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3.4.24.16: neurolysin

This is an abbreviated version!
For detailed information about neurolysin, go to the full flat file.

Word Map on EC 3.4.24.16

Reaction

Preferential cleavage in neurotensin: Pro10-/-Tyr =

Synonyms

endopeptidase 24.16, endopeptidase 24.16B, endopeptidase 3.4.24.16, EP 24.16, ep24.16, EP24.16c, EP24.16m, MEP, Microsomal endopeptidase, mitochondrial peptidase, MOP, More, NEL, neurolisin, neurolysin, neurotensin endopeptidase, neurotensin-cleaving enzyme, Nln, oligopeptidase M, peptidase, neurotensin endo, peptidase, neurotensin endo-, SABP, soluble angiotensin II-binding protein, Soluble angiotensin-binding protein, thimet oligopeptidase II, thimet peptidase II

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.16 neurolysin

Disease

Disease on EC 3.4.24.16 - neurolysin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Characterization and localization of mitochondrial oligopeptidase (MOP) (EC 3.4.24.16) activity in the human cervical adenocarcinoma cell line HeLa.
Brain Ischemia
Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice.
Carcinoma
The role of metalloendopeptidases in oropharyngeal carcinomas assessed by tissue microarray.
Carcinoma, Squamous Cell
The role of metalloendopeptidases in oropharyngeal carcinomas assessed by tissue microarray.
Colorectal Neoplasms
Discovery of Cell-Type-Specific and Disease-Related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism.
Hearing Loss
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Hyperalgesia
Metallopeptidase inhibition potentiates bradykinin-induced hyperalgesia.
Hypertension
Metalloendopeptidases EC 3.4.24.15 and EC 3.4.24.16 and bradykinin B2 receptors do not play important roles in renal wrap hypertension in rabbits.
Hypotension
A novel stable inhibitor of endopeptidases EC 3.4.24.15 and 3.4.24.16 potentiates bradykinin-induced hypotension.
Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin.
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.
Infarction, Middle Cerebral Artery
Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain.
Infertility
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Ischemic Stroke
Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice.
The role of peptidase neurolysin in neuroprotection and neural repair after stroke.
Leukemia, Myeloid, Acute
Targeting neurolysin in acute myeloid leukemia.
The role of mitochondrial proteases in leukemic cells and leukemic stem cells.
Melanoma
Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth.
Neoplasm Metastasis
Metallopeptidase, neurolysin, as a novel molecular tool for analysis of properties of cancer-producing matrix metalloproteinases-2 and -9.
Neoplasms
Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth.
Long-Range Changes in Neurolysin Dynamics Upon Inhibitor Binding.
Metallopeptidase, neurolysin, as a novel molecular tool for analysis of properties of cancer-producing matrix metalloproteinases-2 and -9.
Nervous System Diseases
Long-Range Changes in Neurolysin Dynamics Upon Inhibitor Binding.
Neurodegenerative Diseases
Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders.
Stroke
Experimental stroke: neurolysin back on stage.
Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain.
Peptidase neurolysin: Its function related to the brain renin-angiotensin system and pathophysiology of stroke. Letter to the Editor.
The role of peptidase neurolysin in neuroprotection and neural repair after stroke.