4.1.1.37: uroporphyrinogen decarboxylase
This is an abbreviated version!
For detailed information about uroporphyrinogen decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.37
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4.1.1.37
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porphyria
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cutanea
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tarda
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heme
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erythrocyte
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porphyrinogenic
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hexachlorobenzene
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urinary
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hepatoerythropoietic
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porphobilinogen
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overload
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photosensitivity
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ferrochelatase
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protoporphyrin
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hemochromatosis
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5-aminolaevulinate
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heptacarboxylic
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hexachlorobenzene-induced
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hypertrichosis
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phlebotomy
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erythropoietic
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delta-aminolaevulinic
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polyhalogenated
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5-aminolevulinic
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protoporphyrinogen
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uroporphyria
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tetrapyrrole
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sun-exposed
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blister
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siderosis
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diagnostics
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3,4,3\',4\'-tetrachlorobiphenyl
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medicine
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hcb-induced
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miliae
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coproporphyria
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bulla
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agriculture
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hepta
- 4.1.1.37
- porphyria
-
cutanea
- tarda
- heme
- erythrocyte
-
porphyrinogenic
- hexachlorobenzene
- urinary
-
hepatoerythropoietic
- porphobilinogen
- overload
-
photosensitivity
-
ferrochelatase
- protoporphyrin
- hemochromatosis
-
5-aminolaevulinate
-
heptacarboxylic
-
hexachlorobenzene-induced
- hypertrichosis
-
phlebotomy
-
erythropoietic
-
delta-aminolaevulinic
-
polyhalogenated
-
5-aminolevulinic
- protoporphyrinogen
-
uroporphyria
- tetrapyrrole
-
sun-exposed
- blister
- siderosis
- diagnostics
-
3,4,3\',4\'-tetrachlorobiphenyl
- medicine
-
hcb-induced
-
miliae
- coproporphyria
- bulla
- agriculture
-
hepta
Reaction
Synonyms
ch-UroD, Decarboxylase, uroporphyrinogen, Hem12p, PCL, Porphyrinogen carboxy-lyase, rl-UroD, tobacco UROD, UORO-D, UPD, URO-D, Uro-decarboxylase, uro-III decarboxylase, UroD, UROD protein, UROD1, uroporphyrinogen decarboxylase, uroporphyrinogen decarboxylase 1, Uroporphyrinogen III decarboxylase, uroporphyrinogen-decarboxylase, uroporphyrinogen-III decarboxylase
ECTree
4.1.1.37 uroporphyrinogen decarboxylaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 4.1.1.37 - uroporphyrinogen decarboxylase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
uroporphyrinogen-III
coproporphyrinogen-III + CO2
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first branching point of the ubiquitous tetrapyrrole biosynthetic pathway, chlorophyll and heme biosynthesis
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?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
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fifth enzyme of the heme biosynthetic pathway
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?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
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fifth step in heme biosynthetic pathway, four sequential decarboxylation reactions
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?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
tetrapyrrole coordination, fifth step in the heme biosynthetic pathway
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?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
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fifth enzyme of the heme biosynthetic pathway
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?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
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involved in biosynthesis of chlorophyll and haem
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?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
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tetrapyrrole biosynthetic pathway, normally associated with pathogen defense
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?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
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fifth enzyme of the haem biosynthetic pathway
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?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
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heme pathway enzyme, catalyzes the stepwise decarboxylation of porphyrinogen acetic chains
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?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
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the enzyme functions in the heme biosynthetic pathway, catalyzing the decarboxylation of the four acetate groups of uroporphyrinogen to form coproporphyrinogen
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-
?
Uroporphyrinogen III
Coproporphyrinogen III + 4 CO2
-
fifth enzyme of the haem biosynthetic pathway
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?
additional information
?
-
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the enzyme catalyzes the fifth step in the heme biosynthetic pathway
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-
?
additional information
?
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-
porphyria cutanea tarda and hepatoerythropoietic porphyria result from deficiency of uroporphyrinogen decarboxylase
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-
?
additional information
?
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the familial porphyria cutanea tarda is a genetically determined kinetic abnormality of uroporphyrinogen decarboxylase
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-
?
additional information
?
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the enzyme is involved in biosynthesis of porphyrin
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-
?
additional information
?
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porphyria cutanea tarda results from a decreased activity of uroporphyrinogen decarboxylase, the fifth enzyme in heme biosynthesis. The frequency of familial porphyria cutanea tarda in Chile is approximately 50%
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-
?
additional information
?
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loss of the enzyme activity is a key event in both the induction and the persistence of porphyria
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?
