Cloned (Comment) | Organism |
---|---|
expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
JA-2 | almost complete inhibition at 0.003 mM | Mus musculus | |
additional information | no inhibition by bestatin, captopril, leupeptin, and E64, poor inhibition by PMSF and Z-Pro-prolinal | Mus musculus | |
o-phenanthroline | complete inhibition at 4 mM | Mus musculus | |
Pro-Ile | 48% inhibition at 1 mM | Mus musculus | |
S-nitroso-N-acetylpenicillamine | inhibition is prevented by DTT | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
bradykinin + H2O | Mus musculus | - |
? | - |
? | |
additional information | Mus musculus | the enzyme is involved in angiogenesis and tumor growth, overview | ? | - |
? | |
neurotensin + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B16F10-Nex2 cell | melanoma cell line | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
substrate specificity, and cell proliferation assay, overview | Mus musculus |
0.0088 | - |
purified recombinant enzyme, substrate peptide RPPGFSPFRQ | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-GFSIFR-EDDnp + H2O | - |
Mus musculus | Abz-GFSI + FR-EDDnp | - |
? | |
Abz-GFSPFR-EDDnp + H2O | - |
Mus musculus | Abz-GFS + PFR-EDDnp | - |
? | |
Abz-GFSPFRQ-EDDnp + H2O | - |
Mus musculus | Abz-GFSP + FRQ-EDDnp | - |
? | |
Abz-NKPRRPQ-EDDnp + H2O | - |
Mus musculus | Abz-NKPR + RPQ-EDDnp | - |
? | |
Abz-RPPGFSPFRQ-EDDnp + H2O | - |
Mus musculus | Abz-RPPGFS + PFRQ-EDDnp | - |
? | |
bradykinin + H2O | - |
Mus musculus | ? | - |
? | |
additional information | the enzyme is involved in angiogenesis and tumor growth, overview | Mus musculus | ? | - |
? | |
additional information | substrate and cleavage site specificity, overview, no activity with GFPPFRQ | Mus musculus | ? | - |
? | |
neurotensin + H2O | - |
Mus musculus | ? | - |
? | |
neurotensin + H2O | cleavage of Pro-Tyr bonds | Mus musculus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |