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Literature summary for 3.4.24.35 extracted from

  • Deshmukh, H.S.; Shaver, C.; Case, L.M.; Dietsch, M.; Wesselkamper, S.C.; Hardie, W.D.; Korfhagen, T.R.; Corradi, M.; Nadel, J.A.; Borchers, M.T.; Leikauf, G.D.
    Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production (2008), Am. J. Respir. Cell Mol. Biol., 38, 446-454.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.35

Activating Compound

Activating Compound Comment Organism Structure
acrolein activates MMP-9 via EGFR/MAPK signaling and stimulation of pro-MMP-9 cleavage Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Mus musculus
Zn2+
-
 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
86000
-
 x * 103000, about, pro-MMP9, SDS-PAGE, x * 86000, about, activated MMP-9, SDS-PAGE Mus musculus
103000
-
 x * 103000, about, pro-MMP9, SDS-PAGE, x * 86000, about, activated MMP-9, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Mus musculus
-
 ?
-
 ?
additional information Mus musculus acrolein subtypes A and C from cigarette smoke induces persistent mucin production via activation of matrix metalloproteinase 9 through induction of pro-MMP-9 cleavage and activation and EGFR/MAPK signaling also leading to MMP-9 activation, regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification acrolein stimulates pro-MMP-9 cleavage and activation Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-
respiratory tract
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Mus musculus ?
-
 ?
Gelatin + H2O gelatin zymography Mus musculus ?
-
 ?
additional information acrolein subtypes A and C from cigarette smoke induces persistent mucin production via activation of matrix metalloproteinase 9 through induction of pro-MMP-9 cleavage and activation and EGFR/MAPK signaling also leading to MMP-9 activation, regulation, overview Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 103000, about, pro-MMP9, SDS-PAGE, x * 86000, about, activated MMP-9, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 9
-
 Mus musculus
MMP-9
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus