Reference on EC 3.5.4.16 - GTP cyclohydrolase I
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schoedon, G.; Curtis, H.C.; Niederwieser, A.
Localization of GTP cyclohydrolase I in human peripheral blood smears using a specific monoclonal antibody and an immune-alkaline phosphatase labeling technique
Biochem. Biophys. Res. Commun.
148
1232-1236
1987
Homo sapiens
Ferre, J.; Yim, J.J.; Jacobson, K.B.
Purification of guanosine triphosphate cyclohydrolase I from Escherichia coli. The use of competitive inhibitors versus substrate as ligands in affinity chromatography
J. Chromatogr.
357
283-292
1986
Escherichia coli
Sawada, M.; Horikoshi, T.; Masada, M.; Akino, M.; Sugimoto, T.M.; Matsuura, S.; Nagatsu, T.
A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin
Anal. Biochem.
154
361-366
1986
Homo sapiens, Rattus norvegicus
Blau, N.; Niederwieser, A.
The application of 8-aminoguanosine triphosphate, a new inhibitor of GTP cyclohydrolase I, to the purification of the enzyme from human liver
Biochim. Biophys. Acta
880
26-31
1986
Homo sapiens
Weisberg, E.P.; O'Donnell, J.M.
Purification and characterization of GTP cyclohydrolase I from Drosophila melanogaster
J. Biol. Chem.
261
1453-1458
1986
Drosophila melanogaster
Blau, N.; Niederwieser, A.
GTP-cyclohydrolases: a review
J. Clin. Chem. Clin. Biochem.
23
169-176
1985
Geobacillus stearothermophilus, Comamonas sp., Escherichia coli, Lactiplantibacillus plantarum, Mammalia, Rattus norvegicus, Serratia indica
Blau, N.; Niederwieser, A.
GTP-cyclohydrolases: mini-review
Biochem. Clin. Aspects Pteridines
3
77-92
1984
Geobacillus stearothermophilus, Gallus gallus, Comamonas sp., Drosophila melanogaster, Escherichia coli, Lactiplantibacillus plantarum, Rattus norvegicus, Serratia indica
-
Ferre, J.; Jacobson, K.B.
Formation of beta,gamma-methylene-7,8-dihydroneopterin 3-triphosphate from beta,gamma-methyleneguanosine 5-triphosphate by GTP cyclohydrolase I of Escherichia coli
Arch. Biochem. Biophys.
233
475-480
1984
Escherichia coli
Suzuki, Y.; Yasui, T.; Abe, S.
Occurrence of GTP cyclohydrolase I in Bacillus stearothermophilus
J. Biochem.
86
1679-1685
1979
Geobacillus stearothermophilus
Yim, J.J.; Brown, G.M.
Characteristics of guanosine triphosphate cyclohydrolase I purified from Escherichia coli
J. Biol. Chem.
251
5087-5094
1976
Escherichia coli
Kohashi, M.; Itadani, T.; Iwai, K.
Purification and characterization of guanosine triphosphate cyclohydrolase from Serratia indica
Agric. Biol. Chem.
44
271-278
1980
Serratia indica
-
Kobashi, M.; Hariu, H.; Iwai, K.
Some properties of GTP cyclohydrolase from Serratia indica and the pterin product by its enzymatic reaction
Agric. Biol. Chem.
40
1597-1603
1976
Serratia indica
-
Cone, J.E.; Plowman, J.; Guroff, G.
Purification and properties of guanosine triphosphate cyclohydrolase and a stimulating protein from Comamonas sp. (ATCC 11299a)
J. Biol. Chem.
249
5551-5558
1974
Comamonas sp.
Burg, A.W.; Brown, G.M.
The biosynthesis of folic acid. 8. Purification and properties of the enzyme that catalyzes the production of formate from carbon atom 8 of guanosine triphosphate
J. Biol. Chem.
243
2349-2358
1968
Escherichia coli
Sohta, Y.; Ohta, T.; Masada, M.
Purification and some properties of GTP cyclohydrolase I from spinach leaves
Biosci. Biotechnol. Biochem.
61
1081-1085
1997
Spinacia oleracea
-
Hatakeyama, K.; Harada, T.; Kagamiyama, H.
IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels
J. Biol. Chem.
267
20734-20739
1992
Homo sapiens, Rattus norvegicus
Xie, L.; Smith, J.A.; Gross, S.S.
GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine
J. Biol. Chem.
273
21091-21098
1998
Rattus norvegicus
Yoneyama, T.; Brewers, J.M.; Hatakeyama, K.
GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits
J. Biol. Chem.
272
9690-9696
1997
Rattus norvegicus
Milstien, S.; Jaffe, H.; Kowlessu, D.; Bonner, T.I.
Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP
J. Biol. Chem.
271
19743-19751
1996
Rattus norvegicus
Cha, K.W.; Jacobson, K.B.; Yim, J.J.
Isolation and characterization of GTP cyclohydrolase I from mouse liver. Comparison of normal and the hph-1 mutant
J. Biol. Chem.
266
12294-12300
1991
Mus musculus
Sakamoto, H.; Fujita, K.; Idegame, M.; Teradaira, R.; Kuzuya, H.
Different complex forms of human liver GTP cyclohydrolase I
Biogenic Amines
12
55-67
1996
Homo sapiens
-
Yoo, J.C.; Han, J.M.; Ko, O.H.; Bang, H.J.
Purification and characterization of GTP cyclohydrolase I from Streptomyces tubercidicus, a producer of tubercidin
Arch. Pharm. Res.
21
692-697
1998
Streptomyces tubercidicus
Suzuki, T.; Ohye, T.; Inagaki, H.; Nagatsu, T.; Ichinose, H.
Characterization of wild-type and mutants of recombinant human GTP-cyclohydrolase I: Relationship to etiology of dopa-responsive dystonia
J. Neurochem.
73
2510-2516
1999
Homo sapiens
Schmid, C.; Ladenstein, R.; Luecke, H.; Huber, R.; Bacher, A.
Crystallization and preliminary crystallographic characterization of GTP cyclohydrolase I from Escherichia coli
J. Mol. Biol.
226
1279-1281
1992
Escherichia coli
De Saizieu, A.; Vankan, P.; van Loon, A.P.G.M.
Enzymic characterization of Bacillus subtilis GTP cyclohydrolase I. Evidence for a chemical dephosphorylation of dihydroneopterin triphosphate
Biochem. J.
306
371-377
1995
Bacillus subtilis
Hattori, Y.; Gross, S.S.
GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: Characterization, sequence and relationship to nitric oxide synthase
Biochem. Biophys. Res. Commun.
195
435-441
1993
Rattus norvegicus
Schoedon, G.; Redweik, U.; Frank, G.; Cotton, R.G.H.; Blau, N.
Allosteric characteristics of GTP cyclohydrolase I from Escherichia coli
Eur. J. Biochem.
210
561-568
1992
Escherichia coli
Bracher, A.; Schramek, N.; Bacher, A.
Biosynthesis of pteridines. Stopped-flow kinetic analysis of GTP cyclohydrolase I
Biochemistry
40
7896-7902
2001
Escherichia coli
Suzuki, T.; Kurita, H.; Ichinose, H.
GTP cyclohydrolase I utilizes metal-free GTP as its substrate
Eur. J. Biochem.
271
349-355
2004
Homo sapiens
Lee, S.; Ahn, C.; Park, E.; Hwang, D.S.; Yim, J.
Biochemical characterization of oligomerization of Escherichia coli GTP cyclohydrolase I
J. Biochem. Mol. Biol.
35
255-261
2002
Escherichia coli
Maita, N.; Hatakeyama, K.; Okada, K.; Hakoshima, T.
Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory proteins
J. Biol. Chem.
279
51534-51540
2004
Rattus norvegicus
Bader, G.; Schiffmann, S.; Herrmann, A.; Fischer, M.; Gutlich, M.; Auerbach, G.; Ploom, T.; Bacher, A.; Huber, R.; Lemm, T.
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP
J. Mol. Biol.
312
1051-1057
2001
Rattus norvegicus
Schramek, N.; Bracher, A.; Fischer, M.; Auerbach, G.; Nar, H.; Huber, R.; Bacher, A.
Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate
J. Mol. Biol.
316
829-837
2002
Escherichia coli
Rebelo, J.; Auerbach, G.; Bader, G.; Bracher, A.; Nar, H.; Hosl, C.; Schramek, N.; Kaiser, J.; Bacher, A.; Huber, R.; Fischer, M.
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I
J. Mol. Biol.
326
503-516
2003
Escherichia coli (P0A6T5), Escherichia coli
Auerbach, G.; Herrmann, A.; Bracher, A.; Bader, G.; Gutlich, M.; Fischer, M.; Neukamm, M.; Garrido-Franco, M.; Richardson, J.; Nar, H.; Huber, R.; Bacher, A.
Zinc plays a key role in human and bacterial GTP cyclohydrolase I
Proc. Natl. Acad. Sci. USA
97
13567-13572
2000
Escherichia coli, Homo sapiens (P30793), Homo sapiens
Maita, N.; Okada, K.; Hatakeyama, K.; Hakoshima, T.
Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP
Proc. Natl. Acad. Sci. USA
99
1212-1217
2002
Rattus norvegicus
He, A.; Simpson, D.R.; Daniels, L.; Rosazza, J.P.
Cloning, expression, purification, and characterization of Nocardia sp. GTP cyclohydrolase I
Protein Expr. Purif.
35
171-180
2004
Nocardia iowensis (Q8GLS8), Nocardia iowensis, Nocardia iowensis NRRL 5646 (Q8GLS8)
Yoneyama, T.; Hatakeyama, K.
Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes
Protein Sci.
10
871-878
2001
Rattus norvegicus
Basset, G.; Quinlivan, E.P.; Ziemak, M.J.; Diaz de la garza, R.; Fischer, M.; Schiffmann, S.; Bacher, A.; Gregory II, J.F.; Hanson, A.D.
Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I
Proc. Natl. Acad. Sci. USA
99
12489-12494
2002
Arabidopsis thaliana (Q8S3C2), Solanum lycopersicum (Q8VYU3), Solanum lycopersicum
Hung, Y.C.; Tsai, P.S.; Huang, C.J.; Yang, S.; Skimming, J.W.; Hsieh, M.C.
Change in expression of the guanosine triphosphate cyclohydrolase I in LPS-stimulated rats is tissue specific
Acta Anaesthesiol. Taiwan.
42
23-31
2004
Rattus norvegicus
Fujiwara, K.; Mori, K.; Kaneko, Y.S.; Nakashima, A.; Nagasaka, A.; Itoh, M.; Ota, A.
Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide
Biochim. Biophys. Acta
1670
181-198
2004
Mus musculus (Q05915), Mus musculus
Christensen, R.; Alhonen, L.; Wahlfors, J.; Jakobsen, M.; Jensen, T.G.
Characterization of transgenic mice with the expression of phenylalanine hydroxylase and GTP cyclohydrolase I in the skin
Exp. Dermatol.
14
535-542
2005
Mus musculus
Futahashi, R.; Fujiwara, H.
Expression of one isoform of GTP cyclohydrolase I coincides with the larval black markings of the swallowtail butterfly, Papilio xuthus
Insect Biochem. Mol. Biol.
36
63-70
2006
Papilio xuthus
Tanaka, Y.; Nakagawa, N.; Kuramitsu, S.; Yokoyama, S.; Masui, R.
Novel reaction mechanism of GTP cyclohydrolase I. High-resolution X-ray crystallography of Thermus thermophilus HB8 enzyme complexed with a transition state analogue, the 8-oxoguanine derivative
J. Biochem.
138
263-275
2005
Thermus thermophilus (Q5SH52), Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SH52)
Kolinsky, M.A.; Gross, S.S.
The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein
J. Biol. Chem.
279
40677-40682
2004
Rattus norvegicus
Serova, L.I.; Filipenko, M.; Schilt, N.; Veerasirikul, M.; Sabban, E.L.
Estrogen-triggered activation of GTP cyclohydrolase 1 gene expression: Role of estrogen receptor subtypes and interaction with cyclic AMP
Neuroscience
140
1253-1263
2006
Rattus norvegicus
Nandi, M.; Leiper, J.; Arrigoni, F.; Hislop, A.; Vallance, P.; Haworth, S.
Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxation
Pediatr. Res.
59
767-772
2006
Sus scrofa
Diaz de la Garza, R.; Quinlivan, E.P.; Klaus, S.M.; Basset, G.J.; Gregory, J.F.; Hanson, A.D.
Folate biofortification in tomatoes by engineering the pteridine branch of folate synthesis
Proc. Natl. Acad. Sci. USA
101
13720-13725
2004
Mus musculus (Q05915)
Gibson, C.L.; La Rosa, S.; Ohta, K.; Boyle, P.H.; Leurquin, F.; Lemacon, A.; Suckling, C.J.
The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase I
Tetrahedron
60
943-959
2004
Escherichia coli
-
Seujange, Y.; Eiam-Ong, S.; Tirawatnapong, T.; Eiam-Ong, S.
Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion
Am. J. Nephrol.
28
692-700
2008
Rattus norvegicus (P22288), Rattus norvegicus
Grochowski, L.L.; Xu, H.; Leung, K.; White, R.H.
Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii
Biochemistry
46
6658-6667
2007
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii MJ0775
Eells, J.B.; Misler, J.A.; Nikodem, V.M.
Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice
Brain Res. Bull.
70
186-195
2006
Mus musculus
Liao, S.J.; Lin, L.; Zeng, J.S.; Huang, R.X.; Channon, K.M.; Chen, A.F.
Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery
Clin. Exp. Pharmacol. Physiol.
34
1260-1266
2007
Mus musculus, Mus musculus C57BL/6
Funderburk, C.D.; Bowling, K.M.; Xu, D.; Huang, Z.; ODonnell, J.M.
A typical N-terminal extensions confer novel regulatory properties on GTP cyclohydrolase isoforms in Drosophila melanogaster
J. Biol. Chem.
281
33302-33312
2006
Drosophila melanogaster
Zhang, L.; Rao, F.; Zhang, K.; Khandrika, S.; Das, M.; Vaingankar, S.M.; Bao, X.; Rana, B.K.; Smith, D.W.; Wessel, J.; Salem, R.M.; Rodriguez-Flores, J.L.; Mahata, S.K.; Schork, N.J.; Ziegler, M.G.; OConnor, D.T.
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk
J. Clin. Invest.
117
2658-2671
2007
Homo sapiens (P30793), Homo sapiens
Lopez-Laso, E.; Camino, R.; Mateos, M.E.; Perez-Navero, J.L.; Ochoa, J.J.; Lao-Villadoniga, J.I.; Ormazabal, A.; Artuch, R.
Dopa-responsive infantile hypokinetic rigid syndrome due to dominant guanosine triphosphate cyclohydrolase 1 deficiency
J. Neurol. Sci.
256
90-93
2007
Homo sapiens
Wang, W.; Zolty, E.; Falk, S.; Summer, S.; Zhou, Z.; Gengaro, P.; Faubel, S.; Alp, N.; Channon, K.; Schrier, R.
Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1
Am. J. Physiol. Renal Physiol.
294
F571-F576
2008
Homo sapiens
Chiou, Y.W.; Hwu, W.L.; Lee, Y.M.
Hsp27 decreases inclusion body formation from mutated GTP-cyclohydrolase I protein
Biochim. Biophys. Acta
1782
169-179
2008
Homo sapiens
Du, Y.H.; Guan, Y.Y.; Alp, N.J.; Channon, K.M.; Chen, A.F.
Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension
Circulation
117
1045-1054
2008
Homo sapiens
Wenzel, P.; Schulz, E.; Oelze, M.; Mueller, J.; Schuhmacher, S.; Alhamdani, M.S.; Debrezion, J.; Hortmann, M.; Reifenberg, K.; Fleming, I.; Muenzel, T.; Daiber, A.
AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats
Free Radic. Biol. Med.
45
619-626
2008
Rattus norvegicus
Souza, C.P.; Valadares, E.R.; Trindade, A.L.; Rocha, V.L.; Oliveira, L.R.; Godard, A.L.
Mutation in intron 5 of GTP cyclohydrolase 1 gene causes dopa-responsive dystonia (Segawa syndrome) in a Brazilian family
Genet. Mol. Res.
7
687-694
2008
Homo sapiens
Wang, S.; Xu, J.; Song, P.; Wu, Y.; Zhang, J.; Chul Choi, H.; Zou, M.H.
Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure
Hypertension
52
484-490
2008
Bos taurus, Mus musculus
Peterson, T.E.; dUscio, L.V.; Cao, S.; Wang, X.L.; Katusic, Z.S.
Guanosine triphosphate cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells
Hypertension
53
189-195
2009
Mus musculus
Phillips, G.; El Yacoubi, B.; Lyons, B.; Alvarez, S.; Iwata-Reuyl, D.; de Crecy-Lagard, V.
Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I
J. Bacteriol.
190
7876-7884
2008
Escherichia coli, Haloferax volcanii
Bowling, K.M.; Huang, Z.; Xu, D.; Ferdousy, F.; Funderburk, C.D.; Karnik, N.; Neckameyer, W.; O'Donnell, J.M.
Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis
J. Biol. Chem.
283
31449-31459
2008
Drosophila melanogaster
Tatham, A.L.; Crabtree, M.J.; Warrick, N.; Cai, S.; Alp, N.J.; Channon, K.M.
GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression
J. Biol. Chem.
284
13660-13668
2009
Mus musculus
Chavan, B.; Beazley, W.; Wood, J.M.; Rokos, H.; Ichinose, H.; Schallreuter, K.U.
H2O2 increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo
J. Inherit. Metab. Dis.
32
86-94
2009
Homo sapiens
Chiarini, A.; Armato, U.; Pacchiana, R.; Dal Pra, I.
Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions
Proteomics
9
1850-1860
2009
Homo sapiens
Nandi, M.; Kelly, P.; Vallance, P.; Leiper, J.
Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production
Vasc. Med.
13
29-36
2008
Mus musculus
Tie, L.; Li, X.J.; Wang, X.; Channon, K.M.; Chen, A.F.
Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes
Am. J. Physiol. Endocrinol. Metab.
296
E1423-E1429
2009
Mus musculus
Kumar, S.; Sun, X.; Sharma, S.; Aggarwal, S.; Ravi, K.; Fineman, J.R.; Black, S.M.
GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP
Am. J. Physiol. Lung Cell Mol. Physiol.
297
L309-L317
2009
Ovis aries
Du, J.; Wei, N.; Xu, H.; Ge, Y.; Vasquez-Vivar, J.; Guan, T.; Oldham, K.T.; Pritchard, K.A.; Shi, Y.
Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I
Arterioscler. Thromb. Vasc. Biol.
29
2161-2168
2009
Rattus norvegicus
Du, J.; Xu, H.; Wei, N.; Wakim, B.; Halligan, B.; Pritchard, K.A.; Shi, Y.
Identification of proteins interacting with GTP cyclohydrolase I
Biochem. Biophys. Res. Commun.
385
143-147
2009
Rattus norvegicus
Hu, F.Y.; Xu, Y.M.; Yu, L.H.; Ma, M.Y.; He, X.H.; Zhou, D.
A novel missense mutation in GTP cyclohydrolase I (GCH1) gene causes dopa-responsive dystonia in Chinese Han population
Eur. J. Neurol.
18
362-364
2011
Homo sapiens
Sankaran, B.; Bonnett, S.A.; Shah, K.; Gabriel, S.; Reddy, R.; Schimmel, P.; Rodionov, D.A.; de Crecy-Lagard, V.; Helmann, J.D.; Iwata-Reuyl, D.; Swairjo, M.A.
Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB
J. Bacteriol.
191
6936-6949
2009
Bacillus subtilis, Neisseria gonorrhoeae (Q5F9K6)
Ionova, I.A.; Vasquez-Vivar, J.; Cooley, B.C.; Khanna, A.K.; Whitsett, J.; Herrnreiter, A.; Migrino, R.Q.; Ge, Z.D.; Regner, K.R.; Channon, K.M.; Alp, N.J.; Pieper, G.M.
Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection
Am. J. Physiol. Heart Circ. Physiol.
299
H88-H96
2010
Homo sapiens, Mus musculus, Mus musculus C57BL6
Sun, X.; Fratz, S.; Sharma, S.; Hou, Y.; Rafikov, R.; Kumar, S.; Rehmani, I.; Tian, J.; Smith, A.; Schreiber, C.; Reiser, J.; Naumann, S.; Haag, S.; Hess, J.; Catravas, J.D.; Patterson, C.; Fineman, J.R.; Black, S.M.
C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow
Am. J. Respir. Cell Mol. Biol.
45
163-171
2011
Ovis aries
Li, L.; Rezvan, A.; Salerno, J.; Husain, A.; Kwon, K.; Jo, H.; Harrison, D.; Chen, W.
GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide
Circ. Res.
106
328-336
2010
Homo sapiens
Higgins, C.E.; Gross, S.S.
The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP
J. Biol. Chem.
286
11919-11928
2011
Rattus norvegicus
Ferdousy, F.; Bodeen, W.; Summers, K.; Doherty, O.; Wright, O.; Elsisi, N.; Hilliard, G.; O'Donnell, J.M.; Reiter, L.T.
Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism
Neurobiol. Dis.
41
669-677
2011
Drosophila melanogaster (D8FT24), Drosophila melanogaster (E4NKN2), Drosophila melanogaster (P48596)
Du, J.; Teng, R.J.; Lawrence, M.; Guan, T.; Xu, H.; Ge, Y.; Shi, Y.
The protein partners of GTP cyclohydrolase I in rat organs
PLoS ONE
7
e33991
2012
Rattus norvegicus, Rattus norvegicus Sprague Dawley
Kuempornsin, K.; Kotanan, N.; Chobson, P.; Kochakarn, T.; Jirawatcharadech, P.; Jaru-ampornpan, P.; Yuthavong, Y.; Chookajorn, T.
Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
Malar. J.
13
150
2014
Plasmodium falciparum (O97071), Plasmodium falciparum
Wolkow, P.P.; Kosiniak-Kamysz, W.; Osmenda, G.; Wilk, G.; Bujak-Gizycka, B.; Ignacak, A.; Kanitkar, M.; Walus-Miarka, M.; Harrison, D.G.; Korbut, R.; Malecki, M.T.; Guzik, T.J.
GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus
PLoS ONE
9
e108587
2014
Homo sapiens (P30793), Homo sapiens
Schuessler, S.; Haase, I.; Perbandt, M.; Illarionov, B.; Siemens, A.; Richter, K.; Bacher, A.; Fischer, M.; Graewert, T.
Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target
Acta Crystallogr. Sect. F
75
586-592
2019
Listeria monocytogenes serotype 1/2a (Q8Y5X1), Listeria monocytogenes serotype 1/2a ATCC BAA-679 (Q8Y5X1)
Paranagama, N.; Bonnett, S.A.; Alvarez, J.; Luthra, A.; Stec, B.; Gustafson, A.; Iwata-Reuyl, D.; Swairjo, M.A.
Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB
Biochem. J.
474
1017-1039
2017
Neisseria gonorrhoeae (Q5F9K6), Neisseria gonorrhoeae, Neisseria gonorrhoeae ATCC 700825 (Q5F9K6)
Wu, H.E.; Baumgardt, S.L.; Fang, J.; Paterson, M.; Liu, Y.; Du, J.; Shi, Y.; Qiao, S.; Bosnjak, Z.J.; Warltier, D.C.; Kersten, J.R.; Ge, Z.D.
Cardiomyocyte GTP cyclohydrolase 1 protects the heart against diabetic cardiomyopathy
Sci. Rep.
6
27925
2016
Mus musculus (Q05915), Mus musculus
Liu, Y.; Baumgardt, S.L.; Fang, J.; Shi, Y.; Qiao, S.; Bosnjak, Z.J.; Vasquez-Vivar, J.; Xia, Z.; Warltier, D.C.; Kersten, J.R.; Ge, Z.D.
Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling
Sci. Rep.
7
3093
2017
Mus musculus (Q05915)
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