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Literature summary for 4.1.1.37 extracted from
- Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes (1997), Methods Enzymol., 281, 349-355.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Reducing agents | required | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoate) | - |
Homo sapiens |  |
| Butanedione | - |
Homo sapiens | |
| Cu2+ | - |
Homo sapiens | |
| diethyldicarbonate | reversed by hydroxylamine | Homo sapiens | |
| Hg2+ | - |
Homo sapiens | |
| NEM | prior incubation with 5-COOH-porphyrinogen III prevents inactivation | Homo sapiens | |
| PCMB | - |
Homo sapiens | |
| Phenylglyoxal | - |
Homo sapiens | |
| Pt2+ | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00005 | - |
5-COOH-porphyrinogen III | - |
Homo sapiens | |
| 0.00007 | - |
5-COOH-porphyrinogen I | - |
Homo sapiens | |
| 0.00035 | - |
uroporphyrinogen III | - |
Homo sapiens | |
| 0.0008 | - |
Uroporphyrinogen I | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40831 | - |
x * 40831, calculation from nucleotide sequence | Homo sapiens |
| 58000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme of the heme biosynthetic pathway | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Oxidation Stability
| Oxidation Stability | Organism |
|---|---|
| rapid inactivation by uroporphyrin-catalyzed photooxidation | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-COOH-porphyrinogen I | - |
Homo sapiens | Coproporphyrinogen I + CO2 | - |
? | |
| 5-COOH-porphyrinogen III | - |
Homo sapiens | Coproporphyrinogen III + CO2 | - |
? | |
| additional information | enzyme of the heme biosynthetic pathway | Homo sapiens | ? | - |
? | |
| uroporphyrinogen I | - |
Homo sapiens | coproporphyrinogen I + 4 CO2 | - |
? | |
| Uroporphyrinogen III | - |
Homo sapiens | Coproporphyrinogen III + 4 CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 40831, calculation from nucleotide sequence | Homo sapiens |
| ? | x * 39500-41000, SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.4 | - |
- |
Homo sapiens |
| 6.2 | - |
- |
Homo sapiens |
| 6.8 | - |
with uroporphyrinogen III or 5-COOH-porphyrinogen III as substrate | Homo sapiens |
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