Crystallization (Comment) | Organism |
---|---|
crystal structure analysis and comparisons, overview | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
606A | a cleavage site mutant with altered substrate specificity | Rattus norvegicus |
Y606F | a cleavage site mutant with altered substrate specificity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Pro-Ile | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-GDSPFRQ-EDDnp + H2O | - |
Rattus norvegicus | Abz-GDSP + FRQ-EDDnp | - |
? | |
Abz-GESPFRQ-EDDnp + H2O | - |
Rattus norvegicus | Abz-GESP + FRQ-EDDnp | - |
? | |
Abz-GGSPFRQEDDnp + H2O | - |
Rattus norvegicus | Abz-GGSP + FRQ-EDDnp | - |
? | |
Abz-GPSPFRQ-EDDnp + H2O | - |
Rattus norvegicus | Abz-GPSP + FRQ-EDDnp | - |
? | |
additional information | the catalytic site, with the active site sequence motif HEXXH, is located in a deep channel that provides access only to short peptides, but NEL shows a broad substrate specificity, in part due to the presence of a flexible loop lined with the enzyme binding site of the peptidase | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | structure analysis and comparisons, modelling, overview | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the M3A family | Rattus norvegicus |
NEL | - |
Rattus norvegicus |
neurolisin | - |
Rattus norvegicus |