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3.5.4.16: GTP cyclohydrolase I

This is an abbreviated version!
For detailed information about GTP cyclohydrolase I, go to the full flat file.

Word Map on EC 3.5.4.16

Reaction

GTP
+
H2O
=
formate
+
7,8-dihydroneopterin 3'-triphosphate

Synonyms

dihydroneopterin triphosphate synthase, FelE, folE, GCH, GCH-1, GCH1, GCHI, GCYH-IA, GCYH-IB, GTP 8-formylhydrolase, GTP CHase I, GTP cyclohydrolase, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP cyclohydrolase IA, GTP cyclohydrolase IB, GTP cyclohydrolase-1, GTP-CH, GTP-CH-I, GTP-CH1, GTP-cyclohydrolase 1, GTP-cyclohydrolase I, GTPCH, GTPCH I, GTPCH-1, GTPCH1, GTPCHI, guanosine 5'-triphosphate-cyclohydrolase I, guanosine triphosphate 8-deformylase, guanosine triphosphate cyclohydrolase, guanosine triphosphate cyclohydrolase 1, guanosine triphosphate cyclohydrolase I, guanosine-5'-triphosphate cyclohydrolase 1, hydrolase, guanosine triphosphate cyclo-, MptA, Punch, Punch protein

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.16 GTP cyclohydrolase I

Specific Activity

Specific Activity on EC 3.5.4.16 - GTP cyclohydrolase I

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000001
wild-type native enzyme and recombinant HAT10-tagged enzyme from expression in Escherichia coli BL21(DE3)
0.000029
recombinant enzyme from expression in Mycobacterium smegmatis/pSMT-260
0.0001
0.00027
recombinant HAT-tagged enzyme from expression in Escherichia coli JM109
0.00088
recombinant HAT-217-tagged enzyme from expression in Escherichia coli BL21(DE3)
0.088
wild-type enzyme, substrate 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate
0.091
wild-type enzyme, substrate GTP
6
purified recombinant HAT-tagged enzyme expressed in Escherichia coli
67
Serratia indica
-
-
additional information