Literature summary for 3.4.24.35 extracted from

Choi, J.H.; Han, E.H.; Hwang, Y.P.; Choi, J.M.; Choi, C.Y.; Chung, Y.C.; Seo, J.K.; Jeong, H.G.
Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression (2010), Food Chem. Toxicol., 48, 564-571.

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Activating Compound

Activating Compound	Comment	Organism	Structure
phorbol 12-myristate 13-acetate	30 nM 12-phorbol 13-myristate acetate is used to activate MMP-9, aqueous extract isolated from Prunella vulgaris reduces 12-phorbol 13-myristate acetate-induced activation of MMP-9	Mus musculus
phorbol 12-myristate 13-acetate	30 nM 12-phorbol 13-myristate acetate is used to activate MMP-9, aqueous extract isolated from Prunella vulgaris reduces 12-phorbol 13-myristate acetate-induced activation of MMP-9	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
B16-F1 cell	-	Mus musculus	-
B16-F10 cell	-	Mus musculus	-
HT-1080 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gelatin + H2O	-	Mus musculus	?	-	?
Gelatin + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
matrix metalloproteinase-9	-	Mus musculus
matrix metalloproteinase-9	-	Homo sapiens
MMP-9	-	Mus musculus
MMP-9	-	Homo sapiens

Expression

Organism	Comment	Expression
Mus musculus	aqueous extract isolated from Prunella vulgaris suppresses 12-phorbol 13-myristate acetate-enhanced expression of MMP-9 protein, mRNA and transcription activity levels through suppression of nuclear factor-kappaB activation	down
Homo sapiens	aqueous extract isolated from Prunella vulgaris suppresses 12-phorbol 13-myristate acetate-enhanced expression of MMP-9 protein, mRNA and transcription activity levels through suppression of nuclear factor-kappaB activation	down

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Release 2023.1 (January 2023)