3.4.24.16: neurolysin

This is an abbreviated version!
For detailed information about neurolysin, go to the full flat file.

Word Map on EC 3.4.24.16

Reaction

Preferential cleavage in neurotensin: Pro10-/-Tyr =

Synonyms

More, neurotensin endopeptidase, peptidase, neurotensin endo, endopeptidase 24.16, oligopeptidase M, peptidase, neurotensin endo-, thimet peptidase II, MOP, EP24.16c, EP24.16m, endopeptidase 24.16B, MEP, Microsomal endopeptidase, SABP, Soluble angiotensin-binding protein, ep24.16, thimet oligopeptidase II, soluble angiotensin II-binding protein, NEL, EP 24.16, neurolisin, neurolysin, Nln, mitochondrial peptidase, endopeptidase 3.4.24.16, neurotensin-cleaving enzyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.16 neurolysin

Inhibitors

Inhibitors on EC 3.4.24.16 - neurolysin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R)-2-[(4-biphenylylsulfonyl)amino]-3-phenylpropionic acid
-
-
(2R)-[(4-biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide
-
-
1,10-phenanthroline
1-adamantan-2-yl-3-[2-[2,3-bis-(2-chloro-phenyl)-pyrazolidin-1-yl]-2-oxo-ethyl]-urea
racemic
3-(4-phenoxyphenylsulfonyl)-propylthiirane
-
-
3-[(2S)-1-[(3R)-3-(2-chlorophenyl)-2-(2-fluorophenyl)pyrazolidin-1-yl]-1-oxopropan-2-yl]-1-(adamantan-2-yl)urea
R-stereomer, allosteric inhibition of neurolysin, mixed-type inhibition kinetics, the bound inhibitor disrupts activity by preventing a hinge-like motion associated with substrate binding and catalysis. The inhibitor reverses a substrate-associated conformational change
acetyl-neurotensin(8-13)
acetyl-neurotensin(8-13)aminde
-
degradation of tritiated neurotensin
agaricoglyceride A
-
main active principle of the crude extract of Agaricus macrosporus shows strong activity against neurolysin
agaricoglyceride B
-
agaricoglyceride C, agaricoglyceride D, known cometabolites agaricic ester show no activity against neurolysin up to 0.01 mM
alpha-melanotrophin-stimulating hormone
-
weak
angiotensin I
angiotensin II
Arg-Pro
-
-
Arg-Pro-Pro
bombesin
-
weak
bradykinin
carboxy-2-phenylethyl-Ala-Ala-Phe-4-aminobenzoate
-
-
carboxyphenylethyl-Ala-Ala-Phe-4-aminobenzoate
carboxyphenylethyl-Ala-Ala-Tyr-4-aminobenzoate
-
-
cPP-Ala-Ala-Tyr-pAB
dithiothreitol
dynorphin A(1-13)
-
-
dynorphin A1-13
-
inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
dynorphin(1-8)
-
degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl
dynorphin(1-9)
-
degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl
H-Cys1-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys10-OH
-
-
HONHCO-CH2-CH(CH2-C6H5)CO-Ile-Ala
-
potent and selective inhibitor of neurolysin
iodoacetamide
JMV390-1
kinetensin
-
degradation of 3-carboxy-7-methoxycoumaryl-Pro-Leu-Gly-Pro-D-Lys-dinitrophenyl
-
leupeptin
LVVYPWTQRY
-
inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
Mcc-Pro-Leu
molecular inhibitors of Gbetagama-dimer function
-
strain-dependent increases in EP24.16 activity are substantially attenuated by betaARK.ct by 86.4%
-
molecular inhibitors of Gialpha-subunit function
-
force-dependent increase in cellular EP24.16 activity is strongly attenuated by Gialpha1-G202T by 69.6% and Gialpha2-G203T by 101.7%, whereas Gialpha2-G202T has no significant effect
-
N-(1(R,S)-carboxy-3-phenylpropyl)-Ala-Ala-Tyr-p-aminobenzoate
-
inhibits EP24.16 resulting in a 1000fold increase in type-2 BK receptor sensitivity to bradykinin as measured by inositol phosphate accumulation
N-(phenylethylphosphonyl)-Gly-L-Pro-L-aminohexanoic acid
-
-
N-(phenylethylphosphonyl)-Gly-Pro-L-norleucine
-
-
N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-4-aminobenzoate
-
-
N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-4-aminobenzoate
-
-
N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Pro-Phe-4-aminobenzoate
-
-
Neuromedin N
neurotensin
neurotensin(8-13)
-
degradation of tritiated neurotensin
neurotensin(9-13)
NF023
-
attenuates the strain-dependent elevation of endopeptidase activity by 82.2%
o-phenanthroline
phosphodiepryl 03
-
-
phosphodiepryl 08
phosphodiepryl 21
phosphodiepryl 33
Pro-DL-Phe-Psi(PO2CH2)-Gly-Pro-NH2
-
-
Pro-Ile
Pro-L-PhePsi(PO2CH2)Gly-Pro
Pro-Phe-PSI(PO2CH2)Gly-Pro
-
potent and selective inhibitor of neurolysin
Pro-Phe-PSI(PO2CH2)Leu-Pro-NH2
-
potent and selective inhibitor of neurolysin
Pro-Xaa dipeptides
-
most potent inhibitors, Xaa-Pro dipeptides are ineffective
PTX
-
completely attenuates the cyclic strain-dependent increase in endopeptidase activity
-
PVNFKFLSH
-
inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
S-nitroso-N-acetylpenicillamine
-
inhibition is prevented by DTT
Somatostatin
-
weak
Substance P
Tuftsin
-
weak
VVYPWTQRY
-
inhibits hydrolysis of 7-methoxycoumarin-4-acetyl-Pro-Leu-Gly-Pro-D-Lys-(2,4-dinitrophenyl)
Xenopsin
[acetylPhe12]neurotensin(8-13)
-
degradation of tritiated neurotensin
[Ala12]neurotensin(8-13)
-
degradation of tritiated neurotensin
[Ala13]neurotensin(8-13)
-
degradation of tritiated neurotensin
[D-Arg8]neurotensin(8-13)
-
degradation of tritiated neurotensin
[D-Arg9]neurotensin(8-13)
-
degradation of tritiated neurotensin
[D-Leu11]neurotensin
-
degradation of tritiated neurotensin
[D-Phe11]neurotensin
-
degradation of tritiated neurotensin
[D-Trp11]neurotensin
-
degradation of tritiated neurotensin
[D-Tyr11]neurotensin
-
degradation of tritiated neurotensin
[D-Tyr3]neurotensin
-
degradation of tritiated neurotensin
[Dopa11]neurotensin
-
degradation of tritiated neurotensin
[His11]neurotensin
-
degradation of tritiated neurotensin
[naphthylalanyl11]neurotensin(8-13)
-
degradation of tritiated neurotensin
[Phe11]neurotensin
-
degradation of tritiated neurotensin
[Ser11]neurotensin(8-13)
-
degradation of tritiated neurotensin
[Thr11]neurotensin
-
degradation of tritiated neurotensin
[Trp11]neurotensin
-
degradation of tritiated neurotensin
[Tyr-ethyl ester11]neurotensin(8-13)
-
degradation of tritiated neurotensin
[Tyr13]neurotensin(8-13)
-
degradation of tritiated neurotensin
additional information
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