Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | MMP-9-/- mice show reduced bacterial burdens in pulmonary and extrapulmonary tissues, less extensive histopathology predominated by neutrophils, and decreased morbidity and mortality compared to wild-type mice, MMP-9-/- mice are able to resolve infection with either the virulence-attenuated type B, live vaccine strain, or the highly virulent type A strain of Francisella tularensis, overview | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus | |
Zn2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Mus musculus | - |
? | - |
? | |
Gelatin + H2O | Mus musculus FVB/NJ | - |
? | - |
? | |
additional information | Mus musculus | MMP-9 activity plays a central role in modulating the clinical course and severity of respiratory tularemia, Pro-Gly-Pro, a potent neutrophil chemotactic tripeptide, is released from extracellular matrix through the action of MMP-9, MMP-9 is involved in leukocyte recruitment, pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression, MMP-9 is associated with higher bacterial burdens in pulmonary and extrapulmonary tissues, development of more extensive histopathology predominated by neutrophils, and increased morbidity and mortality compared to mice lacking MMP-9 | ? | - |
? | |
additional information | Mus musculus FVB/NJ | MMP-9 activity plays a central role in modulating the clinical course and severity of respiratory tularemia, Pro-Gly-Pro, a potent neutrophil chemotactic tripeptide, is released from extracellular matrix through the action of MMP-9, MMP-9 is involved in leukocyte recruitment, pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression, MMP-9 is associated with higher bacterial burdens in pulmonary and extrapulmonary tissues, development of more extensive histopathology predominated by neutrophils, and increased morbidity and mortality compared to mice lacking MMP-9 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
FVB/NJ mice | - |
Mus musculus FVB/NJ | - |
FVB/NJ mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | activated, MMP-9 secretion | Mus musculus | - |
neutrophil | MMP-9 secretion | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
Gelatin + H2O | gelatin zymography | Mus musculus | ? | - |
? | |
Gelatin + H2O | - |
Mus musculus FVB/NJ | ? | - |
? | |
Gelatin + H2O | gelatin zymography | Mus musculus FVB/NJ | ? | - |
? | |
additional information | MMP-9 activity plays a central role in modulating the clinical course and severity of respiratory tularemia, Pro-Gly-Pro, a potent neutrophil chemotactic tripeptide, is released from extracellular matrix through the action of MMP-9, MMP-9 is involved in leukocyte recruitment, pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression, MMP-9 is associated with higher bacterial burdens in pulmonary and extrapulmonary tissues, development of more extensive histopathology predominated by neutrophils, and increased morbidity and mortality compared to mice lacking MMP-9 | Mus musculus | ? | - |
? | |
additional information | MMP-9 activity plays a central role in modulating the clinical course and severity of respiratory tularemia, Pro-Gly-Pro, a potent neutrophil chemotactic tripeptide, is released from extracellular matrix through the action of MMP-9, MMP-9 is involved in leukocyte recruitment, pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, induces MMP-9 expression, MMP-9 is associated with higher bacterial burdens in pulmonary and extrapulmonary tissues, development of more extensive histopathology predominated by neutrophils, and increased morbidity and mortality compared to mice lacking MMP-9 | Mus musculus FVB/NJ | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase 9 | - |
Mus musculus |
MMP-9 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |