Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | not activated by thiol compounds | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Rattus norvegicus |
Crystallization (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Rattus norvegicus | |
EDTA | - |
Rattus norvegicus | |
HONHCO-CH2-CH(CH2-C6H5)CO-Ile-Ala | potent and selective inhibitor of neurolysin | Rattus norvegicus | |
additional information | inhibitor of neurolysin potentiates the neurotensin-induced anti-nociception | Mus musculus | |
Pro-Ile | selective inhibitor of neurolysin, inhibition by milimolar concentrations | Rattus norvegicus | |
Pro-Phe-PSI(PO2CH2)Gly-Pro | potent and selective inhibitor of neurolysin | Rattus norvegicus | |
Pro-Phe-PSI(PO2CH2)Leu-Pro-NH2 | potent and selective inhibitor of neurolysin | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Sus scrofa | 5829 | - |
cytosol | shorter form of neurolysin, lacking the cleavable mitochondrial targeting sequence, remains in the cytosol | Rattus norvegicus | 5829 | - |
mitochondrion | - |
Sus scrofa | 5739 | - |
mitochondrion | longer form of neurolysin that contains a cleavable mitochondrial targeting sequence at the N-terminus | Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
78000 | - |
- |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Sus scrofa | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Sus scrofa | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Sus scrofa | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
lung | - |
Rattus norvegicus | - |
lung | - |
Sus scrofa | - |
spleen | - |
Rattus norvegicus | - |
spleen | - |
Sus scrofa | - |
testis | - |
Rattus norvegicus | - |
testis | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dynorphin A(1-17) + H2O | - |
Rattus norvegicus | ? | - |
? | |
neurotensin + H2O | cleavage at the Pro-Tyr bond | Rattus norvegicus | ? | - |
? | |
Pz-Pro-Leu-Gly-Pro-D-Arg + H2O | - |
Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
endopeptidase 24.16 | - |
Rattus norvegicus |
Microsomal endopeptidase | - |
Rattus norvegicus |
oligopeptidase M | - |
Rattus norvegicus |
soluble angiotensin II-binding protein | - |
Rattus norvegicus |
thimet oligopeptidase II | neurolysin is most likely to be confused with thimet oligopeptidase II, but it is distinguished by its lack of activation by thiol compounds, inhibition by millimolar concentrations of Pro-Ile, cleavage of neurotensin at the Pro-Tyr bond, and different mobility in column chromatography | Rattus norvegicus |