3.4.24.35: gelatinase B
This is an abbreviated version!
For detailed information about gelatinase B, go to the full flat file.
Word Map on EC 3.4.24.35
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3.4.24.35
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mmp-2
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metalloproteinases
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zymography
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metastasis
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timp-1
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endothelial
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necrosis
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angiogenesis
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tnf
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artery
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fibrosis
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neutrophil
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chemokine
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infarct
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plaque
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monocyte
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vessel
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pulmonary
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myocardial
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cerebral
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mapks
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stroke
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erk
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transwell
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basement
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aortic
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invasiveness
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plasminogen
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blood-brain
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matrigel
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bcl-2
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nf-kappab
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airway
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upa
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osteoclast
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cox-2
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fibronectin
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aneurysm
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c-reactive
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mt1-mmp
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e-cadherin
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coronary
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tnf-alpha
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angiogenic
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atherosclerotic
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anti-metastatic
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tartrate-resistant
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urokinase-type
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drug development
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diagnostics
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elastin
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rankl
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medicine
- 3.4.24.35
- mmp-2
- metalloproteinases
-
zymography
- metastasis
- timp-1
- endothelial
- necrosis
- angiogenesis
- tnf
- artery
- fibrosis
- neutrophil
- chemokine
- infarct
- plaque
- monocyte
- vessel
- pulmonary
- myocardial
- cerebral
- mapks
- stroke
- erk
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transwell
-
basement
- aortic
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invasiveness
- plasminogen
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blood-brain
- matrigel
- bcl-2
- nf-kappab
- airway
- upa
- osteoclast
- cox-2
- fibronectin
- aneurysm
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c-reactive
- mt1-mmp
- e-cadherin
- coronary
- tnf-alpha
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angiogenic
- atherosclerotic
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anti-metastatic
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tartrate-resistant
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urokinase-type
- drug development
- diagnostics
- elastin
- rankl
- medicine
Reaction
Cleavage of gelatin types I and V and collagen types IV and V =
Synonyms
92 kDa gelatinase, 92 kDa type IV collagenase, 92 kDa type IV collagenase proMMP-9, 92-kDa Gelatinase, 92-kDa gelatinase B, 92-kDa Type IV collagenase, 95 kDa type IV collagenase/gelatinase, Collagenase IV, Collagenase type IV, gelatinase, gelatinase B, Gelatinase MMP 9, gelatinolytic enzyme, GELB, Macrophage gelatinase, matrix metallopeptidase 9, matrix metallopeptidase 9 gelatinase B, matrix metalloprotease-9, Matrix metalloproteinase 9, matrix metalloproteinase-9, metrix metalloproteinase-9, MMP 9, MMP-9, MMP9, neutrophil collagenase, pro-matrix metalloproteinase-9, progelatinase, Type IV collagen metalloproteinase, Type IV collagenase, Type IV collagenase/gelatinase, Type V collagenase
ECTree
3.4.24.35 gelatinase BAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.24.35 - gelatinase B
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dentin sialoprotein + H2O
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the enzyme highly efficiently cleaves dentin sialoprotein into distinct fragments in vitro, and the deletion of Mmp9 causes improper processing of dentin sialoprotein in natural teeth
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epidermal growth factor + H2O
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MMP-9 induces TGF-beta1 production in the airway epithelium through the cleavage of epidermal growth factor, EGF, and membrane-bound EGF-like ligands and activating epidermal growth factor receptor
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?
transforming growth factor-beta + H2O
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MMP9 mediates activation of latent transforming growth factor-beta
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?
Elastin + H2O
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MMP-9 activity leads to elastin breakdown in an animal model of Kawasaki disease, a multisystem vasculitis leading to damage in the coronary circulationand aneurysm formation, overview
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?
fibrillar collagen + H2O
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degradation, MMP-9 is involved in development of osteoarthritis, overview
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?
Gelatin + H2O
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?
Gelatin + H2O
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MMP-9 is involved in the degradation of the extracellular matrix, and is implicated in a variety of pathological conditions including cardiovascular and neoplastic diseases
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?
Gelatin + H2O
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?
islet amyloid polypeptide + H2O
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enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
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?
islet amyloid polypeptide + H2O
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enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
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?
islet amyloid polypeptide + H2O
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enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
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?
pro-urokinase + H2O
active urokinase + prosequence of urokinase
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?
additional information
?
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active host MMP-9 is expressed in walls and fluids of hydatid cysts of parasite Echinococcus granulosus in the environment of granulomatous reaction, in vivo activation of MMP-9 suggests its involvement in inflammatory reaction and in the chemotaxis of inflammatory cells to the cyst. However, the parasite can deal efficiently with MMP-9, overview
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?
additional information
?
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may be responsible for the pathological degradation and/or normal turnover of vitronectin
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?
additional information
?
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possible role of the enzyme in the structural tissue remodeling of the developing embryo
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?
additional information
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plays a role in tumor cell invasion and in destruction of cartilage in arthritis
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?
additional information
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enzyme may play a role in the destruction of the extracellular matrix, perhaps acting in concert with the metalloproteases produced by activated endothelial cells
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?
additional information
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associated with degradation of the extracellular matrix in normal and pathological conditions
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?
additional information
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central role in the degradation of the extracellular matrix
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?
additional information
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leading role in the catabolism of the macromolecular components of the extracellular matrix in a variety of normal and pathological processes, involved in inflammation, tissue remodeling and cancer
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?
additional information
?
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cells resistant to protein kinase C potentiated, transkription factor p53 mediated apoptosis express a higher level of matrix metalloproteinases MMP-9 and MMP-10. Matrix metalloproteinases function confers protection from protein kinase C/p53 induced apoptosis and are implicated in tumor cell resistance
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?
additional information
?
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collagen binding domains of matrix metalloproteinases MMP-2 and MMP-9 bind the same or closely positioned sites on type I collagen
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?
additional information
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enzyme and leucocyte elastase are essential for granulocyte-mediated proteolysis resulting in dermal-epidermal separation in epidermolysis bullosa acquisita and bullous pemphigoid patients skin
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?
additional information
?
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activated MMP-9 initially induces conformational changes in platelet membranes, affecting membrane fluidity, and hydroxyl radical formation and inhibits the Na+/H+ pump, both leading to inhibition of platelet aggregation, the latter via reduced Ca2+ mobilization, overview. MMP-9 also inhibits arachidonic acid, ADP, and U46619 inducetion of platelet aggregation, overview
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?
additional information
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activation of MMP-9 may contribute to dentin matrix degradation, which occurs during caries progression and follows resin bonding. Inhibition of MMP-9 proteolytic activity may slow caries progression and increase the durability of resin-dentin bond, overview
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additional information
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gelatinase B expression is a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy, overview
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additional information
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MMP-9 activity is associated with poor prognosis in T3-T4 node-negative colorectal cancer, its expression is not correlated with MMP-2 and reversion-inducing cysteine-rich protein, RECK, expression in cancer cells, overview
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additional information
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MMP-9 expression is increased in cancers, inhibition of MMP-9 has a therapeutic benefit to cancer
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additional information
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MMP-9 is activated by monomeric hemin and by MMP-3 cleaving at Glu40-Met41 and Arg87-Phe88, and at Glu40-Met41 and Leu52-Leu53, respectively, no effect by hemoglobin, overview
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?
additional information
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MMP-9 is involved in development of endometriosis, MMP-9 levels are decreased by about 50% after operation of endometriosis, overview
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additional information
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MMP-9 is secreted by macrophages at wound sites and is involved in wound repair together with relaxin, molecular mechanism, overview. Transcription factor NF-kappaB is important in MMP gene regulation in macrophage cells, overview, relaxin-induced tissue remodeling through increasing MMP-9 expression is dependent on NF-kappaB activation
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?
additional information
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the enzyme is involved in breakdown of extracellular matrix components, and basement membrane disruption, stroma and blood vessel penetration, and metastasis. It participates in tumor growth and angiogensis, overview
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?
additional information
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acrolein subtypes A and C from cigarette smoke induces persistent mucin production via activation of matrix metalloproteinase 9 through induction of pro-MMP-9 cleavage and activation and EGFR/MAPK signaling also leading to MMP-9 activation, regulation, overview
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?
additional information
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gastric gelatinase B is rapidly increased in Helicobacter felis-infected mice and is involved in induction of gastritis
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additional information
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MMP-9 activity plays a central role in modulating the clinical course and severity of respiratory tularemia, Pro-Gly-Pro, a potent neutrophil chemotactic tripeptide, is released from extracellular matrix through the action of MMP-9, MMP-9 is involved in leukocyte recruitment, pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression, MMP-9 is associated with higher bacterial burdens in pulmonary and extrapulmonary tissues, development of more extensive histopathology predominated by neutrophils, and increased morbidity and mortality compared to mice lacking MMP-9
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?
additional information
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MMP-9 inhibitor completely inhibits PAF-induced B16F10 metastasis
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additional information
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MMP-9 is essential for neutrophil infiltration during zymosan peritonitis
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additional information
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MMP-9 is involved in murine peritonitis by participating in cellular migration, molecular mechanism, overview
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additional information
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MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview
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?
additional information
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nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways, Sper/NO shows biphasic regulation of MMP-9 inactivated macrophages, overview
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?
additional information
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MMP-9 is involved in murine peritonitis by participating in cellular migration, molecular mechanism, overview
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?
additional information
?
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MMP-9 plays an important role in degradation of gastric extracellular matrix proteins, MMP-9 is reduced by melatonin produced during gastric ulcer development, overview
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?
additional information
?
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gastric gelatinase B is rapidly increased in Helicobacter felis-infected mice and is involved in induction of gastritis
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?
additional information
?
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MMP-9 is essential for neutrophil infiltration during zymosan peritonitis
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?
additional information
?
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nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways, Sper/NO shows biphasic regulation of MMP-9 inactivated macrophages, overview
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?
additional information
?
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MMP-9 activity plays a central role in modulating the clinical course and severity of respiratory tularemia, Pro-Gly-Pro, a potent neutrophil chemotactic tripeptide, is released from extracellular matrix through the action of MMP-9, MMP-9 is involved in leukocyte recruitment, pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression, MMP-9 is associated with higher bacterial burdens in pulmonary and extrapulmonary tissues, development of more extensive histopathology predominated by neutrophils, and increased morbidity and mortality compared to mice lacking MMP-9
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?
additional information
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enzyme may be necessary for initiating or completing degradation of type I/type V copolymeric fibrils for growth and remodeling of extracellular collagen
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additional information
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independent of its proteolytic function, enzyme has a biphasic effect on smooth muscle cell-mediated collagen gel contraction
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additional information
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astrocyte-released MMP-9 is involved in interleukin-1beta induced neurotoxicity, probably via urokinase plasminogen activator, overview
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additional information
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inhibition of MMP-9 prevents neutrophilic inflammation in ventilator-induced lung injury, VILI, and pulmonary hemorrhage, overview
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additional information
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myogenic reactivity, inhibited in small renal arteries isolated from nonpregnant rats treated with recombinant human relaxin, is completely restored by incubation with MMP-9, MMP-9 rather than MMP-2 plays a central role in the vasodilatory effect of short-term relaxin administration, overview
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