3.4.24.35: gelatinase B
This is an abbreviated version!
For detailed information about gelatinase B, go to the full flat file.
Word Map on EC 3.4.24.35
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3.4.24.35
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mmp-2
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metalloproteinases
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zymography
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metastasis
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timp-1
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endothelial
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necrosis
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angiogenesis
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tnf
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artery
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fibrosis
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neutrophil
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chemokine
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infarct
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plaque
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monocyte
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vessel
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pulmonary
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myocardial
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cerebral
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mapks
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stroke
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erk
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transwell
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basement
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aortic
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invasiveness
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plasminogen
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blood-brain
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matrigel
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bcl-2
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nf-kappab
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airway
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upa
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osteoclast
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cox-2
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fibronectin
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aneurysm
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c-reactive
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mt1-mmp
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e-cadherin
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coronary
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tnf-alpha
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angiogenic
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atherosclerotic
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anti-metastatic
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tartrate-resistant
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urokinase-type
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drug development
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diagnostics
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elastin
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rankl
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medicine
- 3.4.24.35
- mmp-2
- metalloproteinases
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zymography
- metastasis
- timp-1
- endothelial
- necrosis
- angiogenesis
- tnf
- artery
- fibrosis
- neutrophil
- chemokine
- infarct
- plaque
- monocyte
- vessel
- pulmonary
- myocardial
- cerebral
- mapks
- stroke
- erk
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transwell
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basement
- aortic
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invasiveness
- plasminogen
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blood-brain
- matrigel
- bcl-2
- nf-kappab
- airway
- upa
- osteoclast
- cox-2
- fibronectin
- aneurysm
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c-reactive
- mt1-mmp
- e-cadherin
- coronary
- tnf-alpha
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angiogenic
- atherosclerotic
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anti-metastatic
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tartrate-resistant
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urokinase-type
- drug development
- diagnostics
- elastin
- rankl
- medicine
Reaction
Cleavage of gelatin types I and V and collagen types IV and V =
Synonyms
92 kDa gelatinase, 92 kDa type IV collagenase, 92 kDa type IV collagenase proMMP-9, 92-kDa Gelatinase, 92-kDa gelatinase B, 92-kDa Type IV collagenase, 95 kDa type IV collagenase/gelatinase, Collagenase IV, Collagenase type IV, gelatinase, gelatinase B, Gelatinase MMP 9, gelatinolytic enzyme, GELB, Macrophage gelatinase, matrix metallopeptidase 9, matrix metallopeptidase 9 gelatinase B, matrix metalloprotease-9, Matrix metalloproteinase 9, matrix metalloproteinase-9, metrix metalloproteinase-9, MMP 9, MMP-9, MMP9, neutrophil collagenase, pro-matrix metalloproteinase-9, progelatinase, Type IV collagen metalloproteinase, Type IV collagenase, Type IV collagenase/gelatinase, Type V collagenase
ECTree
3.4.24.35 gelatinase BAdvanced search results
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results (Activating Compound
Activating Compound on EC 3.4.24.35 - gelatinase B
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2,3,7,8-tetrachlorodibenzo-p-dioxin
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both MMP-9 mRNA expression and enzymatic activity are gradually increased with the concentration increase of 2,3,7,8-tetrachlorodibenzo-p-dioxin in media and these changes can be reversed by resveratrol treatment in a dose-dependent manner, c-Jun mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced MMP-9 expression and activity
4-amino phenylmercuric acetate
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pro-MMP-9 is activated with 1 mM 4-amino phenylmercuric acetate in assay buffer at 37°C for 1.5 h
acrolein
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activates MMP-9 via EGFR/MAPK signaling and stimulation of pro-MMP-9 cleavage
cathepsin G
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MMP9 is released in an inactive form and requires proteolytic activation, cathepsin G mediates activation of pro-matrix metalloproteinase 9
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chymase
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chymase converts promatrix metalloproteinase-9 to matrix metalloproteinase-9
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fibronectin
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fibronectin enhances, in a PKC-dependent manner, the net activity of MMP-9, but not its expression
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homocysteine
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homocysteine activates matrix metalloproteinase-9, muscimol ameliorates the homocysteine-mediated MMP-9 activation
lipopolysaccharide
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lipopolysaccharide challenge (0.001 mg/ml) increases the protein level of MMP-9 and induces the activity of MMP-9 in H9c2 cardiomyoblasts through ERK1/2 signaling pathway
matrix metalloproteinase-7
MMP-9 is activated by matrix metalloproteinase-7
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platelet-activating factor
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i.e. 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, induces MMP-9 enzyme expression, and increases enzyme content and activity
4-aminophenylmercuric acetate
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APMA activation of MMP-9 affects tissue inhibitor of metalloproteinase-1 binding to the enzyme resulting in the loss of natural enzyme inhibition
4-aminophenylmercuric acetate
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1 mM 4-aminophenylmercuric acetate-mediated activation of MMP-9 provokes autocatalytic cleavage of recombinant MMP-9
4-aminophenylmercuric acetate
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after treatment with 4-aminophenylmercuric acetate, affinity-purified W-256 cell gelatinase is converted to a final processed form of 66000 Da
phorbol 12-myristate 13-acetate
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the effect of phorbol 12-myristate 13-acetate (1.3 nM), a known activator of MMP-9 secretion, is about 10fold greater than that of 0.01 mM arachidonic acid. Addition of 0.001 mM and 0.01 mM arachidonic acid, eicosapentaenoic acid or docosapentaenoic acid along with phorbol 12-myristate 13-acetate does not affect MMP-9 production.
phorbol 12-myristate 13-acetate
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30 nM 12-phorbol 13-myristate acetate is used to activate MMP-9, aqueous extract isolated from Prunella vulgaris reduces 12-phorbol 13-myristate acetate-induced activation of MMP-9
phorbol 12-myristate 13-acetate
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30 nM 12-phorbol 13-myristate acetate is used to activate MMP-9, aqueous extract isolated from Prunella vulgaris reduces 12-phorbol 13-myristate acetate-induced activation of MMP-9
additional information
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binding of the zymogen to fetuin or asialofetuin results in activation
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additional information
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activation by trypsin, MMP3, and MMP10, computational model of MMP9 activation and inhibition, overview
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additional information
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activation of pro-MMP-9 by 4-aminophenylmercuric acetate
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additional information
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beta-hematin, and not hemin, accelerates the activation of MMP-9, activation of MMP-9 by hemin and MMP-3, overview
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additional information
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relaxin induces enzyme expression in THP-1 cells, while it reduces expression of NF-kappaB inhibitor protein, IkappaB-alpha, overview
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additional information
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0.001-0.04 mM arachidonic acid increases matrix metalloproteinase 9 secretion and expression at the mRNA level
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additional information
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activator protein-4 expression may play an important role in the induction of synthesis of MMP-9
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additional information
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cells treated with more than 1 ng/ml of tissue growth factor-beta1 secrete pro-MMP-9 in a dose dependant manner, addition of 20 ng/ml of tissue necrosis factor-alpha further upregulates pro-MMP-9 expression
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additional information
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dermal fibroblasts and hepatic stellate cells require type-I collagen which boosts Jun N-terminal kinase activity to maximally induce MMP-9
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additional information
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eicosapentaenoic acid, docosapentaenoic acid or docosahexaenoic acid by themselves have no effect on MMP-9 secretion
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additional information
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human arteries subjected to ex vivo angioplasty and stent implantation display increased in-stent intimal hyperplasia and higher MMP-9 activity in the presence of leukotriene B4
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additional information
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MMP-9 expression is increased after a 16 h acetaldehyde treatment (0.1 mM)
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additional information
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MMP-9 is activated by a whole-cell extract from Prevotella nigrescens ATCC 33563
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additional information
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Notch1 may be involved in MMP9 activation either by enhancing its expression or by stabilizing the protein
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additional information
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several members of the vascular endothelial growth factor family and the three vascular endothelial growth factor receptors are responsible for secretion of MMP-9 via an autocrine loop
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additional information
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the MMP-9 mRNA expression is inducible by vascular endothelial growth factor
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additional information
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treatment with phorbol 12-myristate 13-acetate (100 ng/ml) induces MMP-9 expression in glandular epithelia, supportive connective tissue, and muscle tissue cell lines
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additional information
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treatment with tissue necrosis factor increases MMP9 release while pre-treatment with alpha-lipoic acid (6,8-dithio-octanoic acid) inhibits this tissue necrosis factor-induced effect
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additional information
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the presence of an intact active site and hemopexin domain are required for full angiogenesis-inducing activity of the MMP-9 enzyme
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additional information
enzyme MMP-9 is released in the inactive form as proenzyme and can be secreted in physical association with its specific tissue inhibitor (TIMP-1) as proMMP-9/TIMP-1 complex or as TIMP-1 free protein. Activation of MMP-9 requires a complex network of mechanisms involving other matrix metalloproteases
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additional information
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gastric gelatinase B is rapidly increased in Helicobacter felis-induced gastritis
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additional information
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MMP-9 is upregulated by tumor necrosis factor alpha, TNFalpha
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additional information
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pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression
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additional information
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ectopic Fra-1 markedly stimulates MMP-9 mRNA expression
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additional information
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MMP-9 is significantly upregulated on day 2 after wounding in the impaired healing (macrophage depleted) animals that receive hyperbaric oxygen treatment as compared with impaired healing animals that does not receive hyperbaric oxygen treatment
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additional information
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ATP non-transcriptionally increases MMP-9 activity by activation of P2Y and PI3K, the increased activity of secreted MMP-9 is due to the increased protein secretion, but not by the increased MMP-9 mRNA and protein expression
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additional information
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implantation of 9L glioma cells into brain increases the expression of MMP-9, overview
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additional information
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MMP-9 is induced in small renal arteries by recombinant human relaxin, up-regulation of 70%
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additional information
an increase in hypoxia-inducible factor-1alpha is followed by a significant increase in MMP-9 gene expression at 4 h at 24 h post-traumatic brain injury, traumatic brain injury increases MMP-9 mRNA and protein levels in cortical and hippocampal regions early at 4 h post-traumatic brain injury, persisting for 5 days
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additional information
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benzo[a]pyrene increases the mRNA level of matrix metalloproteinase 9
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additional information
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high glucose (25 mM) induces expression of MMP-9
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additional information
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tissue kallikrein is a potent activator of latent proenzyme
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