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3.5.4.16: GTP cyclohydrolase I

This is an abbreviated version!
For detailed information about GTP cyclohydrolase I, go to the full flat file.

Word Map on EC 3.5.4.16

Reaction

GTP
+
H2O
=
formate
 +
7,8-dihydroneopterin 3'-triphosphate

Synonyms

dihydroneopterin triphosphate synthase, FelE, folE, GCH, GCH-1, GCH1, GCHI, GCYH-IA, GCYH-IB, GTP 8-formylhydrolase, GTP CHase I, GTP cyclohydrolase, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP cyclohydrolase IA, GTP cyclohydrolase IB, GTP cyclohydrolase-1, GTP-CH, GTP-CH-I, GTP-CH1, GTP-cyclohydrolase 1, GTP-cyclohydrolase I, GTPCH, GTPCH I, GTPCH-1, GTPCH1, GTPCHI, guanosine 5'-triphosphate-cyclohydrolase I, guanosine triphosphate 8-deformylase, guanosine triphosphate cyclohydrolase, guanosine triphosphate cyclohydrolase 1, guanosine triphosphate cyclohydrolase I, guanosine-5'-triphosphate cyclohydrolase 1, hydrolase, guanosine triphosphate cyclo-, MptA, Punch, Punch protein

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.16 GTP cyclohydrolase I

Molecular Weight

Molecular Weight on EC 3.5.4.16 - GTP cyclohydrolase I

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
105000
-
gel filtration
108600
isozyme GCYH-1B, apparent molecular weight estimated from gel filtration
120000
-
wild-type enzyme in presence of 0.3 M KCl, mutants C110G, E111K, H112D, and C181S, gel filtration
135000
170000
Serratia indica
-
gel filtration
200000
Serratia indica
-
gel filtration, D-I, D-II
210000
-
gel filtration
230000
-
gel filtration
24500
10 * 24563, sequence calculation, 10 * 24500, MALDI-TOF mass spectrometry, 10 * 35000, recombinant HAT-tagged enzyme
24563
10 * 24563, sequence calculation, 10 * 24500, MALDI-TOF mass spectrometry, 10 * 35000, recombinant HAT-tagged enzyme
25000
250000
-
decameric wild-type enzyme, gel filtration
260000
-
GTP cyclohydrolase I
28568
4 * 28568, isozyme GCYH-1B, apparent molecular weight estimated from gel filtration
30000
300000
-
larger than 300000, gel filtration
35000
362000
-
gel filtration
37000
-
2 * 37000, SDS-PAGE
39000
400000
-
low molecular weight form, gel filtration
41000
-
x * 41000, SDS-PAGE
45000
-
isoform B, SDS-PAGE
47000
-
isoform C, SDS-PAGE
50000
51000
-
4 * 51000, SDS-PAGE
55700
-
6-8 * 55700, SDS-PAGE
575000
-
gel filtration
58000
-
4 * 58000, SDS-PAGE
600000
-
high molecular weight form, gel filtration
84000
-
gel filtration
91000
gel filtration
additional information
-
MW of mutant E152K is very high in gel filtration approximately corresponding to a didecameric form