Literature summary for 3.4.24.35 extracted from

Solakivi, T.; Kunnas, T.; Kaerkkaeinen, S.; Jaakkola, O.; Nikkari, S.T.
Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells (2009), Lipids Health Dis., 8, 11.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	0.001-0.04 mM arachidonic acid increases matrix metalloproteinase 9 secretion and expression at the mRNA level	Homo sapiens
additional information	eicosapentaenoic acid, docosapentaenoic acid or docosahexaenoic acid by themselves have no effect on MMP-9 secretion	Homo sapiens
phorbol 12-myristate 13-acetate	the effect of phorbol 12-myristate 13-acetate (1.3 nM), a known activator of MMP-9 secretion, is about 10fold greater than that of 0.01 mM arachidonic acid. Addition of 0.001 mM and 0.01 mM arachidonic acid, eicosapentaenoic acid or docosapentaenoic acid along with phorbol 12-myristate 13-acetate does not affect MMP-9 production.	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Mono-Mac-6 cell	-	Homo sapiens	-
monocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gelatin + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
gelatinase B	-	Homo sapiens
matrix metalloproteinase-9	-	Homo sapiens
MMP-9	-	Homo sapiens

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Release 2023.1 (January 2023)