3.4.24.16: neurolysin

This is an abbreviated version!
For detailed information about neurolysin, go to the full flat file.

Word Map on EC 3.4.24.16

Reaction

Preferential cleavage in neurotensin: Pro10-/-Tyr =

Synonyms

More, neurotensin endopeptidase, peptidase, neurotensin endo, endopeptidase 24.16, oligopeptidase M, peptidase, neurotensin endo-, thimet peptidase II, MOP, EP24.16c, EP24.16m, endopeptidase 24.16B, MEP, Microsomal endopeptidase, SABP, Soluble angiotensin-binding protein, ep24.16, thimet oligopeptidase II, soluble angiotensin II-binding protein, NEL, EP 24.16, neurolisin, neurolysin, Nln, mitochondrial peptidase, endopeptidase 3.4.24.16, neurotensin-cleaving enzyme

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.16 neurolysin

Reference

Reference on EC 3.4.24.16 - neurolysin

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dahms, P.; Mentlein, R.
Purification of the main somatostatin-degrading proteases from rat and pig brains, their action on other neuropeptides, and their identification as endopeptidases 24.15 and 24.16
Eur. J. Biochem.
208
145-154
1992
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Rioli, V.; Kato, A.; Portaro, F.C.V.; Cury, G.K.; te Kaat, K.; Vincent, B.; Checler, F.; Camargo, A.C.M.; Glucksman, M.J.; Roberts, J.L.; Hirose, S.; Ferro, E.S.
Neuropeptide specificity and inhibition of recombinant isoforms of the endopeptidase 3.4.24.16 family: comparison with the related recombinant endopeptidase 3.4.24.15
Biochem. Biophys. Res. Commun.
250
5-11
1998
Sus scrofa
Manually annotated by BRENDA team
Barrett, A.J.; Brown, M.A.; Dando, P.M.; Knight, C.G.; McKie, N.; Rawlings, N.D.; Serizawa, A.
Thimet oligopeptidase and oligopeptidase M or neurolysin
Methods Enzymol.
248
529-556
1995
Rattus norvegicus
Manually annotated by BRENDA team
Checler, F.; Vincent, J.P.; Kitabgi, P.
Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes
J. Biol. Chem.
261
11274-11281
1986
Rattus norvegicus
Manually annotated by BRENDA team
Checler, F.; Barelli, H.; Vincent, J.P.
Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies
Biochem. J.
257
549-554
1989
Rattus norvegicus
Manually annotated by BRENDA team
Yoshikawa, S.; Tashiro, T.; Takahashi, K.
Specificity of action on neuropeptides of an endopeptidase from the synaptosomal membranes of guinea pig brain
J. Biochem.
104
1007-1010
1988
Cavia porcellus
Manually annotated by BRENDA team
Barelli, H.; Vincent, J.P.; Checler, F.
Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum
Eur. J. Biochem.
175
481-489
1988
Rattus norvegicus
Manually annotated by BRENDA team
Vincent, B.; Vincent, J.P.; Checler, F.
Purification and characterization of human endopeptidase 3.4.24.16. Comparison with the porcine counterpart indicates a unique cleavage site on neurotensin
Brain Res.
709
51-58
1996
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Vincent, B.; Beaudet, A.; Dauch, P.; Vincent, J.P.; Checler, F.
Distinct properties of neuronal and astrocytic endopeptidase 3.4.24.16: a study on differentiation, subcellular distribution, and secretion processes
J. Neurosci.
16
5049-5059
1996
Mus musculus
Manually annotated by BRENDA team
Krause, D.R.; Piva, T.J.; Brown, S.B.; Ellem, K.A.O.
Characterization and localization of mitochondrial oligopeptidase (MOP) (EC 3.4.24.16) activity in the human cervical adenocarcinoma cell line HeLa
J. Cell. Biochem.
66
297-308
1997
Homo sapiens
Manually annotated by BRENDA team
Rodd, D.; Hersh, L.B.
Endopeptidase 24.16B. A new variant of endopeptidase 24.16
J. Biol. Chem.
270
10056-10061
1995
Rattus norvegicus
Manually annotated by BRENDA team
Dauch, P.; Vincent, J.P.; Checler, F.
Specific inhibition of endopeptidase 24.16 by dipeptides
Eur. J. Biochem.
202
269-276
1991
Rattus norvegicus
Manually annotated by BRENDA team
Checler, F.; Barelli, H.; Dauch, P.; Vincent, B.; Dive, V.; Beaudet, A.; Daniel, E.E.; Fox-Threlkeld, J.E.T.; Masuo, Y.; Vincent, J.P.
Recent advances on endopeptidase-3.4.24.16
Biochem. Soc. Trans.
21
692-697
1993
Rattus norvegicus
Manually annotated by BRENDA team
Barelli, H.; Fox-Threlkeld, J.E.T.; Dive, V.; Daniel, E.E.; Vincent, J.P.; Checler, F.
Role of endopeptidase 3.4.24.16 in the catabolism of neurotensin, in vivo, in the vascularly perfused dog ileum
Br. J. Pharmacol.
112
127-132
1994
Canis lupus familiaris
Manually annotated by BRENDA team
Mentlein, R.; Dahms, P.
Endopeptidases 24.16 and 24.15 are responsible for the degradation of somatostatin, neurotensin, and other neuropeptides by cultivated rat cortical astrocytes
J. Neurochem.
62
27-36
1994
Rattus norvegicus
Manually annotated by BRENDA team
Vincent, B.; Dauch, P.; Vincent J.P.; Checler, F.
Stably transfected human cells overexpressing rat brain endopeptidase 3.4.24.16: biochemical characterization of the activity and expression of soluble and membrane-associated counterparts
J. Neurochem.
68
837-845
1997
Rattus norvegicus
Manually annotated by BRENDA team
Millican, P.E.; Kenny, A.J.; Turner, A.J.
Purification and properties of a neurotensin-degrading endopeptidase from pig brain
Biochem. J.
276
583-591
1991
Sus scrofa
Manually annotated by BRENDA team
Serizawa, A.; Dando, P.M.; Barrett, A.J.
Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase
J. Biol. Chem.
276
2092-2098
1995
Rattus norvegicus
Manually annotated by BRENDA team
Dauch, P.; Vincent, J.P.; Checler, F.
Molecular cloning and expression of rat brain endopeptidase 3.4.24.16
J. Biol. Chem.
270
27266-27271
1995
Rattus norvegicus
Manually annotated by BRENDA team
Barelli, H.; Vincent, J.P.; Checler, F.
Rat kidney endopeptidase 24.16. Purification, physico-chemical characteristics and differential specificity towards opiates, tachykinins and neurotensin-related peptides
Eur. J. Biochem.
211
79-90
1993
Rattus norvegicus
Manually annotated by BRENDA team
Lian, W.; Chen, G.; Wu, D.; Brown, C.K.; Madauss, K.; Hersh, L.B.; Rodgers, D.W.
Crystallization and preliminary analysis of neurolysin
Acta Crystallogr. Sect. D
56
1644-1646
2000
Rattus norvegicus
-
Manually annotated by BRENDA team
Oliveira, V.; Campos, M.; Hemerly, J.P.; Ferro, E.S.; Camargo, A.C.; Juliano, M.A.; Juliano, L.
Selective neurotensin-derived internally quenched fluorogenic substrates for neurolysin (EC 3.4.24.16): comparison with thimet oligopeptidase (EC 3.4.24.15) and neprilysin (EC 3.4.24.11)
Anal. Biochem.
292
257-265
2001
Sus scrofa
Manually annotated by BRENDA team
Oliveira, V.; Campos, M.; Melo, R.L.; Ferro, E.S.; Camargo, A.C.; Juliano, M.A.; Juliano, L.
Substrate specificity characterization of recombinant metallo oligo-peptidases thimet oligopeptidase and neurolysin
Biochemistry
40
4417-4425
2001
Sus scrofa
Manually annotated by BRENDA team
Oliveira, V.; Gatti, R.; Rioli, V.; Ferro, E.S.; Spisni, A.; Camargo, A.C.; Juliano, M.A.; Juliano, L.
Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase
Eur. J. Biochem.
269
4326-4334
2002
Sus scrofa
Manually annotated by BRENDA team
Rioli, V.; Gozzo, F.C.; Heimann, A.S.; Linardi, A.; Krieger, J.E.; Shida, C.S.; Almeida, P.C.; Hyslop, S.; Eberlin, M.N.; Ferro, E.S.
Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme
J. Biol. Chem.
278
8547-8555
2003
Rattus norvegicus
Manually annotated by BRENDA team
Cotter, E.J.; von Offenberg Sweeney, N.; Coen, P.M.; Birney, Y.A.; Glucksman, M.J.; Cahill, P.A.; Cummins, P.M.
Regulation of endopeptidases EC3.4.24.15 and EC3.4.24.16 in vascular endothelial cells by cyclic strain: role of Gi protein signaling
Arterioscler. Thromb. Vasc. Biol.
24
457-463
2004
Bos taurus
Manually annotated by BRENDA team
Machado, M.F.; Cunha, F.M.; Berti, D.A.; Heimann, A.S.; Klitzke, C.F.; Rioli, V.; Oliveira, V.; Ferro, E.S.
Substrate phosphorylation affects degradation and interaction to endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme
Biochem. Biophys. Res. Commun.
339
520-525
2006
More
Manually annotated by BRENDA team
Barrett, A.J.; Dando, P.M.
Neurolysin
Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
356-360
2004
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
-
Manually annotated by BRENDA team
Stadler, M.; Hellwig, V.; Mayer-Bartschmid, A.; Denzer, D.; Wiese, B.; Burkhardt, N.
Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin
J. Antibiot.
58
775-786
2005
Rattus norvegicus
Manually annotated by BRENDA team
Jeske, N.A.; Berg, K.A.; Cousins, J.C.; Ferro, E.S.; Clarke, W.P.; Glucksman, M.J.; Roberts, J.L.
Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia
J. Neurochem.
97
13-21
2006
Rattus norvegicus
Manually annotated by BRENDA team
Kadonosono, T.; Kato, M.; Ueda, M.
Metallopeptidase, neurolysin, as a novel molecular tool for analysis of properties of cancer-producing matrix metalloproteinases-2 and -9
Appl. Microbiol. Biotechnol.
75
1285-1291
2007
Rattus norvegicus
Manually annotated by BRENDA team
Kadonosono, T.; Kato, M.; Ueda, M.
Substrate specificity of rat brain neurolysin disclosed by molecular display system and putative substrates in rat tissues
Appl. Microbiol. Biotechnol.
75
1353-1360
2007
Rattus norvegicus
Manually annotated by BRENDA team
Machado, M.F.; Rioli, V.; Dalio, F.M.; Castro, L.M.; Juliano, M.A.; Tersariol, I.L.; Ferro, E.S.; Juliano, L.; Oliveira, V.
The role of Tyr605 and Ala607 of thimet oligopeptidase and Tyr606 and Gly608 of neurolysin in substrate hydrolysis and inhibitor binding
Biochem. J.
404
279-288
2007
Rattus norvegicus
Manually annotated by BRENDA team
Bertazolli-Filho, R.; Coca-Prados, M.; Haddad, A.; Laicine, E.M.
Molecular analysis of neurolysin expression in the rat and bovine ciliary body
Curr. Eye Res.
32
751-756
2007
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Lim, E.J.; Sampath, S.; Coll-Rodriguez, J.; Schmidt, J.; Ray, K.; Rodgers, D.W.
Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase
J. Biol. Chem.
282
9722-9732
2007
Rattus norvegicus
Manually annotated by BRENDA team
Paschoalin, T.; Carmona, A.K.; Rodrigues, E.G.; Oliveira, V.; Monteiro, H.P.; Juliano, M.A.; Juliano, L.; Travassos, L.R.
Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth
Mol. Cancer
6
44
2007
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Kitabgi, P.
Inactivation of neurotensin and neuromedin N by Zn metallopeptidases
Peptides
27
2515-2522
2006
Canis lupus familiaris, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Kadonosono, T.; Kato-Murai, M.; Ueda, M.
Alteration of substrate specificity of rat neurolysin from matrix metalloproteinase-2/9-type to -3-type specificity by comprehensive mutation
Protein Eng. Des. Sel.
21
507-513
2008
Rattus norvegicus
Manually annotated by BRENDA team
Lorenzon, R.Z.; Cunha, C.E.; Marcondes, M.F.; Machado, M.F.; Juliano, M.A.; Oliveira, V.; Travassos, L.R.; Paschoalin, T.; Carmona, A.K.
Kinetic characterization of the Escherichia coli oligopeptidase A (OpdA) and the role of the Tyr(607) residue
Arch. Biochem. Biophys.
500
131-136
2010
Rattus norvegicus
Manually annotated by BRENDA team
Wangler, N.J.; Santos, K.L.; Schadock, I.; Hagen, F.K.; Escher, E.; Bader, M.; Speth, R.C.; Karamyan, V.T.
Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC 3.4.24.16) as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site
J. Biol. Chem.
287
114-122
2012
Mus musculus
Manually annotated by BRENDA team
Swindle, J.D.; Santos, K.L.; Speth, R.C.
Pharmacological characterization of a novel non-AT1, non-AT2 angiotensin binding site identified as neurolysin
Endocrine
44
525-531
2013
Rattus norvegicus (P42676), Rattus norvegicus Sprague-Dawley (P42676)
Manually annotated by BRENDA team
Hines, C.S.; Ray, K.; Schmidt, J.J.; Xiong, F.; Feenstra, R.W.; Pras-Raves, M.; de Moes, J.P.; Lange, J.H.; Melikishvili, M.; Fried, M.G.; Mortenson, P.; Charlton, M.; Patel, Y.; Courtney, S.M.; Kruse, C.G.; Rodgers, D.W.
Allosteric inhibition of the neuropeptidase neurolysin
J. Biol. Chem.
289
35605-35619
2014
Rattus norvegicus (P42676)
Manually annotated by BRENDA team
Rashid, M.; Wangler, N.J.; Yang, L.; Shah, K.; Arumugam, T.V.; Abbruscato, T.J.; Karamyan, V.T.
Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain
J. Neurochem.
129
179-189
2014
Mus musculus
Manually annotated by BRENDA team
Wangler, N.J.; Jayaraman, S.; Zhu, R.; Mechref, Y.; Abbruscato, T.J.; Bickel, U.; Karamyan, V.T.
Preparation and preliminary characterization of recombinant neurolysin for in vivo studies
J. Biotechnol.
234
105-115
2016
Rattus norvegicus (P42676)
Manually annotated by BRENDA team
Teixeira, P.F.; Masuyer, G.; Pinho, C.M.; Branca, R.M.M.; Kmiec, B.; Wallin, C.; Waermlaender, S.K.T.S.; Berntsson, R.P.; Ankarcrona, M.; Graeslund, A.; Lehtioe, J.; Stenmark, P.; Glaser, E.
Mechanism of peptide binding and cleavage by the human mitochondrial peptidase neurolysin
J. Mol. Biol.
430
348-362
2018
Homo sapiens (Q9BYT8), Homo sapiens
Manually annotated by BRENDA team
Karamyan, V.T.
Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders
Med. Hypotheses
131
109309
2019
Mus musculus (Q91YP2)
Manually annotated by BRENDA team
Checler, F.; Ferro, E.S.
Neurolysin from initial detection to latest advances
Neurochem. Res.
43
2017-2024
2018
Bos taurus (A2VDQ5), Rattus norvegicus (P42676), Sus scrofa (Q02038), Mus musculus (Q91YP2), Homo sapiens (Q9BYT8), Mus musculus C57BL6 (Q91YP2)
Manually annotated by BRENDA team