4.1.1.37: uroporphyrinogen decarboxylase
This is an abbreviated version!
For detailed information about uroporphyrinogen decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.37
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4.1.1.37
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porphyria
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cutanea
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tarda
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heme
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erythrocyte
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porphyrinogenic
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hexachlorobenzene
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urinary
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hepatoerythropoietic
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porphobilinogen
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overload
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photosensitivity
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ferrochelatase
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protoporphyrin
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hemochromatosis
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5-aminolaevulinate
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heptacarboxylic
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hexachlorobenzene-induced
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hypertrichosis
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phlebotomy
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erythropoietic
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delta-aminolaevulinic
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polyhalogenated
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5-aminolevulinic
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protoporphyrinogen
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uroporphyria
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tetrapyrrole
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sun-exposed
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blister
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siderosis
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diagnostics
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3,4,3\',4\'-tetrachlorobiphenyl
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medicine
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hcb-induced
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miliae
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coproporphyria
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bulla
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agriculture
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hepta
- 4.1.1.37
- porphyria
-
cutanea
- tarda
- heme
- erythrocyte
-
porphyrinogenic
- hexachlorobenzene
- urinary
-
hepatoerythropoietic
- porphobilinogen
- overload
-
photosensitivity
-
ferrochelatase
- protoporphyrin
- hemochromatosis
-
5-aminolaevulinate
-
heptacarboxylic
-
hexachlorobenzene-induced
- hypertrichosis
-
phlebotomy
-
erythropoietic
-
delta-aminolaevulinic
-
polyhalogenated
-
5-aminolevulinic
- protoporphyrinogen
-
uroporphyria
- tetrapyrrole
-
sun-exposed
- blister
- siderosis
- diagnostics
-
3,4,3\',4\'-tetrachlorobiphenyl
- medicine
-
hcb-induced
-
miliae
- coproporphyria
- bulla
- agriculture
-
hepta
Reaction
Synonyms
ch-UroD, Decarboxylase, uroporphyrinogen, Hem12p, PCL, Porphyrinogen carboxy-lyase, rl-UroD, tobacco UROD, UORO-D, UPD, URO-D, Uro-decarboxylase, uro-III decarboxylase, UroD, UROD protein, UROD1, uroporphyrinogen decarboxylase, uroporphyrinogen decarboxylase 1, Uroporphyrinogen III decarboxylase, uroporphyrinogen-decarboxylase, uroporphyrinogen-III decarboxylase
ECTree
4.1.1.37 uroporphyrinogen decarboxylaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 4.1.1.37 - uroporphyrinogen decarboxylase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
7-COOH-porphyrin III
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most effective inhibitor of decarboxylation of both uroporphyrinogen III and 7-COOH-porphyrinogen III
Fe2+
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0.45 mM Fe(NH4)2, 50% inhibition under anaerobic conditions in the dark. Competitive with uroporphyrinogen I and uroporphyrinogen II as substrates. Preincubation with 5-COOH-porphyrinogen protects
Uroporphyrinogen I
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light-dependent and light-independent inactivation. The velocity of dark inactivation increases with increasing temperature in the range of 0-45 C
uroporphyrinogen III
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inhibits decarboxylation of uroporphyrinogen I, no inhibition of 7-COOH-series II porphyrinogens and 5-COOH-series II porphyrinogens decarboxylation
additional information
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the P-448 isoenzyme of cytochrome P-450 plays an obligatory role in the inhibition of the uroporphyrinogen decarboxylase caused by halogenated biphenyls
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additional information
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inhibitor derived from a soluble component of the homogenate of a xenobiotic-treated chicken embryo hepatocyte culture
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additional information
not inhibited by acebutulol, naproxen, verapramil, and furosemide
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additional information
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uroporphyrinogen oxidation catalyzed by microsomes from a methylcholanthrene-treated mouse inhibits the uroporphyrinogen decarboxylase activity
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additional information
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no inhibition of pentacarboxyporphyrinogen III decarboxylation
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additional information
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neither DTT or GSH affects enzyme activity significantly
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