphate
glycerone phosphate + D-erythrose 4-phosphate
show the reaction diagram
sedoheptulose 1,7-bisphosphate
?
show the reaction diagram
-
-
-
?
sedoheptulose 1,7-bisphosphate
glycerone phosphate + D-erythrose 4-phosphate
show the reaction diagram
sedoheptulose 7-phosphate
?
show the reaction diagram
additional information
?
-