Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21-RIL(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not inhibited by acebutulol, naproxen, verapramil, and furosemide | Homo sapiens | |
PI-16 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Uroporphyrinogen III | Homo sapiens | - |
Coproporphyrinogen III + 4 CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P06132 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography and gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Uroporphyrinogen III | - |
Homo sapiens | Coproporphyrinogen III + 4 CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UroD | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0099 | - |
in 0.1 M Tris, pH 7.7, 7.5 mM dithiothreitol, at 37°C` | Homo sapiens | PI-16 |
General Information | Comment | Organism |
---|---|---|
malfunction | humans deficient in UROD present with porphyria cutanea tarda, a condition characterized by light-sensitive dermatitis, excretion of excess uroporphyrins, and associated hepatic porphyrin accumulation | Homo sapiens |