4.1.1.37: uroporphyrinogen decarboxylase
This is an abbreviated version!
For detailed information about uroporphyrinogen decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.37
-
4.1.1.37
-
porphyria
-
cutanea
-
tarda
-
heme
-
erythrocyte
-
porphyrinogenic
-
hexachlorobenzene
-
urinary
-
hepatoerythropoietic
-
porphobilinogen
-
overload
-
photosensitivity
-
ferrochelatase
-
protoporphyrin
-
hemochromatosis
-
5-aminolaevulinate
-
heptacarboxylic
-
hexachlorobenzene-induced
-
hypertrichosis
-
phlebotomy
-
erythropoietic
-
delta-aminolaevulinic
-
polyhalogenated
-
5-aminolevulinic
-
protoporphyrinogen
-
uroporphyria
-
tetrapyrrole
-
sun-exposed
-
blister
-
siderosis
-
diagnostics
-
3,4,3\',4\'-tetrachlorobiphenyl
-
medicine
-
hcb-induced
-
miliae
-
coproporphyria
-
bulla
-
agriculture
-
hepta
- 4.1.1.37
- porphyria
-
cutanea
- tarda
- heme
- erythrocyte
-
porphyrinogenic
- hexachlorobenzene
- urinary
-
hepatoerythropoietic
- porphobilinogen
- overload
-
photosensitivity
-
ferrochelatase
- protoporphyrin
- hemochromatosis
-
5-aminolaevulinate
-
heptacarboxylic
-
hexachlorobenzene-induced
- hypertrichosis
-
phlebotomy
-
erythropoietic
-
delta-aminolaevulinic
-
polyhalogenated
-
5-aminolevulinic
- protoporphyrinogen
-
uroporphyria
- tetrapyrrole
-
sun-exposed
- blister
- siderosis
- diagnostics
-
3,4,3\',4\'-tetrachlorobiphenyl
- medicine
-
hcb-induced
-
miliae
- coproporphyria
- bulla
- agriculture
-
hepta
Reaction
Synonyms
ch-UroD, Decarboxylase, uroporphyrinogen, Hem12p, PCL, Porphyrinogen carboxy-lyase, rl-UroD, tobacco UROD, UORO-D, UPD, URO-D, Uro-decarboxylase, uro-III decarboxylase, UroD, UROD protein, UROD1, uroporphyrinogen decarboxylase, uroporphyrinogen decarboxylase 1, Uroporphyrinogen III decarboxylase, uroporphyrinogen-decarboxylase, uroporphyrinogen-III decarboxylase
ECTree
4.1.1.37 uroporphyrinogen decarboxylaseAdvanced search results
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Reference on EC 4.1.1.37 - uroporphyrinogen decarboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mauzerall, D.; Granick, S.
Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase
J. Biol. Chem.
232
1141-1162
1958
Oryctolagus cuniculus
Tomio, J.M.; Garcia, R.C.; San Martin de Viale, L.C.; Grinstein, M.
Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties
Biochim. Biophys. Acta
198
353-363
1970
Gallus gallus
Garcia, R.C.; San Martin de Viale, L.C.; Tomio, J.M.; Grinstein, M.
Porphyrin biosynthesis. X-Porphyrinogen carboxy-lyase from avian erythrocytes. Further properties
Biochim. Biophys. Acta
309
203-210
1973
Gallus gallus
De Verneuil, H.; Grandchamp, B.; Nordmann, Y.
Some kinetic properties of human red cell uroporphyrinogen decarboxylase
Biochim. Biophys. Acta
611
174-186
1980
Homo sapiens
Barnard, G.F.; Akhtar, M.
Stereochemical and mechanistic studies on the decarboxylation of uroporphyrinogen III in haem biosynthesis
J. Chem. Soc. Perkin Trans. I
1979
2354-2363
1979
Gallus gallus
Smith, A.G.; Francis, J.E.
Decarboxylation of porphyrinogens by rat liver uroporphyrinogen decarboxylase
Biochem. J.
183
455-458
1979
Rattus norvegicus
Kardish, R.M.; Woods, J.S.
Measurement of heme biosynthetic enzymes in mammalian tissues. I. Uroporphyrinogen decarboxylase
J. Appl. Biochem.
2
159-167
1980
Rattus norvegicus
-
Smith, A.G.; Francis, J.E.
Investigations of rat liver uroporphyrinogen decarboxylase. Comparisons of porphyrinogens I and III as substrates and the inhibition by porphyrins
Biochem. J.
195
241-250
1981
Rattus norvegicus
De Verneuil, H.; Sassa, Sh.; Kappas, A.
Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes
J. Biol. Chem.
258
2454-2460
1983
Homo sapiens
Kawanishi, S.; Seki, Y.; Sano, S.
Uroporphyrinogen decarboxylase. Purification, properties, and inhibition by polychlorinated biphenyl isomers
J. Biol. Chem.
258
4285-4292
1983
Gallus gallus
Straka, J.G.; Kushner, J.P.
Purification and characterization of bovine hepatic uroporphyrinogen decarboxylase
Biochemistry
22
4664-4672
1983
Bos taurus
Elder, G.H.; Tovey, J.A.; Sheppard, D.M.
Purification of uroporphyrinogen decarboxylase from human erythrocytes
Biochem. J.
215
45-55
1983
Homo sapiens
Francis, J.E.; Smith, A.G.
Assay of mouse liver uroporphyrinogen decarboxylase by reverse-phase-performance liquid chromatography
Anal. Biochem.
138
404-410
1984
Mus musculus
Elder, G.H.; Urquhart, A.J.
Human uroporphyrinogen decarboxylase. Do tissue-specific isoenzymes exist?
Biochem. Soc. Trans.
12
663-664
1984
Homo sapiens
-
Sinclair, P.R.; Bement, W.J.; Bonkovsky, H.L.; Sinclair, J.F.
Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures
Biochem. J.
222
737-748
1984
Gallus gallus
Mukerji, S.K.; Pimstone, N.R.
Reduced substrate affinity for human erythrocyte uroporphyrinogen decarboxylase constitutes the inherent biochemical defect in porphyria cutanea tarda
Biochem. Biophys. Res. Commun.
127
517-525
1985
Homo sapiens
Mukerji, S.K.; Pimstone, N.R.
In vitro studies of the mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron under anaerobic conditions
Arch. Biochem. Biophys.
224
619-629
1986
Rattus norvegicus
Seki, Y.; Kawanishi, S.; Sano, S.
Uroporphyrinogen decarboxylase purification from chicken erythrocytes
Methods Enzymol.
123
415-421
1986
Gallus gallus
Koopmann, G.E.; Juknat de Geralnik, A.A.; del C.Batlle, A.M.
Porphyrin biosynthesis in Rhodopseudomonas palustris - V. Purification of porphyrinogen decarboxylase and some unusual properties
Int. J. Biochem.
18
935-944
1986
Rhodopseudomonas palustris
-
Francis, J.E.; Smith, A.G.
Oxidation of uroporphyrinogens by hydroxyl radicals. Evidence for nonporphyrin products as potential inhibitors of uroporphyrinogen decarboxylase
FEBS Lett.
233
311-314
1988
Mus musculus
Romana, M.; le Boulch, P.; Romeo, P.H.
Rat uroporphyrinogen decarboxylase cDNA: nucleotide sequence and comparison to human uroporphyrinogen decarboxylase
Nucleic Acids Res.
15
7211
1987
Rattus norvegicus
Mukerji, S.K.; Pimstone, N.R.
Evidence for two uroporphyrinogen decarboxylase isoenzymes in human erythrocytes
Biochem. Biophys. Res. Commun.
146
1196-1203
1987
Homo sapiens
Mock, H.P.; Trainotti, L.; Kruse, E.; Grimm, B.
Isolation, sequencing and expression of cDNA sequences encoding uroporphyrinogen decarboxylase from tobacco and barley
Plant Mol. Biol.
28
245-256
1995
Hordeum vulgare, Nicotiana tabacum
Roberts, A.G.; Elder, G.H.
Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes
Methods Enzymol.
281
349-355
1997
Homo sapiens
Green-Thompson, R.P.; Kimmett, S.M.; Marks, G.S.
Inhibition of chick embryo hepatic uroporphyrinogen decarboxylase by components of xenobiotic-treated chick embryo hepatocytes in culture. II.
Can. J. Physiol. Pharmacol.
70
939-942
1992
Gallus gallus
Laterriere, M.; Langlois d'Estaintot, B.; Dautant, A.; Precigoux, G.; Hombrados, I.; de Verneuil, H.
Expression, purification, crystallization and preliminary X-ray diffraction analysis of human uroporphyrinogen decarboxylase
Acta Crystallogr. Sect. D
54
476-478
1998
Homo sapiens
-
Felix, F.; Brouillet, N.
Purification and properties of uroporphyrinogen decarboxylase from Saccharomyces cerevisiae
Eur. J. Biochem.
188
393-403
1990
Saccharomyces cerevisiae
Juknat, A.A.; Seubert, A.; Seubert, S.; Ippen, H.
Studies on uroporphyrinogen decarboxylase of etiolated Euglena gracilis Z
Eur. J. Biochem.
179
423-428
1989
Euglena gracilis, Euglena gracilis Z
Jones, R.M.; Jordan, P.M.
Purification and properties of the uroporphyrinogen decarboxylase from Rhodobacter sphaeroides
Biochem. J.
293
703-712
1993
Cereibacter sphaeroides
Lambrecht, R.W.; Jacobs, J.M.; Sinclair, P.R.; Sinclair, J.F.
Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation
Biochem. J.
269
437-441
1990
Mus musculus
Mylchreest, E.; Charbonneau, M.
Studies on the mechanism of uroporphyrinogen decarboxylase inhibition in hexachlorobenzene-induced porphyria in the female rat
Toxicol. Appl. Pharmacol.
145
23-33
1997
Rattus norvegicus
Afonso, S.G.; Chinarro, S.; de Salamanca, R.E.; del C.Batlle, A.M.
Further evidence on the photodynamic and the novel non-photodynamic inactivation of uroporphyrinogen decarboxylase by uroporphyrin I
J. Enzyme Inhib.
5
225-233
1991
Homo sapiens
Mukerji, S.K.; Pimstone, N.R.
Uroporphyrinogen decarboxylases from human erythrocytes: purification, complete separation and partial characterization of two isoenzymes
Int. J. Biochem.
24
105-119
1992
Homo sapiens
Elder, G.H.; Roberts, A.G.
Uroporphyrinogen decarboxylase
J. Bioenerg. Biomembr.
27
207-214
1995
Homo sapiens
Phillips, J.D.; Whitby, F.G.; Kushner, J.P.; Hill, C.P.
Characterization and crystallization of human uroporphyrinogen decarboxylase
Protein Sci.
6
1343-1346
1997
Homo sapiens
Mock, H.P; Heller, W.; Molina, A.; Neubohn, B.; Sandermann, H.; Grimm, B.
Expression of uroporphyrinogen decarboxylase or coproporphyrinogen oxidase antisense RNA in tobacco induces pathogen defense responses conferring increased resistance to tobacco mosaic virus
J. Biol. Chem.
274
4231-4238
1999
Nicotiana tabacum
Martins, B.M.; Grimm, B.; Mock, H.P.; Richter, G.; Huber, R.; Messerschmidt, A.
Tobacco uroporphyrinogen-III decarboxylase: characterization, crystallization and preliminary X-ray analysis
Acta Crystallogr. Sect. D
57
1709-1711
2001
Nicotiana tabacum
Billi de Catabbi, S.; Wainstok de Calmanovici, R.; Minutolo, C.; Aldonatti, C.; San Martin de Viale, L.C.
Porphyria-induced hepatic porphyrinogen carboxy-lyase inhibitor and its interaction with the active site(s) of the enzyme
Biochem. Mol. Biol. Int.
47
945-956
1999
Rattus norvegicus
Phillips, J.D.; Parker, T.L.; Schubert, H.L.; Whitby, F.G.; Hill, C.P.; Kushner, J.P.
Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase
Blood
98
3179-3185
2001
Homo sapiens (P06132), Homo sapiens
Tavazzi, D.; Di Montemuros, F.M.; Fargion, S.; Fracanzani, A.L.; Fiorelli, G.; Cappellini, M.D.
Levels of uroporphyrinogen decarboxylase (URO-D) in erythrocytes of Italian porphyria cutanea tarda patients
Cell. Mol. Biol.
48
27-32
2002
Homo sapiens
Chaufan, G.; Corvi, M.; Armesto, A.; San Martin de Viale, L.C.; Luquet, C.; Rios de Molina, M.
Comparison between crab hepatopancreas and rat liver uroporphyrinogen decarboxylase
Comp. Biochem. Physiol. B
133
251-256
2002
Neohelice granulata, Rattus norvegicus, Rattus norvegicus Wistar
Phillips, J.D.; Whitby, F.G.; Kushner, J.P.; Hill, C.P.
Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
EMBO J.
22
6225-6233
2003
Homo sapiens (P06132)
Christiansen, L.; Ged, C.; Hombrados, I.; Brons-Poulsen, J.; Fontanellas, A.; de Verneuil, H.; Horder, M.; Petersen, N.E.
Screening for mutations in the uroporphyrinogen decarboxylase gene using denaturing gradient gel electrophoresis. Identification and characterization of six novel mutations associated with familial PCT
Hum. Mutat.
14
222-232
1999
Homo sapiens
Chaufan, G.; Rios de Molina, M.C.; San Martin de Viale, L.C.
How does hexachlorobenzene treatment affect liver uroporphyrinogen decarboxylase?
Int. J. Biochem. Cell Biol.
33
621-630
2001
Rattus norvegicus
Martins, B.M.; Grimm, B.; Mock, H.P.; Huber, R.; Messerschmidt, A.
Crystal structure and substrate binding modeling of the uroporphyrinogen-III decarboxylase from Nicotiana tabacum. Implications for the catalytic mechanism
J. Biol. Chem.
276
44108-44116
2001
Nicotiana tabacum
Jones, M.A.; Taneja, M.; Xu, Y.; Chung, W.; Stob, C.M.; Lash, T.D.
An effective chromatographic separation of chicken red blood cell coproporphyrinogen oxidase and uroporphyrinogen decarboxylase, two enzymes in heme biosynthesis
Bioorg. Med. Chem. Lett.
14
5559-5564
2004
Gallus gallus
Nezamzadeh, R.; Seubert, A.; Pohlenz, J.; Brenig, B.
Identification of a mutation in the ovine uroporphyrinogen decarboxylase (UROD) gene associated with a type of porphyria
Anim. Genet.
36
297-302
2005
Ovis aries
Poblete-Gutierrez, P.; Mendez, M.; Wiederholt, T.; Merk, H.F.; Fontanellas, A.; Wolff, C.; Frank, J.
The molecular basis of porphyria cutanea tarda in Chile: identification and functional characterization of mutations in the uroporphyrinogen decarboxylase gene
Exp. Dermatol.
13
372-379
2004
Homo sapiens
Chaufan, G.; Corvi, M.M.; San Martin de Viale, L.C.; Cardenas, M.L.; Rios de Molina Mdel, C.
Abnormal kinetic behavior of uroporphyrinogen decarboxylase obtained from rats with hexachlorobenzene-induced porphyria
J. Biochem. Mol. Toxicol.
19
19-24
2005
Rattus norvegicus
Christiansen, L.; Brons-Poulsen, J.; Horder, M.; Brock, A.; Petersen, N.E.
Expression and characterization of six clinically relevant uroporphyrinogen decarboxylase gene mutations
Scand. J. Clin. Lab. Invest.
65
227-235
2005
Homo sapiens
Juarez, A.B.; Aldonatti, C.; Vigna, M.S.; Rios de Molina, M.d.e.l.C.
Studies on uroporphyrinogen decarboxylase from Chlorella kessleri (Trebouxiophyceae, Chlorophyta)
Can. J. Microbiol.
53
303-312
2007
Parachlorella kessleri
Fan, J.; Liu, Q.; Hao, Q.; Teng, M.; Niu, L.
Crystal structure of uroporphyrinogen decarboxylase from Bacillus subtilis
J. Bacteriol.
189
3573-3580
2007
Bacillus subtilis
Phillips, J.D.; Bergonia, H.A.; Reilly, C.A.; Franklin, M.R.; Kushner, J.P.
A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda
Proc. Natl. Acad. Sci. USA
104
5079-5084
2007
Homo sapiens, Mus musculus
Cunha, L.; Kuti, M.; Bishop, D.F.; Mezei, M.; Zeng, L.; Zhou, M.M.; Desnick, R.J.
Human uroporphyrinogen III synthase: NMR-based mapping of the active site
Proteins
71
855-873
2007
Homo sapiens
Wang, Y.; Gatti, P.; Sadilek, M.; Scott, C.R.; Turecek, F.; Gelb, M.H.
Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase
Anal. Chem.
80
2599-2605
2008
Homo sapiens
Saito, M.; Watanabe, S.; Yoshikawa, H.; Nakamoto, H.
Interaction of the molecular chaperone HtpG with uroporphyrinogen decarboxylase in the cyanobacterium Synechococcus elongatus PCC 7942
Biosci. Biotechnol. Biochem.
72
1394-1397
2008
Synechococcus elongatus
Remenyik, E.; Lecha, M.; Badenas, C.; Koszo, F.; Vass, V.; Herrero, C.; Varga, V.; Emri, G.; Balogh, A.; Horkay, I.
Childhood-onset mild cutaneous porphyria with compound heterozygotic mutations in the uroporphyrinogen decarboxylase gene
Clin. Exp. Dermatol.
33
602-605
2008
Homo sapiens
Cribier, B.; Chiaverini, C.; Dali-Youcef, N.; Schmitt, M.; Grima, M.; Hirth, C.; Lacour, J.P.; Chosidow, O.
Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study
Dermatology
218
15-21
2009
Homo sapiens
Nagaraj, V.A.; Arumugam, R.; Chandra, N.R.; Prasad, D.; Rangarajan, P.N.; Padmanaban, G.
Localisation of Plasmodium falciparum uroporphyrinogen III decarboxylase of the heme-biosynthetic pathway in the apicoplast and characterisation of its catalytic properties
Int. J. Parasitol.
39
559-568
2008
Homo sapiens, Plasmodium falciparum
Lewis, C.A.; Wolfenden, R.
Uroporphyrinogen decarboxylation as a benchmark for the catalytic proficiency of enzymes
Proc. Natl. Acad. Sci. USA
105
17328-17333
2008
Homo sapiens (P06132), Homo sapiens
Bergonia, H.A.; Phillips, J.D.; Kushner, J.P.
Reduction of porphyrins to porphyrinogens with palladium on carbon
Anal. Biochem.
384
74-78
2009
Homo sapiens (P06132)
Warby, C.A.; Phillips, J.D.; Bergonia, H.A.; Whitby, F.G.; Hill, C.P.; Kushner, J.P.
Structural and kinetic characterization of mutant human uroporphyrinogen decarboxylases
Cell. Mol. Biol. (Noisy-le-grand)
55
40-45
2009
Homo sapiens (P06132), Homo sapiens
Aarsand, A.K.; Boman, H.; Sandberg, S.
Familial and sporadic porphyria cutanea tarda: characterization and diagnostic strategies
Clin. Chem.
55
795-803
2009
Homo sapiens
Badenas, C.; To-Figueras, J.; Phillips, J.D.; Warby, C.A.; Munoz, C.; Herrero, C.
Identification and characterization of novel uroporphyrinogen decarboxylase gene mutations in a large series of porphyria cutanea tarda patients and relatives
Clin. Genet.
75
346-353
2009
Homo sapiens (P06132), Homo sapiens
Phillips, J.D.; Warby, C.A.; Whitby, F.G.; Kushner, J.P.; Hill, C.P.
Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen
J. Mol. Biol.
389
306-314
2009
Homo sapiens (P06132)
Ryali, M.E.; Whittier, W.L.
Bullous skin lesions in a patient undergoing chronic hemodialysis
Semin. Dial.
23
83-87
2010
Homo sapiens
To-Figueras, J.; Phillips, J.; Gonzalez-Lopez, J.M.; Badenas, C.; Madrigal, I.; Gonzalez-Romaris, E.M.; Ramos, C.; Aguirre, J.M.; Herrero, C.
Hepatoerythropoietic porphyria due to a novel mutation in the uroporphyrinogen decarboxylase gene
Br. J. Dermatol.
165
499-505
2011
Homo sapiens
Bushnell, E.A.; Erdtman, E.; Llano, J.; Eriksson, L.A.; Gauld, J.W.
The first branching point in porphyrin biosynthesis: a systematic docking, molecular dynamics and quantum mechanical/molecular mechanical study of substrate binding and mechanism of uroporphyrinogen-III decarboxylase
J. Comput. Chem.
32
822-834
2011
Homo sapiens
Ito, E.; Yue, S.; Moriyama, E.H.; Hui, A.B.; Kim, I.; Shi, W.; Alajez, N.M.; Bhogal, N.; Li, G.; Datti, A.; Schimmer, A.D.; Wilson, B.C.; Liu, P.P.; Durocher, D.; Neel, B.G.; OSullivan, B.; Cummings, B.; Bristow, R.; Wrana, J.; Liu, F.F.
Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer
Sci. Transl. Med.
3
67ra7
2011
Homo sapiens
McDonagh, B.; Pedrajas, J.R.; Padilla, C.A.; Barcena, J.A.
Thiol redox sensitivity of two key enzymes of heme biosynthesis and pentose phosphate pathways: uroporphyrinogen decarboxylase and transketolase
Oxid. Med. Cell. Longev.
2013
932472
2013
Saccharomyces cerevisiae (P32347), Saccharomyces cerevisiae
Yip, K.W.; Zhang, Z.; Sakemura-Nakatsugawa, N.; Huang, J.W.; Vu, N.M.; Chiang, Y.K.; Lin, C.L.; Kwan, J.Y.; Yue, S.; Jitkova, Y.; To, T.; Zahedi, P.; Pai, E.F.; Schimmer, A.D.; Lovell, J.F.; Sessler, J.L.; Liu, F.F.
A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase
PLoS ONE
9
e89889
2014
Homo sapiens (P06132)
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