3.5.4.16: GTP cyclohydrolase I

This is an abbreviated version!
For detailed information about GTP cyclohydrolase I, go to the full flat file.

Reaction

Synonyms

dihydroneopterin triphosphate synthase, FelE, folE, GCH, GCH-1, GCH1, GCHI, GCYH-IA, GCYH-IB, GTP 8-formylhydrolase, GTP CHase I, GTP cyclohydrolase, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP cyclohydrolase IA, GTP cyclohydrolase IB, GTP cyclohydrolase-1, GTP-CH, GTP-CH-I, GTP-CH1, GTP-cyclohydrolase 1, GTP-cyclohydrolase I, GTPCH, GTPCH I, GTPCH-1, GTPCH1, GTPCHI, guanosine 5'-triphosphate-cyclohydrolase I, guanosine triphosphate 8-deformylase, guanosine triphosphate cyclohydrolase, guanosine triphosphate cyclohydrolase 1, guanosine triphosphate cyclohydrolase I, guanosine-5'-triphosphate cyclohydrolase 1, hydrolase, guanosine triphosphate cyclo-, MptA, Punch, Punch protein

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.16 GTP cyclohydrolase I

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Results	in table
17	Activating Compound
48611	AA Sequence
9	Application
1	CAS Registry Number
30	Cloned(Commentary)
10	Crystallization (Commentary)
1199	Disease/ Diagnostics
5	Expression
34	General Information
1	General Stability
170	Inhibitors
10	Ki Value [mM]
39	KM Value [mM]
14	Localization
24	Metals/Ions
41	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
273	Organism
15	Pathway
286	PDB ID
39	pH Optimum
1	pH Range
2	pH Stability
3	Posttranslational Modification
68	Protein Variants
31	Purification (Commentary)
11	Reaction
2	Reaction Type
118	Reference
2	Renatured (Commentary)
86	Source Tissue
29	Specific Activity [micromol/min/mg]
5	Storage Stability
161	Substrates and Products (Substrate)
30	Subunits
120	Synonyms
1	Systematic Name
24	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
5	Turnover Number [1/s]

Application

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Application on EC 3.5.4.16 - GTP cyclohydrolase I

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

biotechnology

2 entries

medicine

4 entries

molecular biology

2 entries

nutrition

Mus musculus

Q05915

construction of transgenic tomato plants expressing GCHI for engineering of the peteridine branch of folate synthesis in Lycopersicon esculentum by folate biofortification, overview

670660

biotechnology

Mus musculus

Q05915

construction of transgenic tomato plants expressing GCHI for engineering of the peteridine branch of folate synthesis in Lycopersicon esculentum by folate biofortification, overview

670660

biotechnology

Mus musculus

-

creation of a phenylalanine sink by transgenic overexpression of phenylalnine hydroxylase and GTP cyclohydrolase I in the skin to reduce high phenylalanine concentrations in the blood in phenylketonuria metabolic disease

668507

medicine

Homo sapiens

-

endothelium-specific GTPCH I overexpression retards the progression of hypertension through preservation of the structure and function of resistance mesenteric arteries, endothelium-specific GTPCH I overexpression abrogates superoxide anion production and preserves endothelial nitric oxide synthase phosphorylation, which results in preserved structural and functional integrity of resistance mesenteric arteries and lowered blood pressure in low-renin hypertension

697359

medicine

Homo sapiens

-

mutations in GCH are associated with dopa-responsive dystonia and hyperphenylalaninemia

696398

medicine

Homo sapiens

-

the mutation in the intron 5 splicing site of the GCH1 gene, IVS5+3insT, causes Dopa-responsive dystonia (also known as Segawa syndrome or hereditary progressive dystonia with diurnal fluctuation)

698116

medicine

Mus musculus

Q05915

cardiomyocyte GTP cyclohydrolase 1 is a therapeutic target for cardiac remodeling and dysfunction after myocardial infarction

758404

molecular biology

Drosophila melanogaster

D8FT24, E4NKN2, P48596

mutations in Punch can act as genetic enhancers of Dube3a over-expression phenotypes

720551

molecular biology

Drosophila melanogaster

D8FT24, E4NKN2, P48596

mutations in Punch can act as genetic enhancers of Dube3a overexpression phenotypes

720551