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Literature summary for 3.4.24.16 extracted from

  • Lorenzon, R.Z.; Cunha, C.E.; Marcondes, M.F.; Machado, M.F.; Juliano, M.A.; Oliveira, V.; Travassos, L.R.; Paschoalin, T.; Carmona, A.K.
    Kinetic characterization of the Escherichia coli oligopeptidase A (OpdA) and the role of the Tyr(607) residue (2010), Arch. Biochem. Biophys., 500, 131-136.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure analysis and comparisons, overview Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
606A a cleavage site mutant with altered substrate specificity Rattus norvegicus
Y606F a cleavage site mutant with altered substrate specificity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Pro-Ile
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-GDSPFRQ-EDDnp + H2O
-
Rattus norvegicus Abz-GDSP + FRQ-EDDnp
-
?
Abz-GESPFRQ-EDDnp + H2O
-
Rattus norvegicus Abz-GESP + FRQ-EDDnp
-
?
Abz-GGSPFRQEDDnp + H2O
-
Rattus norvegicus Abz-GGSP + FRQ-EDDnp
-
?
Abz-GPSPFRQ-EDDnp + H2O
-
Rattus norvegicus Abz-GPSP + FRQ-EDDnp
-
?
additional information the catalytic site, with the active site sequence motif HEXXH, is located in a deep channel that provides access only to short peptides, but NEL shows a broad substrate specificity, in part due to the presence of a flexible loop lined with the enzyme binding site of the peptidase Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
More structure analysis and comparisons, modelling, overview Rattus norvegicus

Synonyms

Synonyms Comment Organism
More the enzyme belongs to the M3A family Rattus norvegicus
NEL
-
Rattus norvegicus
neurolisin
-
Rattus norvegicus