4.1.2.13: fructose-bisphosphate aldolase

This is an abbreviated version!
For detailed information about fructose-bisphosphate aldolase, go to the full flat file.

Reaction

Synonyms

1,6-Diphosphofructose aldolase, 37 kDa major allergen, 41 kDa antigen, ALD, ALDC, aldoA, Aldob, aldolase, aldolase A, aldolase B, aldolase C, aldolase, fructose diphosphate, ALDP, bifunctional fructose-1,6-bisphosphate aldolase/phosphatase, Brain-type aldolase, Ca-FBA-II, CE1, CE2, class I Fba, class I fructose 1,6-bisphosphate aldolase, class I fructose bisphosphate aldolase, class I fructose-1,6-bisphosphate aldolase, class I muscle fructose bis-phosphate aldolase, class II aldolase, class II FBA, class II FBP aldolase, class II fructose 1,6-bisphosphate aldolase, class II fructose bisphosphate aldolase, class II fructose-1,6-bisphosphate aldolase, class IIa fructose 1,6-bisphosphate aldolase, class IIb fructose 1,6-bisphosphate aldolase, ClassII FBP-aldolase, CoFBA1, CoFBA2, CoFBA3, CoFBA4, D-fructose-1,6-bisphosphate aldolase, D-fructose-1,6-bisphosphate D-glyceraldehyde-3-P-lyase, D-fructose-6-phosphate aldolase, Diphosphofructose aldolase, DLF, EC 4.1.2.7, F1,6-P2 aldolase, F1,6P2 aldolase, F16BP aldolase, FBA, FBA class II, FBA-II, Fba1, Fba1p, Fba2, FBA7, FbaA, FbaB, FbaC, FBAld, FbaP, FBP aldolase, FBP aldolase/phosphatase, FBP-aldolase, FBPA, FBPA I, FBPA-1, FBPA/P, FDP aldolase, FPA, Fru-1,6-P2 aldolase, Fru-P2A, Fructoaldolase, fructose 1,6 bisphosphate aldolase, fructose 1,6-bisphosphatase/aldolase, Fructose 1,6-bisphosphate aldolase, fructose 1,6-bisphosphate aldolase/phosphatase, Fructose 1,6-diphosphate aldolase, Fructose 1-monophosphate aldolase, Fructose 1-phosphate aldolase, fructose bis-phosphate aldolase, Fructose bisphosphate aldolase, Fructose diphosphate aldolase, fructose-1,6-biphosphate aldolase, fructose-1,6-bisphosphate (FBP) aldolase/phosphatase, fructose-1,6-bisphosphate aldolase, fructose-1,6-bisphosphate aldolase A, fructose-1,6-bisphosphate aldolase B, fructose-1,6-bisphosphate aldolase class II, fructose-1,6-bisphosphate aldolase/phosphatase, fructose-1,6-bisphosphate muscle aldolase, Fructose-1,6-bisphosphate triosephosphate-lyase, fructose-bisphosphate aldolase, fructose-bisphosphate aldolase A, FSA, fuculose aldolase, heat-induced protein 44, HIP44, IgE-binding allergen, ketose 1-phosphate aldolase, Leishmania aldolase, Liver-type aldolase, MGA3_01355, MJ0400-His6, More, MtFBA, Muscle-type aldolase, Ov-fba-1, OvFBPA-1, Pcal_0111, Phosphofructoaldolase, SMALDO, SSO0286, STK_03180, TgALD1, Tneu_0133, TnFBPAP, Tt-FBPA, zerebrin II, zymohexase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.13 fructose-bisphosphate aldolase

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Results	in table
28	Activating Compound
54370	AA Sequence
78	Application
1	CAS Registry Number
110	Cloned(Commentary)
42	Crystallization (Commentary)
3645	Disease/ Diagnostics
15	Expression
101	General Information
8	General Stability
52	IC50 Value
368	Inhibitors
24	kcat/KM [mM/s]
83	Ki Value [mM]
290	KM Value [mM]
137	Localization
150	Metals/Ions
139	Molecular Weight [Da]
124	Natural Substrates/ Products (Substrates)
25	Organic Solvent Stability
405	Organism
28	Pathway
490	PDB ID
69	pH Optimum
17	pH Range
8	pH Stability
12	pI Value
114	Protein Variants
134	Purification (Commentary)
16	Reaction
2	Reaction Type
351	Reference
2	Renatured (Commentary)
141	Source Tissue
84	Specific Activity [micromol/min/mg]
12	Storage Stability
466	Substrates and Products (Substrate)
140	Subunits
457	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
8	Temperature Range [°C]
73	Temperature Stability [°C]
165	Turnover Number [1/s]

General Stability

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General Stability on EC 4.1.2.13 - fructose-bisphosphate aldolase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

10% w/v ethanol results in 2fold reduction in thermal stability

Thermus aquaticus

-

4962

at 1-4 M urea, slight decrease in activity of the immobilized enzyme. In 5 M urea significant decrease in activity after 2 h. In 3 M urea the soluble enzyme unfolded and dissociated totally during 2 h

Sus scrofa

-

4932

carboxypeptidase A treatment results in 20% inactivation. Complete protection by D-fructose 1,6-bisphosphate

Mycolicibacterium smegmatis

-

4924

freezing inactivates

Trypanosoma brucei

-

2572

high degree of stability towards frequent freezing and thawing

Aspergillus oryzae

-

665415

immobilization by covalent attachment to a polyacrylamide matrix containing carboxylic functional groups increases stability

Sus scrofa

-

4932

stored in the 50 mM Tris-HCl buffer, pH 7.4 containing 1 mM 2-mercaptoethanol and 100 microM ZnCl2, stable at 4°C for over 10 months without significant loss of activity.

Mycobacterium tuberculosis

P9WQA3

692126

the enzyme is totally inactivated within 75 min in 0.5 - 0.05 mM Tris/HCI pH 8.0, whereas 80% activity is retained in 3 M KCl, 50 mM Tris/HCI pH 8.0 at the end of 72 h. Addition of 1 M (NH4)2S04 to the enzyme in 1.5 M KCI stabilizes the enzyme activity for at least 48 h

Haloarcula vallismortis

-

727401